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更新日期：2024年8月27日
姓 名 高磊 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 研究员 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 主任 Email raygaolei@smu.edu.cn
工作单位 中医药学院 邮政编码 510515
个人简介

高磊，研究员，博士生导师，博士后合作导师，中医证候研究所所长，国家中医药管理局三级实验室（分子生物学实验室）副主任，国家中医药管理局高水平中医药重点学科“中西医结合基础”后备学科带头人，广东省自然科学基金“杰青”项目获得者，广东省中西医结合学会杰出青年人才奖获得者，入选中华中医药学会青年人才托举工程项目，教育部第二批“全国高校黄大年式教师团队”核心成员（南方医科大学中西医结合教师团队）。兼任广东省医师协会中西医结合分会和广东省中医药学会肝病专业委员会常务委员、《中华中医药杂志》青年编委等。

主要从事肝病中西医结合临床与基础研究工作，搭建了CRISPR/cas9系统分析平台、模式生物研究平台（线虫、斑马鱼），系统性开展了高通量分析中药防治肝病的生物靶标与物质基础研究。

以一作或通讯作者身份发表研究论文50余篇，包括Hepatology、redox biology、military medical research等期刊论文；授权发明专利6项。主持国家自然科学基金项目4项，获得广东省自然科学杰出青年项目，累计承担科研项目10余项。

 

研究领域

肝病证中西医结合临床与基础研究及模式生物研究（斑马鱼、线虫）

个人成果
  1. Li Y, Qin M, Zhong W, Liu C, Deng G, Yang M, Li J, Ye H, Shi H, Wu C, Lin H, Chen Y, Huang S, Zhou C, Lv Z, Gao L. RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease. Redox Biology 2023;59:102559.
  2. Deng G, Liu C, Zhao J, Wang M, Li Y, Yang M, Ye H, Li J, Qin M, Wu C, Shi H, Liao Y, Zhou Z, Zhang S, Lam YK, Lei G. Exocarpium Citri Grandis alleviates the aggravation of NAFLD by mitigating lipid  accumulation and iron metabolism disorders. J Ethnopharmacol 2023:116559.
  3. Shi H, Zhao J, Li Y, Li J, Li Y, Zhang J, Qiu Z, Wu C, Qin M, Liu C, Zeng Z, Zhang C, Gao L. Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans. Journal of Ginseng Research 2023;47:524-533.
  4. Shi H, Zheng Y, Zhao J, Li Y, Jia H, Hou X, Li Y, Li J, Wu C, Gao L. Zexie decoction reduce glucose-dependent lipid accumulation and oxidative stress  in Caenorhabditis elegans. Phytomedicine 2023;120:155036.
  5. Gao, L.; Zhou, Y.; Zhong, W.; Zhao, X.; Chen, C.; Chen, X.; Gu, Y.; Chen, J.; Lv, Z.; Shen, J. Caveolin-1 is essential for protecting against binge drinking-induced liver damage through inhibiting reactive nitrogen species. HEPATOLOGY 60:687-699; 2014.
  6. Huang, S, Wang, Y, Xie, S, Lai, Y, Mo, C, Zeng, T, Kuang, S, Deng, G, Zhou, C, Chen, Y, Huang, S, Gao, L, Lv, Z, Hepatic TGFbetar1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure through Inhibiting GSK3beta-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis. Cell Mol Gastroenterol Hepatol 2022, 13 (6), 1649-1672.
  7. Ye, H, Ma, S, Qiu, Z, Huang, S, Deng, G, Li, Y, Xu, S, Yang, M, Shi, H, Wu, C, Li, M, Zhang, J, Zhang, F, Qin, M, Huang, H, Zeng, Z, Wang, M, Chen, Y, Lin, H, Gao, Z, Cai, M, Song, Y, Gong, S, Gao, L, Poria Cocos Polysaccharides Rescue Pyroptosis-Driven Gut Vascular Barrier Disruption in Order to Alleviates Non-Alcoholic Steatohepatitis. J ETHNOPHARMACOL 2022, 296, 115457.
  8. Mo, C, Xie, S, Liu, B, Zhong, W, Zeng, T, Huang, S, Lai, Y, Deng, G, Zhou, C, Yan, W, Chen, Y, Huang, S, Gao, L, Lv, Z, Indoleamine 2,3-Dioxygenase 1 Limits Hepatic Inflammatory Cells Recruitment and Promotes Bile Duct Ligation-Induced Liver Fibrosis. CELL DEATH DIS 2021, 12 (1), 16.
  9. Li, Y, Song, Y, Deng, G, Tan, Q, Xu, S, Yang, M, Shi, H, Hong, M, Ye, H, Wu, C, Ma, S, Huang, H, Zhang, Y, Zeng, Z, Wang, M, Chen, Y, Wang, Y, Ma, J, Li, J, Gao, L, Indoleamine 2, 3-Dioxygenase 1 Aggravates Acetaminophen-Induced Acute Liver Failure by Triggering Excess Nitroxidative Stress and Iron Accumulation. Free Radic Biol Med 2021, 172, 578-589.
  10. Deng, G, Li, Y, Ma, S, Gao, Z, Zeng, T, Chen, L, Ye, H, Yang, M, Shi, H, Yao, X, Zeng, Z, Chen, Y, Song, Y, Liu, B, Gao, L, Caveolin-1 Dictates Ferroptosis in the Execution of Acute Immune-Mediated Hepatic Damage by Attenuating Nitrogen Stress. FREE RADICAL BIO MED 2020, 148, 151-161.
  11. Zeng, T, Deng, G, Zhong, W, Gao, Z, Ma, S, Mo, C, Li, Y, Huang, S, Zhou, C, Lai, Y, Xie, S, Xie, Z, Chen, Y, He, S, Lv, Z, Gao, L, Indoleamine 2, 3-Dioxygenase 1Enhanceshepatocytes Ferroptosis in Acute Immune Hepatitis Associated with Excess Nitrative Stress. Free Radic Biol Med 2020.
  12. Mo, C, Xie, S, Zhong, W, Zeng, T, Huang, S, Lai, Y, Deng, G, Zhou, C, Yan, W, Chen, Y, Huang, S, Gao, L, Lv, Z, Mutual Antagonism Between Indoleamine 2,3-Dioxygenase 1 and Nuclear Factor E2-related Factor 2 Regulates the Maturation Status of DCs in Liver Fibrosis. Free Radic Biol Med 2020, 160, 178-190.
  13. Wu C, Li J, Jia H, Zhao J, Qin M, Shi H, Liu C, Lin J, Cai M, Gu Y, Liu B, Gao L. Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes  to lipid deposition in nonalcoholic steatohepatitis. J Gastroenterol 2024.
  14. Zhao J, Yi Z, Deng G, Li Y, Li J, Qin M, Wu C, Luo P, Ma S, Gao L. STING modulates iron metabolism to promote liver injury and inflammation in acute  immune hepatitis. Free Radic Biol Med 2024;210:367-377.
  15. Deng GH, Wu CF, Li YJ, Shi H, Zhong WC, Hong MK, Li JJ, Zhao JM, Liu C, Qin MC, Zeng ZY, Zhang WM, Yung K, Lv ZP, Gao L. Caveolin-1 is critical for hepatic iron storage capacity in the development of  nonalcoholic fatty liver disease. Mil Med Res 2023;10:53.
  16. Zeng T, Li J, Xie L, Dong Z, Chen Q, Huang S, Xie S, Lai Y, Li J, Yan W, Wang Y, Xie Z, Hu C, Zhang J, Kuang S, Song Y, Gao L, Lv Z. Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity  damage in depression. J Neuroinflammation 2023;20:212.
  17. Qin M, Ou R, He W, Han H, Zhang Y, Huang Y, Chen Z, Pan X, Chi Y, He S, Gao L. Salvianolic acid B enhances tissue repair and regeneration by regulating immune  cell migration and Caveolin-1-mediated blastema formation in zebrafish. Phytomedicine 2024;130:155553.
  18. Shi H, Yang J, Lin J, Hong X, Zhou Z, Zhao J, Li Y, Li J, Wu C, Yan J, Wong NK, Gao L. A facile fluorescence-coupling approach to visualizing leonurine uptake and  distribution in living cells and Caenorhabditis elegans. Phytomedicine 2024;130:155737.