主要研究中枢神经系统疾病的发病机制,围绕转录因子PPARgamma在中枢神经系统的作用,研究神经元存活和死亡的分子机制,以及代谢综合征和神经退行性疾病、抑郁症等共发病的机制。研究结果以第一作者(含共同第一)或者通讯作者发表在Gastroenterology、J. Neurosci、J Biol Chem、Mol Neurobiol、Neuropharmacology等国际刊物上。
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2. Su X, Gu X, Zhang Z, Li W, Wang X*. Retinoic acid receptor gamma is targeted by microRNA-124 and inhibits neurite outgrowth. Neuropharmacology, 2020, 163:107657.
3. Xu L#, Xu S#, Lin L, Gu X, Fu C, Fang Y, Li X, Wang X*. High-fat diet mediates anxiolytic-like behaviors in a time-dependent manner through the regulation of SIRT1 in the brain. Neuroscience,2018, 372:237-245.
4. Gu X, Fu C, Lin L, Liu S, Su X, Li A, Wu Q, Jia C, Zhang P, Chen L, Zhu X, Wang X*. miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway. Journal of Cellular Physiology. 2018,233(1):673-687.
5. Gu X#, Li A#, Liu S, Lin L, Xu S, Zhang P, Li S, Li X, Tian B, Zhu X, Wang X* . MicroRNA124 Regulated Neurite Elongation by Targeting OSBP. Molecular Neurobiology,2016,53(9):6388-6396.
6. Qin X#, Wu Q#, Lin L, Sun A, Liu S, Li X, Cao X, Gao T, Luo P, Zhu X, Wang X*. Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism. Molecular Neurobiology,2015, 52(1):187-195.
7. Wang X#,She H#,Mao Z*. Phosphorylation of Neuronal Survival Factor MEF2D by Glycogen Synthase Kinase 3 beta in Neuronal Apoptosis. Journal of Biological Chemistry,2009,284(47):32619-32626.
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9. Wang X#,Tang X#,Li M,Marshall J,Mao Z*. Regulation of Fu CC, Zhang XY, Xu Liu, Huang HX, Xu S, Wu QQ, Wang Z, Gu X, Lin LF, Lin S, Fang YY, Cao X, Wang X* PPARγ dysfunction in the medial prefrontal cortex mediates high-fat diet-induced depression. Molecular Neurobiology.activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. Journal of Biological Chemistry,2005,280(17):16705-16713.
10. Xuemin Wang, Xiaoli Tang, Xiaoming Gong, Efsevia Albanis, Scott L Friedman, Zixu Mao. Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology, 2004 Oct;127(4):1174-88.