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更新日期：2024年3月5日
姓 名 丁长海 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 科室主任 Email changhai.ding@utas.edu.au
工作单位 珠江医院 邮政编码
个人简介

国家特聘专家，“珠江人才计划”引进科技创新领军人才，广东省医学领军人才，南方医科大学教授，澳大利亚塔斯马尼亚大学、莫纳什大学、中山大学三院等院校兼职教授。 珠江医院临床研究中心执行主任，广东省临床研究质控中心秘书长，广东省医疗卫生机构临床研究专家委员会主任委员，广东省医学会临床研究学分会副主任委员。

为澳大利亚政府未来院士基金（ARC Future Fellowship）、澳大利亚政府国立卫生和医学研究院(NHMRC)职业发展奖获得者。曾任国际骨关节炎研究协会（OARSI）理事会理事;现任OARSI研究和教育委员会主任委员；国际华人国际骨关节炎研究协会（ICOARS）副主席；澳洲华人生物医学会副主席、塔斯马尼亚分会主席；塔斯马尼亚专家学者协会主席。任Reviews on Recent Clinical Trials副主编,Osteoarthritis & Cartilage、Arthritis Research & Therapy、Journal of Orthopaedic Translation、Nutrients等多个国际杂志编委。

在JAMA、JAMA Internal Medicine、Annals of Internal Medicine、Annals of the Rheumatic Diseases、Arthritis & Rheumatology、 Radiology等杂志共发表SCI论文320余篇，影响因子超10.0者58篇，被引15000余次，H指数为68（Google Scholar）。入选全球前2%顶尖科学家终身科学影响力排行榜，连续多次入选“中国高被引学者”。

1999年曾获法国施维雅研究院和中国药理学会颁发的“施维雅青年研究奖”，2008年被塔斯马尼亚大学授予“冉起之星”称号，2013年获NHMRC“十佳研究课题”奖；2015年获“皖江学者”称号。2016年获塔斯马尼亚大学“校长杰出研究”奖。已经、正在指导11名博士后、23名博士生、15名硕士生和16名访问学者，指导的博士后和博士生有1人获得国家“博士后创新人才支持计划”，3人获得博士后基金特别资助（站前）资助，3人获“中国博士后科学基金”，7人获国家自然科学基金青年项目。在澳洲指导的博士生有7人获中国留学基金委“国家优秀自费留学生奖学金”。

 

研究领域

1.骨与关节疾病的临床研究；

2.骨与关节疾病干细胞、纳米材料治疗的基础研究及临床转化；

3.骨与关节疾病发病机制的基础研究；

4.先进肌肉骨骼系统的定量影像学研究；

5.骨关节炎等慢病的基因组学、代谢组学等多组学研究。

个人成果
  1. Tang S, Yao L, Ruan J, Kang J, Cao Y, Nie X, Lan W, Zhu Z, Han W, Liu Y, Tian J, Seale P, Qin L, Ding C. Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology. Sci Transl Med. 2024 Jan 24;16(731):eadf4590. doi: 10.1126/scitranslmed.adf4590. (IF 17.1)
  2. Cao Y, Ruan J, Kang J, Nie X, Lan W, Ruan G, Li J, Zhu Z, Han W, Tang S, Ding C. Extracellular Vesicles in Infrapatellar Fat Pad from Osteoarthritis Patients Impair Cartilage Metabolism and Induce Senescence. Advanced Science 2023; DOI: 10.1002/ADVS.202303614 (IF 15.1)
  3. Duong V, Oo WM, Ding C, Culvenor AG, Hunter DJ. Evaluation and Treatment of Knee Pain: A Review. JAMA. 2023 Oct 24;330(16):1568-1580. doi: 10.1001/jama.2023.19675. PMID: 37874571. (IF 120.7)
  4. Zhang Y, Xie J, Wen S, Cao P, Xiao W, Zhu J, Li S, Wang Z, Cen H, Zhu Z, Ding C*, Ruan G. Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits. Ann Rheum Dis. 2023 Aug 18:ard-2023-224459. doi: 10.1136/ard-2023-224459.  (IF 27.4)
  5. Zhang C, Huang H, Chen J, Zuo T, Ou Q, Ruan G, He J, Ding C*. DNA Supramolecular Hydrogel-Enabled Sustained Delivery of Metformin for Relieving Osteoarthritis. ACS Appl Mater Interfaces. 2023 Mar 21. doi: 10.1021/acsami.2c20496.  (IF 10.383)
  6. Zhu Z, Huang JY, Ruan G, Cao P, Chen S, Zhang Y, Han W, Chen T, Cai X, Liu J, Tang Y, Yu N, Wang Q, Hunter D, Wei JCC, Ding C*. Association between metformin use and risk of total joint replacement in patients with type 2 diabetes: a population-based matched cohort study. CAMJ.  2022 Dec 19;194(49):E1672-E1684 (IF: 16.859)
  7. Tang S, Cao Y, Cai Z, Nie X, Ruan J, Zhou Z, Ruan G, Zhu Z, Han W, Ding C*. The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1. Sci Signal. 2022;15(735):eabm6265. (IF 9.517)
  8. Li J, Fu S, Gong Z, Zhu Z, Zeng D, Cao P, Lin T, Chen T, Wang X, Lartey R, Kwoh CK, Guermazi A, Roemer FW, Hunter DJ, Ma J, Ding C*. MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict Knee Osteoarthritis Incidence. Radiology. 2022 31:212009. (IF 29.146)
  9. Cai Y, Wu C, Ou Q, Zeng M, Xue S, Chen J, Lu Y, Ding C*. Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1. Bioact Mater. 2022;19:444-457. (IF 16.874)
  10. Lu Y, Li Z, Li L, Chen J, Xu X, Lin Z, Zhang T, Zhu Y, Ding C*, Mao C. Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells. Biomaterials. 2022;283:121474.(IF 15.304)
  11. Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C*. Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling. Cell Death Dis. 2022;13(8):695.  (IF 9.685)
  12. Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Zhu Z, Ding C*. Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression. EBioMedicine. 2021;65:103283.  (IF 11.205)
  13. Zhou R, Chen Y, Li S, Wei X, Hu W, Tang S, Ding J, Fu W, Zhang H, Chen F, Hao W, Lin Y, Zhu R, Wang K, Dong L, Zhao Y, Feng X, Chen F, Ding C*, Hu W. TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis. Redox Biol. 2022 Jul 19;55:102411. (IF 10.787)
  14. Xue S, Xu Y, Xu S, Zhong Y, Ruan G, Ma J, Hu Y, Ding C*, Sang W. Mitophagy impairment mediates the pathogenesis of CoCrMo particle-induced osteolysis via NLRP3/caspase-1/GSDMD-dependent pyroptosis in macrophages. Chemical Engineering Journal, 2022, 435, 135115. (IF 16.744)
  15. Lu Y, Li L, Du J, Chen J, Xu X, Yang X, Ding C*, Mao C. Immunotherapy for Tumor Metastasis by Artificial Antigen-Presenting Cells via Targeted Microenvironment Regulation and T-Cell Activation. ACS Appl Mater Interfaces. 2021;13(47):55890-55901. (IF 10.383)
  16. Jin X, Jones G, Cicuttini F, Wluka AE, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard CL, Ding C*. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA: the journal of the American Medical Association 2016; 313 (10): 1005-13. (IF: 157.335)
  17. Han W, Aitken D, Zhu Z, Halliday A, Wang X, Antony B, Cicuttini F, Jones G, Ding C*. Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study. Ann Rheum Dis. 2016; 75(10): 1783-8 (IF: 27.973)
  18. Wang X, Blizzard L, Halliday A, Han W, Jin X, Cicuttini F, Jones G, Ding C*. Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study. Ann Rheum Dis 2016; 75: 519-25. (IF: 27.973)
  19. Wang X, Blizzard L, Jin X, Chen Z, Zhu Z, Halliday A, Cicuttini F, Jones G, Ding C*. Quantitative knee effusion-synovitis assessment in older adults: associations with knee structural abnormalities. Arthritis & Rheumatology 2016; 68(4):837-44 (IF: 15.483)
  20. Antony B, Jones, G, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Cross M, Ding C*. The association between childhood overweight measures and adulthood knee pain, stiffness and dysfunction: a 25-year cohort study. Annals of the Rheumatic Diseases 2015; 74(4):711-7. (IF: 27.973)
  21. Jin X, Beguerie J, Zhang W, Blizzard L, Ttahal P, Jones G, Ding C*. Circulating C-Reactive Protein in Osteoarthritis: a Systematic Review and Meta-Analysis. Annals of the Rheumatic Diseases 2015; 74(4):703-10 (IF: 27.973)
  22. Stannus O, Cao Y, Jones G, Blizzard L, Antony B, Ding C*. Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults. Annals of the Rheumatic Diseases 2015; 74(1): 82-8 (IF: 27.973)
  23. Pan F, Han W, Wang X, Liu Z, Jin X, Antony B, Cicuttini F, Jones G, Ding C*. A longitudinal study of the association between infrapatellar fat pad maximal area and changes in knee symptoms and structure in older adults. Ann Rheum Dis. 2015; 74(10): 1818-24 (IF: 27.973)
  24. Cao Y, Stannus O, Aitken D, Cicuttini F, Jones G, Antony B, Ding C*. Cross-sectional and longitudinal associations between systemic, subchondral bone mineral density and knee cartilage thickness in older adults with or without radiographic osteoarthritis. Annals of the Rheumatic Diseases 2014; 73(11): 2003-9 (IF: 27.973)
  25. Stannus O, Jones G, Blizzard, Cicuttini F, Ding C*. Associations between serum levels of inflammatory markers L and change in knee pain over 5 years in older adults: a prospective cohort study. Annals of the Rheumatic Diseases 2013; 72(4):535-40. (IF: 27.973)
  26. Ding C, Cicuttini F, Jones G. Vitamin D supplementation in patients with osteoarthritis (letter). JAMA. 2013;309(15):1583 (IF: 157.335)
  27. Ding C*, Parameswaran V, Blizzard, Burgess J, Jones G. Not a simple fat soluble vitamin: changes in serum 25(OH)D levels are predicted by adiposity, adipocytokines and lipids in older adults. Journal of Internal medicine 2010; 268:  501-10 (IF: 6.051) (IF 13.068)
  28. Ding C*, Parameswaran V, Cicuttini F, Burgess J, Jones G. Serum levels of vitamin D, sunlight exposure and knee cartilage loss in older adults: the Tasmania Older Adult Cohort (TASOAC) study. Arthritis & Rheumatism 2009; 60(5): 1381-1389 (IF 15.483)
  29. Ding C*, Parameswaran V, Cicuttini F, Burgess J, Zhai G, Quinn S, Jones G. Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian Older Adult Cohort (TASOAC) study. Annals of Rheumatic Diseases 2008: 67(9):1256-61 (IF: 27.973)
  30. Ding C*, Cicuttini F, Scott F, Cooley H, Boon C, Jones G. Natural history of knee cartilage defects and factors affecting change. JAMA of Internal Medicine 2006; 166 (6): 651-8 (IF 44.409)
  31. Ding C, Cicuttini F, Scott F, Boon C, Jones G. Prevalent and incident knee cartilage defects are associated with tibial and patellar cartilage loss: a longitudinal study. Arthritis & Rheumatism 2005; 52: 3918-27 (IF 15.483)
  32. Ding C, Cicuttini F, Scott F, Cooley H, Jones G. The association between age and knee structural change: a cross-sectional MRI-based study. Annals of the Rheumatic Disease 2005; 64:549-55(IF: 27.973)