主持课题：
1、南方医科大学第三附属医院院长基金，超细腹腔镜器械条件下精索静脉高位结扎术中保留睾丸动脉与否的临床疗效对比：前瞻性、单中心、随机对照试验，2023-02至2028-01，50万元，主持，在研
2、广州市科技计划项目，JUN-MAPK信号通路介导铁死亡参与精索静脉曲张睾丸生精功能障碍的作用与机制研究，2022-04至2024-03，5万元，主持，在研
3、南方医科大学第三附属医院院长基金，ROS-AR-FTH介导的铁死亡新通路在精索静脉曲张所致睾丸组织损伤的作用机制及治疗策略研究，2022-01至2023-12，30万元，主持，在研
4、国家自然科学基金委员会，面上项目，81772257，血浆外泌体 miRNA-200 家族作为抗氧化应激调控因子早期诊断精索静脉曲张所致弱精子症可行性研究，2018-01至2021-12，52 万元，主持，已结题。
5、南方医科大学临床研究启动项目，实时超声造影与常规多普勒超声引导经直肠前列腺穿刺活检前列腺癌检出率比较的随机对照研究，2016-01至2020-12，主持，40万元，主持，已结题
6、广州市天河区科技计划项目，基于3D打印技术的肾脏结石个性化治疗手术方式选择的研发与应用研究，2015-01至2017-12，8万元，主持，已结题
7、广东省自然科学基金项目，2014A030313291，miR-27b 沉默 CRISP2 降低精子活力的新机制及在弱精症中的临床意义，2015-01至2018-01，10 万元，主持，已结题
8、广东省科技计划项目，2013B021800317，精索静脉曲张致男性不育关键功能蛋白基因的筛选、鉴定及机制研究，2015-01至2017-12，5 万元，主持，已结题
9、广州市科技局，20130102，南方医科大学男科疾病的社区科普教育，2013-07至2013-12，2万元，主持，已结题
10、广东省自然科学基金面上项目，S2012010009126，CRISP2 基因/蛋白与精子活力的关系研究，2012-10至2014-10，5 万元，主持，已结题
发表论文：
[1] Zhou R, Liang J, Chen Q, Tian H, Yang C, and Liu C. A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes[J]. Reprod Sci, 2023, 30(1): 233-246.（3区，2021IF=2.924）
[2] Chen Q, Zhou R, Yang C, Jiang Q, Yuan H, Qiu X, Tian H, Zhou J, and Liu C. Ergothioneine attenuates varicocele-induced testicular damage by upregulating HSP90AA1 in rats[J]. J Biochem Mol Toxicol, 2023: e23301.（3区，2021IF=3.568）
[3] Zhou R, Liang J, Tian H, Chen Q, Yang C, and Liu C. An Immunosenescence-Related Gene Signature to Evaluate the Prognosis, Immunotherapeutic Response, and Cisplatin Sensitivity of Bladder Cancer[J]. Dis Markers, 2022, 2022: 2143892.（3区，2021IF=3.464）
[4] Zhu T, Xiao Z, Yuan H, Tian H, Chen T, Chen Q, Chen M, Yang J, Zhou Q, Guo W, Xue K, Xia M, Bao J, Yang C, Duan H, Wang H, Huang Z, Liu C, and Zhou J. ACO1 and IREB2 downregulation confer poor prognosis and correlate with autophagy-related ferroptosis and immune infiltration in KIRC[J]. Front Oncol, 2022, 12: 929838. （3区，2021IF=5.738）
[5] Liang H Y, Peng F, Pan M J, Liao S L, Wei C, Wei G Y, Xie X, Xue K Y, Chen M K, Yang J K, Guo W B, Liu C D, and Zhou Q Z. Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway[J]. Asian J Androl, 2022.（2区，2021IF=3.054）
[6] Xie X, Dou C X, Luo M R, Zhang K, Liu Y, Zhou J W, Huang Z P, Xue K Y, Liang H Y, Ouyang A R, Ma S X, Yang J K, Zhou Q Z, Guo W B, Liu C D, Zhao S C, and Chen M K. Plasma cell subtypes analyzed using artificial intelligence algorithm for predicting biochemical recurrence, immune escape potential, and immunotherapy response of prostate cancer[J]. Front Immunol, 2022, 13: 946209. （2区，2021IF=8.787）
[7] Xiao-Bin G, Fang-Lei W, Hui X, Cheng Y, Zhi-Xuan C, Zhi-Peng H, Cun-Dong L, and Wen-Bin G. The association between body mass index and varicocele: A meta-analysis[J]. Int Braz J Urol, 2021, 47(1): 8-19. （4区，2021IF=3.050）
[8] Zhou J W, Mao Y H, Liu Y, Liang H T, Samtani C C, Fu Y W, Ye Y L, Xiao G, Qin Z K, Liu C D, Yang J K, Zhou Q Z, Guo W B, Xue K Y, Zhao S C, and Chen M K. A novel robust nomogram based on peripheral monocyte counts for predicting lymph node metastasis of prostate cancer[J]. Asian J Androl, 2021, 23(4): 409-414.（2区，2021IF=3.054）
[9] Guo X B, Zhai J W, Xia H, Yang J K, Zhou J H, Guo W B, Yang C, Xia M, Xue K Y, Liu C D, and Zhou Q Z. Protective effect of bone marrow mesenchymal stem cell-derived exosomes against the reproductive toxicity of cyclophosphamide is associated with the p38MAPK/ERK and AKT signaling pathways[J]. Asian J Androl, 2021, 23(4): 386-391.（2区，2021IF=3.054）
[10] JiaWei Z, ChunXia D, CunDong L, Yang L, JianKun Y, HaiFeng D, Cheng Y, ZhiPeng H, HongYi W, DeYing L, ZhiJian L, Xiao X, QiZhao Z, KangYi X, WenBing G, Ming X, JunHao Z, JiMing B, ShanChao Z, and MingKun C. M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer[J]. Ann Med, 2021, 53(1): 730-740. （3区，2021IF=5.348）
[11] Liu Y, Zhou J W, Liu C D, Yang J K, Liao D Y, Liang Z J, Xie X, Zhou Q Z, Xue K Y, Guo W B, Xia M, Zhou J H, Bao J M, Yang C, Duan H F, Wang H Y, Huang Z P, Zhao S C, and Chen M K. Comprehensive signature analysis of drug metabolism differences in the White, Black and Asian prostate cancer patients[J]. Aging (Albany NY), 2021, 13(12): 16316-16340. （3区，2021IF=5.955）
[12] Zhou R, Liang J, Tian H, Chen Q, Yang C, and Liu C. Development of a Ferroptosis-Related lncRNA Signature to Predict the Prognosis and Immune Landscape of Bladder Cancer[J]. Dis Markers, 2021, 2021: 1031906.（3区，2021IF=3.464）
[13] Chen M K, Zhou J H, Wang P, Ye Y L, Liu Y, Zhou J W, Chen Z J, Yang J K, Liao D Y, Liang Z J, Xie X, Zhou Q Z, Xue K Y, Guo W B, Xia M, Bao J M, Yang C, Duan H F, Wang H Y, Huang Z P, Qin Z K, and Liu C D. BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell[J]. Aging (Albany NY), 2021, 13(14): 18310-18330.（3区，2021IF=5.955）
[14] Zhou R, Liang J, Chen Q, Tian H, Yang C, and Liu C. Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq[J]. Aging (Albany NY), 2021, 13(15): 19415-19441.（3区，2021IF=5.955）
[15] Zhou R, Lv X, Chen T, Chen Q, Tian H, Yang C, Guo W, and Liu C. Construction and external validation of a 5-gene random forest model to diagnose non-obstructive azoospermia based on the single-cell RNA sequencing of testicular tissue[J]. Aging (Albany NY), 2021, 13(21): 24219-24235.（3区，2021IF=5.955）
[16] Zhou R, Chen X, Liang J, Chen Q, Tian H, Yang C, and Liu C. A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer[J]. Aging (Albany NY), 2021, 13(23): 25153-25179.（3区，2021IF=5.955）
[17] Zhou J, Tian H, Zhi X, Xiao Z, Chen T, Yuan H, Chen Q, Chen M, Yang J, Zhou Q, Xue K, Guo W, Xia M, Bao J, Yang C, Duan H, Wang H, Huang Z, Zhu T, and Liu C. Activating transcription factor 5 (ATF5) promotes tumorigenic capability and activates the Wnt/b-catenin pathway in bladder cancer[J]. Cancer Cell Int, 2021, 21(1): 660.（3区，2021IF=6.435）
[18] Yang Z, Li S, Yin J, Bao J, Zeng H, Xu W, Zhang X, Xing Z, Zhao W, and Liu C. A prediction model for risk factors of testicular atrophy after orchiopexy in children with undescended testis[J]. Transl Pediatr, 2021, 10(4): 882-892. （3区，2021IF=4.047）
[19] Chen M K, Chen Z J, Xiao K H, Qin Z K, Ye Y L, Wen W J, Bian J, Xue K Y, Zhou Q Z, Guo W B, Zhou J H, Xia M, Li X, and Liu C D. Predictive value of cadherin-11 for subsequent recurrence and progression in non-muscle invasive bladder cancer[J]. Jpn J Clin Oncol, 2020, 50(4): 456-464.（4区，2021IF=2.925）
[20] Yang Z, Li S, Zeng H, Yin J, Xu W, Li J, Xie J, and Liu C. Laparoscopic Orchiopexy Versus Open Orchiopexy for Palpable Undescended Testis in Children: A Prospective Comparison Study[J]. J Laparoendosc Adv Surg Tech A, 2020, 30(4): 453-457.
[21] Chen Z, Xiao K, Zhang H, Liu C, Yang J, Liang H, Lin Z, Qin Z, Chen M, and Ye Y. MAP kinase-interacting kinase 1 (MNK1) plays as a tumor suppressor in bladder cancer[J]. Transl Cancer Res, 2020, 9(4): 2588-2598. （4区，2021IF=0.496）
[22] Guo W B, Huang Z H, Yang C, Lv X Y, Xia H, Tian H, Yang J K, Zhou Q Z, Chen M K, Xue K Y, and Liu C D. Down regulating PHGDH affects the lactate production of sertoli cells in varicocele[J]. Reprod Biol Endocrinol, 2020, 18(1): 70.（1区，2021IF=4.982）
[23] Liu Y, Xiao G, Zhou J W, Yang J K, Lu L, Bian J, Zhong L, Wei Q Z, Zhou Q Z, Xue K Y, Guo W B, Xia M, Zhou J H, Bao J M, Yang C, Liu C D, and Chen M K. Optimal Starting Age and Baseline Level for Repeat Tests: Economic Concerns of PSA Screening for Chinese Men - 10-Year Experience of a Single Center[J]. Urol Int, 2020, 104(3-4): 230-238.（4区，2021IF=1.934）
[24] Guo W B, Yang C, Bian J, Xia H, Yang J K, Zhou Q Z, Chen M K, Xue K Y, Zhang W S, Wang P, Li X, and Liu C D. With a new clip technique surgically inducing varicocele in Sprague-Dawley rats[J]. BMC Urol, 2018, 18(1): 58.（4区，2021IF=2.090）
[25] Chen M, Wu R, Li G, Liu C, Tan L, Xiao K, Ye Y, and Qin Z. Motor neuron and pancreas homeobox 1/HLXB9 promotes sustained proliferation in bladder cancer by upregulating CCNE1/2[J]. J Exp Clin Cancer Res, 2018, 37(1): 154. （4区，2021IF=2.090）
[26] Zhou J H, Zhou Q Z, Yang J K, Lyu X M, Bian J, Guo W B, Chen Z J, Xia M, Xia H, Qi T, Li X, and Liu C D. MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients[J]. Asian J Androl, 2017, 19(5): 591-595.（2区，2021IF=3.054）
[27] Yang C, Guo W B, Zhang W S, Bian J, Yang J K, Zhou Q Z, Chen M K, Peng W, Qi T, Wang C Y, and Liu C D. Comprehensive proteomics analysis of exosomes derived from human seminal plasma[J]. Andrology, 2017, 5(5): 1007-1015.（2区，2021IF=4.456）
[28] Chen M, Ye Y, Zou B, Guo S, Zhou F, Lu K, Liu J, Xu Z, Han H, Liu Z, Li Y, Yao K, Liu C, and Qin Z. C14orf166 is a high-risk biomarker for bladder cancer and promotes bladder cancer cell proliferation[J]. J Transl Med, 2016, 14: 55.（3区，2021IF=8.448）
[29] Kan H P, Guo W B, Tan Y F, Zhou J, Liu C D, and Huang Y Q. Statin use and risk of gallstone disease: A meta-analysis[J]. Hepatol Res, 2015, 45(9): 942-948.（3区，2021IF=4.942）
[30] Zhou J H, Zhou Q Z, Lyu X M, Zhu T, Chen Z J, Chen M K, Xia H, Wang C Y, Qi T, Li X, and Liu C D. The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia[J]. Biol Reprod, 2015, 92(1): 28.（2区，2021IF=4.161）