一、主持课题：
1. 国家自然科学基金面上项目(82473544):T细胞来源的工程化纳米囊泡与Cu-EGCG酶协同靶向清除真表皮PDL1high光老化细胞的作用及机制，49万元，2025.01-2028.12，主持
2. 国家自然科学基金面上项目(81673085)：长非编RNALnc-SPRY调控光老化皮肤Cathepsins在变性弹性纤维胞吞降 解中作用机制研究，60万元，2017.01.01-2020.12.31 ，主持
3. 国家自然科学基金青年项目(81201241)：光老化皮肤 CatG、MMPS 对 TGF-β/Smad 通路的调控及交互作用研究，23万元，2013.01.01-2015.12.31，主持
4. 广东省自然科学基金(2022A1515012253)：UV通过新型免疫检查点通路CD155-TIGIT/CD96/CD226轴介导CD8+T细胞功能 耗竭诱发真皮免疫微环境失衡的日光致皮肤恶性肿瘤调控及机制研究，10万元，2022.01.01-2024.12.31，主持
5. 广东省自然科学基金(2020A1515010305)：miR4298通过LncRNA-CTSD2调控CathepsinD阻断AGEs异常堆积在皮肤慢性紫 外线损伤中的作用机制研究，10万元，2019.10.01-2022.9.30，主持
6. 广州市科学技术局(202102010284)：控释cathepsinD+cathepsinK新型复合生物微球在防治皮肤光老化中 的作用及机制研究，20万元，2021.04.01-2023.3.31，主持
二、第一作者或通讯作者发表论文
1. Hou W#, Lin Z#, Chen X, Sun Y, Lin Y, Peng M, Zhou F, Jiang H, Li Y*, Zheng Y*. Sustained release of cathepsin d / cathepsin k from injectable hydrogel microspheres in anti-photoaging. Mater Today Bio 2025, 34: 13.
2. Su Z#, Zheng Y#, Yi J, Lai W*, Ye C*. The effectiveness and safety of a skin care product with centella asiatica leaf extract, ceramide np, and panthenol in subjects with sensitive skin: a prospective, observational study. J Cosmet Dermatol 2025, 24(7): e70324
3. Wang M#, Yang Q#, Xiao W, Luo Y, Chen J, Tang Z, Wei Y, Li H, You W, Zheng Y*, Li L*. Mechanism of pisd/spg7-mediated mptp opening in necroptosis of inflammatory hacat cells induced by nano-zinc oxide. Toxicology 2025, 518: 154258.
4. Li L#, Huang Y, Xue R, Li G, Li L, Liang L, Lai K, Huang X*, Qin Y*,Zheng Y* . T cell-mediated mechanisms of immune-related adverse events induced by immune checkpoint inhibitors. Crit Rev Oncol Hematol 2025, 213: 10.
5. Sun Y#, Du Y#, Hu Y, Li L, Zheng Y*. Editorial: advances and novel intervention in photodermatology. Front Med (Lausanne) 2025, 12: 1601630.
6. Wang Q#, Liu Y#, Ye C, Shen J, Lin J, Du Y, Li L, Huang X*, Zheng Y*. SSA‐ZP on scalp seborrheic dermatitis: regulating sebum levels and scalp barrier. J Cosmet Dermatol 2025, 24(1): e16617.
7. Chen X#, Zhou F#, Lin Y#, Xia Y, Zhang J, Hou W, Sun Y*, Lai W*, Zheng Y*. Mir-4298 and lnckrtap5-6-3 regulated cathepsin d expression through erk-mapk signaling pathway in chronic uvb-damaged hacat cells. Front Med (Lausanne) 2025, 11: 1485224.
8. Wang M#, Chen J#, Luo Y, Feng M, Yang Q, Tang Y, Tang Z, Xiao W, Zheng Y*, Li L. Design strategies and application potential of multifunctional hydrogels for promoting angiogenesis. Int J Nanomedicine 2024, 19: 12719-12742.大类2区/小类2区
9. Lin Y#, Sun Y#, Hou W, Chen X, Zhou F, Xu Q*, Zheng Y*. FTO-mediated regulation of m6a methylation is closely related to apoptosis induced by repeated uv irradiation. J Dermatol Sci 2024, 114(3): 124-132.
10. Hong Y# , Huang Y , Li X ,Zhu L , Zheng Y* , Gong Z* . Independent risk factor of drug eruption in immune checkpoint inhibitors treated liver cancer patients: high systemic immune-inflammation index. Cutan Ocul Toxicol 2024, 43(4): 258-263.
11. Ye C#, Yi J#, Su Z, Gao X, Jiang X, Yu N, Xiang L, Zeng W, Li J, Jin H, Liu W, Zheng Y*, Lai W*. 2% supramolecular salicylic acid hydrogel vs. Adapaline gel in mild to moderate acne vulgaris treatment: a multicenter, randomized, evaluator‐blind, parallel‐controlled trial. J Cosmet Dermatol 2024, 23(6): 2125-2134.
12. Zhou F#, Sun Y#, Chen X#, Hou W, Shen J, Lai W, Han K*, Zheng Y*. Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case. Front Med (Lausanne) 2024, 11: 1453940.
13. Cen X#, Li M, Yao A, Zheng Y*, Lai W*. Immune infiltration and clinical significance analyses of the cancer‐associated fibroblast‐related signature in skin cutaneous melanoma. The Journal of Gene Medicine 2024, 26(1): e3614.
14. Ju E#, Peng M#, Xu Y, Wang Y, Zhou F, Wang H, Li M, Zheng Y*, Tao Y*. Nanozyme-integrated microneedle patch for enhanced therapy of cutaneous squamous cell carcinoma by breaking the gap between h2o2 self-supplying chemodynamic therapy and photothermal therapy. J Mater Chem B 2023, 11(28): 6595-6602.
15. Xie Y#, Zhang J, Li M, Zhang Y, Li Q, Zheng Y*, Lai W*. Identification of lactate-related gene signature for prediction of progression and immunotherapeutic response in skin cutaneous melanoma. Front Oncol 2022, 12: 818868.
16. Xie Y#, Zhu G#, Yi J, Ji Y, Xia Y, Zheng Y*, Ye C*. A new product of multi‐plant extracts improved skin photoaging: an oral intake in vivo study. J Cosmet Dermatol 2022, 21(8): 3406-3415.
17. Peng M#, Ju E#, Xu Y#, Wang Y, Lv S, Shao D, Wang H, Tao Y*, Zheng Y*, Li M*. Dual-responsive disassembly of core-shell nanoparticles with self-supplied h2o2 and autocatalytic fenton reaction for enhanced chemodynamic therapy. NPG Asia Mater 2022, 14(1): 95.
18. Ye C#, Zhang Y#, Su Z#, Wu S#, Li Y, Yi J, Lai W*, Chen J*, Zheng Y*. HMSC exosomes as a novel treatment for female sensitive skin: an in vivo study. Front Bioeng Biotechnol 2022, 10: 1053679
19. Pan N#, Xia Y, Hou W, Zhu G, Zhang J, Lai W, Zheng Y*. Assessment of skin photoallergy risk in cosmetics containing herbal extract ingredients. Skin Pharmacol Physiol 2021, 34(5): 253-261.
20. Hou W#, Lin Y#, Xu W#, Chen H#, Liu Y, Li C*, Zheng Y*. Identification and biological analysis of lncspry4‐it1‐targeted functional proteins in photoaging skin. Photodermatology, Photoimmunology & Photomedicine 2021, 37(6): 530-538.
三、以主要执笔人制定团体标准或专家共识
1. 团体标准（T/GDICST 005-2024）化妆品原料可豁免皮肤光毒性和皮肤光变态反应试验的判断方法
2. 团体标准（T/CRHA 081-2024） 油橄榄叶来源的纳米囊泡
3. 团体标准（TZGKSL 001-2022）人体衰老评价标准
4. 团体标准（T/CPQS E0007—2020）家用和类似用途皮肤美容器评价规范
5. 团体标准(T/GDICST 003-2023《化妆品舒缓功效评价脂多糖诱导巨噬细胞炎症因子IL-6测定方法》
6.中层复合酸在皮肤美容中的应用专家共识 [J]. 临床皮肤科杂志, 2025, 54 (08): 501-504. DOI:10.16761/j.cnki.1000-4963.2025.08.014.