代表性论文（*代表通讯作者）：
1. Yang J, Gao Y, Liu J, Zeng Q, Xiao Z, Chai J, Osman AAK, Lu W, Chen X*, Xu X. FS145 exerts anti-inflammatory and analgesic effects through blocking integrin αvβ3 on macrophages. Eur J Pharmacol. 2025 Jul 2;1003:177891. doi: 10.1016/j.ejphar.2025.177891. Epub ahead of print. PMID: 40615104.（IF=4.7）
2. Luo P, Fan C, Li A, Jiang T, Jiang A, Qi C, Gan W, Zhu L, Mou W, Zeng D, Tang B, Xiao M, Chu G, Liang Z, Shen J, Liu Z, Wei T, Cheng Q, Lin A, Chen X*. Performance analysis of large language models in multi-disease detection from chest computed tomography reports: a comparative study: Experimental Research. Int J Surg. 2025 Jun 5. doi: 10.1097/JS9.0000000000002582. Epub ahead of print. PMID: 40497825.（IF=10.1）
3. Zhang S, Zhou H, Liu Y, Chen G, Li Q, Xu Y, Zheng R, Li S, Chen X*, Zhao L. A stimuli-responsive immunostimulant to activate chemo-immunotherapeutic effects by inducing DNA damage and STING activation. J Colloid Interface Sci. 2025 Jun 15;688:664-676. doi: 10.1016/j.jcis.2025.02.179. Epub 2025 Feb 26. PMID: 40022787.（IF=9.7）
4. Li Y, Yang S, Jiang F, Luo S, Liang J, Jiang L, Chen Z, Chen X*, Yang J. Cilnidipine exerts antiviral effects in vitro and in vivo by inhibiting the internalization and fusion of influenza A virus. BMC Med. 2025 Apr 7;23(1):200. doi: 10.1186/s12916-025-04022-0. PMID: 40189517; PMCID: PMC11974063.（IF=8.3）
5. Chen JH, Li KX, Fan CF, Yang H, Zhang ZR, Chen YH, Qi C, Li AH, Lin AQ, Chen X*, Luo P. Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates. Acta Pharmacol Sin. 2025 Apr 15. doi: 10.1038/s41401-025-01539-1. Epub ahead of print. PMID: 40234619.（IF=8.4）
6. Yao L, Chen Z, Gan S, Fu C, Xie Z, Zhang H, Yang C, Fu L, Liu Y, Luo M, Kuang D, Cao J, Hu G, Li S, Yang L, Li L, Chen X*, Tang H. Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling. Cell Commun Signal. 2025 Feb 27;23(1):113. doi: 10.1186/s12964-025-02110-5. PMID: 40011876; PMCID: PMC11866821.（IF=8.9）
7. Xiao S, Tian M, Liao H, Xie J, Chai J, Li J, Nguyen T, Wu J, Gao Y, Li J, Chen X*, Xu X, Qingwen W. The first Ranatuerin antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo. Life Sci. 2025 Feb 15;363:123375. doi: 10.1016/j.lfs.2025.123375. Epub 2025 Jan 7. PMID: 39788417.（IF=5.1）
8. Chen Z, Jia P, Xie D, Xie J, Liu J, Cao W, Han L, Ran J, Sun S, Zhao S, Ge Y, Martinez L, Chen X*, Cao P. Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis. BMC Public Health. 2025 Jan 17;25(1):210. doi: 10.1186/s12889-025-21422-2. PMID: 39833787; PMCID: PMC11745008.（IF=3.6）
9. Tang H, Li Z, Yang C, Fu L, Ji X, Chen Z, Gan S, Zhang H, Zhang P, Li S, Zhang W, Chen X*, Yao L, Li J. CTSS contributes to airway neutrophilic inflammation in mixed granulocytic asthma. Respir Res. 2024 Dec 24;25(1):441. doi: 10.1186/s12931-024-03077-6. PMID: 39719614; PMCID: PMC11669210.（IF=5.0）
10. Chen Z, Tian Y, Liu J, Ran J, Sun S, Zhao S, Ge Y, Martinez L, Chen X*, Cao P. COVID-19 and sepsis-related excess mortality in the US during the first three years: A national-wide time series study. Am J Epidemiol. 2024 Oct 30:kwae411. doi: 10.1093/aje/kwae411. Epub ahead of print. PMID: 39479803.（IF=4.8）
11. Chai J, Wu J, Yang J, Ye T, Gao Y, Zeng B, Xiong W, Kotsyfakis M, Dijkgraaf I, Liu J, Chen X*, Xu X. Cath-HG improves the survival rates and symptoms in LPS-induced septic mice due to its multifunctional properties. Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113332. doi: 10.1016/j.intimp.2024.113332. Epub 2024 Oct 11. PMID: 39395379.（IF=4.7）
12. Zheng R, Yang N, Li Q, Chen Z, Huang C, Zhao L, Chen X*, Li S. Chimeric peptide-engineered immunostimulant for endoplasmic reticulum targeted photodynamic immunotherapy against metastatic tumor. J Control Release. 2024 Oct;374:230-241. doi: 10.1016/j.jconrel.2024.08.013. Epub 2024 Aug 20. PMID: 39151829.（IF=11.5）
13. Chen S, Chen P, Su M, Jiang J, Liu X, Shen P, Li X, Rong F, Zhang S, Liu J, Zeng Y, Lei W, Li J, Wang K, Chen G, Zheng X, Chen X*, Xiao Q. Integrative Analyses Reveal the Correlation Between the Airway Microbiome and Host Metabolism in Severe Community-acquired Pneumonia. Am J Respir Cell Mol Biol. 2024 Aug 5. doi: 10.1165/rcmb.2024-0030OC. Epub ahead of print. PMID: 39102869.（IF=5.3）
14. Wang K, Nguyen T, Gao Y, Guo R, Fan C, Liao H, Li J, Chai J, Xu X, Gong Y, Chen X*. Androcin 18-1, a novel scorpion-venom peptide, shows a potent antitumor activity against human U87 cells via inducing mitochondrial dysfunction. Insect Biochem Mol Biol. 2024 Jul;170:104137. doi: 10.1016/j.ibmb.2024.104137. Epub 2024 May 15. PMID: 38759703.（IF=3.7）
15. Li J, Li Y, Chen G, Liang Y, Xie J, Zhang S, Zhong K, Jiang T, Yi H, Tang H, Chen X*. GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury. Am J Pathol. 2024 Jul;194(7):1185-1196. doi: 10.1016/j.ajpath.2024.03.003. Epub 2024 Mar 26. PMID: 38548270.（IF=3.6）
16. Lu W, Xiao Z, Liao H, Xie J, Gao Y, Xiong W, Zeng Q, Deng Z, Wu J, Chai J, Chen X*, Xu X. FS145, the first flea-derived disintegrin, inhibits angiogenesis through specifically binding integrin αvβ3. Int J Biol Macromol. 2024 Feb;259(Pt 2):129289. doi: 10.1016/j.ijbiomac.2024.129289. Epub 2024 Jan 9. PMID: 38211910.（IF=8.2）
17. Liang Y, Zhang H, Li J, Wang X, Xie J, Li Y, Li J, Qian Y, Zhang H, Wang T, Tang H, Chen X*. GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury. Cell Biol Int. 2024 Jan 15. doi: 10.1002/cbin.12127. Epub ahead of print. PMID: 38225684.(IF=3.9)
18. Zhang H, Li J, Wang X, Wang K, Xie J, Chen G, Li Y, Zhong K, Li J, Chen X*. IRE1α/XBP-1 promotes β-catenin signaling activation of airway epithelium in lipopolysaccharide-induced acute lung injury. Pulm Pharmacol Ther. 2023 Dec;83:102263. doi: 10.1016/j.pupt.2023.102263. Epub 2023 Nov 5. PMID: 37935327.(IF=3.2)
19. Xiong W, Xie J, Liang Y, Chai J, Guo R, Zeng B, Wu J, Lai S, Zhang H, Huang X, Chen X*, Xu X. Cath-DM-NT, a peptide derived from the skin of Duttaphrynus melanostictus, shows dual lectin-like and antioxidant activity. Eur J Pharmacol. 2023 Oct 5;956:175941. doi: 10.1016/j.ejphar.2023.175941. Epub 2023 Aug 1. PMID: 37536626.（IF=5.0）
20. Nguyen TT, Deng Z, Guo RY, Chai JW, Li R, Zeng QY, Lai SA, Chen X*, Xu XQ. Periplaneta Americana Extract Ameliorates LPS-induced Acute Lung Injury Via Reducing Inflammation and Oxidative Stress. Curr Med Sci. 2023 Jun;43(3):445-455. doi: 10.1007/s11596-023-2723-8. Epub 2023 May 16. PMID: 37191939. (IF= 2.4)
21. Deng Z, Gao Y, Nguyen T, Chai J, Wu J, Li J, Abdel-Rahman MA, Xu X, Chen X*. The Potent Antitumor Activity of Smp43 against Non-Small-Cell Lung Cancer A549 Cells via Inducing Membranolysis and Mitochondrial Dysfunction. Toxins (Basel). 2023 May 19;15(5):347. doi: 10.3390/toxins15050347. PMID: 37235381; PMCID: PMC10223799. (IF= 4.2)
22. Li J, Liang Y, Su M, Wu J, Chai J, Xiong W, Mo G, Chen X*, Xu X. Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae). Biochem Pharmacol. 2023 Apr;210:115471. doi: 10.1016/j.bcp.2023.115471. Epub 2023 Mar 7. PMID: 36893813.(IF=5.8)
23. Tian M, Wang K, Liang Y, Chai J, Wu J, Zhang H, Huang X, Chen X*, Xu X. The first Brevinin-1 antimicrobial peptide with LPS-neutralizing and anti-inflammatory activities in vitro and in vivo. Front Microbiol. 2023 Mar 3;14:1102576. doi: 10.3389/fmicb.2023.1102576. PMID: 36937273; PMCID: PMC10020232.(IF=5.2)
24. Xiong W, Fan H, Zeng Q, Deng Z, Li G, Lu W, Zhang B, Lai S, Chen X*, Xu X. The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels. Acta Pharm. 2023 Jan 24;73(1):145-155. doi: 10.2478/acph-2023-0010. PMID: 36692462. (IF=2.8)
25. Zheng RR, Zhao LP, Yang N, Chen ZX, Kong RJ, Huang CY, Rao XN, Chen X*, Cheng H, Li SY. Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor. Small. 2023 Jan;19(3):e2205694. doi: 10.1002/smll.202205694. Epub 2022 Nov 11. PMID: 36366925. (IF= 13.3)
26. Xiong W, Xie J, Liang Y, Chai J, Guo R, Zeng B, Wu J, Lai S, Zhang H, Huang X, Chen X*, Xu X. Cath-DM-NT, a peptide derived from the skin of Duttaphrynus melanostictus, shows dual lectin-like and antioxidant activity. Eur J Pharmacol. 2023 Oct 5;956:175941. doi: 10.1016/j.ejphar.2023.175941. Epub 2023 Aug 1. PMID: 37536626. (IF=5.0)
27. Gao Y, Chai J, Wu J, Zeng Q, Guo R, Chen X*, Xu X. Molecular Cloning and Characterization of a Novel Antimicrobial Peptide from the Skin of Kaloula pulchra. Curr Pharm Biotechnol. 2022;23(15):1873-1882. doi: 10.2174/1389201023666220304204645. PMID: 35249479. (IF=2.8)
28. Guo R, Chen X, Nguyen T, Chai J, Gao Y, Wu J, Li J, Abdel-Rahman MA, Chen X*, Xu X. The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation. Toxins (Basel). 2022 Aug 27;14(9):590. doi: 10.3390/toxins14090590. PMID: 36136528; PMCID: PMC9502404. (IF= 4.2)
29. Zeng Q, Lu W, Deng Z, Zhang B, Wu J, Chai J, Chen X*, Xu X. The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation. J Biol Chem. 2022 Jan;298(1):101497. doi: 10.1016/j.jbc.2021.101497. Epub 2021 Dec 14. PMID: 34919963; PMCID: PMC8732088. (IF= 4.8)
30. Li J, Wang K, Huang B, Li R, Wang X, Zhang H, Tang H, Chen X*. The receptor for advanced glycation end products mediates dysfunction of airway epithelial barrier in a lipopolysaccharides-induced murine acute lung injury model. Int Immunopharmacol. 2021 Apr;93:107419. doi: 10.1016/j.intimp.2021.107419. Epub 2021 Feb 3. PMID: 33548580. (IF= 5.6)
31. Chai J, Chen X*, Ye T, Zeng B, Zeng Q, Wu J, Kascakova B, Martins LA, Prudnikova T, Smatanova IK, Kotsyfakis M, Xu X. Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties. Elife. 2021 Apr 20;10:e64411. doi: 10.7554/eLife.64411. PMID: 33875135; PMCID: PMC8057816. (IF= 7.7)
32. Deng Z, Zeng Q, Tang J, Zhang B, Chai J, Andersen JF, Chen X*, Xu X. Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis. J Biol Chem. 2021 Jan-Jun;296:100670. doi: 10.1016/j.jbc.2021.100670. Epub 2021 Apr 15. PMID: 33864815; PMCID: PMC8131326. (IF= 4.8)