姓名：成红

职称：教授

导师类型：博导

研究方向：生物医用纳米材料、药物递送

联系方式：chengh@smu.edu.cn

学习经历：

2008.09-2012.06 中南大学，应用化学，学士

2012.09-2017.06 武汉大学，高分子化学与物理，博士

工作经历：

2017.07-2021.11 南方医科大学，生物医学工程学院，副教授

2021.12至今 南方医科大学，生物医学工程学院，教授

主要学术成果：

近五年主持国家自然科学基金-面上项目1项、国家自然科学基金-青年项目1项、广东省自然科学基金-杰出青年项目1项、广东省自然科学基金-面上项目1项、广州市科技计划1项。

近五年以独立或共同通讯作者在ACS Nano、Nano Letters、Biomaterials、Small、Journal of Controlled Release、Chemical Engineering Journal、Advanced Healthcare Materials、Acta Biomaterialia等专业学术期刊发表相关研究性论文40余篇。

  癌症严重威胁人类的生命健康，但传统治疗方法在实际应用过程中面临着诸多问题，例如药效低、副作用高、患者个体差异大等。如何将药物安全有效地递送至病灶部位，在提高药效的同时降低其对正常组织的毒副作用，一直是该领域研究人员致力于解决的关键问题之一。因此，我们希望通过结合材料学、纳米医学、肿瘤学等多学科研究手段，开发适应肿瘤微环境的多功能纳米递送体系，突破体内生理屏障，实现药物在肿瘤组织的靶向递送与有效控释，改善肿瘤微环境，增强药物的抗肿瘤疗效。

1. Chen S Y, Zhao L P, Chen Z X, Huang C Y, Kong R J, Wang Y Q, Zhang D W*, Li S Y*, Ti H H*,  Cheng H*. Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy. Acta Biomater. 2023, 158, 599-610.

2. Zhao L P, Rao X N, Huang C Y, Zheng R R, Kong R J, Chen Z X, Yu X Y*,  Cheng H*, Li S Y*. Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition. Biomaterials 2023, 293, 121952.

3. Kong R J, Li X Y, Huang J Q, Zhou X, Deng F A, Li Y M, Liu L S, Li S Y, Cheng H*. Self-delivery photodynamic sensitizer for enhanced DNA damage by PARP inhibition. Biomater. Sci. 2023, 11, 162-169.

4. Zhou X, Kong R J, Deng F A, Xie Y C, Huang J Q, Li Y M, Li X Y, Wu Y Y, Li S Y*, Cheng H*. Self-delivery photothermal converter for feedback enhanced tumor therapy by cascade inflammation inhibition. Chem. Eng. J. 2023, 453, 139887.

5. Zhong Y T, Cen Y, Xu L*, Li S Y*, Cheng H*. Recent progress in carrier-free nanomedicine for tumor phototherapy. Adv. Healthc. Mater. 2022, 2202307.

6. Zhou X, Li Y M, Li X Y, Huang J Q, Kong R J, Liu L S, Cheng H*. Carrier free nanomedicine to reverse anti-apoptosis and elevate endoplasmic reticulum stress for enhanced photodynamic therapy. Acta Biomater. 2022, 152, 507-518.

7. Zheng R R, Liu Y B, Yu B X, Zhao L P, Yang N, Chen A L, Xu L, Cheng H*, Jiang X Y*, Li S Y*. Carrier free nanomedicine for synergistic cancer therapy by initiating apoptosis and paraptosis. J. Colloid Interf. Sci. 2022, 612, 562-571.

8. Deng F A, Yan M Y, Liu Y B, Wang R X, He H Q, Chen A L, Wang J J, Xu L, Cheng H*, Li S Y*. Self-delivery of metal-coordinated mitochondria protonophore uncoupler for O₂-exhausting enhanced bioreductive therapy. Biomaterials 2022, 286, 121576.

10. Zhao L P, Zheng R R, Kong R J, Huang C Y, Rao X N, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery ternary bioregulators for photodynamic amplified immunotherapy by tumor microenvironment reprogramming. ACS Nano 2022, 16, 1182-1197.

11. Chen X Y, Zheng R R, Zhao L P, Kong R J, Yang N, Liu Y B, Chen A L, Wang C, Cheng H*, Li S Y*. Photodynamic therapy initiated immunotherapy of self-delivery re-educator by inducing immunogenic cell death and macrophage polarization. Chem. Eng. J. 2022, 435, 134783.

12. Huang J Q, Zhao L P, Zhou X, Liu L S, Zheng R R, Deng F A, Liu Y B, Yu X Y, Li S Y, Cheng H*. Carrier free O₂-economizer for photodynamic therapy against hypoxic tumor by inhibiting cell respiration. Small 2022, 2107467.

13. Li X Y, Deng F A, Zheng R R, Liu L S, Liu Y B, Kong R J, Chen A L, Yu X Y, Li S Y*, Cheng H*. Carrier free photodynamic synergists for oxidative damage amplified tumor therapy. Small 2021, 17, 2102470.

14. Zhao L P, Zheng R R, Liu L S, Chen X Y, Guan R T, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy. Biomaterials 2021, 275, 120970. 

15. Fan G L, Deng F A, Zhou X, Liu L S, Huang J Q, Zhang D W, Sun Y X, Chen A L*, Cheng H*, Li S Y*. Plasma membrane targeted photodynamic O₂ economizer for hypoxic tumor therapy. Biomaterials 2021, 273, 120854.

16.  Zheng R R, Zhao L P, Chen X Y, Liu L S, Liu Y B, Chen X T, Wang C, Yu X Y*, Cheng H*, Li S Y*. Metal-coordinated nanomedicine for combined tumor therapy by inducing paraptosis and apoptosis. J. Control. Release 2021, 336, 159-168.

17. Liu L S, Zhou X, Zheng R R, Huang J Q, Kong R J, Li Y M, Wang C, Chen A L*, Li S Y*, Cheng H*. Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy. Chem. Commun. 2021, 57, 7296-7299.

18. Zhao L P, Zheng R R, Huang J Q, Chen X Y, Deng F A, Liu Y B, Huang C Y, Yu X Y*, Cheng H*, Li S Y*. Self-delivery photo-immune stimulators for photodynamic sensitized tumor immunotherapy. ACS Nano 2020, 14, 17100-17113.

19. Zhao L P, Zheng R R, Fan G L, Fan J H, Yuan P, Liu L S, Qiu X Z, Yu X Y*, Cheng H*, Li S Y*. Self-delivery nanomedicine for O₂-economized photodynamic tumor therapy. Nano Lett. 2020, 20, 2062-2071.

20. Yuan P, Fan G L, Fan J H, Zhao L P, Zheng R R, Liu L S, Qiu X Z, Yu X Y, Cheng H*, Li S Y*. Tumor targeted self-synergistic nanoplatforms for aresnic sensitized photodynamic therapy. Acta Biomater. 2020, 117, 349-360.

21. Cheng H, Fan G L, Fan J H, Yuan P, Deng F A, Qiu X Z, Yu X Y, Li S Y*, Epigenetics-inspired photosensitizer modification for plasma membrane-targeted photodynamic tumor therapy. Biomaterials 2019, 224, 119497.

22. Cheng H, Fan J H, Zhao L P, Fan G L, Zheng R R, Qiu X Z, Yu X Y*, Li S Y*, Zhang X Z. Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy. Biomaterials 2019, 211, 14-24.

23. Cheng H, Zheng R R, Fan G L, Fan J H, Zhao L P, Jiang X Y, Yang B, Yu X Y*, Li S Y*, Zhang X Z. Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy. Biomaterials 2019, 188, 1-11.

24. Cheng H*, X Y Jiang, Zheng R R, Zuo S J, Zhao L P, Fan G L, Xie B R, Yu X Y, Li S Y*, Zhang X Z. A biomimetic cascade nanoreactor for tumor targeted starvation therapy amplified chemotherapy. Biomaterials 2019, 195, 75-85.

25. Cheng H, Yuan P, Fan G L, Zhao L P, Zheng R R, Yang B, Qiu X Z, Yu X Y, Li S Y*, Zhang X Z. Chimeric peptide nanorods for plasma membrane and nuclear targeted photosensitizer delivery and enhanced photodynamic therapy. Appl. Mater. Today. 2019, 16, 120-131.

26. Li S Y, Jiang X Y, Zheng R R, Zuo S J, Zhao L P, Fan G L, Fan J H, Liao Y H, Yu X Y*, Cheng H*. An azobenzene-based heteromeric prodrug for hypoxia-activated chemotherapy by regulating subcellular localization. Chem. Commun. 2018, 54, 7983-7986.

27. Cheng H, Li S Y, Zheng H R, Li C X, Xie B R, Chen K W, Li B, Zhang X Z*. Multi-förster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging. Anal. Chem. 2017, 89, 4349-4354.

28. Cheng H, Zhu J Y, Li S Y, Zeng J Y, Lei Q, Chen K W, Zhang C, Zhang X Z*. An O₂ self-sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy. Adv. Funct. Mater. 2016, 26, 7847-7860.