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更新日期：2025年10月8日
姓 名 颜建云 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 Email yanjy790@163.com
工作单位 南方医科大学珠江医院 邮政编码 510280
个人简介

南方医科大学珠江医院心内科教授，博士生导师，博士后合作导师，英国曼彻斯特大学博士，美国西奈山伊坎医学院博士后，科研处负责人，心脏中心实验室学术负责人，国家卫健委辅助循环及血管相关疾病重点实验室学术委员会委员，中国微循环学会心血管代谢与微循环专业委员会副主任委员，中国病理生理学会动脉粥样硬化专业委员会委员，国际动脉粥样硬化学会中国分会委员，ISHR中国转化医学工作委员会委员，广东省精准医学应用学会理事，广东省医院协会医院科教与成果转化专业委员会副主任委员，广东省研究型医院学会理事，广东省医学会医学科研实验室建设与管理学分会常务委员，广东省药理学会心血管药理委员会常务委员，广东省病理生理学会心血管专业委员会常务委员，国家自然科学基金通讯评审专家，广东省科技评审专家，广东省高层次人才评审专家，教育部学位中心论文评审专家。2010年获英国曼彻斯特大学医学博士学位，主要研究血管钙化的发生机制。2010-2013年在美国西奈山伊坎医学院从事心脏发育和再生研究工作。目前主要研究血管钙化和心肌再生机制，先后主持6项国家自然科学基金项目和6项省部级科研基金项目。已发表SCI论文50余篇，以第一、通讯作者（含共同）在Circulation, Circ Res, Kidney Int (2022, 2025), Cardiovasc Res, ATVB (2011, 2020, 2025), Nat Commun, Aging Cell, J Pathol (2019, 2022, 2025), J Biol Chem等国际知名期刊发表论文30余篇。兼职担任Circulation, Kidney Int, ATVB, STTT, Redox Biol, Clin Transl Med, Free Radic Biol Med, FASEB J等80多个SCI杂志审稿人和Renal Failure的编辑。2006-2009年获英国政府Overseas Research Scholarship（ORS）全额奖学金。

 

 

研究领域

心血管疾病机制，主要采用基因敲除小鼠模型和细胞谱系示踪技术，研究血管钙化和心肌再生机制。

个人成果
  1. Lan Z#, Liang Q#, Li L#, Liu F, Chen A, Ye Y, Feng L, Zhang Z, Zhang X, Ou JS, Lu L*, Yan J*(通讯作者). TRIM16 Mediates K63-Linked Ubiquitination of DAB2 to Facilitate Vascular Calcification. Circ Res. 2025;137(4):551-568. (IF=16.2)
  1. Fu M#, Lan Z#, Ye Y#, Gong Y, Liang Q, Li M, Feng L, Chen A, Dong Q, Li Y, Wang S, Liu X, Zhang X, Ou JS, Lu L*, Yan J*(通讯作者). The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of TET2/NLRP3 inflammasome signaling pathway. Kidney Int. 2025;108(2):233-252. (IF=12.6)
  1. Dong Q#, Lu L#, Zhang X#, Feng L, Li L, Liu H, Chen A, Lan Z, Ye Y, Zhu J, Liu X, Li Y, Liang Q*, Yan J*(通讯作者). NAMPT Is A Novel Inhibitor of Vascular Calcification in Chronic Kidney Disease. Arterioscler Thromb Vasc Biol. 2025;45(10):1872-1892. (IF=7.4).
  1. Liu F#, Liang Q#, Li L#, Gong Y, Li M, Feng L, Chen A, Ye Y, Lan Z, Li Y, Ou JS, Lu L*, Yan J*(通讯作者). Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway. J Pathol. 2025;266(1):109-123. (IF=5.2)
  1. Zhu Z#, Liu H#, Feng L#, Lu L, Zhu J, Liang Q, Lan Z, Ye Y, Wang S, Chen A, Yan J*(通讯作者). Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal. Atherosclerosis. 2025; 404:119190. (IF=5.7)
  1. Lu L#, Liu X#, Gong Y#, Zhou X, Chen A, Li M, Feng L, Lan Z, Ye Y, Liang Q*, Yan J*(通讯作者). STING Facilitates Vascular Calcification via p-STAT1/NLRP3 Signal. FASEB J. 2025;39(7):e70530. (IF=4.2)
  1. Lu L#, Ye Y#, Chen Y, Feng L, Huang J, Liang Q, Lan Z, Dong Q, Liu X, Li Y, Zhang X, Ou JS, Chen A*, Yan J*(通讯作者). Oxidized phospholipid POVPC contributes to vascular calcification by triggering ferroptosis of vascular smooth muscle cells. FASEB J. 2024;38(7):e23592. (IF= 4.8)
  1. Chen A#, Lan Z#, Li L#, Xie L, Liu X, Yang X, Wang S, Liang Q, Dong Q, Feng L, Li Y, Ye Y, Fu M, Lu L*, Yan J*(通讯作者). Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome. Cardiovasc Res. 2023;119(13):2368-2381. (IF= 14.239)
  1. Ye Y#, Chen A#, Li L#, Liang Q, Wang S, Dong Q, Fu M, Lan Z, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Repression of the antiporter SLC7A11/Glutathione/Glutathione Peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification. Kidney Int. 2022;102(6):1259-1275. (IF=18.998)
  1. Wang S#, Li L#, Liang Q#, Ye Y, Lan Z, Dong Q, Chen A, Fu M, Li Y, Liu X, Ou JS, Lu L*, Yan J* (通讯作者). Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair. J Mol Cell Cardiol. 2022; 173:154-168. (IF=5.763)
  1. Lan Z#, Chen A#, Li L#, Ye Y, Liang Q, Dong Q, Wang S, Fu M, Li Y, Liu X, Zhu Z, Ou JS, Qiu X, Lu L*, Yan J* (通讯作者). Downregulation of HDAC9 by the ketone metabolite β-hydroxybutyrate suppresses vascular calcification. J Pathol. 2022;258(3):213-226. (IF=9.883)
  1. Liu X#, Chen A#, Liang Q#, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L*, Yan J* (通讯作者). Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. Aging Cell. 2021;20(6):e13377. (IF=11.005)
  1. Yang X#, Chen A#, Liang Q#, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L*, Yan J* (通讯作者). Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease. Free Radic Biol Med. 2021;172:530-540. (IF=8.101)
  1. Zhang X#, Li Y#, Yang P#, Liu X, Lu L, Chen Y, Zhong X, Li Z, Liu H, Ou C, Yan J*(共同通讯), Chen M*. Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals. Arterioscler Thromb Vasc Biol. 2020;40(3):751-765. (IF=10.514).
  1. Dong Q#, Chen Y#, Liu W, Liu X, Chen A, Yang X, Li Y, Wang S, Fu M, Ou JS, Lu L*, Yan J*(通讯作者). 25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress. Eur J Pharmacol. 2020;880:173165. (IF=5.195) 
  1. Li Z#, Wu J#, Zhang X#, Ou C, Zhong X, Chen Y, Lu L, Liu H, Li Y, Liu X, Wu B, Wang Y, Yang P, Yan J*(共同通讯), Chen M*. CDC42 promotes vascular calcification in chronic kidney disease. J Pathol. 2019;249(4):461-471. (IF=9.883)
  1. Zhang L#, Sultana N#, Yan J# (共同第一), Yang F, Chen F, Chepurko E, Yang FC, Du Q, Zangi L, Xu M, Bu L, Cai CL*. Cardiac Sca-1+ cells are not intrinsic stem cells for myocardial development, renewal and repair. Circulation. 2018;138(25):2919-2930. (IF=39.918)
  1. Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W, Cai CL*. Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018;293(24):9162-9175. (IF=5.486)
  1. Kong Y#, Liang Q#, Chen Y#, Yang P, Liu X, Li Y, Feng S, Wu J, Liu W, Tang J, Yu H, Ou JS, Lu L*, Yan J*(通讯作者). Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Lab Invest. 2018;98(10):1320-1332. (IF=5.502)
  1. Yan J#, Zhang L#, Sultana N#, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL*. A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol. 2016;97:278-285. (IF=5.763)
  1. Sultana N#, Zhang L#, Yan J# (共同第一), Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL*. Resident c-kit+ cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701. (IF=17.694)
  1. Yan J, Stringer SE, Hamilton A, Charlton-Menys V, Götting C, Müller B, Aeschlimann D, Alexander MY*. Decorin GAG Synthesis and TGF-β Signaling Mediate Ox-LDL-Induced Mineralization of Human Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2011; 31(3):608-615. (IF=10.514)