在研课题
1. 负责人孙尔维. snRNA通过抗RNP和PARP9激活DC在SLE中的作用和机制. 2023年度国家自然科学基金面上项目. 2024.1-2027.12. 48万元
2. 负责人孙尔维. 阻止NETs DNA进入内皮细胞激活DNA感受器在SLE治疗中的意义. 2021年度国家自然科学基金面上项目. 2022.1-2025.12. 55万元
代表性论文（*通信作者）：
1. Li Y, He Y, Yang F, Liang R, Xu W, Li Y, Cheng J, Liang B, Tang M, Shi X, Zhuang J, Luo M, Li L, Zhang R, Liu H, Jie H, Li X, Han X, Sun E*, Zhai Z*. Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation. Br J Dermatol. 2024 Aug 14;191(3):385-396.
2. Li Z, Lei Z, Yang W, Jing C, Sun X, Yang G, Zhao X, Zhang M, Xu M, Tang Y, Wang Q, Zhao J, Zhou Z, Wen Z, Chen X, Peng Q, Wang G, Zhang P, Sun E, Shen N, Xu W*, Li Z, Yang H*, Yin Z*. Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus. Parasit Vectors. 2024 Jan 30;17(1):44-51.
3. Vitale I*, Pietrocola F, Guilbaud E, ..., Sun E, ..., Galluzzi L*. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 Apr 26;30(5):1097-154.
4. Ye H, Liu S, Xu J, Chai K, He D, Fang Y, Xie Q, Liu H, Liu Y, Hua B, Hu J, Zhang Z, Zhou M, Zhao D, Li Y, Jiang Z, Wang M, Li J, Zhang Z, Li X, Li Y, Sun E, Bi L, Wei W, Tie N, He L, Huang X, Zhang Y, Huang Q, Wang X, Liu X, Li J, Su Y*. Efficacy and safety of CMAB008 compared with innovator infliximab in patients with moderate-to-severe rheumatoid arthritis receiving concomitant methotrexate: a randomized, double-blind, multi-center, phase III non-inferiority study. Rheumatol Ther. 2023 Mar 25;10(3):757-73.
5. Xiao L, Lin S, Xu W, Sun E*. Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis. Cell Death Discov. 2023 Mar 14;9(1):95-105.
6. Zhao Z, Bian Z, Lin Z, Wu S, Long J, Cui Y, Li Y, Li W, Sun E*, Lian Z*, He Y*. Single-cell analysis of patients with axial spondyloarthritis after anti-TNFα treatment: experimental data and review of the literature. Clin Rev Allergy Immunol. 2023 Mar 8;65(2):136-47.
7. Song R, Han X, Jie H, Zhang X, Li S, Sun E*. Effects and mechanisms of Celastrol on the formation of neutrophil extracellular traps (NETs). Ann Transl Med. 2023 Jan 15;11(1):16-27.
8. Shi X, Zhuang L, Zhai Z, He Y, Sun E*. Polydatin protects against gouty nephropathy by inhibiting renal tubular cell pyroptosis. Int J Rheum Dis. 2023 Jan;26(1):116-123.
9. Zhuang L, Luo X, Wu S, Lin Z, Zhang Y, Zhai Z, Yang F, Li Y, Zhuang J, Luo G, Xu W, He Y, Sun E*. Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis. Cell Death Discov, 2022, Sep 3; 8(1):379.
10. Luo G, He Y, Yang F, Zhai Z, Han J, Xu W, Zhang J, Zhuang L, Zhang Y, Li Y, Song R, Luo X, Liang J, Sun E*. Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice. Cell Death Discov, 2022,Mar 12; 8(1):113.
11. Deng S, He Y, Deng S, Sun E, Li L*. Association between clinical characteristics and pain relief in patients with axial spondyloarthritis treated with nonsteroidal anti-inflammatory drugs. Arch Rheumatol. 2022,37(2): 271-9.
12. Zhai Z, Yang F, Xu W, Han J, Luo G, Li Y, Zhuang J, Jie H, Li X, Shi X, Han X, Luo X, Song R, Chen Y, Liang J, Wu S, He Y, Sun E*. Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis. Arthritis Rheumatol. 2022 Mar;74(3):427-40.
13. Li J, Zhuang L, Luo X, Liang J, Sun E*, He Y. Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice. Exp Brain Res. 2020 Nov;238(11):2603-14.
14. Zhang M, Jie H, Wu Y, Han X, Li X, He Y, Shi X, Luo Y, Sun Y, Yang J, Yang J, Quan S, Lao X, Tan L, Sun E*. Increased MLKL mRNA level in the PBMCs is correlated with autoantibody production, renal involvement, and SLE disease activity. Arthritis Res Ther. 2020 Oct 14;22(1):239.
15. Han J, Li X, Luo X, He J, Huang X, Zhou Q, Han Y, Jie H, Zhuang J, Li Y, Yang F, Zhai Z, Wu S, He Y, Yang B, Sun E*. The mechanisms of hydroxychloroquine in rheumatoid arthritis treatment: Inhibition of dendritic cell functions via Toll like receptor 9 signaling. Biomed Pharmacother. 2020 Oct 10;132:110848.
16. Li X, Wang Y, Agostinis P, Rabson A, Melino G, Carafoli E, Shi Y, Sun E*. Is hydroxychloroquine beneficial for COVID-19 patients? Cell Death Dis. 2020 Jul 8;11(7):512.
17. Zhuang J, Cui H, Zhuang L, Zhai Z, Yang F, Luo G, He J, Zhao H, Zhao W, He Y, Sun E*. Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma. Biomed Pharmacother. 2020 May;125:109925.
18. Han XA, Jie HY, Wang JH, Zhang XM, Wang J, Yu CX, Zhang JL, He J, Chen JQ, Lai KF, Sun EW*. Necrostatin-1 Ameliorates Neutrophilic Inflammation in Asthma by Suppressing MLKL Phosphorylation to Inhibiting NETs Release. Front Immunol. 2020 Apr 24;11:666.
19. Yang F, Zhai Z, Luo X, Luo G, Zhuang L, Zhang Y, Li Y, Sun E*, He Y*. Bioinformatics identification of key candidate genes and pathways associated with systemic lupus erythematosus. Clin Rheumatol. 2020 Feb;39(2):425-34.
20. Deng SS, He Y, Nian XY, Sun EW*, Li L*. Relationship between Vitamin D Levels and pain and disease activity in patients with newly diagnosed axial spondyloarthritis. Int J Nurs Sci. 2020 ,7(1):54-9.
21. Yang F, He Y, Zhai Z, Sun E*. Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus. J Immunol Res. 2019 Dec 1;2019:3638562.
22. Yang F, Luo X, Luo G, Zhai Z, Zhuang J, He J, Han J, Zhang Y, Zhuang L, Sun E*, He Y. Inhibition of NET formation by polydatin protects against collagen-induced arthritis. Int Immunopharmacol. 2019 Dec;77:105919.
23. Huang X, He Y, Han J, Zhuang J, He J, Sun E*. Not only anti-inflammation, etanercept abrogates collagen-induced arthritis by inhibiting dendritic cell migration and maturation. Cent Eur J Immunol. 2019;44(3):237-45.
24. Ji Y, He Y, Nian X, Sun E*, Li L*. Inflammatory or Neuropathic Pain: Characteristics and Their Relationships with Disease Activity and Functional Status in Axial Spondyloarthritis Patients. Pain Med. 2019 May 1;20(5):882-8.
25. Nian X, He Y, Ji Y, Huang Y, Sun E*, Li L*. Associations Between Pain Patterns and SelfReported Clinical Outcomes in Patients with Knee Osteoarthritis. Pain Med. 2019 Apr 1;20(4):818-25.
26. He J, Li X, Zhuang J, Han J, Luo G, Yang F, Sun Y, Liao P, Han Y, He Y, Shi H, Sun E*. Blocking Matrix Metalloproteinase-9 Abrogates Collagen-Induced Arthritis via Inhibiting Dendritic Cell Migration. J Immunol. 2018 Dec 15;201(12):3514-23.
27. Liao P, He Y, Yang F, Luo G, Zhuang J, Zhai Z, Zhuang L, Lin Z, Zheng J, Sun E*. Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation. Arthritis Res Ther. 2018 Nov 12;20(1):254.
28. Huang XC, He Y, Zhuang J, He J, Luo GH, Han JC, Sun EW*. Mycophenolic Acid Synergizing with Lipopolysaccharide to Induce Interleukin-1β Release via Activation of Caspase-1. Chin Med J (Engl). 2018 Jul 5;131(13):1533-40.
29. He Y, Yang FY, Sun EW*. Neutrophil Extracellular Traps in Autoimmune Diseases. Chin Med J (Engl). 2018 Jul 5;131(13):1513-9.
30. Shi H, He J, Li X, Han J, Wu R, Wang D, Yang F, Sun E*. Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. Int Immunopharmacol. 2018 Feb;55:216-22.
31. Han J, Zhou Q, Li X, He J, Han Y, Jie H, He Y, Sun E*. Novel function of hydroxychloroquine: Down regulation of T follicular helper cells in collagen-induced arthritis. Biomed Pharmacother. 2018 Jan;97:838-43.
32. Li X, Han Y, Sun E*. Sniping the scout: Targeting the key molecules in dendritic cell functions for treatment of autoimmune diseases. Pharmacol Res. 2016 May;107:27-41.
33. Li X, Han Y, Zhou Q, Jie H, He Y, Han J, He J, Jiang Y, Sun E*. Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis. J Cell Mol Med. 2016 Jan;20(1):170-80.
34. Han Y, Li X, Zhou Q, Jie H, Lao X, Han J, He J, Liu X, Gu D, He Y, Sun E*. FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes. J Immunol. 2015 Nov 1;195(9):4126-35.
35. He Y, Luo Y, Lao X, Tan L, Sun E*. Cytokine signatures of human whole blood for monitoring immunosuppression. Cent Eur J Immunol. 2014;39(3):271-8.
36. Liu Z, Yuan X, Luo Y, He Y, Jiang Y, Chen ZK*, Sun E*. Evaluating the effects of immunosuppressants on human immunity using cytokine profiles of whole blood. Cytokine. 2009 Feb;45(2):141-7.
37. Wang Y, Gao Y, Yuan X, Xia W, Luo Y, Sun E*, Chen ZK. The liver mediates apoptotic cellinduced immune regulation. Scand J Immunol. 2008 Sep;68(3):297-305.
38. Sun E. Cell death recognition model for the immune system. Med Hypotheses. 2008;70(3):585-96.
39. Shi Y, Roberts AI, Sun E. Dying T lymphocytes call for the death of tumor cells. Cell Res. 2006 Aug;16(8):679-80.
40. Feng Z, Sun E, Lan H, Zhang C, Li Q, Zhu W. Unrelated donor bone marrow transplantation for beta-thalassemia major: an experience from China. Bone Marrow Transplant. 2006 Jan;37(2):171-4.
41. Sun E, Gao Y, Chen J, Roberts AI, Wang X, Chen Z, Shi Y. Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient. Cell Death Differ. 2004 Dec;11(12):1258-64.
42. Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol Res. 2003;28(3):285-93.
43. Zhang L, Zhu T, Sun EW, Shen SQ, Min ZL, Chen ZK. Pretreatment with FTY720 alone induced long-term survival of mouse heart allograft. Transplant Proc. 2003 Feb;35(1):567-8.
44. Sun EW*, Shi YF. Apoptosis: the quiet death silences the immune system. Pharmacol Ther. 2001 Nov-Dec;92(2-3):135-45.
45. Sun E, Zhang L, Zeng Y, Ge Q, Zhao M, Gao W. Apoptotic cells actively inhibit the expression of CD69 on Con A activated T lymphocytes. Scand J Immunol. 2000 Mar;51(3):231-6.
46. Nakajima H, Sun E, Mizuta N, Fujiwara I, Oka T. FTY720 inhibits the mRNA expression of intragraft cytotoxic molecules, leading to cardiac allograft survival. Transplant Proc. 1998 Aug;30(5):2217-20.