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更新日期：2025年9月25日
姓 名 闫文娟 性 别 女
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 口腔医学博士专业学位
行政职务 主任 Email 645613053@qq.com
工作单位 南方医科大学南方医院 邮政编码
个人简介

闫文娟，医学博士，主任医师，博士生导师，美国贝勒牙学院访问学者，现南方医科大学南方医院牙体牙髓科主任，担任中华口腔医学会牙体牙髓病专委会委员，中华口腔医学会老年专委会委员，广东省口腔医学会牙体牙髓病学专业委员会副主委，广东省口腔医学会老年口腔专委会常委，广东省整形美容协会口腔常委，第五届广东省口腔医学会理事群。研究方向：牙髓再生的机制研究；生物活性因子影响骨代谢及骨修复的研究；血管再生的机制研究；牙体缺损的椅旁CAD/CAM数字化修复的临床研究。主持国家自然科学基金2项，参与国家自然科学基金4项，发表中英文文章30余篇，擅长疑难根管的诊断及显微治疗，椅旁CAD/CAM的数字化修复，前牙美学修复。

研究领域

牙髓再生的机制研究；生物活性因子影响骨代谢及骨修复的研究；血管再生的机制研究；大面积牙体缺损的椅旁数字化修复临床研究；

个人成果

主持国家自然科学基金面上项目2项：

1.国家自然科学基金面上项目 (NO.82571819): 2026.01-2029.12，49万，在研，主持

2.国家自然科学基金面上项目（No.82171573): 2022.01-2025.12，55万，在研，主持

中国高校产学研创新基金1项：2024.10-2026.11；

近期以通讯作者发表文章20篇，单篇最高IF20.3:

 

  1. Simin Wang, Yanli Zhang, Yuting Zeng, Xin Luo, Jiaping Chen, Qianwen Deng ,Ping Xiao  , Ruofei Lin, Xiuwen Chen, Xian Ding, Qianlin Li, Sijie Qiu, Dehong Yang ⁎,Yan W*.Bioactive Materials doi：https://doi.org/10.1016/j.bioactmat.2025.09.024（中科院I区，IF: 20.3）
  2. Zheng Z, Li W, Yan X, Zhong W, Zeng Y, Xiao P, Mo J, Yan W*.Biomechanical influence of residual lateral wall thickness and resin reinforcement on the performance of endocrowns in premolars. Dent Mater. 2025 Aug 19:S0109-5641(25)00739-0.（中科院I区，IF: 6.3）
  3. Luo X, Zhang Y, Zeng Y, Yang D, Zhou Z, Zheng Z, Xiao P, Ding X, Li Q, Chen J, Deng Q, Zhong X, Qiu S, Yan W*. Nanotherapies Based on ROS Regulation in Oral Diseases. Adv Sci (Weinh). 2025 Mar;12(9):e2409087 （中科院I区，IF: 15.1）
  4. Zhou Z, Zhang Y, Zeng Y, Yang D, Mo J, Zheng Z, Wang J, Zhang Y, Zhou Z, Zhong X, Yan W*. Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix. ACS Nano, 2024,18(11):7688-7710. （中科院I区，IF: 15.8）
  5. Zhou C, Cai Z, Guo J, Li C, Qin C, Yan W*, Yang D. Injective hydrogel loaded with liposomes-encapsulated MY-1 promotes wound healing and increases tensile strength by accelerating fibroblast migration via the PI3K/AKT-Rac1 signaling pathway. J Nanobiotechnology. 2024 Jul 5;22(1):396. (中科院I区，IF: 10.2)
  6. Zhang Y , Mo J , Zheng C, Zeng Y, Zhou Z, Zhang Y, Li M, Shao L*, Yang D*, Yan W*. MY-1 Loaded Nano-hydroxyapatite Accelerated Bone Regeneration by Increasing Type Ⅲ Collagen Deposition in Early-stage ECM via a Hsp47 Dependent Mechanism[J]. Advanced Healthcare Materials. 2023,e2300332. （中科院I区，IF: 10.08）
  7. Luo X, Zhang Y, Zeng Y, Yang D, Zhou Z, Yan W* . Nanotherapies based on ROS regulation in oral diseases. 2024, Advanced Science (中科院I区，IF: 17.52, Under Review)
  8. Zhang Y , Mo J , Zheng C, Zeng Y, Zhou Z, Zhang Y, Li M, Shao L*, Yang D*, Yan W*. MY-1 Loaded Nano-hydroxyapatite Accelerated Bone Regeneration by Increasing Type Ⅲ Collagen Deposition in Early-stage ECM via a Hsp47 Dependent Mechanism[J]. Advanced Healthcare Materials. 2023,e2300332. （I区，IF: 10.8）
  9. Xiao P, Zhang Y, Zeng Y, Yang D, Mo J, Zheng Z, Wang J, Zhang Y, Zhou Z, Zhong X, Yan W. Impaired angiogenesis in ageing: the central role of the extracellular matrix. J Transl Med. 2023 Jul 11;21(1):457.（II区，IF=7.4）
  10. Zhou C, Guan D, Guo J, Niu S, Cai Z, Li C, Qin C, Yan W*, Yang D*. Human Parathyroid Hormone Analog (3-34/29-34) promotes wound re-epithelialization through inducing keratinocyte migration and epithelial-mesenchymal transition via PTHR1-PI3K/AKT activation. Cell Commun Signal. 2023 Aug 23;21(1):217. （II区，IF=8.4）
  11. Ziting Zheng, Hebi Wang, Jiayao Mo , Zhiting Ling , Yuting Zeng, Yuxin Zhang , Jilei Wang and Yan W*. Efect of virtual cement space and restorative materials on the adaptation of CAD-CAM endocrowns, BMC Oral Health, 2022 Dec 9;22(1):580
  12. Zheng Z, Sun J, Jiang L, Wu Y, He J, Ruan W, Yan W*. Influence of margin design and restorative material on the stress distribution of endocrowns: a 3D finite element analysis. BMC Oral Health. 2022 Feb 5;22(1):30
  13. Ruan W, Zheng Z, Jiang L, He J, Sun J, Yan W*. Optimal cuspal coverage of ceramic restorations using CAD/CAM: Biomechanical characteristic analysis by 3D finite element analysis and in vitro investigation. Int J Comput Dent. 2022,Sep 20;25(3):267-276.
  14. He J, Zheng Z, Wu M, Zheng C, Zeng Y, Yan W*. Influence of restorative material and cement on the stress distribution of endocrowns: 3D finite element analysis. BMC Oral Health. 2021 Oct 5;21(1):495.
  15. Wang J, Ling Z, Zheng Z, Zheng C, Gai Y, Zeng Y, Zhu X, Chen L, Wu B, Yan W*. Clinical efficacy of ceramic versus resin-based composite endocrowns in Chinese adults: study protocol for a randomized controlled trial. Trials. 2020 Jun 22;21(1):559.
  16. He Y, Li M, Tong G, Meng Y, Hao S, Hu S, Yan W*, Yang D*. hPTH(3-34)(29-34) selectively activated PKC and mimicked osteoanabolic effects of hPTH(1-34). Bone, 2020, 115326.
  17. Zheng Z,Yan W* et al. Biomechanical behavior of endocrown restorations with different CAD/CAM materials: 3D Finite Element and In Vitro Analysis. The Journal of Prosthetic Dentistry. 2020;20:480-485.
  18. Sun J, Yan W* et al. Clinical efficacy of different marginal forms of endocrowns: study protocol for a randomized controlled trial. Trials. 2019;20:454.
  19. He J., Ruan W.,Sun J., Yan W*, Functional Characterization of c-di-GMP Signaling-Related Genes in the Probiotic Lactobacillus acidophilus, Front Microbiol,2018; 9: 193.
  20. Wen-Juan Yan, Pan Ma, Ye Tian, Xiao-Fang Wang*, The importance of a potential phosphorylation site in enamelin on enamel formation, International Journal of Oral Science,2017, 9;e4; doi:10.1038

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