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更新日期：2025年9月25日
姓 名 段晓品 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 理学博士学位
行政职务 副所长 Email xpduan@smu.edu.cn
工作单位 南方医科大学 邮政编码
个人简介

段晓品，教授，博士生导师，国家海外高层次引进青年人才，南方医科大学肿瘤研究所党支部书记/副所长。主持和参与国家、广东省及广州市等多项课题，主要研究方向为智能递药系统的开发，在Sci. Adv., Nat. Commun.，J. Am. Chem. Soc.，Adv. Mater.，Adv. Funct. Mater.，Angew. Chem. Int. Ed.，ACS Nano等高影响力杂志上发表SCI论文40余篇，8篇入选ESI“高被引论文”，单篇最高被引1008次。授权中国发明专利2项，PCT专利1项，研发的两款药物制剂已在美国完成I期临床试验；任中国抗癌协会纳米肿瘤学专业委员会委员，Eur. J. Pharm. Biopharm.青年编委，江苏省、浙江省、河南省、江西省、黑龙江省、湖南省、广东省科技专家。

研究领域

针对肿瘤免疫治疗响应率低及易产生免疫耐受和免疫副作用的核心挑战，致力于开发安全高效的新型自组装肿瘤免疫治疗制剂，开展具有明确临床转化导向的应用基础研究：结合AI技术优化自组装系统，简化制备流程，提升临床转化潜力；设计细胞靶向自组装制剂，突破递送屏障，实现精准递送；调控抗原亚细胞转运路径，增强抗原交叉递呈效率；推动自组装免疫治疗制剂的临床前研究与其临床转化。

个人成果
  1. Z. Wang#, H. Zhou#, Q. Su#, Q. Qiu, W. Deng, M. Zhang, Z. Xu, J. Li, J. Xiao*, X. Duan*, Morphology- and adhesion-dual biomimetic nanovaccine boosts antigens cross-presentation through subcellular transport regulation. Science Advances, 2025, 11: eadx6732.
  2. Z. Chen#, J. Cheng#, Z. Li#, H. Huang#, Y. Ren, Y. Zhou, J. Li, Q. Zhang*, X. Duan*, Y. Hu*, Dual targeted ferritin-based delivery system blocks the crosstalk between cancer cells and cancer-associated fibroblasts to potentiate immunotherapy of colorectal cancer. Journal of Controlled Release, 2025, 2025, 384:113877.
  3. H. Zhou#, Z. Wang#, Q. Su#, Q. Qiu, J. Li, Z. Xu, M. Zhang, J. Xiao*, X. Duan*, Self-assembled nanomedicine potentiates tumor ferroptosis. Chemical Engineering Journal, 2025, 520: 166336.
  4. P. Li#, J. Li#, J. Cheng, J. Huang, J. Li, J. Xiao*, X. Duan*, Hypoxia-responsive liposome enhances intracellular delivery of photosensitizer for effective photodynamic therapy. Journal of Controlled Release, 2025, 377: 277-287.
  5. Q. Su#, Z. Wang#, H. Zhou#, M. Zhang, W. Deng, X. Wei, J. Xiao*, X. Duan*, Eradication of large tumors by nanoscale drug self-assembly. Advanced Matrials, 2024, 36: 2410536.
  6. Z. Wang#, Q. Su#, W. Deng, X. Wang, H. Zhou, M. Zhang, W. Lin, J. Xiao*, X. Duan*, Morphology-mediated tumor deep penetration for enhanced NIR-II photothermal and chemotherapy of colorectal cancer. ACS Nano 2024, 18:28038–28051.
  7. Q. Su#, Z. Wang#, P. Li#, X. Wei, J. Xiao*, X. Duan*, pH and ROS dual-responsive autocatalytic release system potentiates immunotherapy of colorectal cancer, Advanced Healthcare Materials, 2024, 13: 2401126.
  8. J. Cheng#, Q. Yu#, J. Li#, Z. Xu, J. Li, L. Guan, J. Xiao*, X. Duan*, Intrinsic tumor-targeted murine Ferritin nanocage co-delivers GPX4 and FSP1 inhibitors for synergistic ferroptosis-immunotherapy. Nano Today, 2024, 58:102411.
  9. J. Cheng#, J. Li#, Q. Yu#, P. Li, J. Huang, J. Li, L. Guan, Z. Xu, J. Xiao*, X. Duan*, Laser‑activable murine ferritin nanocage for chemo‑photothermal therapy of colorectal cancer, Journal of Nanobiotechnology, 2024, 22:297.
  10. X. Wang#, C. Cai#, W. Lv, K. Chen, J. Li, K. Liao, Y. Zhang, H. Huang, Y. Lin, Z. Rong*, X. Duan*, Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system. Journal of Nanobiotechnology, 2024, 22:284.
  11. Z. Wang#, T. You#, Q. Su#, W. Deng, J. Li, S. Hu, S. Shi, Z. Zou*, J. Xiao*, X. Duan*, Laser-activatable in situ vaccine enhances cancer-immunity cycle. Advanced Materials, 2023, 35: 2307193.
  12. C. Cai#, J. Zhu#, X. Huang#, C. Xu, Z. Wang, T. You, J. Xiao*, X. Duan*. Hypoxia-responsive nanoscale coordination polymer enhances the crosstalk between ferroptosis and immunotherapy, Advanced Functional Materials, 2023, 33, 2214998.
  13. Z. Wang, T. You, C. Cai, Q. Su, J. Cheng, J. Xiao*, X. Duan*. Biomimetic gold nanostructure with virus-like topological surface for enhanced antigen cross-presentation and antitumor immune response. ACS Appl. Mater. Interfaces, 2023, 15: 13929-13940.
  14. J. Xiao#,*, H. Li#, W. Zhao, C. Cai, T. You, Z. Wang, M. Wang, F. Zeng, J. Cheng, J. Li, X. Duan*, Zinc‑metal organic frameworks with tunable UV diffuse‑reflectance as sunscreens. J. Nanobiotechnol. 2022, 20:87.
  15. W. Han#, X. Duan#, Kaiyuan Ni#, Y. Li, C. Chan, W. Lin*, Co-delivery of dihydroartemisinin and pyropheophorbide-iron elicits ferroptosis to potentiate cancer immunotherapy. Biomaterials 2022, 280: 121315.
  16. X. Duan#, C. Chan#, W. Han#, N. Guo, R. Weichselbaum, W. Lin, Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat. Commun. 2019, 10: 1899.
  17. X. Duan#, C. Chan#, W. Lin*, Nanoparticle-mediated immunogenic cell death enables and potentiates cancer immunotherapy. Angew. Chem. Int. Ed. 2019, 58: 670-680.
  18. X. Duan, C. Chan, N. Guo, W. Han, R. Weichselbaum, W. Lin, Photodynamic therapy mediated by nontoxic core-shell nanoparticles synergize with immune checkpoint blockade to elicit antitumor immunity and antimetastatic effect on breast    cancer. J. Am. Chem. Soc. 2016, 138: 16686-16695.
  19. C. He#, X. Duan#, N. Guo#, C. Chan, C. Poon, R. Weichselbaum, W. Lin, Core-shell nanoscale coordination polymers combine chemotherapy and    photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nature Commun. 2016, 7: 12499.
  20. X. Duan#, J. Xiao#, Q. Yin, et al., Smart pH-sensitive and temporal-controlled polymeric micelles for effective     combination therapy of doxorubicin and disulfiram. ACS Nano 2013, 7: 5858-5869.
  21. Z. Zhang#, X. Duan#, S. Yao, et al., Chiral recognition of macroanions for preparing homochiral high-nuclear molecular capsules assembly from achiral building blocks. Chem. Sci. 2016, 7: 4220-4229.
  22. R. Xu, Y. Wang, X. Duan, et al., Nanoscale metal–organic frameworks for ratiometric oxygen sensing in live cells. J. Am. Chem. Soc. 2016, 138: 2158-2161.
  23. X. Duan, D. Liu, C. Chan, W. Lin, Polymeric micelle‐mediated delivery of DNA‐targeting organometallic complexes for resistant ovarian cancer treatment. Small 2015, 11: 3962-3972.
  24. X. Duan, Y. Li, Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. Small 2013, 9: 1521-1532.