南方医科大学南方医院脊柱骨科科室主任、学科带头人、主任医师、教授、博士研究生导师、博士后合作导师。

主持国家重大研发计划项目1项、国家自然基金5项，主持或参与省市级课题10余项；主译著作1部，参编多部；获发明专利4项，实用新型专利1项；发表SCI文章40余篇。曾获军队科技进步二等奖、广东省科学技术二等奖、广东省科学技术一等奖、“广东省杰出青年医学人才”、广东省医学会“先进学会工作者”等称号。

现任中华医学会骨科学分会委员、中国医师协会神经修复专业委员会副主委、国际矫形与创伤外科学会SICOT中国部青年委员会主任委员、中国白求恩基金会基层教育委员会副主任委员、中华医学会结核病学分会骨科专业委员会副主委、中国康复医学会脊柱脊髓专业委员会常委、中国医学教育委员会脊柱外科学会常委兼腰椎外科学组副主任委员、中华预防医学会脊柱外科分会委员、广东省医学会脊柱外科学分会主任委员、广东省医学教育协会脊柱外科专业委员会主任委员、广东省康复医学会脊柱脊髓分会会长、广东省健康管理学会脊柱外科学会副主任委员等多项学术任职。

擅长：1. 采用神经显微镜技术治疗颈椎病。2.上颈椎疾患。寰枢椎脱位、上颈椎肿瘤的切除与重建、椎管内肿瘤切除与重建。3.胸椎黄韧带骨化和胸椎椎间盘突出造成的胸椎管狭窄症。4.脊柱结核。本中心脊柱结核科研成果获得广东省科学技术一等奖，开创了国际脊柱结核外科治疗新纪元。5.儿童先天性脊柱畸形。6. 设计撬拨复位技术治疗重度腰椎滑脱。7.脊柱翻修手术。8.脊柱侧凸、后凸畸形。

1.脊柱外科学；

2.新型骨生物材料；

3.脊柱发育学；

4.脊柱退变的机制；

5.骨代谢

一：以（共同）第一作者发表文章    

1. MTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation — Nat Commun — 2016 — IF 12.124
2. Acellular Spinal Cord Scaffold Seeded With Bone Marrow Stromal Cells Protects Tissue and Promotes Functional Recovery in Spinal Cord-Injured Rats — J. Neurosci. Res. — 2014—IF 4.139

二：以通讯作者发表文章（2区及以上）

1. Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis — PNAS (Proc Natl Acad Sci U S A) — 2025 — IF 9.1
2. An Integrated Microcurrent Delivery System Facilitates Human Parathyroid Hormone Delivery for Enhancing Osteoanabolic Effect — Small Methods — 2025 — IF 9.1
3. Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy — Biomarker Research — 2025 — IF 11.5
4. GPx3 Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglial Pyroptosis Through IRAK4/ROS/NLRP3 Axis — Antioxidants & Redox Signaling — 2025 — IF 6.1
5. The Role of mRNA Modifications in Bone Diseases — Int J Biol Sci — 2025 — IF 10.0
6. Nr4a1 enhances Wnt4 transcription to promote mesenchymal stem cell osteogenesis and alleviates inflammation-inhibited bone regeneration — Molecular Therapy — 2024 — IF 12.0
7. Thrombospondin-1 promotes mechanical stress-mediated ligamentum flavum hypertrophy through the TGFβ1/Smad3 signaling pathway — Matrix Biology — 2024 — IF 4.8
8. Identification and validation of ferroptosis-related biomarkers in intervertebral disc degeneration— Frontiers in Cell and Developmental Biology — 2024 — IF 4.3
9. Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling — International Immunopharmacology — 2023 — IF 4.7
10. Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling — Exp Mol Med — 2022 — IF 12.9
11. An injectable pH neutral bioactive glass-based bone cement with suitable bone regeneration ability — Journal of Orthopaedic Translation — 2022 — IF 7.8
12. EGF Contributes to Hypertrophy of Human Ligamentum Flavum via the TGF-β1/Smad3 Signaling Pathway — International Journal of Medical Sciences — 2022 — IF 3.2
13. Melatonin Promotes Heterotopic Ossification Through Regulation of Endothelial-Mesenchymal Transition in Injured Achilles Tendons in Rats — Front Cell Dev Biol — 2021 — IF 6.617
14. Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/ mTORC1 Signaling Pathway — Stem Cells Int. — 2021 — IF 5.443
15. miR-10396b-3p inhibits mechanical stress-induced ligamentum flavum hypertrophy by targeting IL-11 — FASEB J — 2021 — IF 5.191
16. CRLF1 Is a Key Regulator in the Ligamentum Flavum Hypertrophy — Front Cell Dev Biol — 2020 — IF 6.617
17. A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation — Bioactive Materials — 2020 — IF 14.19
18. Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats — Lab. Invest. — 2020 — IF 3.684
19. Bioactive Glass-Polycitrate Hybrid with Osteogenetic Ability Comparable to Autogenous Bone — J Biomed Nanotechnol — 2019 — IF 5.068
20. Development and Characterization of a Novel Bipedal Standing Mouse Model of Intervertebral Disc and Facet Joint Degeneration — Clin. Orthop. Relat. Res. — 2019 — IF 4.154
21. Neurotrophin-3 acts on the endothelial mesenchymal transition of heterotopic ossification in rat — J. Cell. Mol. Med. — 2019 — IF 4.302
22. Locally Produced IGF-1 Promotes Hypertrophy of the Ligamentum Flavum via the mTORC1 Signaling Pathway — Cell. Physiol. Biochem. — 2018 — IF 5.500
23. Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling — J. Cell. Physiol. — 2018 — IF 4.522
24. Fast degradable citrate-based bone scaffold promotes spinal fusion — J Mater Chem B — 2015 — IF 4.776
25. Citrate-based biphasic scaffods for the repair of large segmental bone defects — J Biomed Mater Res A — 2015 — IF 3.263

三：以通讯作者发表文章

1.      Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway. — Stem Cells Int. —2021 — IF 3.3

2.      Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo. — Inflammation — 2020 — IF 2.939

3.      Baicalein Accelerates Tendon-Bone Healing via Activation of Wnt/β-Catenin Signaling Pathway in Rats. — BioMed Research International — 2018 — IF 2.583

4.      Mechanical loading modulates heterotopic ossification in calcific tendinopathy through the mTORC1 signaling pathway. — Molecular Medicine Reports — 2017 — IF 1.851

5.      Tenuigenin promotes the osteogenic differentiation of bone mesenchymal stem cells in vitro and in vivo. — Cell and Tissue Research — 2017 — IF 3.360

6.      Poly(1,8-octanediolcitrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration. — Chinese Chemical Letters — 2016 — IF 2.631

7.   Regulation of bone formation by baicalein via the mTORC1 pathway. — Drug Design, Development and Therapy — 2015 — IF 2.881

四：主持的主要科研基金项目

                1.        机械应力调控软骨细胞脂代谢诱导脊柱小关节退变的机制 — 2026.01–2029.12 — 国家自然科学基金

2.        Clusterin通过TGF-β1/ALK5轴调控机械应力介导黄韧带肥厚的机制研究 — 2023.01–2026.12 — 国家自然科学基金

3.        基于前瞻性队列研究运用人工智能解析多模态大数据开发骨与关节退行性疾病的数字化预测与诊疗模型 — 2023.01–2025.12 — 国家重点研发项目

4.        一种新型特异性聚集诱导发光（AIE）材料用于可视化监测成骨细胞转化程度和骨折不愈合的早期诊断研究 — 2021.01–2024.12 — 国家自然科学基金

5.        新型椎间盘退变动物模型的构建及其应力生物学的机制研究 — 2019.01–2022.12 — 国家自然科学基金

6.        ω-3/ω-6脂肪酸调控mTORC1信号介导终板软骨细胞自噬的机制研究 — 2017.01–2020.12 — 国家自然科学基金

7.        基于柠檬酸的新型生物支架修复大段骨缺损及其促进骨矿化的机制研究 — 2014.01–2017.12 — 国家自然科学基金

五：发明专利

1. 一种柠檬酸-生物活性玻璃有机无机杂化材料及其制备方法和应用—申请/专利号：CN201710189499.9 — 公开/公告号：CN108653821A — 2018-10-16
2. 一种生物活性复合材料及其制备方法和用途—申请/专利号：CN201710122217.3 — 公开/公告号：CN108530851A — 2018-09-14
3. 一种后纵韧带骨化动物模型的构建方法—申请/专利号：CN201911012894.5 — 公开/公告号：CN110859156A — 2020-03-06
4. 一种小鼠椎间盘退变模型的造模设备、造模方法和应用—申请/专利号：CN201811363263.3 — 公开/公告号：CN109528341A — 2019-03-29

六：实用新型专利

1. 一种小鼠椎间盘退变模型的造模设备 —CN209392139U — 2019-09-17
2. 一种无创黄韧带肥厚动物模型的构建器 — CN211153300U — 2020-08-04
3. 一种用于构建后纵韧带骨化动物模型的装置 — CN211558429U — 2020-09-25