目录
更新日期:2024年3月6日
姓 名 肖姗 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 理学博士学位
行政职务 教研室副主任 Email asdfg@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
跨学科招生
跨学科招生专业1 儿科学 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
研究领域

研究方向为RNA表观修饰与发育调控,主要关注:RNA表观修饰m6A在胚胎发育中的作用和功能;m6A的动态调控机制;其他RNA表观修饰在发育中的功能。

主持国自然项目四项,其中优青项目一项;主持国家重点研发计划项目一项;主持广东省自然科学基金-杰出青年项目一项。

个人成果

以第一作者或通讯作者发表文章

  1. Cao S.#, Zhu H. #, Cui J.#, Liu S.#, Li Y., Shi J., Mo J., Wang Z., Wang H., Hu J., Chen L., Li Y.*, Xia L*. Xiao S.* (2023) Allele-specific RNA N6-methyladenosine modifications reveal functional genetic variants in human tissues. Genome Research, 33, 1369-1380.
  2. Liu X.#, Wang H.#, Zhao X.#, Luo Q.#, Wang Q., Tan K., Wang Z., Jiang J., Cui J., Du E., Xia L., Du W., Chen D.*, Xia L.*, Xiao S.*.(2021) Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells. Nature Communications, 12, 3780.
  3. Li Y. #, Xia L #., Tan K. #, Ye X. #, Zuo Z. #, Li M. #, Xiao R., Wang Z., Liu X., Deng M., Cui J., Yang M., Luo Q., Liu S., Cao X., Zhu H., Liu T., Hu J., Shi J., Xiao S.*, Xia L*. (2020) N(6)-methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2. Nature Genetics, 52, 870-+.
  4. Xiao S.#, Cao S. #, Huang Q. #, Xia L. #, Deng M., Yang M., Jia G., Liu X., Shi J., Wang W., Li Y., Liu S., Zhu H., Tan K., Luo Q., Zhong M.*, He C. * and Xia L.* (2019) The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology, 21, 651-661.
  5. Liu T. #, Wang Q. #, Li W. #, Mao F. #, Yue S., Liu S., Liu X., Xiao S.* and Xia L.* (2017) Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A. FASEB Journal, 31, 2185-2194.
  6. Liu J. Q. #, Xiao S. #, Hao Y. H. and Tan Z. (2015) Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase. Angewandte Chemie International Edition., 54, 8992-8996.
  7. Xiao S., Zhang J. Y., Wu J., Wu R. Y., Xia Y., Zheng K. W., Hao Y. H., Zhou X. and Tan Z. (2014) Formation of DNA:RNA hybrid G-quadruplexes of two G-quartet layers in transcription: expansion of the prevalence and diversity of G-quadruplexes in genomes. Angewandte Chemie International Edition., 53, 13110-13114.
  8. Shrestha P.#, Xiao S. #, Dhakal S., Tan Z. and Mao H. (2014) Nascent RNA transcripts facilitate the formation of G-quadruplexes. Nucleic Acids Research, 42, 7236-7246.
  9. Xiao S., Zhang J. Y., Zheng K. W., Hao Y. H. and Tan Z. (2013) Bioinformatic analysis reveals an evolutional selection for DNA:RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded animals. Nucleic Acids Research, 41, 10379-10390.