目录
更新日期:2025年1月16日
姓 名 尹恝 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 硕士研究生毕业 最后学位 医学硕士学位
行政职务 其他 Email yinj@smu.edu.cn
工作单位 南方医科大学南方医院 邮政编码
跨学科招生
跨学科招生专业1 生物与医药 招生层次类型1 专业学位博导
跨学科招生专业2 招生层次类型2
个人简介

尹恝个人简介:主任医师,教授,博士生导师,南方医院神经内科脑血管病亚专科主任。擅长脑血管疾病预防、诊治、脑病重症监护治疗及神经变性病的诊治,研究方向为肠道微生物与脑代谢、脑损伤研究。在GUT、Critical Care、Cell Reports Medicine、Journal of Neuroinflammation、Brain Behavior and Immunity等期刊发表SCI论文30余篇。主持基金数项,包括:国家自然科学基金(面上4项),广东省自然基金项目4项,广东省科技计划项目1项,广州市科技计划项目1项,南方医科大学临床研究培育项目2项等。获广东省科学技术进步一等奖1项目,广东省科学技术进步二等奖1项,副主编学术专著1部,参编学术专著4部。现任广东省医学会脑血管病学分会主任委员 重症学组组长;广东省医学会神经病学分会肠道微生态与神经系统疾病转化学组组长;中国卒中学会脑小血管病学分会常委;中国卒中学会遗传学分会常委;中国研究型医院学会神经科学专业委员会常委;广东省卒中学会常务理事 脑血流代谢分会副主委;广东省医院协会神经内科分会副主委;广东省医师协会脑血管病学分会卒中中心建设专业组副组长。获2018年广东省杰出青年医学人才称号;获2023年度广东省自然科学奖一等奖,2024年羊城好医生荣誉称号。

研究领域

研究方向为肠道微生物与脑代谢、脑损伤、重症脑血管病、脑血管预防、血管性痴呆研究。

个人成果

1.Xu K, Gao X, Xia G, Chen M, Zeng N, Wang S, You C, Tian X, Di H, Tang W, Li P, Wang H, Zeng X, Tan C, Meng F, Li H, He Y, Zhou H, Yin J. Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn. Gut 2021;70:1486-1494.(I区,IF = 23.051,末位通讯作者)

2.Wang H, Li J, Wu G, Lin X, Chen J, Liang J, Zhang J, Luo X, Mao H, Xie J, Li Z, Zhou H, Xu K, Yin J, He Y. Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier. Cell Rep Med. 2024 Oct 3:101754.(I区,IF = 11.7,共同通讯作者)

3.Chen J, Wu Q, Liu H, Hu W, Zhu J, Ji Z, Yin J. Predictive value of remnant cholesterol inflammatory index for stroke risk: Evidence from the China health and Retirement Longitudinal study. J Adv Res. 2024 Dec 12:S2090-1232(24)00592-7.(I区,IF = 11.4,末位通讯作者)

4.Wang H, Zhang M, Li J, Liang J, Yang M, Xia G, Ren Y, Zhou H, Wu Q, He Y, Yin J. Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate. J Neuroinflammation. 2022 Apr 4;19(1):76.(I区,IF = 9.589,末位通讯作者)

5.Xu R, Tan C, Zhu J, Zeng X, Gao X, Wu Q, Chen Q, Wang H, Zhou H, He Y, Pan S,Yin J. Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death. Crit Care. 2019 May 31;23(1):195. (II区,IF =9.092,末位通讯作者)

6.Zhang F, Deng Y, Wang H, Fu J, Wu G, Duan Z, Zhang X, Cai Y, Zhou H, Yin J, He Y. Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO. Brain Behav Immun. 2023 Nov 19;115:667-679.(区,IF=8.8,共同通讯)

7.Xu R, Tan C, He Y, Wu Q, Wang H, Yin J. Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Encephalitis: A Chinese Pilot Study. Front Immunol. 2020 Aug 20;11:1994.(Ⅱ区,IF:7.561,末位通讯作者)

8.Liang J, Ren Y, Zheng Y, Lin X, Song W, Zhu J, Zhang X, Zhou H, Wu Q, He Y, Yin J. Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota. Mol Neurobiol. 2024 Nov 15.区,IF=4.6,末位通讯作者

9.Chen J, Gao X, Liang J, Wu Q, Shen L, Zheng Y, Ma Y, Peng Y, He Y, Yin J. Association between gut microbiota dysbiosis and poor functional outcomes in acute ischemic stroke patients with COVID-19 infection. mSystems. 2024 Jun 18.Ⅱ区,IF = 5.00,末位通讯作者

10.Liang J, Zhang M, Wang H, Ren Y, Wu Q, Huang R, Xie J, Yin J, Zhu J. Cholestyramine resin administration alleviated cerebral ischemic injury in obese mice by improving gut dysbiosis and modulating the bile acid profile. Exp Neurol. 2023 Jan;359:114234.(Ⅱ区,IF = 5.62,共同通讯作者)

11.Li X, Ren Y, Gao X, Wang H, Zhang J, Xie J, Liang J, Zhao B, Zhou H, Yin J. Gut microbiota-mediated choline metabolism exacerbates cognitive impairment induced by chronic cerebral hypoperfusion. J Cereb Blood Flow Metab. 2024 Dec 24:271678X241309777.(Ⅱ区,IF = 5.0,末位通讯作者

12.Jie Li, Shengnan Chen, Siqi Yang, Wwen Zhang, Xiaoqi Huang, Lang Zhou, Yanchao Liu, Mengxi Li, Yonghui Guo, Jia Yin, Kaiyu Xu. Hypercoagulable State and Gut Microbiota Dysbiosis as Predictors of Poor Functional Outcomes in Acute Ischemic Stroke Patients. mSystems.Ⅱ区,IF = 5.0,共同通讯作者

13.Zhang MS, Liang JH, Yang MJ, Ren YR, Cheng DH, Wu QH, He Y, Yin J. Low Serum Superoxide Dismutase Is Associated With a High Risk of Cognitive Impairment After Mild Acute Ischemic Stroke. Front Aging Neurosci. 2022;14:834114.(Ⅱ区,IF = 5.75,末位通讯作者)

14.Wang H, Song W, Wu Q, Gao X, Li J, Tan C, Zhou H, Zhu J, He Y, Yin J. Fecal Transplantation from db/db Mice Treated with Sodium Butyrate Attenuates Ischemic Stroke Injury. Microbiol Spectr. 2021 Oct 31;9(2):e0004221.(Ⅱ区,IF = 7.171,末位通讯作者)

15.Xia G-H, Zhang M-S, Wu Q-H, Wang H-D, Zhou H-W, He Y, Yin J. Dysbiosis of Gut Microbiota Is an Independent Risk Factor of Stroke-Associated Pneumonia: A Chinese Pilot Study. Front. Cell. Infect. Microbiol. 2021;11:1–13. (Ⅱ区,IF = 5.293,末位通讯作者)

16.Tan C, Wu Q, Wang H, Gao X, Xu R, Cui Z, Zhu J, Zeng X, Zhou H, He Y,Yin J. Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes. JPEN J Parenter Enteral Nutr. 2021 Mar;45(3):518-529.(Ⅱ区,IF:4.011,末位通讯作者)

17.Zeng X, Gao X, Peng Y, Wu Q, Zhu J, Tan C, Xia G, You C, Xu R, Pan S, Zhou H, He Y,Yin J. Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut. Front Cell Infect Microbiol. 2019;9:4.(II区,IF =5.293,末位通讯作者)

18.Xu KY, Xia GH, Lu JQ, Chen MX, Zhen X, Wang S, You C, Nie J, Zhou HW, Yin J. Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients. Sci Rep. 2017 May 3;7(1):1445. (II区,IF =3.8,末位通讯作者)

19.Xuxuan Gao, Qiheng Wu, Xiaofei Lin, Yueran Ren, Jiaying Chen, Yu Ma, Lianghao Ye, Wei Song, Jiajia Zhu, Jia Yin. Impact of Systolic Blood Pressure Trajectories and Variability on Unexplained Early Neurological Deterioration Post-Endovascular Treatment in Acute Ischemic Stroke Patients. Journal of Clinical Hypertension.Ⅲ区,IF=2.7,末位通讯作者)

20.Ren Y, Liang J, Li X, Deng Y, Cheng S, Wu Q, Song W, He Y, Zhu J, Zhang X, Zhou H,Yin J. Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients. BMC Microbiol. 2023 Oct 24;23(1):305.(Ⅲ区,IF=4.3,末位通讯作者)

21.Ren Y, Liang J, Hu W, Xie J, Zheng Y, Song W, Zhu J, Zhou H, Wu Q, He Y, Yin J. Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension. J Oral Microbiol. 2024 Jul 23;16(1):2382620.(Ⅲ区,IF=3.7,末位通讯作者)

22.Huang R, Gong S, Xiong B, Yang X, Chen C, Song W, Wu R, Yang L, Yin J, Chen M. A classic prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis. Heliyon. 2024 Jul 14;10(14):e34596.Ⅲ区,IF=3.7,共同通讯作者)

23.Tian X, Xia G, Zhang M, Tan C, Yang M, Wang H, Song X, Chai S, Yin J, Song W. Effect of Enteral Nutrition on the Intestinal Microbiome and Risk of Death in Ischemic Stroke Patients. JPEN J Parenter Enteral Nutr. 2022 Mar 11.(Ⅲ区,IF = 4.016,共同通讯作者)

24.Tan C, Wang H, Gao X, Xu R, Zeng X, Cui Z, Zhu J, Wu Q, Xia G, Zhou H, He Y, Yin J. Dynamic Changes and Prognostic Value of Gut Microbiota-Dependent Trimethylamine-N-Oxide in Acute Ischemic Stroke. Front Neurol. 2020 Jan 31;11:29. (Ⅲ区,IF=4.004,末位通讯作者)

25.Xia GH, You C, Gao XX, Zeng XL, Zhu JJ, Xu KY, Tan CH, Xu RT, Wu QH, Zhou HW, He Y, Yin J. Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke. Front Neurol. 2019;10:397.(Ⅲ区,IF =4.004,末位通讯作者)

26.Zhu J, Li Y, Zheng D, Wang Z, Pan S, Yin J, Wang H. Elevated Serum and Cerebrospinal Fluid CD138 in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis. Front Mol Neurosci. 2019 May 16;12:116.(Ⅲ区,IF =3.5,共同通讯作者)

27.Wang H, Yang M, Cheng S, Ren Y, Deng Y, Liang J, Lin X, Li J, Yin J, Wu Q. The Spouses of Stroke Patients Have a Similar Oral Microbiome to Their Partners with an Elevated Risk of Stroke. Microorganisms. 2022 Nov 18;10(11):2288. (Ⅲ区,IF=4.1,共同通讯作者)

28.Tian G, Huang J, Zhu J, Wu Q, Yin J. In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis. BMC Neurol. 2024 Nov 4;24(1):426.(Ⅳ区,IF =2.2,末位通讯作者)

29.Tian G, Ji Z, Lin Z, Pan S, Yin J. Cerebral autoregulation is heterogeneous in different stroke mechanism of ischemic stroke caused by intracranial atherosclerotic stenosis. Brain Behav. 2021 Jan;11(1):e01907.(Ⅳ区,IF =2.6,末位通讯作者)

30.Yin J, Liao SX, He Y, Wang S, Xia GH, Liu FT, Zhu JJ, You C, Chen Q, Zhou L, Pan SY, Zhou HW. Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. J Am Heart Assoc. 2015 Nov 23;4(11):e002699. (Ⅱ区,IF = 5.00,独立一作

31.Yin J, M P, Wang S, Liao SX, Peng X, He Y, Chen YR, Shen HF, Su J, Chen Y, Jiang YX, Zhang GX, Zhou HW. Different Dynamic Patterns of β-Lactams, Quinolones, Glycopeptides and Macrolides on Mouse Gut Microbial Diversity. PLoS One. 2015 May 13;10(5):e0126712.(Ⅲ区,IF=2.9,独立一作)

32.Yin J, Lü TM, Qiu G, Huang RY, Fang M, Wang YY, Xiao D, Liu XJ. Intracerebral hematoma extends via perivascular spaces and perineurium. Tohoku J Exp Med. 2013 Jul;230(3):133-9.(Ⅳ区,IF =1.9,独立一作)