目录
更新日期:2025年10月10日
姓 名 刘志刚 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 科室主任 Email Zhigangliu1983@hotmail.com
工作单位 南方医科大学第十附属医院(东莞市人民医院) 邮政编码
个人简介

刘志刚 主任医师,博士研究生导师,肿瘤中心主任、肿瘤科主任 ,肿瘤临床医学研究所所长,肿瘤学国家临床重点(建设)专科负责人,国家放射肿瘤学规培基地主任,入选广东省重大人才工程项目领军人才,BNCT(硼中子俘获治疗)临床试验主要研究者,恶性肿瘤硼中子俘获治疗技术与应用广东省工程研究中心副主任,“全国卫生健康系统先进工作者”“莞邑科技人才”“广东省杰出青年医学人才“。担任中国医师协会放射肿瘤医师分会委员,中华医学会肿瘤学分会青年委员,广东省医学会肿瘤学分会副主任委员,广东省医学会放射肿瘤学分会副主任委员,广东省医师协会肿瘤重症专业委员会副主任委员,广东省医院协会放射治疗科管理专业委员会副主任委员,中国抗癌协会神经肿瘤专业委员会、肿瘤粒子治疗专业委员会委员,中国临床肿瘤学会CSCO头颈肿瘤、鼻咽癌、神经系统肿瘤、青年专家等委员会委员。以第一负责人主持/完成包括国家自然科学基金项目3项、广东省自然基金重点项目、中央高校重点培育项目等20项临床转化研究课题。以研究参与者在Nature Medicine(鼻咽癌一线化疗+免疫治疗)和JAMA Oncology(老年食道癌放疗联合S1)等杂志发表研究论文60余篇,其中通讯作者或第一作者在Trends Pharmacol Sci(IF:19.9),Nature Communications(IF:15.7),Clinical Cancer Research(IF:10.2),Neuro Oncology(两篇, IF:13.4),J Exp Clin Cancer Res(IF:12.8),Journal of Nanobiotechnology(IF:12.6),Cancer Letters(IF:10.1),Nano Letters(IF:9.1),International journal of biological macromolecules(IF:8.5)等主流杂志发表40余篇,其中影响因子大于10分论文15篇。

研究领域

主要研究方向聚焦于:1. 硼中子俘获治疗恶性肿瘤。2.肿瘤辐射抗拒机制及逆转,正常组织放射防护。3.新型材料在抗肿瘤中的应用。

个人成果

1. Liu Z#, Wang D, Li G, Yi M, Zhang Z, Zhong G, Xu L, Jiang R, Zheng Y, Huang L, Peng Y, Liang L, Li J, Liu Y, Lai J, Lv X, Xu Y, Liu Q, Wang Z, Liu Z, Yang Q, Nie L, Lei J, Huang X, Liu Z, Jiang W. Neoadjuvant with low-dose radiotherapy, tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma: phase II single-arm trial. Nat Commun. 2025 May;16(1):4608. (IF: 15.7

2. Zhu H, Zhang Z, Jiang R, Xu L, Yang X, Chen J, Wang Z, Xu X, Liu Z*. MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy. J Nanobiotechnology. 2025 Mar;23(1):203. (IF: 12.6

3. Dong Z, Wang R, Yi J, Wei W, Wang M, Wei X, Shen Y, Wang Z, Jin S, Liu Z*. A novel role for the regulatory NRP1 in immune and inflammatory reactions during radiation-induced lung injury. Int J Biol Macromol. 2025 May;308(Pt 1):142307. (IF: 8.5

4. Lei Chen , Liang Yan , Zhigang Liu *, Xiao Xu. Recent advances in small-molecule radiosensitizers for Cancer therapy. Chemical Engineering Journal. 2025 July;520:165858. IF: 13.2

5. Ling Zhou, Meng Peng, Yuming Chen, Huanqing Liang, Xiumao Yin, Jieming Mo, Xiaotao Huang, Zhigang Liu *. Boron neutron capture therapy: A new era in radiotherapy. Chin Med J. 2025 Aug 18;138(19):2517-2519. (IF: 7.3)

6. Huang S, Zhang J, He T, Zhou J, Liu Z*. Midnolin Correlates With Anti-Tumour Immunity and Promotes Liver Cancer Progression Through β-Catenin. J Cell Mol Med. 2025 Mar;29(6):e70472. (IF: 4.2

7. Guan T, Jiang Y, Tu P, Ye B, Zeng L, Luo Z, Chi K, Liang H, Yang Y, Huang J, Zhang B, Tai R, Ye J, Deng Z, Ke Y, Chen H, Zhang Z, Liu Z*, Ou C. Risk classification for non-cancer death in middle-aged cancer patients. J Adv Res. 2024 Dec:S2090-1232(24)00616-7. (IF: 13

8. Huang ZL, Liu ZG#, Lin Q, Tao YL, Li X, Baxter P, Su JM, Adesina AM, Man C, Chintagumpala M, Teo WY, Du YC, Xia YF, Li XN. Fractionated radiation therapy alters energy metabolism and induces cellular quiescence exit in patient-derived orthotopic xenograft models of high-grade glioma. Transl Oncol. 2024 Jul;45:101988. (IF: 4.1

9. Zhang W, Chen G, Chen Z, Yang X, Zhang B, Wang S, Li Z, Yang Y, Wu Y, Liu Z*, Yu Z. Mitochondria-targeted polyprodrug nanoparticles induce mitochondrial stress for immunogenic chemo-photodynamic therapy of ovarian cancer. J Control Release. 2024 Jul;371:470-483.IF: 11.5

10. Zhou YT, Cheng K, Liu B, Cao YC, Fan JX, Liu ZG*, Zhao YD. Recent progress of nano-drugs in neutron capture therapy.Theranostics. 2024 May 19;14(8):3193-3212. (IF: 13.3)

11. Liu Z#, Wang Y, Huang Y, Kim BYS, Shan H, Wu D, Jiang W. Tumor Vasculatures: A New Target for Cancer Immunotherapy. Trends Pharmacol Sci. 2019 Sep; 40 (9): 613-623.  (IF: 19.9)

12. Zhigang Liu#, Xiumei Zhao, Yue Wang, Hua Mao, Yulun Huang, Mari Kogiso, Lin Qi, Patricia A. Baxter, Tsz-Kwong Man, Adekunle Adesina, Jack M. Su, Daniel Picard, King Ching Ho, Annie Huang, Laszlo Perlaky, Ching C. Lau, Murali Chintagumpala, Xiao-Nan Li. A Patient Tumor-derived Orthotopic Xenograft Mouse Model Replicating the Group 3 Supratentorial Primitive Neuroectodermal Tumor in Children. Neuro Oncol. 2014 Jun;16(6):787-799. IF: 13.4

13. Zhigang Liu#, Xiumei Zhao, Hua Mao, Patricia A. Baxter, Yulun Huang, Litian Yu, Lalita Wadhwa, Jack MF Su, Adekunle Adesina, Lazlo Perlaky, Mary Hurwitz, Neeraja Idamakanti, Seshidhar Reddy Police, Paul L. Hallenbeck, Richard L. Hurwitz, Ching C. Lau, Murali Chintagumpala, Susan M. Blaney, Xiao-Nan Li. Intravenous Injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro Oncol. 2013 Sep;15(9):1173-1185. IF: 13.4

14. Liu Zhigang#, Jiang W, Nam J, Moon JJ, Kim BYS. Immunomodulating Nanomedicine for Cancer Therapy. Nano Lett. 2018 Nov;18(11):6655-6659. IF: 9.1

15. Yifan Wang, Zhigang Liu#, Hengfeng Yuan, Weiye Deng, Jing Li, Yuhui Huang, Betty Y.S. Kim, Michael D Story, Wen Jiang. The reciprocity between radiotherapy and cancer immunotherapy. Clinical Cancer Research. 2019 Mar; 25(6):1709-1717. IF: 10.2

16. Huang X, Liu Q, Zhong G, Peng Y, Liu Y, Liang L, Hong H, Feng W, Yang S, Zhang Y, Xian S, Li Z, Zhou Y, Zhang Z, Jiang W, Liang J, Liu ZG*. Neoadjuvant toripalimab combined with gemcitabine and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoTGP01): An open label, single-arm, phase Ib clinical trial. J Exp Clin Cancer Res. 2022 Oct 12;41(1):300.  (IF: 12.8

17. Tang LQ, Li XY, Li ZM, Liu ZG#, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY. The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial. BMC Med. 2023 Mar 16;21(1):94. (IF: 8.3

18. Wei Xu, Hao Liu, Zhi-Gang Liu#, Hong-Sheng Wang, Fan Zhang, Hao Wang, Ji Zhang, Jing-Jing Chen, Hong-Jun Huang, Yuan Tan, Meng-Ting Cao, Jun Du, Qiu-Gui Zhang, Guan-Min Jiang. Histone deacetylase inhibitors upregulate Snail via Smad2/3 phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells. Cancer Lett. 2018 Apr 28; 420:1-13. IF: 10.1

19. Yao JJ, Jin YN, Liu ZG#, Liu QD, Pei XF, Zhou HL, Zhang WJ, Zhang F, Lin L, Lawrence WR, Wang SY, Ma J, Zhou GQ, Sun Y. Do all patients with advanced N-stage nasopharyngeal carcinoma benefit from the addition of induction chemotherapy to concurrent chemoradiotherapy? Ther Adv Med Oncol. 2019 Mar; 11:1-14. (IF: 4.9

20. Ji-Jin Yao, Zhen-Yu Qi, Zhi-Gang Liu#, Guan-Min Jiang, Xi-Wei Xu, Shao-Yi Chen, Feng-Ting Zhu, Wang-Jian Zhang, Wayne R. Lawrence, Jun Ma, Guan-Qun Zhou, Ying Sun. Clinical features and survival outcomes between ascending and descending types of nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data intelligence platform-based analysis. Radiother Oncol, 2019. 137: p. 137-144. (IF:5.3

21. Huang X#, Zhuang M#, Yang S#, Wang Y#, Liu Q, Xu X, Xiao M, Peng Y, Jiang P, Xu W, Guo S, Wang R, Wei W, Zhong G, Zhou Y, Peng S, Li X, Cui J, Wang S, Zhang Y, Liu Z*. The valuable role of dynamic 18F FDG PET/CT-derived kinetic parameter Ki in patients with nasopharyngeal carcinoma prior to radiotherapy: a prospective study. Radiother Oncol. 2022 Dec 22:109440IF: 5.3

22. Shunli Peng#, Rong Wang#, Yuling Zhou#, Wei Wei, Guihua Zhong, Xiaotao Huang, Shuai Yang, Qiaodan Liu, Zhigang Liu*. Insight of a metabolic prognostic model to identify tumor environment and drug vulnerability for lung adenocarcinoma. Frontiers in Immunology. 2022 Jun 23;13:872910. (IF: 5.9)

23. Li Y, Liao Z, Wang R, Liang Z, Lin Z, Deng S, Chen L, Liu Z*, Feng S. Long non-coding RNA SPRY4-IT1 promotes proliferation and metastasis in nasopharyngeal carcinoma cell. PeerJ. 2022 Mar 30;10:e13221.IF: 2.4

24. Zhou YL, Peng YP, Liu QD, Chen XZ, He J, Wei W, Zhong GH, Zhang YQ, Liu Y, Pan JY, Feng SY, Liu ZG*. Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study. Cancer Control. 2022 Jan-Dec;29:10732748221087075. (IF: 2.6

25. Lei Chen, Yang Yan, Fangen Kong, Jikai Wang, Jia Zeng, Zhen Fang, Zheyan Wang, Zhigang Liu*, Fei Liu. Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance in Glioma Cells. Cancers (Basel). 2022 Apr 18; 14(8):2036. IF: 4.4

26. Guihua Zhong#, Wei Wei#, Wei Liao#, Rong Wang, Yingpeng Peng, Yuling Zhou, Xiaotao Huang, Shiping Xian, Shunli Peng, Zhaoyuan Zhang, Shaoyan Feng, Ye Liu, Haiyu Hong, Yunfei Xia, Yan Yan, Qiaodan Liu, and Zhigang Liu*. Tumor Microbiome in Nasopharyngeal Carcinoma and Its Association with Prognosis. Frontiers in Oncology. 2022 May 23;12:859721.(IF:3.3

27. Peng Y#, Wang R#, Liu Q#, Xu X, Wei W, Huang X, Peng X, Liu Z*. Combination of TMB and specific gene mutations stratifies outcome to immunotherapy across recurrent and metastatic head and neck squamous cell carcinoma. Frontiers in Genetics. 2021 Nov 16;12:756506.(IF: 2.8

28. Shuo Li, Peng He, Zhiwei Wang, Meng Liang, Wei Liao, Yili Huang, Mengshi Chi, Fei Liu, Nan Zen, Rongfei Su, Shulin Chen, Zhigang Liu*, Haiyu Hong. RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2. Cell Cycle. 2021; 20(2): 154–165IF: 3.4

29. Peng Y#, Liu Q#, Lin Y#, Peng S, Wang R, Xu X, Wei W, Zhong G, Zhou Y, Zhang Y, Liu Y, Wang S, Hong H*, Liu Z*. Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma. Radiat Oncol. 2021 Oct 11;16(1):198.(IF: 3.2

30. Deng Z, Liao W, Wei W, Zhong G, He C, Zhang H, Liu Q, Xu X, Liang J, Liu Z*. Anlotinib as a promising inhibitor on tumor growth of oral squamous cell carcinoma through cell apoptosis and mitotic catastrophe. Cancer Cell Int. 2021 Jan 9; 21(1):37. (IF: 5.8

31. Liu Z#*, Xu C, Jiang R, Liu G, Liu Q, Zhou J, Liu F, Yao J, Wang S, Jiang W. Treatment of Locally Advanced Nasopharyngeal Carcinoma by Helical Tomotherapy: An Observational, Prospective Analysis. Transl Oncol. 2019 May; 12 (5): 757-763. (IF: 4.1

32. Wei W, Zhou J, Zhang Q, Liao DH, Liu QD, Zhong BL, Liang ZB, Zhang YC, Jiang R, Liu GY, Xu CY, Li Zhou H, Zhu SY, Yang N, Jiang W, Liu ZG*. Postoperative intensity-modulated radiation therapy reduces local recurrence and improves overall survival in III-N2 non-small-cell lung cancer: A single-center, retrospective study. Cancer Med. 2020 Apr;9(8):2820-2832. (IF: 3

33. Wei Wei, Hao Jiang, Weipeng Chen, Yuling Zhou, Shuanshuan Guo, Guihua Zhong, Huaili Zhou, Siyang Wang, Hongyu Zhang, Wen Jiang, Zhi-Gang Liu*. How should we implement radiotherapy for cancer patients in China during the endemic period of COVID-19? Radiother Oncol. 2020 Jun; 147:100-102. (IF:5.3

34. Liang Jun, Liu Jingang, Deng Zhaoming, Liu Zhigang*, Liang Lizhong*. DLX6 promotes cell proliferation and survival in oral squamous cell carcinoma. Oral Diseases. 2022 Jan;28(1):87-96.IF: 3.8

35. Liu ZG#, Jiang G, Tang J, Wang H, Feng G, Chen F, Tu Z, Liu G, Zhao Y, Peng MJ, He ZW, Chen XY, Lindsay H, Xia YF, Li XN. c-Fos over-expression promotes radioresistance and predicts poor prognosis in malignant glioma. Oncotarget. 2016 Oct 4;7(40):65946-65956. (IF: 5.2)

36. Zhi-Gang Liu#*, Jiao Tang, Zhenghu Chen, Huiyuan Zhang, Hui Wang, Jianhua Yang, Hong Zhang. The novel mTORC1/2 dual inhibitor INK128 enhance radiosensitivity of breast cancer cell line MCF-7. International Journal of Oncology. 2016 Sep ;49(3):1039-1045. (IF: 4.9

37. Yan-fang Qiu, Zhi-gang Liu#, Wen-juan Yang, Yu Zhao, Jiao Tang, Wei-zhi Tang, Yi Jin, Fang Li, Rui Zhong, Hui Wang. Research progress in the treatment of small cell lung cancer. Journal of Cancer. 2017 Jan 1;8(1):29-38. (IF: 3.2

38. Zhao Y, Liu ZG#*, Tang J, Zou RF, Chen XY, Jiang GM, Qiu YF, Wang H. High expression of Sox10 correlates with tumor aggressiveness and poor prognosis in human nasopharyngeal carcinoma. Onco Targets Ther. 2016; 9:1671-1677. (IF: 2.8

39. Yi W, Liu ZG#, Li X, Tang J, Jiang CB, Hu JY, Tu ZW, Wang H, Niu DL, Xia YF. CT-diagnosed severe skull base bone destruction predicts distant bone metastasis in early N-stage nasopharyngeal carcinoma. Onco Targets Ther. 2016 Nov 14;9: 7011-7017. (IF: 2.8

40. Liu ZG#, Zhao Y, Tang J, Zhou YJ, Yang WJ, Qiu YF, Wang H. Nimotuzumab combined with concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: a retrospective analysis. Oncotarget. 2016 Apr 26;7(17):24429-24435. (IF: 5.2)

41. Meng-Ting Cao, Hui-Fang Liu, Zhi-Gang Liu#, Ping Xiao, Fan Zhang, Hao Wang, Yuan Tan, Ji Zhang, Hong-Jun Huang, Zhi-Chao Jiang, Qiu-Gui Zhang, Guan-Min Jiang. Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells. Oncotarget, 2017, 8(65): 108498-108508. (IF: 5.2)

42. Fang Z, Gu Z, Zhang T, Lei J, Lin L, Yan Z, Feng K, Xie M, Guo S, Liu Z*, Hong Z, Li X. The impact of new modes of electronic communication in the treatment of severe acute respiratory syndrome coronavirus 2 infection. Ann Transl Med, 2020 Oct;8(19):1239. (IF: 3.62)

43. Chen Xianzhen, Deng Chuntao, Mi Jiaoping, Chen Mo, Li Yanfei, Liu Zhigang#, Feng Shaoyan. Barrier Protection Measures for the Management of Allergic Rhinitis: A Systematic Review and Meta-analysis. American Journal of Rhinology and Allergy. 2020 Jul; 34(4): 564-572. (IF: 2.6

44. Liu ZG#*, Liu L, Xu LH, Yi W, Tao YL, Tu ZW, Li MZ, Zeng MS, Xia YF. Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells. Oncol Rep. 2012 Apr;27(4):1116-1122. (IF: 4.2