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更新日期：2024年10月15日
姓 名 李晓娟 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 教研室主任 Email lixiaoj@smu.edu.cn
工作单位 药学院 邮政编码 510515
个人简介

李晓娟，三级教授，南方医科大学药学院炎症免疫药物创新群体执行主任、抗炎免疫药理学科PI；现任广东省药理学会抗炎免疫药理专委会主任委员、广东省精准医学应用学会自身免疫分会副主任委员、世界中联中医药免疫学会副会长、中国药理抗炎免疫药理学会常务委员等学术职务；主要从事B细胞免疫调控与疾病，骨破坏和免疫疾病治疗新靶点和药物机制研究；主持国家基金8项；近年在Blood、J Adv Res、Pharmacol Res、Brit J Pharmacol等发表研究论文多篇。

 

研究领域

研究领域：抗炎免疫药理学，主要从事靶向免疫细胞（B细胞、巨噬细胞)的骨和免疫疾病诊疗新靶点发现，新药（含中医药）发现和药理学研究。

个人成果
  1. 1.Chen Y#, Zheng J#, Mo L, Chen F, Li R, Wang Y, Liang Q, Chen Z, Dai W, Chen L, Yan P, Zhou H*, Li X*. Oroxylin A suppresses breast cancer-induced osteoclastogenesis and osteolysis as a natural RON inhibitor. Phytomedicine. 2024 Apr 28;129:155688.
  2. Zheng J#, He W#, Chen Y#, Li L, Liang Q, Dai W, Li R, Chen F, Chen Z, Tan Y*, Li X*. Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction. J Adv Res. 2024 Mar 30:S2090-1232(24)00121-8. doi: 10.1016/j.jare.2024.03.021. （IF：10.7004）
  3. Ding ZB#, Chen Y#, Zheng YR, Wang YY, Deng WD, Zheng JH, Yang Q, Chen ZY, Li LH, Jiang H*, Li XJ*.Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis. Acta Pharmacol Sin. 2024 Apr;45(4):790-802. doi: 10.1038/s41401-023-01209-0. Epub 2024 Jan 8. （IF：8.1996）
  4. Li R#, Liang Q#, Yang Q, Dai W, Xiao Y, Pan H, Zhang Z, Liu L*, Li X*. Hexahydrocurcumin from Zingiberis rhizoma attenuates lipopolysaccharide-induced acute pneumonia through JAK1/STAT3 signaling pathway. Phytomedicine. 2024 Jan;122:155141 （IF：7.8996）
  5. Yang Q, Zhang Z, Chen Z, Wang Y, Chen Y, Zheng J, Li R, Li L, Mo L, Liang Q, Chen F, Wang J*, Li X*. Flot2 deficiency facilitates B cell-mediated inflammatory responses and endotoxic shock. Immunology. 2023 Dec;170(4):567-578.
  6. Wang Y, Liang Q, Chen F, Zheng J, Chen Y, Chen Z, Li R, Li X*. Immune-Cell-Based Therapy for COVID-19: Current Status. Viruses. 2023 Oct 25;15(11):2148.
  7.  Yang Q#, Guo J#, Zheng J, Chen Y, Zou B, Li R, Ding Z, Wang Y, Li L, Chen Z, Mo L, Liang Q, Chen F, Li X*. Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling.Int Immunopharmacol. 2023 Jul;120:110316
  8. Tan Y#, Ke M#, Li Z#, Chen Y, Zheng J, Wang Y, Zhou X*, Huang G*, Li X*. A Nitrobenzoyl Sesquiterpenoid Insulicolide A Prevents Osteoclast Formation via Suppressing c-Fos-NFATc1 Signaling Pathway. Front Pharmacol. 2022 Jan 17;12:753240.(IF:  5.9879  II区)
  9. Deng W#, Ding Z#, Wang Y, Zou B, Zheng J, Tan Y, Yang Q, Ke M, Chen Y, Wang S*, Li X*. Dendrobine attenuates osteoclast differentiation through modulating ROS/NFATc1/ MMP9 pathway and prevents inflammatory bone destruction. Phytomedicine. 2021 Nov 6;153838. （IF:  6.656  I区）
  10. Zou B, Zheng J, Deng W, Tan Y, Jie L, Qu Y, Yang Q, Ke M, Ding Z, Chen Y, Yu Q*, Li X*.Kirenol inhibits RANKL-induced osteoclastogenesis and prevents ovariectomized-induced osteoporosis via suppressing the Ca2+-NFATc1 and Cav-1 signaling pathways. Phytomedicine. 2021 Jan;80:153377. 0944-7113. （IF: 6.656  I区）
  11. Zou BH, Tan YH, Deng WD, Zheng JH, Yang Q, Ke MH, Ding ZB, Li XJ*. Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression. Acta Pharmacol Sin. 2021 May;42(5):744-754（IF:  7.169 I区）
  12. Tan Y#, Deng W#, Zhang Y, Ke M, Zou B, Luo X, Su J, Wang Y, Xu J, Nandakumar KS, Liu Y, Zhou X*, Li X*. A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses RANKL-induced osteoclastogenesis and attenuates inflammatory bone destruction. Br J Pharmacol. 2020 Sep;177(18):4242-4260. (IF:9.473，I区）
  13. Zou B#, Zhang Y#, Li T#, Liu J, Deng W, Tan Y, Yang Q, Ding Z, Liao K, Xu J, Pan H, Li X*, Liu L*.A mutation of cysteine 46 in IKK-β promotes mPGES-1 and caveolin-1 expression to exacerbate osteoclast differentiation and osteolysis. Biochem Pharmacol. 2020 Feb;172:113762.（IF:6.1004， II区）
  14. Zeng XZ#, Zhang YY#, Yang Q, Wang S, Zou BH, Tan YH, Zou M, Liu SW*, Li XJ*. Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca(2+)-NFATc1 signaling pathway. Acta Pharmacol Sin. 2020 Feb;41(2):229-236. （IF:  7.169  I区）
  15. Tao L#, Wang Y#, Xu J#, Su J, Yang Q, Deng W, Zou B, Tan Y, Ding Z, Li X*.  IL-10-producing regulatory B cells exhibit functional defects and play a protective role in severe endotoxic shock. Pharmacol Res. 2019 Oct;148:104457. （IF:10.334，I区） 
  16. Zhang Y#, Zou B#, Tan Y, Su J, Wang Y，Xu J, Tao L, Zhou H, Liu L*, Li X*. Sinomenine inhibits osteolysis in breast cancer by reducing IL-8/CXCR1 and c-Fos/NFATc1 signaling.  Pharmacol Res. 2019 Feb 20. 142,140-150（IF:10.334，I区）
  17. Su J#, Wang K#, Zhou X, Wang Y, Xu J, Tao L, Zeng X, Chen N, Bai X*, Li X*. B-cell-specific-peroxisome proliferator-activated receptor γ deficiency augments contact hypersensitivity with impaired regulatory B cells. Immunology. 2019 Mar;156(3):282-296（IF:7.215， III区）
  18. Tan Y#, Yang B#, Lin X, Luo X, Pang X, Tang L, Liu Y, Li X*, Zhou X*. Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus. J Nat Prod. 2018 Jan 26;81(1):92-97. (IF:4.803 II 区）
  19. Wang K#, Tao L#, Su J, Zhang Y, Zou B, Wang Y, Zou M, Chen N, Lei L, Li X*. TLR4 supports the expansion of FasL+CD5+CD1dhi regulatory B cells, which decreases in contact hypersensitivity. Mol Immunol. 2017 May 12;87:188-199.（IF：4.174， III区）
  20. Zeng X, Zhang Y, Wang S, Wang K, Tao L, Zou M, Chen N, Xu J, Liu S*, Li X*. Artesunate suppresses RANKL–Induced osteoclastogenesis  through  inhibition  of  PLCγ1-Ca2+–NFATc1 signaling pathway and prevents ovariectomy-induced bone loss, Biochem Pharmacol. 2017 Jan 15;124:57-68. （IF:6.1004， II区）
  21. He L, Duan H, Li X, Wang S, Zhang Y, Lei L, Xu J, Liu S*, Li X*. Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis. Eur J Pharmacol. 2016 May 15;779:66-79 (IF:5.195, III区 ) 
  22. Zheng XZ, He LG, Wang S, Wang K, Zhang YY, Tao L, Li XJ*, Liu SW*. Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression. Acta Pharmacol Sin. 2016 Feb;37(2):255-63. （IF:  7.169  I区）
  23. He LG, Li XL, Zeng XZ, Duan H, Wang S, Lei LS, Li XJ* Liu SW*. Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation. Acta Pharmacol Sin. 2014 Feb;35(2):203-10. （IF: 7.169  I区）
  24. Li X, He L, Hu Y, Duan H, Li X, Tan S, Zou M, Gu C, Zeng X, Yu L, Xu J, Liu S. Sinomenine suppresses osteoclast formation and Mycobacterium tuberculosis H37Ra-induced bone loss by modulating RANKL signaling pathways，PLoS One. 2013 Sep 16;8(9):e74274. (IF:3.240， III区)
  25. Li X#, Zhong H#, Bao W, Boulad N, Evangelista J, Haider M, Bussel J, Yazdanbakhsh K*. Defective regulatory B cell compartment in patients with immune thrombocytopenia. Blood, 2012，Oct 18;120(16):3318-25. (IF:25.477， I区)
  26. Li X, Hu Y, He L, Wang S, Zhou H, Liu S. Icaritin inhibits T cell activation and prolongs skin allograft survival in mice. Int Immunopharm, 2012, May, 13(1) :1-7 (IF:5.714，III区)