区彩文，女，1978年11月生，研究员，中共党员，内科学博士，南方医科大学心血管内科学术型、专业型博士生导师，博士后合作导师。南方医科大学科研院副院长，原南方医科大学第十附属医院（东莞市人民医院）副院长、党委委员，分管医院科教工作。研究方向：心血管疾病基础与防治，心血管组织工程。长期致力于药物递送、干细胞与组织再生等领域的研究，以解决临床问题。近五年以通讯作者在 Advanced Materials、Nature Communication、Science Advance、Diabetes Care、Adv Functional Materials、 Biomaterials、Acs Nano、Nano Today、Advanced science、Chest等期刊发表SCI论文40余篇 。荣获全国2012~2016年度“国家自然科学基金管理先进个人”，2020年获得“广东特支计划”科技创新青年拔尖人才，2020年获得中华医学会第二届中青年心血管病学菁英（临床科研创新奖）。先后共主持5项国家自然科学基金项目（1青年、4面上）、广东省粤莞联合基金团队项目1项、3项广东省省级项目，积累了良好的研究工作经验。现任东莞市医学会常务副会长兼秘书长、广东省医学会理事、中华医学会健康管理学分会青年委员、中国生物材料纳米生物技术分会委员、中国解剖学会血管分会委员、中国生物材料学会康复器械与生物材料分会委员、广东省医师协会医学科研管理分会副主任委员、广东省健康管理学会食品安全与营养健康学会常务委员、粤港澳大湾区心血管基础与临床分会副主任委员，现任广东省发改委恶性肿瘤硼中子治疗技术与应用工程中心主任、广东省心功能与微循环重点实验室常务副主任。

心血管组织工程，纳米药物传递，心血管组织再生修复

[1]. Guo W^#, Guo W^#, Chen B^#, Lin Z, Wen Z, Ye J, Feng W, Feng X, Yan J, Yang P, Ouyang K, Li Y, Yang H^*, Ou C^*, Liu C^*. NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization. Nature Communications.2025 Aug 29;16(1):8074.(IF 15.7，1区)

[2]. Guan T^#, Lu Z^#, Tai R^#, Guo S^#, Zhang Z^*, Deng S, Ye J, Chi K, Zhang B, Chen H, Deng Z, Ke Y, Huang A, Chen P^*, Wang C^*, Ou C^*. Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway. Bioactive Materials.2025 Mar 15;49:378-398.（IF 20.3，1区）

[3]. Deng S^#, Hu L^#, Chen G^#, Ye J, Xiao Z, Guan T, Guo S, Xia W, Cheng D, Wan X^*, Cheng K^*, Ou C^*. A PD-L1 siRNA-Loaded Boron Nanoparticle for Targeted Cancer Radiotherapy and Immunotherapy. Advanced Materials.2025 Apr;37(13):e2419418.（IF 26.8，1区）

[4]. Wang H^#, Guan T^#, Hu R^#, Huang Z, Liang Z, Lin X, Qiu Y, Liao P, Guo X, Ke Y, Zhang H, Ou C^*, Li Y^*. Targeting KAT7 inhibits the progression of colorectal cancer. Theranostics.2025 Jan 2;15(4):1478-1495.（IF 13.3，1区）

[5]. Cheng R^#, Tang X^#, Zhao Q^#, Wang Y^#, Chen W, Wang G, Wang C, Mwangi J, Lu Q, Tadese DA, Zhao X^*, Ou C^*, Lai R^*. Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis. Research (Wash D C).2025 Jan 13;8:0578.（IF 10.1，1区）

[6]. Fang C^#, Liu X^#, Yu C, Li S, Liu X, Qiu S, Liang H, Ou C^*, Xiu J^*. Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis. Journal of Translational Medicine.2025 Jan 6;23(1):14.（IF 7.5，2区）

[7]. Guan T^#, Jiang Y^#, Tu P^#, Ye B^#, Zeng L, Luo Z, Chi K, Liang H, Yang Y, Huang J, Zhang B, Tai R, Ye J, Deng Z, Ke Y, Chen H, Zhang Z^*, Liu Z^*, Ou C^*. Risk classification for non-cancer death in middle-aged cancer patients. Journal of Advanced Research. 2024 Dec 25:S2090-1232(24)00616-7.（IF 13.0，1区）

[8]. Zhou H^#, Huang W^#, Li J^#, Chen P, Shen L, Huang W, Mai K, Zou H, Shi X, Weng Y, Liu Y^*, Yang Z^*, Ou C^*. Oral probiotic extracellular vesicle therapy mitigates Influenza A Virus infection via blunting IL-17 signaling. Bioactive Materials. 2024 Dec 3;45:401-416.（IF 24.3，1区）

[9]. Guo S^#, Guan T^#, Ke Y^#, Lin Y, Tai R, Ye J, Deng Z, Deng S^*, Ou C^*. Biologically logic-gated Trojan-horse strategy for personalized triple-negative breast cancer precise therapy by selective ferroptosis and STING pathway provoking. Biomaterials. 2025 Apr;315:122905.（IF 12.9，1区）

[10]. Chen P^#, Ning X^#, Feng W^#, Li Y, Chen G, Shi X, Pan Y, Shi X, Xiao Y, Liu Y, Zhang G^*, Zhou F^*, Ou C^*. Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF-κB/NLRP3 Pathway. Advanced Science (Weinh). 2024 Dec;11(45):e2404142.（IF 14.1，1区）

[11]. Ding D^#, Mo S, Li Q, Wang F, Wang X, Ou C^*, Li Z^*. Fluorinated BPA derivatives enhanced 10B delivery in tumors. Journal of Materials Chemistry b. 2024 Jun 27;12(25):6128-6136.（IF 5.7，2区）

[12]. Guan T^#, Monteiro O, Chen D, Luo Z, Chi K, Li Z, Liang Y, Lu Z, Jiang Y, Yang J, Lin W, Yi M, Zhang K, Ou C^*. Long-term and short-term cardiovascular disease mortality among patients of 21 non-metastatic cancers. Journal of Advanced Research.2025 Mar;69:215-224.（IF 13.0，1区）

[13]. Guo S^#, Li Z^#, Zhou R^#, Feng J*, Huang L, Ren B, Zhu J, Huang Y, Wu G, Cai H, Zhang Q, Ke Y, Guan T, Chen P, Xu Y, Yan C*, Ou C*, Shen Z*. MRI-Guided Tumor Therapy Based on Synergy of Ferroptosis, Immunosuppression Reversal and Disulfidptosis. Small (Weinheim an der Bergstrasse, Germany) 2024: e2309842.（IF 13.3，2区）

[14]. Fu C^#, Li Q^#, Li M^#, Zhang J, Zhou F, Li Z, He D, Hu X, Ning X, Guo W, Li W, Ma J, Chen G, Xiao Y*, Ou C*, Guo W*. An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis After Angioplasty. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024: e2307063.（IF 15.1，1区）

[15]. Chen P^#, Zhang W^#, Fan X^#, Shi X, Jiang Y, Yan L, Li H, Wang C, Han L*, Lu X*, Ou C*. A polyphenol-derived redox-active and conductive nanoparticle-reinforced hydrogel with wet adhesiveness for myocardial infarction repair by simultaneously stimulating anti-inflammation and calcium homeostasis pathways. Nano Today 2024, 55.（IF 17.4，1区）

[16]. Yu B^#, Li H^#, Zhang Z^#, Chen P, Wang L, Fan X, Ning X, Pan Y, Zhou F, Hu X, Chang J*, Ou C*. Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice. Nature communications 2023, 14(1): 2094.（IF 16.6，1区）

[17]. Wang L^#, Chen P^#, Pan Y^#, Wang Z, Xu J, Wu X, Yang Q, Long M, Liu S, Huang W*, Ou C*, Wu Y*. Injectable photocurable Janus hydrogel delivering hiPSC cardiomyocyte-derived exosome for post-heart surgery adhesion reduction. Science advances 2023, 9(31): eadh1753.（IF 13.6，1区）

[18]. Fu C^#, Tao Y^#, Chen H, Li M, Xiao Y, Yao Y, Ma J, Ning X, Li W, Zheng J, Dong S, Chen G, Cao F, Ou C*, Liu L*, Guo W*. Monocyte Differentiation-Surveilling Nano-Shuttles for Activatable Targeted Inhibition of Atherosclerotic Plaque Progression. Adv Funct Mater 2023, 33(37): 2303150.（IF 19，1区）

[19]. Feng W^#, Teng Y^#, Zhong Q, Zhang Y, Zhang J, Zhao P, Chen G, Wang C, Liang XJ*, Ou C*. Biomimetic Grapefruit-Derived Extracellular Vesicles for Safe and Targeted Delivery of Sodium Thiosulfate against Vascular Calcification. ACS nano 2023, 17(24): 24773-24789.（IF 17.1，1区）

[20].Chen P, Ning X, Li W, Pan Y, Wang L, Li H, Fan X, Zhang J, Luo T, Wu Y*, Ou C*, Chen M*. Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization. Bioactive materials 2022, 14: 416-429.（IF 18.9，1区）

[21].  Luo T, Guo Z, Liu D, Guo Z, Wu Q, Li Q, Lin R, Chen P, Ou C*, Chen M*. Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3. Gut microbes 2022, 14(1): 2077602.（IF 12.2，1区）

[22].  Li WR^#, Chen PE^#, Pan YX, Lu L, Ning XD, Liu JM, Wei JT, Chen MS, Zhao P*, Ou CW*. Construction of a Band-Aid Like Cardiac Patch for Myocardial Infarction with Controllable H2S Release. Adv Sci 2022: 15.（IF 15.1，1区）

[23].Li H^#, Yu B^#, Yang P^#, Zhan J, Fan X, Chen P, Liao X, Ou C*, Cai Y*, Chen M*. Injectable AuNP-HA matrix with localized stiffness enhances the formation of gap junction in engrafted human induced pluripotent stem cell-derived cardiomyocytes and promotes cardiac repair. Biomaterials 2021, 279: 121231.（IF 14，1区）

[24].  Chen P, Wang L, Fan X, Ning X, Yu B, Ou C*, Chen M*. Targeted delivery of extracellular vesicles in heart injury. Theranostics 2021, 11(5): 2263-2277.（IF 12.4，1区）

[25]. Feng W, Li Z, Guo W, Fan X, Zhou F, Zhang K, Ou C*, Huang F*, Chen M*. Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age. Diabetes care 2020, 43(10): 2574-2580.（IF 16.2，1区）

[26]. He J^#, Chen G^#, Zhao P*, Ou C*. Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy. Nano Research 2021, 14(11): 3988-3998.（IF 9.9，1区）

[27]. Yi M^#, Li H^#, Wang X, Yan J, Gao L, He Y, Zhong X, Cai Y, Feng W, Wen Z, Wu C, Ou C*, Chang J*, Chen M*. Ion Therapy: A Novel Strategy for Acute Myocardial Infarction. Adv Sci 2019, 6(1): 1801260.（IF 15.1，1区）