南方医科大学珠江医院心内科教授，博士生导师，博士后合作导师，英国曼彻斯特大学博士，美国西奈山伊坎医学院博士后，科研处负责人，心脏中心实验室学术负责人，国家卫健委辅助循环及血管相关疾病重点实验室学术委员会委员，中国病理生理学会动脉粥样硬化专业委员会委员，国际动脉粥样硬化学会中国分会委员，广东省精准医学应用学会生物医药知识产权分会主任委员，广东省研究型医院学会理事，广东省药理学会心血管药理委员会常务委员，广东省病理生理学会心血管专业委员会常务委员，国家自然科学基金通讯评审专家，广东省科技评审专家，广东省高层次人才评审专家，教育部学位中心论文评审专家。从事心血管疾病的机制研究工作，主要采用基因敲除小鼠模型，研究血管钙化和心脏再生的分子调控机制。先后主持6项国家自然科学基金项目和6项省部级科研基金项目。已发表SCI论文38篇，近年来以第一、通讯作者（含共同）在Circulation, Kidney Int, Nat Commun, Cardiovasc Res, ATVB, J Pathol, Aging Cell, Free Radic Biol Med, J Mol Cell Cardiol, J Biol Chem等国际主流期刊发表SCI论文20余篇。兼职担任Kidney Int, ATVB, Redox Biol, STTT, J Pineal Res, Clin Transl Med, Bioact Mater, Transl Res, FASEB J, Atherosclerosis, BBA-Molecular Basis of Disease等60多个SCI杂志的审稿专家和Renal Failure的编辑。多次受邀在国内外心血管会议如英国BSCR Spring Meeting、中国心脏大会、长安国际心血管病论坛、南方国际心血管会议等发言，曾获第17和18届中国南方国际心血管病学术会议论文一等奖。2006-2009年获英国海外研究学生（ORS）全额奖学金。

心血管疾病机制，主要采用基因敲除小鼠模型和细胞谱系示踪技术，研究血管钙化和心肌再生机制。

1. Lu L^#, Ye Y^#, Chen Y, Feng L, Huang J, Liang Q, Lan Z, Dong Q, Liu X, Li Y, Zhang X, Ou JS, Chen A*, Yan J*(通讯作者). Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells. FASEB J. 2024;38(7):e23592. (IF= 4.8)

2. Chen A^#, Lan Z^#, Li L^#, Xie L, Liu X, Yang X, Wang S, Liang Q, Dong Q, Feng L, Li Y, Ye Y, Fu M, Lu L*, Yan J*(通讯作者). Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome. Cardiovasc Res. 2023;119(13):2368-2381. (IF= 14.239)

3. Ye Y^#, Chen A^#, Li L^#, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int. 2022;102(6):1259-1275. (IF=18.998)

4. Wang S^#, Li L^#, Liang Q^#, Ye Y, Lan Z, Dong Q, Chen A, Fu M, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. J Mol Cell Cardiol. 2022; 173:154-168. (IF=5.763)

5. Lan Z^#, Chen A^#, Li L^#, Ye Y, Liang Q, Dong Q, Wang S, Fu M, Li Y, Liu X, Zhu Z, Ou JS, Qiu X, Lu L*, Yan J* (通讯作者). Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification. J Pathol. 2022;258(3):213-226. (IF=9.883)

6. Liu X^#, Chen A^#, Liang Q^#, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L*, Yan J* (通讯作者). Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. Aging Cell. 2021;20(6):e13377. (IF=11.005)

7. Yang X^#, Chen A^#, Liang Q^#, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L*, Yan J* (通讯作者). Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease. Free Radic Biol Med. 2021;172:530-540. (IF=8.101)

8. Zhang X^#, Li Y^#, Yang P^#, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J*(共同通讯), Chen M*. Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals. Arterioscler Thromb Vasc Biol. 2020;40(3):751-765. (IF=10.514).

9. Dong Q^#, Chen Y^#, Liu W, Liu X, Chen A, Yang X, Li Y, Wang S, Fu M, Ou JS, Lu L*, Yan J*(通讯作者). 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. Eur J Pharmacol. 2020;880:173165. (IF=5.195) 

10. Li Z^#, Wu J^#, Zhang X^#, Ou C, Zhong X, Chen Y, Lu L, Liu H, Li Y, Liu X, Wu B, Wang Y, Yang P, Yan J*(共同通讯), Chen M*. CDC42 promotes vascular calcification in chronic kidney disease. J Pathol. 2019;249(4):461-471. (IF=9.883)

11. Zhang L^#, Sultana N^#, Yan J^# (共同第一), Yang F, Chen F, Chepurko E, Yang FC, Du Q, Zangi L, Xu M, Bu L, Cai CL*. Cardiac Sca-1⁺ cells are not intrinsic stem cells for myocardial development, renewal and repair. Circulation. 2018;138(25):2919-2930. (IF=39.918)

12. Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W, Cai CL*. Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018;293(24):9162-9175. (IF=5.486)

13. Kong Y^#, Liang Q^#, Chen Y^#, Yang P, Liu X, Li Y, Feng S, Wu J, Liu W, Tang J, Yu H, Ou JS, Lu L*, Yan J*(通讯作者). Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Lab Invest. 2018;98(10):1320-1332. (IF=5.502)

14. Yan J^#, Zhang L^#, Sultana N^#, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL*. A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol. 2016;97:278-285. (IF=5.763)

15. Sultana N^#, Zhang L^#, Yan J^# (共同第一), Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL*. Resident c-kit⁺ cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701. (IF=17.694)

16. Yan J, Stringer SE, Hamilton A, Charlton-Menys V, Götting C, Müller B, Aeschlimann D, Alexander MY*. Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL-Induced Mineralization of Human Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2011; 31(3):608-615. (IF=10.514)