李咏茵教授

博士生导师，国家优青获得者，南方医院感染内科党支部书记、副主任，广东省肝脏疾病研究所副所长，广东省病毒性肝炎研究重点实验室副主任

中华医学会肝病学分会青委会委员，广东省感染病学分会青委会副主委，广东省医院协会医院科研实验室建设与管理专业委员会委员，中华医学会肝病学会自身免疫性疾病协作组委员，亚太医学生物免疫学会委员、广东省免疫学会理事、临床肝胆病杂志青年编委、实用肝脏病杂志编辑委员会委员

主持国家级课题6项，以第一或通讯作者发表SCI论文36篇，影响因子大于10的13篇，获中华医学科技二等奖和广东省科技进步一等奖，赴德国参加第64届诺贝尔奖获得者大会，2018年和2019年获美国肝病学会青年研究者奖。

教学情况：

【本科生教育】

已经获得《全英教学培训合格证》《教育部来华英语师资培训合格证》，主持广东省高等教育教学改革建设项目1项；承担各年级本科生和留学生传染病学课程的中英文教学，作为基础医学院院士创新班本科生导师，指导本科生申报南方医科大学《科研启蒙计划》并获得资助，指导本科生申报2022年度“大学生创新创业训练计划”获得学院国家级推荐，2023年获得“攀登计划”重点项目，指导本科生获得广东省高校科技成果转化大赛三等奖，授权国家发明专利5项。

【研究生教育】

目前共指导硕士和博士研究生31人，所指导研究生学生曾获得欧洲肝病年会青年研究者奖2人次、国家留学基金委“创新型人才国际合作培养项目”3人次、国家研究生奖学金3人次、优秀毕业研究生2人次，优秀研究生4人次等。

【博士后教育】

招收博士后3名，其中一名博后获得博士后站前特别资助项目，面上项目，广东省自然科学基金面上项目等

慢性肝病免疫调节机制

主持课题                                                      

发表论文 

一、发表论文汇总：以第一作者或通讯作者发表SCI论文30篇

二、代表性发表论文列表：

[1] Chen P, Dong Z, Zhu W, Chen J, Zhou Y, Ye Q, Liao X, Tan Y, Li C, Wang Y, Pang H, Wen C, Jiang Y, Li X, Li B, Aimaier A, Lin L, Sun J, Hou J, Tang L, Hou J, Li Y（李咏茵，最后通讯作者）.Noncanonical regulation of HOIL-1 on cancer stemness and sorafenib resistance identifies pixantrone as a novel therapeutic agent for hepatocellular carcinoma. Hepatology. 2023 Oct 11

[2] Li Y（李咏茵，第一和通讯作者）, Wen C, Gu S, Wang W, Guo L, Li CK, Yi X, Zhou Y, Dong Z, Fu X, Zhong S, Wang Y, Huang K, Yin J, Zhong C, Liang X, Fan R, Chen H, Jiang D, Zhang X, Sun J, Tang L, Peng J, Hou J.Differential response of HBV envelope-specific CD4 + T cells is related to HBsAg loss after stopping nucleos(t)ide analogue therapy.Hepatology. 2023 Aug 1;78(2):592-606

[3] Li Y（李咏茵，第一作者）, Tang L, Guo L, Chen C, Gu S, Zhou Y, Ye G, Li X, Wang W, Liao X, Wang Y, Peng X, Liu G, Zhang X, Sun J, Peng J, Hou J.CXCL13-mediated recruitment of intrahepatic CXCR5+CD8+ T cells favors viral control in chronic HBV infection. J Hepatol. 2020 Mar;72(3):420-430

[4] Li Y（李咏茵，第一作者）, Ma S, Tang L, Li Y, Wang W, Huang X, Lai Q, Zhang M, Sun J, Li CK, Abbott WG, Naoumov NV, Zhang Y, Hou JCirculating chemokine (C-X-C Motif) receptor 5(+) CD4(+) T cells benefit hepatitis B e antigen seroconversion through IL-21 in patients with chronic hepatitis B virus infection. Hepatology. 2013 Oct;58(4):1277-1286

[5]  Li Y（李咏茵，第一作者）, Wang W, Tang L, He X, Yan X, Zhang X, Zhu Y, Sun J, Shi Y, Ma X, Mackay IR, Gershwin ME, Han Y, Hou J.Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis. Hepatology. 2015 Jun;61(6):1998-2007

[6] Tang L, Li Q, Chen L, Li X, Gu S, He W, Pan Q, Wang L, Sun J, Yi X, Li Y（李咏茵，最后通讯作者）.IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection. J Med Virol. 2023 Oct;95(10):e29142

[7] Li Y, Zhong S, Jin Z, Ye G, Zhang T, Liu Z, Liu Z, Zeng Z, Li Q, Wang Y, Zhao Y, Tang L, Chen H, Li Y（李咏茵，最后通讯作者）.Peyer's patch-involved gut microbiota facilitates anti-HBV immunity in mice.Virus Res. 2023 Jul 2;331:199129

[8] Liu Z, Song L, Chen J, Zhou Y, Wang Y, Tang L, Li Y（李咏茵，最后通讯作者）.Causal associations between chronic hepatitis B and COVID-19 in East Asian populations. Virol J. 2023 Jun 1;20(1):109

[9] Wen C, Zhou Y, Zhou Y, Wang Y, Dong Z, Gu S, Wang W, Guo L, Jin Z, Zhong S, Tang L, Li Y（李咏茵，最后通讯作者）.HBV Core-specific CD4+ T cells correlate with sustained viral control upon off-treatment in HBeAg-positive chronic hepatitis B patients. Antiviral Res. 2023 May;213:105585

[10] Yi X, Wang Y, Li Q, Li X, Zhang P, Fu X, Gu S, Zhang D, Liu X, Lou H, Wu Y, Tang L, Hou J, Li Y（李咏茵，最后通讯作者）.Pre-existing immunity to SARS-CoV-2 associates with strong T cell responses induced by inactivated COVID-19 vaccines.J Med Virol.2023 Mar;95(3):e28642

[11] Zhang D, Liu Z, Zhou Y,Tang L, Hou J, Li Y（李咏茵，最后通讯作者）.Alcohol induces intrahepatic humoral immunity-related suppression and delays the clearance of HBV infection. Int Immunopharmacol. 2023 Feb;116：109811

[12] Zhong S, Liu Z, Zhou Y, Zhang T, Fu X, Guo L, Gu S, Tang L, Hou J, Li Y（李咏茵，最后通讯作者）.Longitudinal mapping of hepatitis B vaccine-induced B-cell linear epitopes in healthy individuals. J Med Virol. 2022 Oct;94(10):4993-5006

[13] Gu SQ, Wang WB, Ye GF, Chen CC, Zhou Y, Guo L, Zhong SH, Li XY,  Fu X, Wen CH, Tang LB, Sun J, Hou JL,  Li Y（李咏茵，独立通讯作者）.Hepatocyte-derived L-carnitine restricts hepatitis B surface antigen loss through an immunosuppressive effect on germinal center-related immune cells. J Infect Dis. 2022 Jun 1;225(11):1955-1966.

[14] Zhong S, Zhang T, Tang L, Li Y（李咏茵，独立通讯作者）.Cytokines and Chemokines in HBV Infection. Front Mol Biosci. 2021 Dec 2;8:805625

[15] Gu S, Fu X, Ye G, Chen C, Li X, Zhong S, Tang L, Chen H, Jiang D, Hou J,  Li Y（李咏茵，最后通讯作者）. High L-carnitine levels impede viral control in chronic hepatitis B virus infection. Front Immunol. 2021 Jun 21:12:649197

[16] Chen C, Jiang X, Liu X, Guo L, Wang W, Gu S, Wen C, Yi X, Tang L, Li Y（李咏茵，最后通讯作者） .Identification of the association between HBcAg-specific T cell and viral control in chronic HBV infection using a cultured ELISPOT assay. J Leukoc Biol.2021 Feb;109(2):455-465

[17] Tang L, Chen C, Gao X, Zhang W, Yan X, Zhou Y, Guo L, Zheng X, Wang W, Yang F, Liu G, Sun J, Hou J, Li Y（李咏茵，独立通讯作者）Interleukin 21 Reinvigorates the Antiviral Activity of Hepatitis B Virus (HBV)-Specific CD8+ T Cells in Chronic HBV Infection. J Infect Dis. 2019 Feb 15;219(5):750-759

[18] Zheng X, Zhou Y, Yi X, Chen C, Wen C, Ye G, Li X, Tang L, Zhang X, Yang F, Liu G, Li Y（李咏茵，独立通讯作者）, Hou J.IL-21 receptor signaling is essential for control of hepatocellular carcinoma growth and immunological memory for tumor challenge. Oncoimmunology. 2018 Sep 26;7(12):e1500673

[19] Li X, Zhang Q, Zhang W, Ye G, Ma Y, Wen C, Gu S, Tang L, Li Y（李咏茵，独立通讯作者） .Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infection. J Transl Med. 2020 Nov 7;18(1):417

[20]  Li Y（李咏茵，第一作者）, Tang L, Hou J.Role of interleukin-21 in HBV infection: friend or foe? Cell Mol Immunol. 2015 May;12(3):303-308

[21] Zhu W, Zhang ZM, Chen JZ, Chen XL, Huang L, Zhang XY, Huang X, Ma N, Xu WK, Yi Y, Lu XY, Fu X, Li SW, Mo GH, Wang YY, Yuan GS, Zang MY, Li Q, Jiang XT, He YJ, Wu S, He YK, Li Y（李咏茵，共同通讯作者）, Hou J.A novel engineered IL-21 receptor with constitutive signaling arms TCR-T cells against Hepatocellular Carcinoma.  Signal Transduct Target Ther.  2024.(Accepted)

[22] Qiu X, Zhou J, Xu H, Li Y（李咏茵，共同第一作者）, Ma S, Qiao H, Zeng K, Wang Q, Ouyang J, Liu Y, Ding J, Liu Y, Zhang J, Shi M, Liao Y, Liao W, Lin L.Alcohol reshapes a liver premetastatic niche for cancer by extra- and intrahepatic crosstalk-mediated immune evasion. Mol Ther. 2023 Sep 6;31(9):2662-2680

[23] Wen C, Dong Z, Wang Y, Ye G, Ma Y, Yi X, Zhou Y, Li X, Zheng X, Hou J, Li Y（李咏茵，共同通讯作者） Tang L.CTLA4+CD4+CXCR5-FOXP3+ T cells associate with unfavorable outcome in patients with chronic HBV infection. BMC Immunol. 2023 Jan 12;24(1):3

[24] Zhong S, Li Q, Wen C, Li Y, Zhou Y, Jin Z, Ye G, Zhao Y, Hou J, Li Y（李咏茵，共同通讯作者） Tang L.Interferon α facilitates anti-HBV cellular immune response in a B cell-dependent manner. Antiviral Res. 2022 Nov;207:105420

[25] Ma Y, Liu X, Lou H, Chen L, He W, Pan Q, Liao D, Li J, Wu J, Xiong R, Liu S, Luo M, Wu F, Chen J, Liu Z, Tang L, Li Y（李咏茵，共同通讯作者）, Gao Y.Impaired CD8+T cells in term pregnancy decidua with chronic hepatitis B virus infection. Am J Reprod Immunol. 2022 Oct;88(4):e13610(共同通讯,3.6)

[26] Gu S, Liu Z, Lin L, Zhong S, Ma Y, Li X, Ye G, Wen C, Li Y（李咏茵，共同通讯作者） , Tang L.Identification and Mapping of HBsAg Loss-Related B-Cell Linear Epitopes in Chronic HBV Patients by Peptide Array. Front Immunol. 2021 Oct 15;12:767000

[27] Liu Z, Liu X, Liang J, Liu Y, Hou X, Zhang M, Li Y（李咏茵，共同通讯作者） , Jiang X.Immunotherapy for Hepatocellular Carcinoma: Current Status and Future Prospects. Front Immunol. 2021 Oct 4;12:765101

[28] Liao B, Liu Z, Tang L, Li L, Gan Q, Shi H, Jiao Q, Guan Y, Xie M, He X, Zhao H, Chen W, Liu Y, Li L, Wang Y, Cao Y, Shi Y, Li Y（李咏茵，共同通讯作者） , Lei C.Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19. Int J Med Sci. 2021 Jan 1;18(1):29-41

[29] Tang L, Zhong R, He X, Wang W, Liu J, Zhu Y, Li Y（李咏茵，共同通讯作者）, Hou J.Evidence for the association between IgG-antimitochondrial antibody and biochemical response to ursodeoxycholic acid treatment in primary biliary cholangitis. J Gastroenterol Hepatol. 2017 Mar;32(3):659-666

[30] Ma SW,  Li Y（李咏茵，共同第一作者）, Zhang GW, Huang X, Sun J, Li C, Abbott WG, Hou JLComplementarity-determining region 3 size spectratypes of T cell receptor beta chains in CD8+ T cells following antiviral treatment of chronic hepatitis B. Antimicrob Agents Chemother. 2011 Feb;55(2):888-894