郭晓华，女，南方医科大学病理生理学教研室教授，博士研究生导师，博士后合作导师。从事内皮细胞屏障功能和血管通透性研究，在AGEs介导血管通透性变化及其信号机制方面以及脓毒症所致急性肺损伤机制有深入研究，曾赴美国加州大学戴维斯分校和南佛罗里达大学从事博士后工作近2年。近年来以第一负责人主持多项国家级以及省部级医学自然科学基金的资助，包括国家自然科学基金3项，广东省自然科学基金2项，教育部基金2项。现为中国微循环学会常务理事，中国微循环学会重症微循环专业委员会副主任委员，中国微循环学会糖尿病与微循环专业委员会常务委员，中国中西医结合委员会微循环专业委员会委员，广东省病理生理学会心血管专业副主任委员。

1，糖尿病微血管病变

2，急性肺损伤上皮屏障功能的研究

1) Chen Z ^#, Lin B ^#, Yao X, Fang Y, Liu J, Song K,, Tuolihong L, Zuo Z, He Q, Huang X, Liu Z, Huang Q, Xu Q*, Liu Z*, Guo X*. OAS3 Deubiquitination Due to E3 Ligase TRIM21 Downregulation Promotes Epithelial Cell Apoptosis and Drives Sepsis-induced Acute Lung Injury. Int J Biol Sci. 2024 Oct 14;20(14):5594-5607. doi: 10.7150/ijbs.96089. eCollection 2024. 

2) Liu J, Song K, Lin B, Chen Z, Liu Y, Qiu X, He Q, Zuo Z, Yao X, Huang X,  Liu Z, Liu Z*, Huang Q*, Guo X*. The suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury. Cell Biosci. 2024 May 2;14(1):56. doi: 10.1186/s13578-024-01239-z  

3) Liu J ^#, Song K ^#, Lin B, Chen Z, Zuo Z, Fang Y, He Q, Yao X, Liu Z*, Huang Q*, Guo X*. HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis. Int Immunopharmacol. 2024 Apr 21:133:112130. doi: 10.1016/j.intimp.2024.112130. 

4) Chen Z ^#, Lin B ^#, Yao X, Weng J, Liu J, He Q, Song K, Zhou C, Zuo Z, Huang X, Liu Z, Huang Q, Xu Q*, Guo X*. Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9. Cell Commun Signal. 2024 Mar 15; 22(1):182. doi: 10.1186/s12964-024-01566-1.

5) He Q, Zuo Z, Song K, Wang W, Yu L, Tang Z, Hu S, Li L, Luo H, Chen Z, Liu J, Lin B, Luo J, Jiang Y*, Huang Q*, Guo X*. Keratin7 and Desmoplakin are involved in acute lung injury induced by sepsis through RAGE. Int Immunopharmacol. 2023 Sep 1;124(Pt A):110867. doi: 10.1016/j.intimp.2023.110867.

6) He Q, Chen Z, Li J, Liu J, Zuo Z, Lin B, Song K, Zhou C, Lai H, Huang Q, Guo X*.SENP6-Mediated deSUMOylation of VEGFR2 Enhances Its Cell Membrane Transport in Angiogenesis. Int J Mol Sci. 2023 Jan 29;24(3):2544. doi: 10.3390/ijms24032544.

7) Weng J^#, Chen Z^#, Li J^#, He Q, Chen D, Yang L, Su H, Huang J, Yu S, Huang Q, Xu Q*, Guo X*. Advanced glycation end products induce endothelial hyperpermeability via β-catenin phosphorylation and subsequent up-regulation of ADAM10. J Cell Mol Med. 2021 Jul 5. doi: 10.1111/jcmm.16659. 

8) Zhou G^#, Chen Z^#, Li J, Guo X, Qin K, Luo J, Hu J, Huang Q, Su L*, Guo X*, Xu Q*. Role of the Receptor for Advanced Glycation End Products in Heat Stress-Induced Endothelial Hyperpermeability in Acute Lung Injury. Front. Physiol. 2020; 11: 1087, 07 October 2020 | https://doi.org/10.3389/fphys.2020.01087  

9) Chen L, Cui Y, Li B, Weng J, Wang W, Zhang S, Huang X, Guo X *, Huang Q *. Advanced glycation end products induce immature angiogenesis in in vivo and ex vivo mouse models. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H519-H533. doi: 10.1152/ajpheart.00473.2019. 

10） Guo X^#, Eitnier RA^#, Beard RS Jr^#, Meegan JE, Yang X, Aponte AM, Wang F, Nelson PR, Wu MH*. Focal adhesion kinase and Src mediate microvascular hyperpermeability caused     by fibrinogen- γC- terminal fragments. PLoS One. 2020 Apr 30;15(4):e0231739. doi:    10.1371/journal.pone.0231739. eCollection 2020. 

11) Weng J^#, Yu L^#, Chen Z, Su H, Yu S, Zhang Y, Lei X, Chen L, Cui Y, Huang Q*, Jiang Y*, Guo X*. β-Catenin phosphorylation at Y654 and Y142 is crucial for high mobility group box-1 protein-induced pulmonary vascular hyperpermeability. J Mol Cell Cardiol. 2018 Dec 25;127:174-184. doi: 10.1016/j.yjmcc.2018.12.012.

12) Wang W^#, Weng J^#, Yu L, Huang Q*, Jiang Y*, Guo X*. Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability. BMC Pulm Med. 2018 Nov 27;18(1):178. doi: 10.1186/s12890-018-0735-0. 

13) Li P^#, Chen D^#, Cui Y, Zhang W, Weng J, Yu L, Chen L, Chen Z, Su H, Yu S, Wu J, Huang Q*, Guo X*. Src Plays an Important Role in AGE-Induced Endothelial Cell Proliferation, Migration, and Tubulogenesis. Front Physiol. 2018 Jun 21;9:765. doi: 10.3389/fphys.2018.00765. eCollection 2018.

14) Zhou X^#, Weng J^#, Xu J, Xu Q, Wang W, Zhang W, Huang Q*, Guo X*. Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability. Cell Physiol Biochem. 2018 Feb 23;45(4):1717-1730. doi: 10.1159/000487780. 

15) Wu F^#, Guo X^#, Xu J, Wang W, Li B, Huang Q, Su L, Xu Q*. Role of myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability in vitro and in vivo.Diab Vasc Dis Res. 2016 Mar;13(2):137-44. 

16) Zhang W#, Xu Q#, Wu J, Zhou X, Weng J, Xu J, Wang W, Huang Q*, Guo X*. Role of Src in Vascular Hyperpermeability Induced by Advanced Glycation End Products. Sci Rep2015 Sep 18;5:14090. doi: 10.1038/srep14090. 

17) Guo X, Wang L, Chen B, Li Q, Wang J, Zhao M, Wu W, Zhu P, Huang X, Huang Q*. ERM protein moesin is phosphorylated by advanced glycation end products and modulate vascular permeability Am J Physiol Heart Circ Physiol, 297:H238-246, 2009