南方医科大学珠江医院教授，博士生导师，博士后合作导师，英国曼彻斯特大学博士，美国西奈山伊坎医学院博士后，科研处负责人，心脏中心实验室学术负责人，国家卫健委辅助循环重点实验室学术委员会委员，中国病理生理学会动脉粥样硬化专业委员会委员，国际动脉粥样硬化学会中国分会委员，广东省药理学会心血管药理委员会常务委员，广东省病理生理学会心血管专业委员会委员，国家自然科学基金通讯评审专家，广东省科技评审专家，广东省高层次人才评审专家，教育部学位中心论文评审专家。2010年获英国曼彻斯特大学医学博士学位，2010-2013年在美国西奈山伊坎医学院从事心脏发育和再生研究工作。目前主要研究血管重塑和心肌再生机制，先后主持5项国家自然科学基金项目和5项省部级科研基金项目。已发表SCI论文33篇，以第一、通讯作者（含共同）在Circulation, Kidney Int, Cardiovasc Res, ATVB, Nat Commun, J Pathol, Aging Cell, Free Radic Biol Med, J Mol Cell Cardiol, J Biol Chem等国际主流期刊发表论文20余篇。主要学术贡献包括：1）构建了大量研究心脏发育和再生的knock-in小鼠模型（Circulation, 2018; J Mol Cell Cardiol, 2016; Nat Commun, 2015）；2）首次提出心脏内c-kit和Sca1阳性细胞并非心肌干细胞，而是内皮细胞（Nat Commun, 2015; Circulation, 2018）；3）揭示了钙磷和氧化应激调节血管钙化机制（Cardiovasc Res, 2023; Kidney Int, 2022; J Pathol, 2022; JMCC, 2022; Aging Cell, 2021; Free Radic Biol Med, 2021; ATVB, 2020; J Pathol, 2019; ATVB, 2011）。担任Kidney Int, J Pineal Res, Clin Transl Med, FASEB J, Atherosclerosis等40多个杂志审稿人。2006-2009年获英国政府Overseas Research Studentship（ORS）全额奖学金。曾获第17和18届中国南方国际心血管病学术会议论文一等奖。
1. An Chen#, Zirong Lan#, Li Li#, Luting Xie, Xiaoyu Liu, Xiulin Yang, Siyi Wang, Qingchun Liang, Qianqian Dong, Yining Li, Yuanzhi Ye, Mingwei Fu, Lihe Lu*, Jianyun Yan* (通讯作者). SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome. Cardiovasc Res. 2023. (IF=14.239)
2. Ye Y#, Chen A#, Li L#, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int. 2022;102(6):1259-1275. (IF=18.998)
3. Lan Z#, Chen A#, Li L#, Ye Y, Liang Q, Dong Q, Wang S, Fu M, Li Y, Liu X, Zhu Z, Ou JS, Qiu X, Lu L*, Yan J* (通讯作者). Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification. J Pathol. 2022;258(3):213-226. (IF=9.883)
4. Wang S#, Li L#, Liang Q#, Ye Y, Lan Z, Dong Q, Chen A, Fu M, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. J Mol Cell Cardiol. 2022; 173:154-168. (IF=5.763)
5. Liu X#, Chen A#, Liang Q#, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L*, Yan J* (通讯作者). Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. Aging Cell. 2021;20(6):e13377. (IF=11.005)
6. Yang X#, Chen A#, Liang Q#, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L*, Yan J* (通讯作者). Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease. Free Radic Biol Med. 2021;172:530-540. (IF=8.101)
7. Zhang X#, Li Y#, Yang P#, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J*(共同通讯), Chen M*. Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals. Arterioscler Thromb Vasc Biol. 2020;40(3):751-765. (IF=10.514)
8. Li Z#, Wu J#, Zhang X#, Ou C, Zhong X, Chen Y, Lu L, Liu H, Li Y, Liu X, Wu B, Wang Y, Yang P, Yan J*(共同通讯), Chen M*. CDC42 promotes vascular calcification in chronic kidney disease. J Pathol. 2019;249(4):461-471. (IF=9.883)
9. Zhang L#, Sultana N#, Yan J# (共同第一), Yang F, Chen F, Chepurko E, Yang FC, Du Q, Zangi L, Xu M, Bu L, Cai CL*. Cardiac Sca-1+ cells are not intrinsic stem cells for myocardial development, renewal and repair. Circulation. 2018;138(25):2919-2930. (IF=39.918)
10. Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W, Cai CL*. Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018;293(24):9162-9175. (IF=5.486)
11. Kong Y#, Liang Q#, Chen Y#, Yang P, Liu X, Li Y, Feng S, Wu J, Liu W, Tang J, Yu H, Ou JS, Lu L*, Yan J*(通讯作者). Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Lab Invest. 2018;98(10):1320-1332. (IF=5.502)
12. Yan J#, Zhang L#, Sultana N#, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL*. A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol. 2016;97:278-285. (IF=5.763)
13. Sultana N#, Zhang L#, Yan J# (共同第一), Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL*. Resident c-kit+ cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701. (IF=17.694)
14. Yan J, Stringer SE, Hamilton A, Charlton-Menys V, Götting C, Müller B, Aeschlimann D, Alexander MY*. Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL-Induced Mineralization of Human Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2011; 31(3):608-615. (IF=10.514)