目录
更新日期:2023年9月12日
姓 名 陆云涛 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 副主任 Email lllu2000@163.com
工作单位 南方医科大学南方医院 邮政编码
个人简介

陆云涛(Yuntao Lu

男,神经外科学博士,教授,副主任医师,博士生导师,南方医科大学南方医院神经外科副主任,“广东省杰出青年医学人才”称号获得者,2004~2007年南方医科大学南方医院博士,2007~2009年多伦多大学肿瘤研究中心博士后,回国后一直从事神经脊柱脊髓相关疾病的手术治疗,2011年在美国克利夫兰神经外科进修,师从北美前脊柱联合会主席Dr. Benzel教授,回国后在南方医院神经外科开展神经脊柱脊髓相关工作,结合了神经外科显微技术的特长和脊柱生物力学稳定内固定技术。目前担任中华医学会、中国医师协会神经外科分会脊柱脊髓学组委员,中国研究型医院学会神经脊柱脊髓分会全国委员,中国神经脊柱学会理事,广东省医学会神经外科青年委员会副主任委员,中国医师协会胶质瘤委员会青年委员,中国医师协会神经外科分会英语教育和对外交流委员会委员,中国康复医学会神经再生审委员会委员。受聘为《中华神经外科杂志英文版》、《南方医科大学学报》和《中国临床解剖学杂志》编委,《Journal of hematology and oncology》《Cell death and disease》和《Oncogene》特约审稿人。

临床专长:各种颅脑肿瘤的外科治疗;脊柱脊髓肿瘤、脊髓空洞症、寰枢椎脱位、Chiari畸形,颈椎病,腰椎病,腰椎管狭窄等颈胸腰椎相关疾病的脊柱微创手术治疗,先天性脊柱裂、脊髓脊膜膨出的外科治疗;颅内恶性胶质瘤的外科治疗、辅助放化疗及分子靶向治疗研究。

近五年以课题负责人主持国家自然科学基金项目3项,留学归国人员启动基金1项,广东省自然科学基金项目2项,南方医院杰出青年基金1项,国家杰青培育计划1项,2019年获广东省杰出青年基金项目资助,总经费258万元。至今以第一和通讯作者在国际性杂志Cancer cell(IF= 24.962),Autophagy(IF=11.732),Clinical cancer research (IF=10.199),Theranostics(IF=8.537),Journal of hematology and oncology (IF=7.255),Caricinogenesis (IF=5.87)和Neurosurgery(IF=4.851)等杂志上发表SCI文章20篇;另在国内神经外科核心期刊发表专著20余篇。

研究领域

中枢神经系统恶性肿瘤发生发展及其放化疗抵抗的分子机制研究,寰枕交界区及上颈髓的生物力学研究,脊髓脊柱疾病的综合治疗

个人成果

1.      Linyong Shi, Hanning Chen, Kunxiang Chen, Chengzong Zhong, Chong Song, Yifeng Huang, Tong Wang, Lei Chen, Chiyang Li, Annie Huang, Hong Li, Yuntao Lu (通讯作者). The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in glioblastoma. ×Clin Cancer Res. 2023 Aug 15;29(16):3172-3188. (2023年 IF=11.5/Q1)

2.      Junjie Li, Chong Song, Junwei Gu, Chiyang Li, Linyong Shi, Wenrui Zang, Lei Chen, Liwen Zhu, Min Zhou, Tong Wang, Hong Li, Songtao Qi, Yuntao Lu (通讯作者). RBBP4 regulates the expression of the Mre11-Rad50-NBS1 (MRN) complex and promotes DNA double-strand break repair to mediate glioblastoma chemoradiotherapy resistance.  Cancer Letter. 2023 Jan 31;216078. (2023年IF=9.756/Q1)

3.      Chong Song, Liwen Zhu, Junwei Gu, Tong Wang, Linyong Shi, Chiyang Li, Lei Chen, Sidi Xie, Yuntao Lu (通讯作者). A necroptosis-related lncRNA signature was identified to predict the prognosis and immune microenvironment of IDH-wild-type GBM. Frontiers in Oncology. 2022,12:1024208. doi: 10.3389/fonc.2022.1024208 (IF=5.738/Q2)

4.      Huang, Qinguo; Yang, Xiaoyu; Zheng, Dongying; Zhou, Qiang; Li, Hong MD, PhD; Peng, Lin; Ye, Junhua; Qi, Songtao; Yuntao Lu * (通讯作者). Exploring the Pathogenesis of Atlanto-Occipital Instability in Chiari Malformation With Type II Basilar Invagination: A Systematic Morphological Study. Neurosurgery. 2022 December 16; (IF=5.315/Q1)

5.      Li C, Wang T, Gu J, Qi S, Li J, Chen L, Wu H, Shi L, Song C, Li H, Zhu L, Yuntao Lu * (共同通讯), Zhou Q*. SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastoma. Cell Death Dis. 2022 Nov 23;13(11):990. doi: 10.1038/s41419-022-05439-8. IF=9.685/Q1

6.      Huang Qinguo, Li Junjie, Zhou Qiang, Li Hong, Yang Xiaoyu, Peng Lin, Chen Lei, Qi Songtao, Yuntao Lu * (通讯作者). Management of symptomatic sacral perineural cysts: A new surgical methods. World Neurosurgery. 2022 Sep: S1878-8750 (22) 01234-7. SCI 2.210

7.      Qiang Zhou, Chong Song, Qinguo Huang, Hong Li, Xiaoyu Yang, Lin Peng, Junjie Li, Lei Chen, Linyong Shi, Songtao Qi, Yuntao Lu * (通讯作者). Evaluating Craniovertebral Stability in Chiari Malformation Coexisting with Type II Basilar Invagination: An Observational Study Based on Kinematic Computed Tomography and Its Clinical Application. World Neurosurg. 2022 May 17; S1878-8750(22)00675-1. doi: 10.1016/j.wneu.2022.05.045. SCI 2.210

8.      Li C, Fei C, Li J, Wu H, Chen L, Roshani R, Li H, Shi L, Song C, Gu J, Yuntao Lu * (共同通讯), Zhou Q. SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway. Mol Med Rep. 2021 Aug;24(2):551. doi: 10.3892/mmr.2021.12190. Epub 2021 Jun 3. IF=3.423

9.      Yuntao Lu * (通讯作者). In Reply: A Novel Classification and its Clinical Significance in Spinal Schwannoma Based on the Membranous Hierarchy. Neurosurgery, 2020 Dec 15;88(1):E126-E127. SCI IF= 5.315

10.   Jiyong Gu, Minchan Zhao, Yi Wu, Zhibin Li, Zize Feng, Yalan Jiang, Huixian Hu, Minggu Zhong, Zhongqin Luan, Zhengyuan Xie, Songtao Qi, Yuntao Lu * (通讯作者). Finite element modelling of posterior occiput-axis fixation and biomechanical analysis of C2 intralaminar screw fixation with offset connectors. British journal of neurosurgery. 2021 Oct 6;1-7. SCI,1.124

11.   Weng Z, Ma L, Li J, Zhou Q, Peng L, Li H, Chen L, Xin Z, Shi L, Qi S, Yuntao Lu * (通讯作者). A reproduceable in situ xenograft model of spinal glioma. J Neurosci Methods. 2020;346:108928. doi:10.1016/j.jneumeth.2020.108928. (IF=2.214)

12.       Zong xin, Berdimyrat Orazmyradov, Junjie Li, Qiang Zhou, Lin Peng, Hong Li, Lei Chen, Zhijian Weng, Linyong Shi, Liyi Ma, Songtao Qi, Yuntao Lu * (通讯作者). A Novel Classification and Its Clinical Significance in Spinal Schwannoma Based on the Membranous Hierarchy. Neurosurgery, 2020 Jul 21;nyaa272. doi: 10.1093/neuros/nyaa272. SCI IF=4.853

13.       Hong Li #, Junjie Li #, Lei Chen #, Songtao Qi #, Shishi Yu, Zhijian Weng, Ziyou Hu, Qiang Zhou, Zong Xin, Linyong Shi, Liyi Ma, Annie Huang, and Yuntao Lu * (通讯作者). HERC3-mediated SMAD7 ubiquitination degradation promotes autophagy-induced EMT and chemoresistance in glioblastoma. Clinical Cancer Research. 2019 Jun 15;25(12):3602-3616.(2018年IF=10.199)SCI 引用12

14.       Hong Li, Junjie Li,Guozhong Zhang, Qian Da, Lei Chen, Shishi Yu, Qiang Zhou, Zhijian Weng, Zong Xin, Linyong Shi, Liyi Ma, Annie Huang, Songtao Qi* and Yuntao Lu * (通讯作者). HMGB1-induced p62 overexpression promotes Snail-mediated epithelial–mesenchymal transition in glioblastoma cells via the degradation of GSK-3β. Theranostics, 2019 Mar 16;9(7):1909-1922.(2018年IF=8.537)SCIE 引用10

15.      Hong Li, Lei Chen, Junjie Li, Qiang Zhou, Annie Huang, Wei-wen Liu, Ke Wang, Liang Gao, Songtao Qi, Yuntao Lu(通讯作者). miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway. Journal of Hematology & Oncology. 2018, 11:70.他引5次 (2018年IF=7.333) SCIE 引用19

16.      Jiyong Gu, Weiwei Lei, Zong Xin, Yi Wu, Lin Peng, Zhibin Li, Zize Feng, Minchan Zhao, Songtao Qi, Yuntao Lu(通讯作者). Occiput-axis crossing translaminar screw fixation technique using offset connectors: An in vitro biomechanical study. Clin Neurol Neurosurg. 2018, 169: 49-54. (2018年IF=1.736) SCIE

17.      Zhou Qiang, Li Jun-jie, Wang Hai, Li Hong, Lei Bing-xi, Chen Lei, Xiang Wei, Liu Ya-wei, Annie Huang, Qi Song-tao, Lu Yun-tao(通讯作者). TPD52L2 Impacts Proliferation, Invasiveness and Apoptosis of Glioblastoma Cells via Modulation of Wnt/β-catenin/Snail Signaling. Carcinogenesis. 2018 Feb 9;39(2):214-224. 他引5次 (2018年IF=5.072) SCI

18.      Hong L, Yawei L, Hai W, Qiang Z, Jun-Jie L, Huang A, Songtao Q, Yuntao Lu(通讯作者)MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway. J Neurooncol. 2016 May;128(1):35-45.他引27次 (2018年IF=3.06) SCI

19      Wang H, Feng W, Lu Yuntao(共同一作), Li H, Xiang W, Chen Z, He M, Zhao L, Sun X, Lei B, Qi S, Liu Y. Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide. Sci Rep. 2016, 6: 28948.2015IF=5.228)他引14 SCI

20.      Lu Yuntao(共同通讯), Liming Xiao, Y. Liu, H. Wang, H. Li, Q. Zhou, J. Pan, B. Lei, A. Huang, and S. Qi*, MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy, 2015. 11(12): 2213-32.2015 IF=11.753)他引53 SCIE

9.      Lu Yuntao, Qi ST, Xu JM, Pan J, Shi J. A membranous structure separating the adenohypophysis and neurohypophysis: an anatomical study and its clinical application for craniopharyngioma. J Neurosurg Pediatr. 2015 Mar 6:1-8. 他引5次 SCIE

10.   Lu Yuntao, Qi S, Peng J, Pan J, Zhang X. Malignant transformation of craniopharyngioma in an infradiaphragmatic case. Chin Med J (Engl). 2014;127(17):3187-8. (2017年IF=1.596) 他引3次 SCI

11.   Wang Jianxin, Wang Renzhi, Lu Yuntao(共同一作), Yao Yong, Qi Songtao*. Anatomical analysis on the lateral bone window of the sella turcica: a study on 530 adult dry skull base specimens. Int J Med Sci, 11(2): 134-141, 2014. (2017年IF=2.284)他引7次 SCIE

12.   Lu Yuntao, Wang Leyu, He Mingyi, Huang Wenhua, Li Hong, Kong Jimin, Qi Songtao, Ouyang Jun, Qiu Xiaozhong*. Nix protein positively regulates NF-κB activation in gliomas. PLoS One, 7(9): e44559, 2012. 他引10次SCIE

13.   Lu Yuntao, Wang Hui, Luo Lun, Li WenSheng, Liang ChaoFeng, He HaiYong, Ba Yueyang. MicroRNA-195 Inhibits the Proliferation of Human Glioma Cells by Directly Targeting Cyclin D1 and Cyclin E1. PLOS ONE, 8(1): pp 1-10, 2013. 他引99次 SCIE

14.   Lu Yuntao, Pan Jun, Qi Songtao*, Shi Jin, Zhang Xi’an, Wu Kuncheng. Pneumatization of the sphenoid sinus in Chinese: the differences from Caucasian and its application in the extended transsphenoidal approach. Journal of Anatomy. 219(2): pp 132-42, 2011. 他引54次 SCI

15.   Qi Songtao*, Lu Yuntao(共同一作), Pan Jun, Zhang Xi’an, Long Hao, Fan Jun. Anatomic relations of the arachnoidea around the pituitary stalk: relevance for surgical removal of craniopharyngiomas. Acta Neurochirurgica, 153(4): pp 785-96, 2011. 他引64次 SCI

16.   Qi Songtao*, Pan Jun, Lu Yuntao, Gao Fang, Cao Yongfu, Peng Junxiang, Zhang Xi’an. The impact of the site of origin and rate of tumour growth on clinical outcome in children with craniopharyngiomas. Clin Endocrinol (Oxf), 76(1): pp 103-10, 2012. 引用19

17.   Qi Songtao*, Yu Lei, Lu Yuntao, Ou Yanghui, Li Zhiyong, Wu LX, Yao F. IDH mutations occur frequently in Chinese glioma patients and predict longer survival but not response to concomitant chemoradiotherapy in anaplastic gliomas. Oncol Rep, 26(6): pp 1479-85, 2011. 引用34

18.   Pan Jun, Qi Songtao*, Lu Yuntao, Jun Fan, Xi’an Zhang, Jie Zhou, Junxiang Peng. Intraventricular craniopharyngioma: morphological analysis and outcome evaluation of 17 cases. Acta Neurochirurgica, 153(4): pp 773-84, 2011. 引用32

19.   Li Meihua, Lee Kyle, Lu Yuntao, Clarke I, Shih D, Eberhart C, Collins VP, Van Meter T, Picard D, Zhou L, Boutros PC, Modena P, Liang ML, Scherer SW, Bouffet E, Rutka JT, Pomeroy SL, Lau CC, Taylor MD, Gajjar A, Dirks PB, Hawkins CE, Huang A*., Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell, 16(6): pp 533-546, 2009. 引用202

20.   Qi Songtao*, Lu Yuntao, Pan Jun, Chuanping Huang, Xiaofeng Shi. Membranous coats of pituitary gland: Histological, Anatomical Study and Related Clinical Issues. Neurosurgery, 64(3): pp 1-9, 2009. 引用24

21.   Association between the XRCC1 Arg399Gln polymorphism and risk of cancer: evidence from 297 case-control studies. 引用31

22.   Does the calcification of adamantinomatous craniopharyngioma resemble the calcium deposition of osteogenesis/odontogenesis? 引用9

23.   Growth patterns of craniopharyngiomas: clinical analysis of 226 patients. 引用29

24.   Unusual complications and mechanism: migration of the distal catheter into the heart--report of two cases and review of the literature. 引用12

25.   The arachnoid sleeve enveloping the pituitary stalk: anatomical and histologic study. 引用29

26.   Origin of craniopharyngiomas: implications for growth pattern, clinical characteristics, and outcomes of tumor recurrence. 引用15

27.   Influence of previous treatments on repeat surgery for recurrent craniopharyngiomas in children. 引用9

28.   Growth and weight of children with craniopharyngiomas based on the tumour location and growth pattern. 引用11

29.   Secondary abscess arising in a craniopharyngioma. 引用8

30.   Membrane Structures Between Craniopharyngioma and the Third Ventricle Floor Based on the QST Classification and Its Significance: A Pathological Study. 

31.    陆云涛, 彭林, 李俊杰, 汪鸿皓, 王军, 雷维维, 陈磊, 漆松涛. 脊髓胶质瘤的外科治疗及相关临床问题探讨. 广东医学, 2017, 2017, 38(1): 45-48.

32.   雷维维, 李俊杰, 胡译心, 彭林, 石瑾, 曹阳, 刘俊露, 陈磊, 漆松涛, 陆云涛*(通讯作者). 颈2神经根及其周围静脉丛的临床应用解剖学研究. 中华神经外科杂志, 2017, 33(9): 931-934.

33.    周强, 漆松涛, 向伟, 王海, 张立, 李宏, 刘亚伟, 陆云涛*(通讯作者). 胶质母细胞瘤原代细胞单克隆株的建立. 中华实验外科杂志, 2015, 32(9): 2071-2076.

34.   张立, 漆松涛, 王海, 周强, 李宏, 石瑾, 彭林, 陆云涛. 胸腰骶段脊神经根鞘结构的解剖学和组织学研究. 中国临床解剖学杂志, 2015, (5): 502-506.

35.   陆云涛, 漆松涛, 欧阳辉, 李志勇, 殷延毅, 石瑾, 邱晓喻, 莫益萍. 贝伐株单抗治疗国人复发恶性胶质瘤的初步临床分析与评估. 中华医学杂志, 2014, 94(15): 1165-1168.

36.   李宏, 陆云涛* (通讯作者), 漆松涛, 俞磊, 欧阳辉, 刘亚伟. 病理类型、IDH-1突变和MGMT启动子甲基化状态与间变性胶质瘤假性进展的相关性. 暨南大学学报(自然科学与医学版), 34(2): pp 154-159, 2013.

37.    邱小忠, 胡晓芳, 王乐禹, 余磊, 陆云涛. miRNA 520h影响神经胶质瘤发生的初步研究. 暨南大学学报(自然科学与医学版) , 2012, 33(2): 133-137.

38.   刘翰文, 漆松涛,  陆云涛* (通讯作者), 潘军,  殷延毅. 视交叉—下丘脑胶质瘤的诊断特点及高误诊率分析. 中华神经医学杂志, 11(7): pp 699-702, 2012.

39.   陆云涛, 漆松涛*, 欧阳辉, 李宏, 刘亚伟, 宋烨, 李志勇, 俞磊. 复发难治部位恶性胶质瘤的手术及治疗策略. 中国现代神经疾病杂志, 12: pp 682-690, 2012. 

40.   陆云涛, 漆松涛*, 潘军, 张喜安, 彭俊祥, 樊俊, 龙浩. 垂体的膜性结构及其临床意义. 中华神经外科杂志, 26(10): pp 930-934, 2010.