申请者主要从事多模态多功能分子探针的设计构建，肿瘤成像和治疗研究；光热及其光动力探针设计合成应用；先后获得2项国家自然科学基金的资助(编号21244007和81671749)。近三年来，申请者获得国家发明专利授权10项，以(共同)通讯作者在Small, Biaoctive Materials, Journal of nanobiotechnology, ACS Appl Mater Interfaces, Biomat Sci, Sensor Actuat B-Chem, J Mater Chem B, Talanta, Inter J Nanomed, Nanocale等国外期刊发表SCI论文30篇.
1.Di Zhang, Jinghong Yang, Sheng Ye, Yutong Wang, Chuang Liu, Qianbing Zhang*, Ruiyuan Liu* Combination of Photothermal Therapy with Anti-Inflammation Therapy Attenuates the Inflammation Tumor Microenvironment and Weakens Immunosuppression for Enhancement Antitumor Treatment, Small 2022, 2107071
2.Quan Tao†, Genghan He†, Sheng Ye, Di Zhang, Zhide Zhang*, Li Qi*, Ruiyuan Liu*, Mn doped Prussian blue nanoparticles for T1/ T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor, Journal of Nanobiotechnology,2022,20,18
3.Huajin Pang, Chen Tian, Genghan He, Di Zhang, Jinghong Yang, Qianbing Zhang*, Ruiyuan Liu* NIR-absorbing Prussian blue nanoparticles for transarterial infusion photothermal therapy of
VX2 tumors implanted in rabbits, Nanoscale, 2021, 13, 8490
4.Di Zhang, Jinghong Yang, Chuang Liu, Sheng Ye, Qianbing Zhang*, Ruiyuan Liu* An Acceptor-π-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis, International Journal of Nanomedicine 2021,16, 4901
5.Two cyanoethylene-based fluorescence probes for highly efficient cyanide detection and practical applications in drinking water and living cells Ting Peng, Shining Li, Yuping Zhou, Ruiyuan Liu*, Jinqing Qu,* Talanta,2021, 234, 122615
6. Zikang Chen, Yinuo Tu, Di Zhang, Chuang Liu,Yuping Zhou, Xiang Li, Xu Wu, Ruiyuan Liu* A thermosensitive nanoplatform for photoacoustic imaging and NIR light triggered chemo-photothermal therapy, Biomaterials Science, 2020, 8, 4299.
7. Zishan Sun, Zikang Chen, Jiabao Luo, Zhenpeng Zhu, Xinguo Zhang*, Ruiyuan Liu* Zhan-chao Wu, A yellow-emitting nitrogen-doped carbon dots for sensing of vitamin B12 and their cell-imaging, Dyes and Pigments, 2020,108227
8. Qi Xia, Zikang Chen, Zhiqiang Yu, Lei Wang, Jinqing Qu, Ruiyuan Liu*, Aggregation-Induced Emission-Active Near-Infrared Fluorescent Organic Nanoparticles for Noninvasive Long-Term Monitoring of Tumor Growth, ACS Applied Materials & Interfaces, 2018, 10, 17081.
9. Liwen Hu#, Zikang Chen#, Yanshan Liu, Bishan Tian, Ting Guo*, Ruiyuan Liu*, Chunxiao Wang*, Lei Ying, In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene‑S,S‑dioxide Derivatives, ACS Applied Materials & Interfaces, 2020, 12, 57281.
10.Kailun Deng, Lei Wang, Qi Xia, Ruiyuan Liu*, Jinqing Qu*, A turn-on fluorescent chemosensor based on aggregation-induced emission for cyanide detection and its bioimaging applications, Sensors & Actuators: B. Chemical, 2019, 296,126645