肛肠科学科主任，主任医师，教授，研究员，外科学博士生导师、博士后导师、广东省科技创新青年拔尖人才、广东省杰出青年医学人才，东莞市医学领军人才。中国老年保健协会盆底医学专业委员会常务委员、中国民族卫生协会培训部特邀专家（肛肠科）、中国民族卫生协会卫生健康卫生健康技术推广专家委员会常务委员、中国医师协会外科医师分会加速康复外科专家委员会委员、中华医学会肠外肠内营养学分会肠道微生态与临床营养协作组委员、中国医药教育协会微生态与健康教育专业委员会委员、中国胃肠外科卓异青年联盟委员、广东省自然医学研究会肠道健康专业委员会主任委员、广东省精准医学应用学会结直肠癌分会委员、东莞市医学会结直肠肛门专业委员会主任委员，《中华生物医学工程杂志》、《世界华人消化杂志》、《环球医学进展》、《iMeta》、《Explor Res Hypothesis Med》等杂志编委。从事肛肠科工作多年，作为直肠癌联合门诊资深专家，肛肠科MDT专家，诊疗特色为低位直肠癌保肛术、结直肠外科微创手术、快速康复外科、经肛门直肠癌根治术、直肠癌新辅助治疗、粪菌移植等。擅长结直肠肿瘤、炎症性肠病、便秘、肠瘘的外科治疗和肛门良性病的手术治疗和微创治疗。承担国家自然科学基金项目，教育部产学研项目，广东省自然科学基金重大项目、广东省教育厅重大项目、团队项目等重大基金多项，发表论文80余篇，发明专利6项。

肛肠疾病的治疗；肠道菌群与肠屏障功能；肠道肿瘤的诊治

相关成果目录

1）论文：

[1] Sun N, Du RL, Zheng YY, Guo Q, Cai SY, Liu ZH, Fang ZY, Yuan WC, Liu T, Li XM, Lu YJ, Wong KY. Antibacterial activity of 3-methylbenzo[d]thiazol-methylquinolinium derivatives and study of their action mechanism. J Enzyme Inhib Med Chem. 2018;33(1):879-889.

[2] Liu ZH, Kang L, Huang MJ, Li C, Tong C, Zhang XW, Luo YX, Wang L, Wu XJ, Lan P, Cui J, Wang JP. Decrease of Sphincter Preserving Length Lowers the Postoperative Genital Function for Patients With Rectal Cancer. Surgical Laparoscopy Endoscopy & Percutaneous Techniques 2018;28(1):42-46. 

[3] Sun N, Ban L, Li M, Fang Z, Li X, Yao W, Pan J, Lu Y, Liu Z, Wong WL. Probing the benzofuroquinolinium derivative as a potent antibacterial agent through the inhibition of FtsZ activity. J Pharmacol Sci. 2018;138(1):83-85.

[4] Fang Z, Ban L, Li Y, Yuan W, Liu Z, Liu T, Li X, Wong KY, Lu Y, Sun N, Yao X. A quinoline-based FtsZ inhibitor for the study of antimicrobial activity and synergistic effects with β-lactam antibiotics. J Pharmacol Sci. 2018 Jul;137(3):283-289.

[5] Liu Z, Li C, Chen S, Lin H, Zhao H, Liu M, Weng J, Liu T, Li X, Lei C, Li C, Jiang Y, Moyer MP, Yin C, Zhou X. MicroRNA-21 increases the expression level of occludin through regulating ROCK1 in prevention of intestinal barrier dysfunction. J Cell Biochem. 2019;120(3):4545-4554. 

[6] Ma KY, Schonnesen AA, Brock A, Van Den Berg C, Eckhardt SG, Liu Z, Jiang N. Single-cell RNA sequencing of lung adenocarcinoma reveals heterogeneity of immune response-related genes. JCI Insight 2019;4(4).  

[7] Liu Z, Zou Y, Rong Y, Shi X, Li C, Li C, Tian Y, Lin H, Liu M, Weng J, Liu T, Li X, Lei C, Li W, Zhou X. Intraoperative Chemotherapy with a Novel Regimen Improved the Therapeutic Outcomes of Colorectal Cancer. J Cancer 2019; 10(24):5986-5991. 

[8] He Q, Liu Z, Liu Z, Lai Y, Zhou X, Weng J. TCR-like antibodies in cancer immunotherapy. J Hematol Oncol 2019;12(1):99. 

[9] Li Y, Sun N, Ser HL, Long W, Li YN, Chen CC, Zheng BX, Huang XH, Liu ZH*, Lu YJ*. Antibacterial activity evaluation and mode of action study of novel thiazole-quinolinium derivatives. Rsc Advances 2020;10(25):15000-15014. IF=3.361 

[10] Liu T, Liang X, Lei C, Huang Q, Song W, Fang R, Li C, Li X, Mo H, Sun N, Lv H, Liu Z*. High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota. Front Microbiol. 2020;11: 1604. IF=5.64 

[11] Song L ^#, Liu Z ^#, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC *. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nat Commun 2020;11(1):5842.

[12] Li X, Li C, Li Y, Liu C, Liang X, Liu T and Liu Z. Sodium nitroprusside protects HFD induced gut dysfunction via activating AMPKalpha/SIRT1 signaling. BMC Gastroenterol. 2021; 21(1):359. 

[13] Liu Z, Li C. Risk for Postcolonoscopy Irritable Bowel Syndrome in Patients with and without Antibiotic Exposure. Clinical Gastroenterology and Hepatology. 2021:S1542-3565(21)01092-2. 

[14] Huang Q, Cai G, Liu T, Liu Z. Relationships Among Gut Microbiota, Ischemic Stroke and Its Risk Factors: Based on Research Evidence. Int J Gen Med. 2022;15:2003-2023. 

[15] Liu T, Su D, Lei C, Liu Z. Treatment of Radiation Enteritis With Fecal Transplantation. Am Surg 2022:31348221091954. 

[16] Liu Z, Li C, Liu M, Song Z, Moyer MP, Su D. The Low-density Lipoprotein Receptor-related Protein 6 Pathway in the Treatment of Intestinal Barrier Dysfunction Induced by Hypoxia and Intestinal Microbiota through the Wnt/β-catenin Pathway. Int J Biol Sci 2022; 18(11):4469-4481. 

[17] Lei C, Liu C, Chen EY, Lin LD, Liu T, Liu ZH. Bidirectional Microbiota-Gut-Brain Axis after Stroke and Its Implications for Treating Ischemic Stroke. Explor Res Hypothesis Med. Published online: May 17, 2022. doi: 10.14218/ERHM.2022.00040.

[18] Gong Q, Zhang X, Sun Y, Shen J, Li X, Xue C, Liu Z. Transcription factor EB inhibits non-alcoholic fatty liver disease through fibroblast growth factor 21. J Mol Med (Berl). 2022 Nov;100(11):1587-1597. doi: 10.1007/s00109-022-02256-6. Epub 2022 Sep 14. PMID: 36102936. 

[19] Liu Z, Zheng N, Li J, Li C, Zheng D, Jiang X, Ge X, Liu M, Liu L, Song Z, Bao L, Zhan Y, Gao X. N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells. Drug Resist Updat. 2022;65:100886. 

[20] Lei C, Liu C, Peng Y, Zhan Y, Zhang X, Liu T, Liu Z*. High salt diet induces synaptic loss and memory impairment via gut microbiota and Butyrate in mice. iMeta. 2023;2:1-14. 

[21] 李超，刘敏，刘志华. MicroRNA-21靶调控NCM460细胞ROCK1基因上调occludin表达. 中国病理生理杂志. 2018;34(4):729-34.

[22] 刘亭, 宋玮琦, 庄佳燕, 黄杰, 詹晓玲, 孙宁, 李晓媚, 雷超, 田应海, 李超, 刘敏, 刘志华. 高盐高脂饮食及粪菌移植对肠道及肠道菌群的影响. 中华炎性肠病杂志. 2019,3(3):227-232.

[23]李晨，李晓媚，刘亭，雷超，刘聪，刘志华. 高盐饮食激活肠JAK1/STAT3通路诱导肠上皮屏障功能障碍. 实用医学杂志. 2021,37(1):35-40.

[24] 雷超，刘聪，刘亭，刘志华. 高盐饮食对小鼠认知功能的影响及其与肠道菌群的关系. 山东医药. 2021 ; 61(35): 38-38.

[25] 雷超，刘聪，刘志华. 柔嫩梭菌灌胃的高盐饮食小鼠血清炎症因子及粪便中肠道菌群、短链脂肪酸水平观察. 山东医药. 2022;62(32):49-52.

2) 专利：

① 一种粪菌移植的实验小鼠模型及构建方法.2017. 中国. CN107349225A. 发明专利.（第一发明人）

② 一种抗烟雾防镜污染的腹腔镜切割吸引联动超声刀. 2022.01.28. 中国. 专利号：ZL202022623951.8, CN215651409U实用新型.（第一发明人）

3）专著和奖励：

① 新编肛肠外科疾病手术实践. 2021年.主编.890千字

② 实用肛肠外科手术学. 2022年. 主编. 800千字

详见https://www.researchgate.net/profile/Zhihua-Liu-26/publications