目录
更新日期:2022年9月30日
姓 名 邓凡 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 博士
行政职务 主任 Email fandeng@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
个人简介
南方医科大学基础医学院细胞生物学教研室主任,博士,教授,博士生导师。2005-2007年美国匹兹堡大学医学院博士后。现任广东省细胞生物学学会常务理事,广东省泌尿生殖协会转化医学分会常务理事,中国细胞生物学学会会员。担任国家自然科学基金函审和会评专家。主要研究方向:(1)前列腺癌微环境与肿瘤血管新生、肿瘤转移及休眠;(2)肿瘤代谢与肿瘤恶性进展。主持国家自然科学基金课题5项;以第一作者或通讯作者在国际主流杂志发表论文近20篇,包括Cancer Res.,Cell Mol life Sci., J Cell Sci., J Exp & Clin Cancer Res, Cell Death & Disease,BMC Cancer等, 单篇最高引用100余次。
 
研究领域

前列腺癌是男性泌尿生殖系统最常见的恶性肿瘤,其致死率占全世界男性肿瘤的第六位。高发病率和高死亡率的最直接原因是前列腺癌形成转移性病灶,以致不可逆的临床进展恶化,并最终导致患者死亡。深入研究前列腺癌恶性进展的调控机制、关键信号通路分子的鉴定对于设计合理的治疗药物及判断预后,进一步提高前列腺癌的治疗水平具有重要意义。近期课题组的主要研究方向:

1. 前列腺癌肿瘤微环境与肿瘤的血管新生;2. 前列腺癌代谢调节与肿瘤的恶性进展;3. 骨髓微环境中成骨细胞分化对肿瘤休眠的影响作用及其机制。

个人成果

1.       Guihuan Li#, Zhe Xing#, Wenyang Wang#, Wenyang Luo, Zunya Ma, Zhicong Wu, Hua Chen, Yuhao Li, Chunxia Wang*, Fangyin Zeng*, Fan Deng*. Adipose-Specific Knockout of Protein Kinase D1 Suppresses de novo Lipogenesis in Mice via SREBP1c-dependent Signaling. Experimental Cell Research, 2021 Mar 3;112548. doi:10.1016/j.yexcr.2021.112548.

2.       Zhicong Wu, Hua chen, Wenyang Luo, Hanyun zhang, Guihuan Li, Fangyin Zeng*, Fan Deng*. The landscape of immune cells infiltrating in prostate cancer. Frontiers in Oncology. 2020 Sep 20;10:544288.doi: 10.3389/fonc.2020.544288

3.       Wenjing Guo#, Zhishuai Zhang#, Guihuan Li, Xiaoju Lai, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng*, Fan Deng*. Pyruvate kinase M2 promotes prostate cancer metastasis through regulating ERK1/2-COX-2 signaling. Frontiers in Oncology. 2020 Sep 20;10:544288.doi: 10.3389/fonc.2020.544288

4.       Zhicong Wu#, Hua Chen#, Yanling Liang, Wenyang Luo, Fan Deng*, Fangyin Zeng*. Alternative splicing implicated in immunity and prognosis of colon adenocarcinoma. International Immunopharmacology. 2020, 89,107075.

5.        Wanfu Xu#, Jiabi Qian#, Fangyin Zeng#, Songyu Li, Wenjing Guo, Liping Chen, Guihuan Li, Zhishuai Zhang, Qiming Jane Wang, Fan Deng*; Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment. Journal of Experimental & Clinical Cancer Research. 2019 Mar 6; 38(1):114. doi: 10.1186/s13046-019-1118-y.

6.       Ling Li#, Liang Hua#, Huihui Fan, Yu He, Wanfu Xu, Lin Zhang, Jie Yang, Fan Deng*, Fang-yin Zeng*. Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells. Journal of Cancer . 2019;10(25):6395-6404

7.       Zhibin Huang #, Guihuan Li #, Zhishuai Zhang#, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng*, Shiyuan Xu*, Fan Deng*; β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells, BMC Cancer, 2019 Nov 26;19(1):1142.

8.       Wanfu Xu#, Fangyin Zeng#, Songyu Li#,, Guihuan Li, Xiaoju Lai, Q. Jane Wang, Fan Deng. Crosstalk of Protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis. Cellular and Molecular Life Sciences.2018 ;75(24):4583-4598

9.       Zou Z*, Zeng F*, Xu W, Wang C, Ke Z, Wang QJ, Deng F. PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-κB- and HDAC1-mediated expression and activation of uPA. J Cell Sci. 2012 Oct 15;125(Pt 20):4800-11.

10.    Qu Q, Zeng F, Liu X, Wang QJ, Deng F. Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. Cell death & disease. 2016;7:e2226.

11.    Pan L, Zhang Y, Zhao W, Zhou X, Wang C, Deng F. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway. Cancer Chemother Pharmacol. 2017 Jul;80(1):91-100

12.    Chen J#, Deng F#, Singh SV, Wang QJ. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer research. 2008;68(10):3844-53