目录
更新日期:2023年9月18日
姓 名 张琳 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士
行政职务 主任 Email zlilyzh@126.com
工作单位 基础医学院 邮政编码 510515
个人简介

张琳教授,南方医科大学基础医学院二级教授,博士生和博士后联合导师,组织胚胎学教研室主任,国家药监局化妆品安全评价重点实验室常务副主任,广东省药监局化妆品安全与功效关键技术重点实验室副主任。担任中国解剖学会组织胚胎学专业委员会常务理事,中国解剖学会医学发育生物学分会副主任委员、广东省解剖学会副理事长等学术任职。珠江学者特聘教授,获得教育部“新世纪优秀人才”支持计划,南方医科大学立德树人好导师等荣誉称号。主持20余项国家级和省部级课题,研究工作以通讯作者发表SCI收录期刊60余篇, 累计被SCI-E引用1000余次,从事皮肤的基础与应用研究。

 

研究领域

主要从事皮肤的基础与应用研究。以基因敲除小鼠为模型,揭示了皮肤屏障形成、皮肤衰老、毛发形成、皮肤创伤修复、以及皮肤相关疾病过程中信号调控机制;系统阐明了小G蛋白家族在干细胞对皮肤创伤愈合的治疗作用和信号机制;并聚焦新型生物材料在皮肤创伤愈合过程中的治疗应用。相关研究为解决皮肤创伤愈合附属器官再生难题,构建高质量仿生皮肤提供研究基础和新的治疗依据。

个人成果

代表性论文

1. Yunyao Bo# , Lijun Yang# , Baiting Liu, Guiping Tian, Chenxi Li,Lin Zhang*, Yuan Yan. Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration. J Nanobiotechnology. 2022 Jun 21;20(1):291. doi: 10.1186/s12951-022-01504-8.通讯作者,中科院小2区,IF9.429

2. Simin Huang#, Xueer Wang#, Min Zhang, Mianbo Huang, Yuan Yan, Yinghua Chen, Yijia Zhang, Jinfu Xu, Lingwei Bu, Ruyi Fan, Huiyi Tang, Canjun Zeng, Lu Zhang*, Lin Zhang*. Activin B-activated Cdc42 signaling plays a key role in regulating adipose-derived mesenchymal stem cells-mediated skin wound healing. Stem Cell Research & Therapy. 2022 Jun 11;13(1):248. doi: 10.1186/s13287-022-02918-9. 通讯作者,JCR小2区,IF8.079.

3. Li Ying#, Jinlan Zhao#, Yingshan Ye#, Yutong Liu, Bin Xiao, Tao Xue, Hangfei Zhu, Yue Wu, Jing He, Sifei Qin, Yong Jiang, Fukun Guo, Lin Zhang*, Nuyun Liu*, Lu Zhang*. Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease. Aging Cell. 2022 May;21(5):e13588. doi: 10.1111/acel.13588. Epub 2022 Apr 12. 通讯作者,JCR小1区, IF11.005

4. Ping Wang# , Guodong Hu# , Wen Zhao, Juan Du, Menghan You, Mengying Xv, Hong Yang, Min Zhang, Fang Yan, Mianbo Huang, Xueer Wang, Lin Zhang*, Yinghua Chen*. Continuous ZnO nanoparticle exposure induces melanoma-like skin lesions in epidermal barrier dysfunction model mice through anti-apoptotic effects mediated by the oxidative stress-activated NF-κB pathway. J Nanobiotechnology. 2022 Mar 5;20(1):111. doi: 10.1186/s12951-022-01308-w. 通讯作者,中科院小2区,IF9.429

5. Min Wu, Zhihui Lu, Keke Wu, Changwoo Nam, Lin Zhang*, Jinshan Guo*. Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing. J Mater Chem B. 2021 Sep 15;9(35):7063-7075. doi: 10.1039/d1tb00847a. 通讯作者,中科院小3区,IF7.571

6. Yunyao Bo, Baiting Liu, Lijun Yang, Lin Zhang*, Yuan Yan*. Exosomes derived from miR-16-5p-overexpressing keratinocytes attenuates bleomycin-induced skin fibrosis. Biochemical and Biophysical Research Communications. 2021 Jul 5;561:113-119. doi: 10.1016/j.bbrc.2021.05.046. Epub 2021 May 19.通讯作者,中科院小3区,IF3.322

7. Ang Li#, Hui-Ming Zhu#, Yu Chen, Fang Yan, Zhong-Ying Liu, Zhen-Lin Li, Wei-Ren Dong, Lin Zhang*, Hai-Hong Wang*. Cdc42 Facilitates Axonogenesis by Enhancing Microtubule Stabilization in Primary Hippocampal Neurons. Cellular and Molecular Neurobiology 2021 Oct;41(7):1599-1610. doi: 10.1007/s10571-021-01051-0. Epub 2021 Feb 11. 通讯作者,中科院小3区,IF4.231

8. Huiyi Tang, Xueer Wang, Min Zhang, Yuan Yan, Simin Huang, Jiahao Ji, Jinfu Xu, Yijia Zhang, Yongjie Cai, Bobo Yang, Wenqi Lan, Mianbo Huang*, Lin Zhang*. MicroRNA-200b/c-3p regulate epithellial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling. Cell Death & Disease. 2020;29;11(10):931.  通讯作者,JCR 小2区,IF:9.685(2020年10月29日)

9. Yuan Yan#*, Ruijun Wu#, Yunyao Bo, Min Zhang, Yinghua Chen, Xueer Wang, Mianbo Huang, Baiting Liu, Lin Zhang*. Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration. Theranostics, 2020;10(22):9970-9983. 小1区,IF:11.600(2020年8月8日)

10. Genghong Tu, Li Ying, Liuzhen Ye, Jinlan Zhao, Nuyun Liu, Juan Li, Yutong Liu, Mengjuan Zhu, Yue Wu, Bin Xiao, Huidong Guo, Fukun Guo, Huijun Wang, Lin Zhang*, Lu Zhang*. Dopamine D1 and D2 receptors differentially regulate Rac1 and Cdc42 signaling in the nucleus accumbens to modulate behavioral and structural plasticity after repeated methamphetamine treatment. Biological Psychiatry. 2019;86(11):820-835. 通讯作者,JCR 小1区,IF:13.382(2019年12月1日)

11. Yuan Yan#, Jie Jiang#, Min Zhang, Yinghua Chen, Xueer Wang, Mianbo Huang, Lin Zhang*. Effect of iPSCs-derived Keratinocytes on Healing of Full-Thickness Skin Wounds in mice. Experimental Cell Research. 2019;385(1):111627.通讯作者,JCR 小3区, IF 4.145(2019年12月1日)

12. Ruijun Wu#, Dan Du#, Yunyao Bo, Min Zhang, Lin Zhang*, Yuan Yan*. Hsp90α promotes the migration of iPSCs-derived keratinocyte to accelerate deep second-degree burn wound healing in mice. Biochem Biophys Res Commun. 2019;520(1):145-151.(2019年11月26日)JCR 小3区IF:3.575

13. Chuxi Lin#, Xueer Wang#, Qing Peng, Yang Li, Lin Zhang* and Yi Gao*. Characterization and evaluation of HGF-loaded PLGA nanoparticles in a CCl4-induced acute liver injury mouse model. Journal of nanomaterials. 2019;2019:13.通讯作者,JCR小4区,IF:3.791 (2019年10月7日)

14. Min Zhang#, Xueer Wang#, Fukun Guo, Qin Jia, Nuyun Liu, Yinghua Chen, Yuan Yan, Mianbo Huang, Huiyi Tang, Ying Deng, Simin Huang, Zhitao Zhou, Lu Zhang*, and Lin Zhang*. Cdc42 deficiency leads to epidermal barrier dysfunction by regulating intercellular junctions and keratinization of epidermal cells during mouse skin development. Theranostics.2019; 9(17): 5065-5084. 通讯作者,JCR 小1区,IF:11.600(2019年7月9日)

15. Jinlan Zhao#, Li Ying#, Yutong Liu, N Liu, Genghong Tu, Mengjuan Zhu, Yue Wu, Bin Xiao, Liuzhen Ye, Juan Li, Fukun Guo, Lin Zhang*, Huijun Wang*, and Lu Zhang*. Different roles of Rac1 in the acquisition and extinction of methamphetamine-associated contextual memory in the nucleus accumbens. Theranostics. 2019;9(23):7051-7071. 通讯作者,JCR 小1区,IF:11.600(2019年9月21日)

16. Jinhua Xue#, Yutong Liu#, Mohammad Ali Darabi, Genghong Tu, Lu Huang, Li Ying, Bin Xiao, Yue Wu, Malcolm Xing*, Lin Zhang* and Lu Zhang*. An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment. Materials Science & Engineering C-Materials for Biological Applications. 2019;100: 584-597. 通讯作者,JCR 小2区,IF:7.328 (2019年7月)

17. Pei Tang#, Xueer Wang#, Min Zhang, Simin Huang, Chuxi Lin, Fang Yan, Ying Deng, Lu Zhang* and Lin Zhang*. Activin B stimulates mouse vibrissae growth and regulates cell proliferation and cell cycle progression of hair matrix cells through ERK signaling. International Journal of Molecular Sciences, 2019;20(4), 853,通讯作者,JCR小3区,IF:6.208(2019年2月15日)

18. Xueer Wang, Pei Tang, Fukun Guo, Min Zhang, Yuan Yan, Mianbo Huang, Yinghua Chen, Lu Zhang* and Lin Zhang*. mDia1 and Cdc42 regulate Activin B-induced migration of bone marrow-derived mesenchymal stromal cells. Stem Cells. 2019;37(1):150-162. 通讯作者,JCR小2区,IF:6.277(2019年1月4日)

19. Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang*, Buling Wu*,Lin Zhang*. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018, 1864(8):2623-2632. 通讯作者; JCR小1区,2017IF:5.108; 2018 IF:4.328 2019IF:4.352 2020 IF:5.187;2021IF4.117(2018年8月1日)

20. Yutong Liu#, Juan Li#, Kaige Xu, Jingjing Gu, Lu Huang, Lei Zhang, N. Liu, Jiming Kong, Malcolm Xing,Lin Zhang*, Lu Zhang. Characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in PC12 cells and mouse hippocampus and striatum. Toxicology Letters. 2018;292:151-161. 2018年8月 通讯作者; JCR小2区,2017 IF:3.166;2018 IF:3.499 2019IF:3.569 2020 IF:4.372

21. Lei Zhang#, Singh Gurankit#, Min Zhang, Chen Shixuan, Kaige Xu, Pengcheng Xu, Xueer Wang, Yinghua Chen, Lu Zhang*, Lin Zhang*. Bone marrow-derived mesenchymal stem cells laden novel thermo-sensitive hydrogel for the management of severe skin wound healing. Materials Science & Engineering C-Materials for Biological Applications. 2018, 90, 159-167.通讯作者,JCR 小2区,IF:7.328

22. Pengcheng Xu, Min Zhang, Xueer Wang, Yuan Yan, Yinghua Chen, Wei Wu, Lu Zhang, and Lin Zhang*. Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage. International Journal of Molecular Sciences. 2018, 19(4), 953.通讯作者,JCR小3区,IF:5.923

23. Yang Yu#, Xueer Wang#, Qinglin Li, Min Zhang, Pengcheng Xu, Yinghua Chen, Yuan Yan, Lin Zhang*. Bioinformatics analysis of gene expression alterations conferring drug resistance in tumor samples from melanoma patients with EGFR‑activating BRAF mutations. Oncology Letters, 2018, 15(1): 635-641.通讯作者,JCR小4区,IF:2.967

24. Hai-Hong Wang,Yan Li,Ang Li,Fang Yan,Zhen-Lin Li,Zhong-Ying Liu,Lei Zhang,Jian Zhang,Wei-Ren Dong*,Lin Zhang*. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular Neurobiology. 2018;55(1):696-706. 通讯作者, JCR 小2区,2016IF:6.190; 2017IF:5.076;2018IF:4.586 2019IF:4.5, 2020IF:5.046