目录
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更新日期：2023年3月17日
姓 名 李偲 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位
行政职务 副主任 Email licaisysu@163.com
工作单位 南方医科大学南方医院 邮政编码 510000
个人简介

一、主要学习经历及工作经历

1997.09~2004.07   华中科技大学同济医学院         临床医学  七年制 

2011.09~2014.07   中山大学  附属第一医院         麻 醉 学  博  士 

2004.07~2008.12   中山大学附属第一医院麻醉科     医    师

2008.12~2013.11   中山大学附属第一医院麻醉科     主治医师

2013.12~2016.08   中山大学附属第一医院麻醉科     副主任医师

2016.08~2018.03   南方医科大学南方医院麻醉科    副主任医师

2018.04~至 今     南方医科大学南方医院麻醉科    主任医师

二、出国经历

2014.09~2015.08   美国约翰霍普金斯大学完成临床研究方法学培训课程

三、临床专长

熟练掌握各种临床麻醉方法，主要负责心血管、神经外科及器官移植手术的麻醉。

四、主持科研项目

  1. 国家自然科学基金青年项目, 81401630, TRAIL/死亡受体信号调节凋亡在肢体远程缺血预处理抗肠缺血再灌注损伤中的作用, 2015.01~2017.12, 23万元，结题，主持
  2. 国家自然科学基金面上项目，81871609，miRNA-151调节TLR9/TRAF6信号通路在肠I/R损伤后细菌移位的作用及机制，2019.01 - 2022.12，57万元，在研，主持
  3. 国家自然科学基金面上项目，82072224，VRAC活化NLRP3/Caspase-1/GSDMD焦亡信号通路在肠缺血再灌注后肠损伤中的作用及机制，2021.01 - 2024.12，55万元，在研，主持
  4. 国家自然科学基金重点项目，81730058，从Rab家族介导TLR4受体胞内运输来探讨EGFR调控肠源性内毒素血症的分子机制机器抑制剂的临床应用研究，2018.01~2022.12,295万元，在研，以第二负责人身份参与
  5. 广东省自基础与应用基础研究基金恒瑞医药联合基金，探讨瑞玛唑仑相比于丙泊酚全凭静脉麻醉改善大型非心脏手术后结局及其机制的研究，2022.01~2024.12， 20万元，主持
  6. 南方医科大学“杰青培育计划”， 2017.5~2020.5，30万元，结题

五、学术任职

1. 中国医师协会 麻醉学医师分会青年委员会 副主任委员

2. 广东省医学会 麻醉学分会青年委员会 副主任委员

3. 广东省医学会 麻醉学分会心脏麻醉组 副组长

4. 广东省临床医学学会麻醉学专业委员会 副主任委员

5. 广东省女医师协会麻醉与围术期医学专业委员会 副主任委员

6. 国家自然科学基金等项目评审专家

研究领域

围术期脏器功能损伤的发生机制及其防治措施

围术期肠缺血再灌注的发生机制及其防治措施

个人成果

 

  1. Huang W#, Yan Y#, Wu M, Hu J, Zhao J, Chen X, Liu W*, Liu K*, Li C*. Preoperative fasting confers protection against intestinal ischaemia/reperfusion injury by modulating gut microbiota and their metabolites in a mouse model. Br J Anaesth. 2022 Mar;128(3):501-512.（IF:11.719）
  2. Deng F#, Zhao BC, Yang X, Lin ZB, Sun QS, Wang YF, Yan ZZ, Liu WF, Li C, Hu JJ*, Liu KX*. The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis. Gut Microbes. 2021 Jan-Dec;13(1):1-21.（IF:9.434）
  3. Hu J#, Deng F#, Zhao B, Lin Z, Sun Q, Yang X, Wu M, Qiu S, Chen Y, Yan Z, Luo S, Zhao J, Liu W, Li C*, Liu KX*. Lactobacillus murinus alleviate intestinal ischemia/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via Toll-like receptor 2 signaling. Microbiome. 2022 Mar 3;10(1):38.(IF:16.837)
  4. Wang YH#, Yan ZZ#, Luo SD, Hu JJ, Wu M, Zhao J, Liu WF, Li C*, Liu KX*. Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice. Eur Respir J. 2023 Feb 16;61(2):2200840.(IF:33.795)
  5. Wu M#, Huang Z#, Huang W, Lin M, Liu W, Liu K, Li C*. microRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis. Cell Death Discov. 2022 Jan 28;8(1):40.(IF:7.109)
  6. Deng F#, Hu JJ#, Yang X, Sun QS, Lin ZB, Zhao BC, Yao ZW, Luo SD, Chen ZL, Liu Y, Yan ZZ, Li C, Liu WF*, Liu KX*. Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling. Front Immunol. 2021 Sep 28;12:704836.(IF:8.786)
  7. Zhou B#, Zhang W#, Yan Z, Zhao B, Zhao J, Feng W, Chen X, Li C, Liu KX*. MicroRNA-26b-5p Targets DAPK1 to Reduce Intestinal Ischemia/Reperfusion Injury via Inhibition of Intestinal Mucosal Cell Apoptosis. Dig Dis Sci. 2022 May;67(5):1794-1805.(IF:3.487)
  8. Chen XD#, Zhao J#, Yang X, Zhou BW, Yan Z, Liu WF, Li C*, Liu KX*. Gut-Derived Exosomes Mediate Memory Impairment After Intestinal Ischemia/Reperfusion via Activating Microglia. Mol Neurobiol. 2021 Oct;58(10):4828-4841.(IF:5.682)
  9. Zhao J#, Chen XD#, Yan ZZ, Huang WF, Liu KX*, Li C*. Gut-Derived Exosomes Induce Liver Injury After Intestinal Ischemia/Reperfusion by Promoting Hepatic Macrophage Polarization. Inflammation. 2022 Dec;45(6):2325-2338.(IF:4.657)
  10. Deng F#, Chen Y#, Sun QS#, Lin ZB, Min Y, Zhao BC, Huang ZB, Liu WF, Li C, Hu JJ*, Liu KX*. Gut microbiota dysbiosis is associated with sepsis-induced cardiomyopathy in patients: A case-control study. J Med Virol. 2023 Jan;95(1):e28267.(IF:20.693)
  11. Zhao BC#, Zhuang PP#, Lei SH, Qiu SD, Yang X, Li C, Liu WF, Liu KX*. Pre-operative N-terminal pro-B-type natriuretic peptide for prediction of acute kidney injury after noncardiac surgery: A retrospective cohort study. Eur J Anaesthesiol. 2021 Jun 1;38(6):591-599.(IF:4.183)
  12. Deng W#, Yan Y#, Zhuang P, Liu X, Tian K, Huang W, Li C*. Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management. Drug Deliv. 2022 Dec;29(1):399-412.(IF:6.819)
  13. Zhang XY#, Liang HS#, Hu JJ, Wan YT, Zhao J, Liang GT, Luo YH, Liang HX, Guo XQ, Li C, Liu WF*, Liu KX*. Ribonuclease attenuates acute intestinal injury induced by intestinal ischemia reperfusion in mice. Int Immunopharmacol. 2020 Jun;83:106430.(IF:5.714)
  14. Dong YH#, Hu JJ#, Deng F, Chen XD, Li C, Liu KX*, Zhao BC*. Use of dexmedetomidine to alleviate intestinal ischemia-reperfusion injury via intestinal microbiota modulation in micec. Ann Transl Med. 2022 Nov;10(21):1161.(IF:3.616)
  15. Zhao BC#, Huang TY, Deng QW, Liu WF, Liu J, Deng WT, Liu KX, Li C*. Prophylaxis Against Atrial Fibrillation After General Thoracic Surgery: Trial Sequential Analysis and Network Meta-Analysis. Chest. 2017 Jan;151(1):149-159.(IF:10.262)
  16. Li Y#, Wen S#, Yao X, Liu W, Shen J, Deng W, Tang J, Li C*, Liu K*. MicroRNA-378 protects against intestinal ischemia/reperfusion injury via a mechanism involving the inhibition of intestinal mucosal cell apoptosis. Cell Death Dis. 2017 Oct 12;8(10):e3127.(IF:9.685)
  17. Zhang FL#, Zhou BW#, Yan ZZ, Zhao J, Zhao BC, Liu WF, Li C, Liu KX*. 6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis. Cytokine. 2020 Jan;125:154854.(IF:3.926)
  18. Chen XD#, Zhao J#, Yan Z, Zhou BW, Huang WF, Liu WF, Li C*, Liu KX*. Isolation of extracellular vesicles from intestinal tissue in a mouse model of intestinal ischemia/reperfusion injury. Biotechniques. 2020 May;68(5):257-262(IF:2.746)
  19. Li Y# , Wen S# , Yao X, Liu W, Shen J, Deng W, Tang J, Li C*, Liu K*. MicroRNA-378 protects against intestinal ischemia/reperfusion injury via a mechanism involving the inhibition of intestinal mucosal cell apoptosis. Cell Death Dis. 2017. 12;8(10):e3127（IF: 5.959）
  20. Li C# , Xu M, Wu Y, Li YS, Huang WQ, Liu KX* . Limb remote ischemic preconditioning attenuates lung injury following pulmonary resection: A double-blind randomized controlled study. Anesthesiology. 2014. 121:249-259. （IF: 8.986）
  21. Li C# , Li YS# , Xu M, Wen SH, Yao X, Wu Y, Huang CY, Huang WQ, Liu KX* . Limb remote ischemic preconditioning for intestinal and pulmonary protection during elective open infrarenal abdominal aortic aneurysm repair: a randomized controlled trial. Anesthesiology. 2013. 118:842-852. （IF: 8.986）
  22. Li C# , Yang WH# , Zhou J, Gurung S, Li YS, Wen SH, Yao X, Huang WQ, Liu KX* . Prediction of postoperative complications after open infrarenal abdominal aortic aneurysm repair: results from a single vascular centre in China. J Clin Anesth. 2013. 25:371-151.（IF: 9.375）
  23. Wen S# , Ling Y, Yang W, Shen J, Li C, Deng W, Liu W, Liu K* . Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury. J Cell Mol Med. 2017. 21(3): 432-443. (IF:5.295)
  24. Shen JT# , Li YS, Xia ZQ, Wen SH, Yao X, Yang WJ, Li C, Liu KX* . Remifentanil preconditioning protects the small intestine against ischemia/reperfusin injury via intestinal σ- and μ-opioid receptors. Surgery. 2016. 159: 548-559. (IF:4.384)
  25. Li BC# , Xia ZQ, Li C, Liu WF, Wen SH, Liu KX* . The incidence and risk factors of gastrointestinal complications after hepatectomy: a retrospective observational study of 1329 consecutive patients in a single center. J Surg Res. 2014.151:440-406. (IF:2.741)
  26. Wen SH# , Ling YH, Li Y, Li C, Liu JX, Li YS, Yao X, Liu KX* . Ischemic postconditioning during reperfusion attenuates oxidative stress and intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion via aldose reductase. Surgery. 2013. 153: 555-564. (IF:4.348)
  27. Zhou J# , Huang WQ, Li C, Wu GY, Li YS, Wen SH, Lei WL, Liu KX* . Intestinal ischemia/reperfusion enhances microglial activation and induces cerebral injury and memory dysfunction in rats. Crit Care Med. 2012. 40: 2438-2448. (IF:9.296)
  28. Wen SH# , Li Y, Li C, Xia ZQ, Liu WF, Zhang XY, Lei WL, Huang WQ, Liu KX* . Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation. Shock. 2012. 38: 411-419. (IF:3.533)
  29. Liu KX# , Li C，Li YS, Yuan BL, Xu M, Xia Z, Huang WQ* . Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase. Proteomics. 2010. 10: 4463-4475. (IF:5.393)
  30. Li YS # , Wang ZX, Li C, Xu M, Li Y, Huang WQ, Xia Z, Liu KX* . Proteomics of ischemia/reperfusion injury in rat intestine with and without ischemic postconditioning, J Surg Res. 2010. 164: e173-e180. (IF:2.417)
  31. Liu KX#*, Li YS, Huang WQ, Li C, Liu JX, Li Y. Immediate but not delayed postconditioning during reperfusion attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats: comparison with ischemic preconditioning, J Surg Res. 2009. 157: e55-e62. (IF:2.417)
  32. Liu KX#, Li C, Yang WH. Incorrect P Values in Two Articles by Ke-Xuan Liu, M.D., Ph.D., et al. Anesthesiology. 2019 Jul;131(1):220.（IF:8.986）