南方医科大学基础医学院细胞生物学教研室主任，博士，教授，博士生导师。2005-2007年美国匹兹堡大学医学院博士后。现任广东省细胞生物学学会常务理事，广东省泌尿生殖协会转化医学分会常务理事，中国细胞生物学学会会员。担任国家自然科学基金函审和会评专家。主要研究方向：（1）前列腺癌微环境与肿瘤血管新生、肿瘤转移及休眠；（2）肿瘤代谢与肿瘤恶性进展。主持国家自然科学基金课题5项；以第一作者或通讯作者在国际主流杂志发表论文近20篇，包括Cancer Res.，Cell Mol life Sci., J Cell Sci., J Exp & Clin Cancer Res, Cell Death & Disease，Front Immunol 等, 单篇最高引用100余次。
前列腺癌是男性泌尿生殖系统最常见的恶性肿瘤，其致死率占全世界男性肿瘤的第六位。高发病率和高死亡率的最直接原因是前列腺癌形成转移性病灶，以致不可逆的临床进展恶化,并最终导致患者死亡。深入研究前列腺癌恶性进展的调控机制、关键信号通路分子的鉴定对于设计合理的治疗药物及判断预后，进一步提高前列腺癌的治疗水平具有重要意义。近期课题组的主要研究方向：
1. 前列腺癌肿瘤微环境与肿瘤的血管新生；2. 前列腺癌代谢调节与肿瘤的恶性进展；3. 骨髓微环境中成骨细胞分化对肿瘤休眠的影响作用及其机制。
1. Wanfu Xu#, Jiabi Qian#, Fangyin Zeng#, Songyu Li, Wenjing Guo, Liping Chen, Guihuan Li, Zhishuai Zhang, Qiming Jane Wang, Fan Deng*; Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment. Journal of Experimental & Clinical Cancer Research. 2019 Mar 6; 38(1):114. doi: 10.1186/s13046-019-1118-y. ( IF: 12.658, 1区).
2. Chen J#, Deng F#, Singh SV, Wang QJ. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer Research. 2008;68(10):3844-53 （IF:12.70, JCR 一区).
3. Roy A, Ye J, Deng F, Wang QJ. Protein kinase D signaling in cancer: A friend or foe?. Biochim Biophys Acta Rev Cancer. 2017;1868(1):283-294. doi: 10.1016/j.bbcan.2017.05.008 ( IF:11.414, JCR: 一区) .
4. Wanfu Xu#, Fangyin Zeng#, Songyu Li#,, Guihuan Li, Xiaoju Lai, Q. Jane Wang, Fan Deng. Crosstalk of Protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. Cellular and Molecular Life Sciences.2018 ;75（24）：4583-4598 ( IF: 9.207 JCR二区).
5. Qu Q, Zeng F, Liu X, Wang QJ, Deng F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell death & disease. 2016;7:e2226(IF:8.469，JCR二区).
6. Wanlu. Zhao, Guihuan. Li, Qianbing. Zhang, Meixuan. Chen, Lijun. He, Zhicong. Wu, Yihe. Zhang, Mingming. Fan, Yanling. Liang, Wenlong. Zhang, Fangyin Zeng*, Fan Deng*, Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress, Biochemical Pharmacology (2023), doi: https://doi.org/10.1016/j.bcp.2023.115453 （IF:6.1, JCR 二区）
7. Fei Li #, Henghui Zhang #, Yu Wang #, Zhihao Yao , Kunfeng Xie , Qixin Mo , Qin Fan , Lina Hou* , Fan Deng* , Wanlong Tan* .FGFBP1 as a potential biomarker predicting bacillus Calmette-Guérin response in bladder cancer. Front Immunol. 2022 Sep 2;13:954836.doi: 10.3389/fimmu.2022.954836. eCollection 2022.(F:8.786, JCR 二区).
8. Zhicong Wu#, Hua Chen#, Yanling Liang, Wenyang Luo, Fan Deng*, Fangyin Zeng*. Alternative splicing implicated in immunity and prognosis of colon adenocarcinoma. International Immunopharmacology. 2020 Dec;89(Pt B):107075. doi: 10.1016/j.intimp.2020.107075. Epub 2020 Oct 21( IF:5.714, JCR 二区).
9. Zou Z*, Zeng F*, Xu W, Wang C, Ke Z, Wang QJ, Deng F. PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA. J Cell Sci. 2012 Oct 15;125(Pt 20):4800-11(IF:5.285，JCR 三区).
10. Guihuan Li#, Mingming Fan#, Zenan Zheng, Yihe Zhang, Zhishuai Zhang, Zhibin Huang, Wenyang Luo, Wanlu Zhao, Xiaoju Lai, Hua Chen, Fangyin Zeng*, Fan Deng*. Osteoblastic Protein Kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling. BBA- Molecular Cell Research.. 2022 Sep;1869(9):119296. doi: 10.1016/j.bbamcr.2022.119296. Epub 2022 May 18.（IF: 5.011, JCR 三区）.
11. Xiaoju Lai , Yanling Liang, Jie Jin, Hanyun Zhang, Zhicong Wu, Guihuan Li, Jinxiang Wang, Zhishuai Zhang, Hua Chen, Fangyin Zeng*, Fan Deng*.Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2. Experimental Cell Research. 2022 Nov 15;422(1):113427. doi: 10.1016/j.yexcr.2022.113427（IF:4.145, JCR三区）
12. Wenjing Guo#, Zhishuai Zhang#, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng*, Fan Deng*. Pyruvate kinase M2 promotes prostate cancer metastasis through regulating ERK1/2-COX-2 signaling. Frontiers in Oncology. 2020 Sep 29;10:544288.doi: 10.3389/fonc.2020.544288 (IF: 5.738, JCR 三区).