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更新日期：2023年9月13日
姓 名 郭家松 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士
行政职务 副主任 Email jiasongguo@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
个人简介

南方医科大学基础医学院组胚学教研室（国家重点学科）副主任、三级教授、博士生导师和博士后合作导师。

    2003年博士毕业于中山大学，先后到香港大学和美国范德堡大学从事访问学者和博士后工作。现任中国解剖学会再生医学分会副主任委员、组胚分会委员、神经解剖学分会委员、中国研究型医院学会神经再生与修复专业委员会常委兼基础学组副组长、广东省解剖学会常务理事、广东省脑发育与脑病防治学会干细胞分会副主委；Neural Regeneration Research（IF=6.1）、中国临床解剖学杂志、中国组织化学与细胞化学杂志、神经解剖学杂志等期刊编委；50余个SCI杂志审稿人；国家重点研发项目、国家自然科学基金以及多个省的自然基金项目评审专家。

    主持国家自然科学基金面上项目6项，以子课题负责人参与科技部973项目、中国脑计划（2030-“脑科学与类脑研究”重大项目）及广东省自然基金团队项目等。发表SCI论文70余篇，获授权专利8项，主编教材6本、副主编或参编教材或专著21本。曾评为解放军总后优秀教师和广东省高校千百十人才计划省级对象。

 

研究领域

神经损伤与再生；干细胞与组织工程；信号通路与治疗靶点

个人成果
  1. Liu J, Ma X, Hu X, Wen J, Zhang H, Xu J, He Y, Wang X, Guo J(郭家松)*. Schwann cell-specific RhoA knockout accelerates peripheral nerve regeneration via promoting Schwann cell dedifferentiation. Glia, 
    2023 Jul;71(7):1715-1728.
     doi: 10.1002/glia.24365  IF2021=8.073, 通讯作者
  2. Li M, Xu J , Zou Y, Lu J, Ou A, Ma X, Zhang J, Xu Y, Fu L, Liu J, Wang X, Zhou L, Guo J(郭家松)*. Motor neuron specific RhoA knockout delays degeneration and promotes regeneration of dendrites in spinal ventral horn after brachial plexus injury. Neural Regeneration Research, 
    2023 Dec;18(12):2757-2761.
     doi: 10.4103/1673-5374.373657  IF2021=6.058, 通讯作者
  3. Xu J, Fu L, Deng J, Zhang J, Zou Y, Liao L, Ma X, Li Z, Xu Y, Xu Y, Xu S, Liu J, Wang X, Ma X, Guo J(郭家松)*. miR-301a Deficiency Attenuates the Macrophage Migration and Phagocytosis through YY1/CXCR4 Pathway. Cells. 2022 Dec 7;11(24):3952. doi: 10.3390/cells11243952. PMID: 36552718; PMCID: PMC9777533. IF2021=7.666, 通讯作者
  4. Hu X,  Zhang P,  Liu J， Guan H,  Xie R, Cai L, Guo J(郭家松), Wang L, Tian Y*, Qiu X*. A Self-Association Cross-Linked conductive zwitterionic hydrogel as a myocardial patch for restoring cardiac function. Chemical Engineering Journal, 2022 Oct 15. 446 (2), 136988. doi.org/10.1016/j.cej.2022.136988IF2021=16.744
  5. Yang L, Ren Z, Yan S, Zhao L, Liu J, Zhao L, Li Z, Ye S, Liu A, Li X, Guo J(郭家松), Zhao W, Kuang W, Liu H, Chen D. Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation. Commun Biol. 2022 May 25;5(1):495. doi: 10.1038/s42003-022-03420-x. IF2021=6.548
  6. Jiang C, Liu C, She Z, Tan R, Wang D, Liang J, Zheng H, Guo J(郭家松)*, Zhu L*. Application of collagen-chondroitin sulfate scaffolds with different pore sizes combined with acidic fibroblast growth factor in repairing full thickness skin defects in nude mice. Biomed Mater. 2022 Oct 17;17(6). doi: 10.1088/1748-605X/ac95e8. IF2021=4.103， 共同通讯作者
  7. Xie C, Wang Y, Wang J, Xu Y, Liu H, Guo J(郭家松)*, Zhu L*. Perlecan Improves Blood Spinal Cord Barrier Repair Through the Integrin β1/ROCK/MLC Pathway After Spinal Cord Injury. Molecular Neurobiology. 2022 Oct 10. doi: 10.1007/s12035-022-03041-9. IF2021=5.682， 共同通讯作者
  8. Liu C, Peng Z, Xu H, Gao H, Li J, Jin Y, Wang Y, Wang C, Liu Y, Hu Y, Jiang C,Guo J(郭家松)*, Zhu L*. 3D print Platelet-rich plasma loaded scaffold with sustained cytokine release for bone defect repair. Tissue Eng Part A. 2022 Feb 12. doi: 10.1089/ten.TEA.2021.0211.IF2021=4.080， 共同通讯作者
  9. Zou Y, Zhang J, Liu J, Xu J, Fu L, Ma X, Xu Y, Xu S, Wang X, Guo J(郭家松)*. SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury. Molecular Neurobiology. 2022 Jan;59(1):429-444. doi: 10.1007/s12035-021-02607-3.IF2021=5.682, 通讯作者
  10. Liu J, Li L, Fu L, Zhang H, Xu Y, Zou Y, Ma X, Xu J, Zhang J,  Li M, Hu X, Li Z, Wang X, Sun H, Zheng H, Zhu L, Guo J (郭家松) *，Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury，Neural Regeneration Research, 2022 Mar;17(3):673-681. doi: 10.4103/1673-5374.320997.IF2021=6.058, 通讯作者
  11. Xu H, Wang C, Liu C, Li J, Peng Z, Guo J (郭家松) *, Zhu L*. Stem Cell-Seeded 3D-Printed Scaffolds Combined with Self-Assembling Peptides for Bone Defect Repair.Tissue Eng Part A. 2022 Feb;28(3-4):111-124. doi: 10.1089/ten.TEA.2021.0055.  IF2021=4.080， 共同通讯作者
  12. Xu J, Wen J, FuL, LiaoL, ZouY, ZhangJ, DengJ, ZhangH, LiuJ, WangX, ZuoD, Guo J(郭家松)*, Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral  nerve injury in mice. J Neuroinflammation.2021:18, 234.doi: 10.1186/s12974-021-02292-y.IF2021=9.587, 通讯作者
  13. Zou Y, Zhang J, Xu J, Fu L, Xu Y, Wang X, Li Z, Zhu L, Sun H, Zheng H, Guo J(郭家松)*.SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages. Cell and Bioscience. 2021:11:210 Dec 14. doi: 10.1186/s13578-021-00725-yIF2021=9.584, 通讯作者
  14. Zhang Z, Rong Z, Wu G, Wang Y, Tan Z, Zheng J, Jin Y, Liang Z, Liu C, Guo J(郭家松)*, Zhu L*. Gelatin-CaO2/SAP/PLGA composite scaffold enhances the reparation of critical-sized cranial defects by promoting seed cell survival. Applied Materials today. 2021:22 Mar; doi.org/10.1016/j.apmt.2021.100960  IF2021=8.663， 共同通讯作者
  15. Xu H#, Wang C#, Liu C#, Peng Z, Li J, Jin Y, Wang Y, Guo J(郭家松)*, Zhu L*. Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head. Stem Cells Translational Medicine. 2021 May;10(5):781-796. doi: 10.1002/sctm.20-0346.  IF2021=7.655， 共同通讯作者
  16. Wang C#, Xu H#, Liu C#, Peng Z, Min R, Zhang Z, Li J, Jin Y, Wang Y, Li Z, Guo J(郭家松)*, Zhu L*. CaO2/Gelatin Oxygen Slow-Releasing Microspheres Facilitate Tissue Engineering Efficiency for Osteonecrosis of Femoral Head via Enhancing Angiogenesis and Survival of Grafted Bone Marrow Mesenchyml Stem Cells, Biomaterials Science, 2021 Apr 21;9(8):3005-3018. doi: 10.1039/d0bm02071k.IF2021=7.590， 共同通讯作者
  17. Peng Z, Wang C, Liu C, Xu H, Wang Y, Liu Y，Hu Y，Li J, Jin Y, Jiang C, Liu L, Guo J(郭家松)*, Zhu L*. 3D printed Polycaprolactone/ beta-tricalcium phosphate/ magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing large bone defect. Journal of Materials Chemistry B，2021 Jul 21;9(28):5698-5710. doi: 10.1039/d1tb00178g IF2021=7.571， 共同通讯作者
  18. Li L, Xu Y, Wang X, Hu X, Tan D, Li Z, Guo J (郭家松) *. Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury, Neural Regeneration Research, 2021 Jun;16(6):1078-1085.  doi: 10.4103/1673-5374.300459.IF2021=6.058, 通讯作者
  19. Hu X, Wang X, Xu Y, Li L, Liu J, He Y, Zou Y, Yu L, Qiu X, Guo J(郭家松) *.Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve，Advanced Healthcare Materials,2022 Jun;9(11):e1901570:1-12. doi: 10.1002/adhm.201901570  IF2021=11.092, 通讯作者
  20. Bu Y#, Wang X#, Li L, Hu X , Tan D, Li Z, Lai M, Qiu X, Sun F, Wang H, Yang F*, Wu D*, Guo J(郭家松) *. Lithium loaded octa-poly(ethylene glycol) based adhesive facilitates axon regeneration and reconnection of transected peripheral nerves. Advanced Healthcare Materials, 2020 Jul;9(13):e2000268:1-12；doi:10.1002/adhm.202000268.   IF2021=11.092， 共同通讯作者
  21. Lai M#, Pan M#,, Ge L, Liu J, Deng J, Wang X, Li L, Wen J, Tan D, Zhang H, Hu X, Fu L, Xu Y, Li Z, Qiu X, Chen G, Guo J(郭家松)*. NeuroD1 overexpression in spinal neurons accelerates axonal regeneration after sciatic nerve injury. Experimental Neurology. 2020 Jan 25;327:113215. doi: 10.1016/j.expneurol.2020.113215.   IF2021=5.620, 通讯作者
  22. Tan D, Zhang H, Deng J, Liu J, Wen J, Li L, Wang X, Pan M, Hu X, Guo J(郭家松)*. RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Cells. 2020 Jan 16;9(1):230. doi: 10.3390/cells9010230 IF2021=7.666, 通讯作者
  23. Li L#, Li Y#，Fan Z#，Wang X, Li Z, Wen J, Deng J, Tan D, Pan M, Hu X, Zhang H, Lai M, Guo J (郭家松)*.Ascorbic acid facilitates neural regeneration after sciatic nerve crush injury. Frontiers in Cellular Neuroscience. 2019 Mar 21;13:108. doi: 10.3389 IF2021=6.147, 通讯作者
  24. Yang M, Liu H, Wang Y, Wu G, Qiu S, Liu C,Tan Z, Guo J(郭家松)*, Zhu L*. Hypoxia reduces the osteogenic differentiation ofperipheral blood mesenchymal stem cells by upregulating Notch-1 expression, Connective Tissue Research. 2019 Nov;60(6):583-596. doi: 10.1080/03008207.2019.1611792IF2021=3.342， 共同通讯作者
  25. Liu H, Yang M, Wu G, Yang L, Cao Y, Liu C, Tan Z, Jin Y, Guo J(郭家松)*, Zhu L*. Effectsof different oxygen concentrations on the proliferation, survival, migration, andosteogenic differentiation of MC3T3-E1 cells. Connective Tissue Research. 2019 May;60(3):240-253. doi: 10.1080/03008207  IF2021=3.342， 共同通讯作者
  26. Tan D, Wen J, Li L, Wang X, Qian C, Pan M, Lai M, Deng J, Hu X, Zhang H, Guo J(郭家松)*.Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway. Frontiers in Cellular Neuroscience. 2018 Nov 20;12:437. doi: 10.3389/fncel.2018.00437.  IF2021=6.147, 通讯作者
  27. Wen J, Tan D, Li L, Wang X, Pan M, Guo J(郭家松)*. RhoA regulates Schwann cell differentiation through JNK pathway. Experimental Neurology, 2018 Oct;308:26-34. IF2021=5.620, 通讯作者
  28. Zhang Z, Wu G, Yang L, Cao Y, Liu C, Jin Y, Wang Y, Yang L, Guo J(郭家松)*, Zhu L*.Self-assembling peptide and nHA/CTS composite scaffolds increase seed cell adhesion and promote femoral condylar bone regeneration. Materials Science & Engineering C, 2018 Dec 1, 93：445-454  IF2021=8.457， 共同通讯作者
  29. Qian C#, Tan D#, Wang X, Li L, Wen J, Pan M, Li Y, Wu W, Guo J(郭家松)*.Peripheral nerve injury induced astrocyte activation in spinal ventral horn contributes to nerve regeneration, Neural Plasticity. 2018 Apr 3;doi: 10.1155/2018/8561704. IF2021=3.144, 通讯作者
  30. Wen J, Qian C, Pan M, Wang X, Li Y, Lu Y, Zhou Z, Yan Q, Li L, Liu Z, Wu W, Guo J(郭家松)*. Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells. Molecular Neurobiology, 2017; 54(2): 1229-1239.  IF2021=5.682, 通讯作者
  31. Pan M, Wang X, Chen Y, Cao S, Wen J, Wu G, Li Y, Li L, Qian C, Qin Z, Li Z, Tan D, Fan Z, Wu W, Guo J(郭家松)*. Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves. Experimental Neurology, 2017 Jun;292:92-101. doi: 10.1016/j.expneurol.2017.03.005，F2021=5.620, 通讯作者
  32. Zeng Y, Cheng S, Lin X, Hu X, Wang X, Guo J(郭家松)*. A Mini Review on the Progress of Using Extracts of Traditional Chinese Medicines (Tcm) to Facilitate the Peripheral Nerve Regeneration.  Biomed J Sci&Tech Res 5(5)- 2018. BJSTR.MS.ID.001269.DOI: 10.26717/ BJSTR.2018.05.001269. , 通讯作者
  33. Wen J, Li L, Tan D, Guo J(郭家松)*. Preparation of Teased Nerve Fibers from Rat Sciatic Nerve. Bio-protocols，2017; 7(19) DOI:10.21769/BioProtoc.2572. , 通讯作者
  34. Wen J, Tan D, Li L, Guo J(郭家松)*. Isolation and Purification of Schwann Cells from Spinal Nerves of Neonatal Rat. Bio-protocols，2017; 7(20) DOI:10.21769/BioProtoc.2588. , 通讯作者
  35. Qin ZQ, Zheng H, Zhou L, Ou YH, Huang B, Yan B, Qin ZS, Yang CL, Su YC, Bai XC*,Guo J(郭家松)*, Lin J*. Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins. Scientific Reports, 2016 Jan 22;6:19587. doi: 10.1038/srep19587IF2021=4.996， 共同通讯作者
  36. Qian CH, Wen JK,Guo J(郭家松)*. Inhibiting the RhoA signaling pathway promotes regeneration of axons and myelin sheath.  Neural Regen Res. 2015; 10(12):1957.IF=6.058, 通讯作者
  37. Wang XH, Guo J(郭家松)*. Significance and strategy of promoting seed cell survival in tissue-engineered artificial nerve construction. Neural Regen Res. 2015; 10(11):1795. IF2021=6.058,通讯作者
  38. Wu G, Pan M, Wang X, Wen J, Cao S, Li Z, Li Y, Qian C, Liu Z, Wu W, Zhu L*,Guo J(郭家松)*. Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect，Sci Rep, 2015; 5:16681. doi: 10.1038/srep16681.IF2021=4.996， 共同通讯作者
  39. Guo J(郭家松)*, Qian CH, Ling EA, Zeng YS*. Nanofiber scaffolds for treatment of spinal cord injury. Current Medical Chemistry. 2014; 21:4282-4289. IF2021=4.740， 共同通讯作者
  40. Wang XH, Pan MJ, Wen JK, Tang YJ, Hamilton AD, Li YY, Qian CH, Liu ZY, Wu WT,Guo J(郭家松)*. A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit. Neural Regen Res. 2014; 9(24):2132-2141. IF2021=6.058, 通讯作者
  41. Zhan XD, Gao MY, Jiang YW,  Zhang WW, Wong WM, Yuan Q, Su H,  Kang X,  Dai X,  Zhang W, Guo J(郭家松)*, Wu W*. Nanofiber nerve scaffolds facilitate functional regeneration of peripheral nerve injury, Nanomedicine-Nanotechnology Biology and Medicine, 2013;9(3):305-315. IF2021=6.458， 共同通讯作者
  42. Zhang WW, Zhan XD, Gao MY, Hamilton AD, Liu ZY, Jiang Y, Su H, Dai X, He B, Kang XN, Zeng YS, Wu W*, Guo J(郭家松)*. Self assembling peptide nanofiber scaffold enhanced with RhoA inhibitor CT04 improves axonal regeneration in the transected spinal cord，Journal of Nanomaterials, 2012; doi:10.1155/2012/724857.IF2021=3.791， 共同通讯作者
  43. Kang XN, Wen JK, Wang XH, Pan MJ, Zhang WW, Zhan XD, Liu ZY, Wu WT, Guo J(郭家松)*. Temporal and spatial pattern of RhoA expression in injured spinal cord of adult mice. J South Med Univ. 2013; 33(4):463-468. , 通讯作者
  44. Guo J(郭家松), Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD, Suter U, Li J*. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Annals of Neurology.2014; 75(2):255-265.IF2021=11.274
  45. Guo J(郭家松), Ma YH, Yan Q, Wang L, Zeng YS, Wu JL, Li J*. Fig4 Expression in the Nervous System and Its Protection against Abnormal Lysosomal Accumulation. Journal of Neuropathology and Experimental Neurology, 2012;71(1),28-39.IF2021=3.148
  46. Guo J(郭家松), Leung KKG, Su H, Yuan QJ, Wang L, Chu TH, Zhang W, Pu JKS, Ng GKP, Wong WM, Dai X, Wu WT*. Self assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine-Nanotechnology Biology and Medicine, 2009; 5(3):345-351.IF2021=6.458
  47. Guo J(郭家松), Su H, Zeng Y, Liang YX, Ellis-Behnke RG, So KF, Wu W*. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine-Nanotechnology Biology and Medicine, 2007; 3(4):311-321.IF2021=6.458
  48. Guo J(郭家松), Zeng YS*, Li HB, Huang WL, Liu RY, Li XB, Ding Y, Wu LZ, Cai DZ. Cotransplant of neural stem cells and NT-3 genetically modified Schwann cells promote the recovery transected spinal cord injury. Spinal Cord, 2007; 45(1): 15-24. IF2021=2.473
  49. Guo J(郭家松), Zeng Y, Liang YX, Wang L, Su H, Wu W*. Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. Neuroreport, 2007;18(9):863-868.Cover storyIF2021=1.703
  50. Guo J(郭家松), So KF, Wu W. Self assembling peptides mediate neural regeneration. In So KF, Xu XM. Edited《Neural Regeneration》 Elsevier, 2015
  51. Guo J(郭家松), Leung KKG, Wu W. Bridging the Gap for Regeneration after CNS Injury by Nanofiber Scaffolds: use of SAPNS for Traumatic Brain and Spinal Cord Injury. In Martin CR, Preedy VR, Hunter RJ, edited 《Nanomedicine and the Nervous System》. Science Publishers, New York, 2012:330-346