个人简介

南方医科大学药学院教授，博士生导师。主要研究方向为利用合成致死理念为难以直接靶向的肿瘤驱动突变探索治疗靶点和药物以及靶向治疗生物标志物的发现。主持多项国家自然科学基金面上项目和广东省自然科学基金面上项目。获得广东省高校优秀青年教师和广州市珠江科技新星等人才项目支持。担任Journal of Clinical Laboratory Analysis杂志副主编和Exploration of Digestive Diseases杂志编委。

研究领域

抗肿瘤精准个体化治疗的基础和转化研究

个人代表性成果

近三年代表性论文

(1) Gui-Ming Zhang, Si-Si Huang, Lin-Xuan Ye, Xiao-Lian Liu, Wen-Hui Shi, Zhong-Lu Ren, Run-Hua Zhou, Jia-Jie Zhang, Jing-Xuan Pan, Shu-Wen Liu, Le Yu*, Yi-Lei Li*. Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors. Pharmacological Research, 2022, 184:106464. (IF:10.334)

(2) Xiao-Lian Liu, Gui-Ming Zhang, Si-Si Huang, Wen-Hui Shi, Lin-Xuan Ye, Zhong-Lu Ren, Jia-Jie Zhang, Shu-Wen Liu, Le Yu*, Yi-Lei Li*. PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma. Acta Pharmacologica Sinica, 2022, 43(9):2397-2409. (IF:7.169)

(3) Yu-Yan Xu, Zhong-Lu Ren, Xiao-Lian Liu, Gui-Ming Zhang, Si-Si Huang, Wen-Hui Shi, Lin-Xuan Ye, Xin Luo, Shu-Wen Liu, Yi-Lei Li*, Le Yu*. BAP1 loss augments sensitivity to BET inhibitors in cancer cells. Acta Pharmacologica Sinica, 2022, 43(7):1803-1816. (IF:7.169)

(4) Le Yu*, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu*, Kun-liang Guan*. Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Molecular Oncology, 2022, 16(3):607-629. (IF:7.449)

(5) Xin Luo, Yuyan Xu, Yilei Li, Guiming Zhang, Sisi Huang, Xiaolian Liu, Zhonglu Ren, Shuwen Liu, Le Yu*. BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma. Melanoma research, 2021, 31(2):119-129. (IF:3.199)