黄文东,中山大学药理学博士,主任药师、南方医科大学/广东医科大学硕士研究生导师。现任茂名市人民医院科研部负责人、临床试验机构办主任、I期临床试验研究室负责人(PI)、广东省精准质谱分析与转化医学工程技术研究中心主任、广东省GCP检查专家。兼任广东省转化医学理事、广东省人类遗传资源与保藏学会理事、广东省药学会药物临床试验委员会常委、广东省医疗器械管理学会医疗器械临床试验专业委员会常委等。 从事医院科研管理工作和心血管药理、代谢性疾病基础研究,主持广东省基础与应用基础研究基金自然科学基金项目(面上)、广东省科技项目等科研课题共9项;以第一/通讯(含共同)作者身份发表SCI论文21篇;荣获2019年广东省优秀科技奖,2022年茂名市企事业科技进步奖一等奖。
主要研究方向为心血管药理和代谢性疾病,围绕高脂血症、肥胖和胰岛素抵抗等开展相关研究。
一、主持的主要科研项目(课题)情况:
(1)广东省基础与应用基础研究基金自然科学基金项目(面上项目),2023A1515010710,乙酰紫草素激活Sirt3抑制PKCδ/NLRP3减轻焦亡缓解糖尿病心肌病的机制研究,2023/01-2025/12,10万;
(2)广东省基础与应用基础研究基金自然科学基金项目(面上项目),2021A1515010884,基于PPARγ信号通路探讨乙酰紫草素改善内皮功能障碍机制研究,2021/01-2023/12,10万;
(3)茂名市人民医院双优人才计划项目,SY2020006,优秀青年人才,2020/01-2023/01,20万
(4)茂名市人民医院高水平医院建设科研专项,ZX2020001,乙酰紫草素通过调节FFAs转运保护血管内皮功能障碍及其机制研究,2020/01-2022/12,10万;
(5)茂名市人民医院博士科研启动资金项目,202001,乙酰紫草素对游离脂肪酸诱导的血管内皮功能障碍的调控机制研究,2020/01-2022/12,20万;
(6)广东省科技专项资金("大专项+任务清单"),2020S00049,乙酰紫草素对动脉粥样硬化中巨噬细胞自噬功能调控及其机制研究,2019/11–2022/12,10万元;
(7) 茂名市科技计划项目-社会公益科技研究专题,2019018023,化橘红提取物柚皮苷对血脂代谢的调控作用及其机制研究,2019/01–2020/12,5万元;
(8) 广东省医学科学技术研究基金项目,B2018061,Apelin-13通过VEGF促进糖尿病伤口愈合及其机制研究,2018/07-2020/06,立项非资助;
(9) 广东省医学科学技术研究基金项目,A2017490,基于Apelin-13改善糖尿病并发心肌梗死的临床预后及其机制研究,2017.07–2019.06,0.5万元
二、部分代表性论著
(1)Furong Huang, PeiwenGuang, Fucui Li, Xuewen Liu, Weimin Zhang, Wendong Huang,AML, ALL, and CML classification and diagnosis based on bone marrow cell morphology combined with convolutional neural network: A STARD compliant diagnosis research, Medicine (Baltimore). 2020 Nov 6;99(45):e23154.(期刊论文,通讯作者)
(2)PeiwenGuang, Wendong Huang, Liu Guo, Xinhao Yang, Furong Huang, Maoxun Yang, Wangrong Wen, Li Li, Blood-based FTIR-ATR spectroscopy coupled with extreme gradient boosting for the diagnosis of type 2 diabetes: A STARD compliant diagnosis research, Medicine (Baltimore).2020 Apr;99(15):e19657.(期刊论文,通讯作者)
(3)Huang, Wendong#; Zeng, Jiacheng#; Liu, Zhaochun#; Su, Meiling; Li, Qisen; Zhu, Banghao*; Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-beta 3/PKC delta-dependent pathway, Biomedicine & Pharmacotherapy, 2019, 112: 0-108588. (期刊论文)
(4)Lu, Yaoyong; Deng, Xubin; Xiao, Guanghui; Zheng, Xin; Ma, Lei; Huang, Wendong*; circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells, Epigenomics, 2019, 11(11): 1335-1353. (期刊论文)
(5)Lu, Yaoyong; Liang, Yingying; Zheng, Xin; Deng, Xubin*; Huang, Wendong*; Zhang, Gong*; EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo-/radioresistance in nasopharyngea carcinoma, Journal of Experimental & Clinical Cancer Research, 2019, 38: 0-82. (期刊论文)
(6)Lu, Yaoyong; Huang, Wendong#; Chen, Haiwen; Wei, Huajun; Luo, Aihua; Xia, Guangsheng; Deng, Xubin; Zhang, Gong*;MicroRNA-224, negatively regulated by c-jun, inhibits growth andepithelial-to-mesenchymal transition phenotype via targeting ADAM17 in oral squamous cell carcinoma,Journal of Cellular and Molecular Medicine, 2019, 23(8): 4913-4920. (期刊论文)
(7)Huang, Wendong#; Zhou, Huazhong; Li, Qisen; Pi, Lei; Xu, Yufen; Fu, LanYan; Yang, Yanfang; Lu, Zhaoliang; Che, Di; Gu, Xiaoqiong*;Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population,Journal of Clinical Laboratory Analysis, 2019, 33(9): 0-e22992. (期刊论文)
(8)Che, Di#; Huang, Wendong#; Fang, Zhenzhen#; Li, Li; Wu, Haiying; Pi, Lei; Zhou, Huazhong; Xu, Yufen; Fu, LanYan; Tan, Yaqian; Lu, Zhaoliang; Li, Qingfeng*; Gu, Xiaoqiong*; The lncRNA CCAT2 rs6983267 G allele is associated with decreased susceptibility to recurrent miscarriage, Journal of Cellular Physiology, 2019, 234(11): 20577-20583. (期刊论文)
(9)Huang, Wendong#; Zhou, Huazhong#; Pi, Lei; Xu, Yufen; Fu, LanYan; Yang, Yanfang; Che, Di*; Gu, Xiaoqiong*; Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population, Journal of Clinical Laboratory Analysis, 2019, 33(6): 0-e22919. (期刊论文)
(10) Su, Meiling#; Huang, Wendong#; Zhu, Banghao*; Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis, PLos One, 2016, 11(1). (期刊论文)