目录
更新日期:2024年10月11日
姓 名 何坚 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 哲学博士学位
行政职务 Email jianhe@smu.edu.cn
工作单位 药学院 邮政编码 510515
研究领域

抗感染药物研究

1.抗感染肽类药物的设计、合成、作用机制研究

2. 天然化合物研究

个人成果

1. Runhong Zhou, Ruifeng Huang, Shaofen Zhou, Shengsheng Lu, Haixing Lin, Jingnan Qiu, Shuaiqi Ma, Jian He*, Sorbicillinoid HSL-2 inhibits the infection of influenza A virus via interaction with the PPAR-γ/NF-κB pathway. Infection and Chemotherapy, 2024 Jun 26:S1341-321X(24)00168-5.

2. Haixing Lin, Runhong Zhou, Ruifeng Huang, Cuiqiong Fan, Minna Zhang, Jingnan Qiu, Shaofen Zhou, Jian He*, In vitro antibacterial activity of a novel acid-activated antimicrobial peptide against Streptococcus mutans. Current Protein & Peptide Science, 2024,25(1), 83-93.

3. Ruifeng Huang, Shuaiqi Ma, Jiale Wu, Asma Riaz, Li Song, Shaofen Zhou, Runhong Zhou, Jingnan Qiu, Jian He*,A new tetrahydroxybenzophenone from a marine-associated fungus of Penicillium sp. and its potential antibacterial activity. Natural Product Research 2024 Sep 16:1-8.

4. Haixing Lin, Li Song, Shaofen Zhou, Cuiqiong Fan, Minna Zhang, Ruifeng Huang, Runhong Zhou, Jingnan Qiu, Shuaiqi Ma, Jian He*, A hybrid antimicrobial peptide targeting Staphylococcus aureus with a dual function of inhibiting quorum sensing signaling and antibacterial effect,Journal of Medicinal Chemistry,2023,Dec 28;66(24):17105-17117.

5.Runhong Zhou, Jingnan Qiu, Jianan Hu, Shengsheng Lu, Haixing Lin, Guoqing Huang, Ruifeng Huang, Shaofen Zhou, Jian He*,Anti-influenza A virus activity of 2-hydroxymethyl-1,4-hydroquinone via activation of Nrf2/HO-1 pathway, Biochem Pharmacol, 2023, 210, 115495.

6. Xi Xie, Jian He*, Multivalent Peptide Dendrimers Inhibiting the Fusion of Viral-Cellular Membranes and Cellular NF-κB Signaling Pathway, European Journal of Medicinal Chemistry,2022, 230, 114140

7. Haixing Lin,Runhong Zhou, Taojing Yu, Jian He*An Acid-targeting Peptide can be used as a Carrier for Photodynamic Therapy (PDT),Materials Today Communications 2022, 31, 103659

8. Shengsheng Lu, Xi Xie, Jianan Hu, Haixing Lin, Fangfang Li, Runhong Zhou, Jiayin Guo, Shaohua Wu, Jian He*, New Anti-influenza A viral Norsesquiterpenoids isolated from feces-residing Streptomyces sp.  Fitoterapia, 2021 Dec 21;105107

9. Shengsheng Lu, Jianan Hu, Xi Xie, Ruifeng Huang, Jian He*, Sesquiterpenoids isolated from feces-residing Streptomyces sp. block the cellular entry of influenza A viruses, Natural Product Research 2022 Feb 2;1-11

10. Shengsheng Lu, Jianan Hu,Xi Xie, Runhong Zhou, Fangfang Li, Ruifeng Huang, Jian He*, Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equus quagga, Molecules 2021, 26(24), 7556

11. Jianan Hu, Jirui Zhang, Jian He*, Structures, Synthesis, and Biological Activities of Nonactic Acid and Its Derivatives, Current Medicinal Chemistry, 2021; 28(42): 8673-8691

12. Xi Xie, Shengsheng Lu, Xiaoyan Pan, Min Zou, Fangfang Li, Haixing Lin, Jianan Hu, Sheng Fan, Jian He*, Antiviral Bafilomycins from a Feces-inhabiting Streptomyces sp. J Nat Prod.  2021, 84(2), 537-543

13. Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, Xi Xie, Yan Wu,Weijuan Shang, Xiaming Jiang, Yuan Sun, Sheng Fan, Jian He*, The broad-spectrum antivirals of protoporphyrins inhibiting the entry of highly pathogenic emerging viruses. Bioorganic Chemistry, 2021, February; 107, 104619

14. Daiwei Chen, Shengsheng Lu, Guang Yang, Xiaoyan Pan, Sheng Fan, Xi Xie, Qi Chen, Fangfang Li, Zhonghuang Li, Shaohua Wu, Jian He*, The seafood Musculus senhousei shows anti-influenza A virus activity by targeting virion envelope lipids, Biochem Pharmacol  2020 Jul;177:113982

15. Fangfang Li, Shengsheng Lu, Xi Xie, Sheng Fan, Daiwei Chen, Shaohua Wu*, Jian He*, Antiviral properties of extracts of Streptomyces sp. SMU 03 isolated from the feces of Elephas maximus Fitoterapia  2020 Jun;143:104600

16. Kai-Xuan Zheng, Yi Jiang, Ju-Xing Jiang, Rong Huang, Jian He*, Shao-Hua Wu*, A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.,Fitoterapia 2019,135, 85–89

17. Guang Yang, Jingyu Wang, Shengsheng Lu, Zhao Chen, Sheng Fan, Daiwei Chen, Huanxin Xue, Wenyuan Shi, Jian He* Short lipopeptides specifically inhibit the growth of Propionibacterium acnes through antibacterial and anti-inflammatory dual action, British Journal of Pharmacology 2019, 176(13):2321-2335 

18. Zhao Chen, Guang Yang, Shengsheng Lu, Daiwei Chen, Sheng Fan, Junyang Xu, Buling Wu*, Jian He*,Design and antimicrobial activities of LL-37 derivatives inhibiting the formation of  Streptococcus mutans biofilm Chemical Biology and Drug Design 2019 Jun;93(6):1175-1185

19. Fangfang Li, Daiwei Chen, Shengsheng Lu, Guang Yang, Xiaoling Zhang, Zhao Chen, Sheng Fan, Shaohua Wu, Jian He*, Anti-influenza A Viral Butenolide from Streoptomyces sp Smu03 Inhabiting the Intestine of Elephas maximus, Viruses 2018, 10, 356

20. Rong Huang, Bo-Guang Jiang, Xiao-Nian Li, Ya-Ting Wang, Si-Si Liu, Kai-Xuan Zheng, Jian He,* and Shao-Hua Wu*, Polyoxygenated Cyclohexenoids with Promising a-Glycosidase Inhibitory Activity from the Endophytic Fungus Phomopsis sp. YE3250, Journal of Agricultural and Food Chemistry 2018, 66 (5), 1140–1146  

21.Dongguo Lin, Yinzhu Luo, Guang Yang, Fangfang Li, Xiangkun Xie, Daiwei Chen, Lifang He, Jingyu Wang, Chunfeng Ye, Shengsheng Lu, Lin Lv, Shuwen Liu*, Jian He*, Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin Biochem Pharmacol. 2017,144,35–51