目录
更新日期:2023年3月10日
姓 名 王雪峰 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 专业型
最后学历 博士研究生毕业 最后学位 临床医学博士专业学位
行政职务 主任 Email 15913130306@163.com
工作单位 南方医科大学珠江医院 邮政编码 510630
个人简介

       王雪峰,主任医师,博士生导师,南方医科大学第三附属医院妇产科主任,兼任广东省自然医学研究会产后康复专业委员会主任委员、广东省健康管理协会生育力保护专委会副主任委员、广东省医学会妇产科分会青年委员会副主任委员、广东省泌尿生殖协会盆底学分会第二届委员会常务委员、广东省医师协会微创外科学分会第一届委员常务委员、广东省中西医结合学会妇瘤组常务委员。

       专攻妇科内分泌、不孕不育、卵巢早衰、多囊卵巢综合症等疾病的规范化系统化诊治,擅长宫腹腔镜微创技术对不孕不育及妇科恶性肿瘤的手术治疗。曾在美国亚利桑那州立大学博士后,凤凰城Maricopa Medical Center及亚利桑那州生殖中心Fertility Treatment Center 和Boston IVF访问学者。

       指导硕士研究生23名,博士生9名,承担国家自然科学基金1项及省级科研课题10余项,在国内外核心期刊发表论文50余篇,其中SCI收录20余篇,副主编及参编专著近10部。

       先后获评“实力中青年医生”、“羊城好医生”、“岭南名医”、“南方医科大学高被引学者”、“南方医科大学2021年教育教学成果奖二等奖”荣誉、中国医院人文品牌峰会2021年度“风尚人物”、南方医科大学第八届“立德树人好导师”、省级优秀教学成果奖。

研究领域

主要研究卵巢癌耐药、妇科内分泌、不孕不育、月经失调、多囊卵巢综合征等方向,对不孕症及妇科肿瘤等疾病的诊治具有丰富的临床经验,擅长宫腹腔镜微创手术在不孕不育及妇科肿瘤的临床治疗。

个人成果

(1) Cai X, Shi S, Chen G, Zhong M, Yang Y, Mai Z, Tian Y, Tan J, He L, Cui C, Yu Z, Wang X*(通讯作者). Glutamine metabolism targeting liposomes for synergistic chemosensitization and starvation therapy in ovarian cancer. Acta Biomater. 2022 Dec 31:S1742-7061(22)00865-0. doi: 10.1016/j.actbio.2022.12.052. Epub ahead of print. PMID: 36596434.(IF=10.633)

(2) Li G, Ling M, Yu K, Yang W, Liu Q, He L, Cai X, Zhong M, Mai Z, Sun R, Xiao Y, Yu Z, Wang X*(通讯作者). Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy. J Nanobiotechnology. 2022 Nov 5;20(1):471. doi: 10.1186/s12951-022-01676-3. PMID: 36335352; PMCID: PMC9636721.(IF=9.429)

(3) Yang Z, Fu H, Su H, Cai X, Wang Y, Hong Y, Hu J, Xie Z, Wang X*(通讯作者). Multi-omics analyses reveal the specific changes in gut metagenome and serum metabolome of patients with polycystic ovary syndrome. Front Microbiol. 2022;13:1017147.(IF: 6.064)

(4) Yang ZD#, Cai XZ#, Xu XX#, Xu ZM, Ye SM, Wang Y, Hong YJ, Shen BC, Liao QF, Xie ZY*, Wang XF*(通讯作者). Urinary metabolomics identified metabolic disturbance associated with polycystic ovary syndrome. Anal Biochem. 2022 23:114665. (IF: 3.365)

(5) Cai Xuzi., Wang Kang-Nan., Ma Wen., Yang Yuanyuan., Chen Gui., Fu Huijiao., Cui Chunhui., Yu Zhiqiang., Wang Xuefeng*(通讯作者). Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy. J Nanobiotechnology. 2021 Aug 23;19(1):254. (IF: 10.435)

(6) Li Guang, Liu Guobing, Wang Xuefeng*(通讯作者). PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.[J] .Biomed Res Int, 2021, 2021: 5512340. (IF: 3.411)

(7) Xie Ruirui., Yang Peipei., Liu Jiamin., Zou Xun., Tan Yilin., Wang Xuefeng*(共同通讯作者), Tao Jia., Zhao Peng. Lanthanide-functionalized metal-organic frameworks based ratiometric fluorescent sensor array for identification and determination of antibiotics. Talanta. 2021 Aug 15;231:122366.(SCI, IF 5.339)

(8) Li Yibing, Zhu Yilin, Cai Xuzi, Guo Jimin, Yao Cuiping, Pan Qiling, Wang Xuefeng*(共同通讯作者), Wang Kang-Nan. A benzothiazole-based near-infrared fluorescent probe for sensing SO derivatives and viscosity in HeLa cells.[J] .Spectrochim Acta A Mol Biomol Spectrosc, 2021, 251: 119457.(SCI, IF 3.232)

(9) Xuzi Cai,Huijiao Fu ,Yan Wang,Qiwen Liu, Xuefeng Wang *(通讯作者) . Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro.[J] .J Ovarian Res, 2020, 13: 136.(SCI, IF 2.989)

(10) Zhigang Chen, Xiaoxu Kang, Yixin Wu, Haihua Xiao, Xuzi cai, Shihou Sheng*, Xuefeng Wang *(共同通讯作者), Shiguo Chen*.A Mitochondria Targeting Artesunate Prodrug Loaded Nanoparticle Exerting Anticancer Acitivity via Iron-Mediated Generation of Reactive Oxygen Species. Chemical Communications.Pub Date:2019-03-20, DOI: 10.1039/C9CC00531E. (SCI, IF 6.29)

(11) Qiling Chen #,Yuanyuan Yang #, Xun Lin,Wen Ma,Gui Chen,Wenliang Li,Xuefeng Wang* (共同通讯作者) and Zhiqiang Yu *.Platinum( IV) prodrugs with long lipid chains for drug delivery and overcoming cisplatin resistance.Chem Commun (Camb).2018 May 22;54(42):5369-5372(SCI, IF 6.29)

(12) Zhou Chen, Cao Wu, Zhenfeng Zhang, Wangping Wu , Xuefeng Wang*(共同通讯作者), Zhiqiang Yu*. Synthesis, functionalization, and nanomedical applications of functional magnetic  nanoparticles[J]. Chinese Chemical Letters, Available online August 18th, 2018.(SCI, IF 2.631)

(13) Xuefeng Wang(王雪峰), Yuanli He, Mubiao Liu, Xiafei FU. Lentivirus-mediated bcl-2 gene therapy improves functions and structure of chemotherapy-damaged ovaries in rats . American Journal of Reproductive Immunology.2013,69(5):427–528.  (SCI,IF 3.05)

(14) Xuefeng Wang(王雪峰),Yue Yang, Yanbing Huang, Qiongyao Wang. Association study of polymorphism of  FXIIIVal34Leu gene and polycystic ovary syndrome.Int J Clin Exp Med 2014;7(11):4466-4470(SCI, IF 1.947)

(15) Peng Wu, Xuefeng Wang*(共同第一作者), Zigui Wang, Wen Ma, Jinshan Guo, Jianjun Chen, Zhiqiang Yu, Jizhen Li, and Dongfang Zhou.Light-Activatable Prodrug and AIEgen Copolymer Nanoparticle for Dual-Drug Monitoring and Combination Therapy[J].ACS Appl Mater Interfaces,,2019,11(20):18691-18700.(SCI, IF 8.097)

(16) Lu MZ#*, Li DY, Wang XF*(共同通讯作者). Effect of metformin use on the risk and prognosis of ovarian cancer: an updated systematic review and meta-analysis. Panminerva Med. 2019 Jul 8.(SCI, IF3.467)

(17) Yingmei Luo, Xuefeng Wang, Yi Cao. Transcriptomic-based toxicological investigations of graphene oxide with modest cytotoxicity to human umbilical vein endothelial cells: changes of Toll-like receptor signaling pathways. Toxicology Research. 2021 Oct 16;, tfab091, https://doi.org/10.1093/toxres/tfab091

(18) Lin Min., Weng Huinan., Wang Xuefeng., Zhou Bing., Yu Ping., Wang Yifeng. The role of tissue factor and protease-activated receptor 2 in endometriosis.[J] .Am J Reprod Immunol, 2012, 68: 251-7.(IF: 2.739)

(19) Fu Xiafei., He Yuanli., Wang Xuefeng., Peng Dongxian., Chen Xiaoying., Li Xinran., Wang Qing.(2017). Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis. Stem Cell Res Ther, 8(1), 187. (IF4.21)

(20) Yi X, Liu F, Gao K, Chen F, Wang Y, Li H, Wang X, Huang Y, Fu H, Zhou W, Fan JB, Wang S, Gao Y. Reconstructable Uterus-Derived Materials for Uterus Recovery towards Efficient Live Births. Adv Mater. 2021 Dec 1:e2106510. (IF: 30.849).

(21) 何丽清#,蔡序子,王艳,王雪峰*(通讯作者).生育指数预测EAI术后妊娠率及指导治疗的临床价值.解放军医学杂志.2018,43(08):668-673.

(22) 何丽清#,蔡序子,王艳,王雪峰*(通讯作者).子宫内膜异位症腹腔镜保守治疗术后联用GnRHa对临床妊娠率的影响[J].南方医科大学学报,2018,38(05):596-600.

(23) 王艳,何丽清,蔡序子,王雪峰*(通讯作者).派特灵治疗高危人乳头瘤病毒持续感染患者的疗效及安全性研究[J].中国全科医学,2019,22(11):1323-1327.

(24) 池佼妮#,庞永辉,刘娜,方俊杰,李焕强,王雪峰*(通讯作者).遗传学因素与早发性卵巢功能不全的研究进展[J].实用妇产科杂志,2018,34(01):26-29.