学习经历：

1994.09-1998.07 沈阳药科大学药物化学专业    本科

2001.09-2004.07 第一军医大学药理学专业    硕士

2006.09-2010.07 南方医科大学药理学专业    博士

工作经历：

1998.07-2004.06 第一军医大学基础部  助教

2004.06-2008.06 南方医科大学药学院  讲师

2008.08-2010.05 美国纽约血液中心LFK研究所 访问学者

2008.06-2012.12 南方医科大学药学院  副教授

2013.01-2013.03 美国加州大学洛杉矶分校 访问学者

2013.01-至今   南方医科大学药学院  教授

1. HIV病毒潜伏感染的分子机制及宿主调控因子的研究； 

2. 病毒进入抑制剂的高通量药物筛选研究；

3. 新发突发传染病的防治药物研究

代表性科研论文：

1. Ding K^#, Wu Z^#, Zhang N, He J, Wu J, Bai H, Zhang W*, Li L*, Xu J*. Stelleratenoids A−F, macrocyclic daphnane orthoesters with anti-HIV activity from the roots of Stellera chamaejasme. Phytochemistry. 2023 Mar 22;113648. IF: 4.004 2区
2. Zhang X ^#, Li A^#, Li T, Shou Z, Li Y, Qiao X, Zhou R, Zhong X, Li S, Li L*. A potential anti-HIV-1 compound, Q308, inhibits HSV-2 infection and replication in vitro and in vivo. Biomedicine & Pharmacotherapy. 2023 Mar 27;162:114595. IF: 7.419 一区
3. Li Y^#, Wu Y, Li S, Li Y, Zhang X, Shou Z,  Gu S, Zhou C,Xu D，Zhao K, Tan S,  Qiu J,  Pan X, Li L*. Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome. Biomed Pharmacother. 2022 Dec;156:113946. IF:7.419. 一区
4. Liang T^#, Wu Z^#, Li Y^#, Li C, Zhao K, Qiao X, Duan H, Zhang X, Liu S, Xi B*, Li L*. A synthetic resveratrol analog termed Q205 reactivates latent HIV-1 through activation of P-TEFb. Biochem Pharmacol.  2021 Dec 29; 197:114901. IF:5.858.一区
5. Niu X^#,  Wang W^#,  Liang T^#,  Li S,  Yang C,  Xu X,  Li L*,  Liu S*. CPI-203 improves the efficacy of anti-PD-1 therapy by inhibiting the induced PD-L1 overexpression in liver cancer. Cancer Science. 2021 Nov 2. doi: 10.1111/cas.15190. IF：6.7160 二区.
6. Zhou C^#, Huang Y^#, Li Y, Liang T, Zheng T, Chen P, Wu Z, Lai F, Liu S, Xi B*, Li L*. A new small-molecule compound, Q308, silences latent HIV-1 provirus by suppressing Tat and FACT mediated transcription. Antimicrobial Agents and Chemotherapy. 2021 Sep 7; AAC0047021; 二区，IF: 5.191 小类一/二区.
7. Liang T^#, Zhang Q^#, Wu Z, Chen P, Huang Y, Liu S, Li L*. UHRF1 suppresses HIV-1 transcription and promotes HIV-1 latency by competing with p-TEFb for ubiquitination-proteasomal degradation of Tat. mBio. 2021; Aug 31; 12(4):e0162521. IF: 7.867. 小类一区
8. Zheng T^#, Chen P^#, Zhou C, Wu Z, Huang Y, Li Li*. CPI-637 as a potential bifunctional latency reversing agent by targeting both BRD4 and TIP60 proteins. Frontiers in Cellular and Infection Microbiology. 2021;  Jul 19; 11:686035. IF: 5.293. 大类二区，小类三区。
9. Xiong W^#, Zhou C^#, Yin S, Chai J, Zeng B, Wu J, Li Y, Li L*, Xu X*. Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV-1 Entry by Targeting Gp41. ACS Omega. 2021; 6(9):6414-6423. IF: 3.512. 三区
10. Liang T^#, Qiu J^#, Niu X^#, Ma Q^#, Zhou C, Chen P, Zhang Q, Chen M, Yang Z*, Liu S* and Li L*. Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor. Front. Pharmacol. 2021; 11:603830. IF: 5.810. 二区
11. Ding LQ^#, Jiang P^#, Xu XF, Lu WZ, Yang C, Li L*, Zhou PZ*, Liu SW*. T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication. European Journal of Pharmacology, 2021; 892: 173782.  IF: 4.432 二区
12. Qiu J^#, Liang T^#, Wu J, Yu F, He X, Tian Y*, Xie L, Jiang S, Liu S*, Li L*. N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein. Front Pharmacol. 2019; 10:859. IF: 5.810. 二区
13. Liang T^#, Zhang X^#, Lai F, Lin J, Zhou C, Xu X, Tan X, Liu S*, Li L*. A novel bromodomain inhibitor, CPI-203, serves as an HIV-1 latency-reversing agent by activating positive transcription elongation factor b. Biochem Pharmacol. 2019 Jun; 164:237-251. IF:5.858.一区

在研科研课题：

1.国家自然科学基金面上项目。基于宿主硫氧还蛋白互作蛋白TXNIP的HIV潜伏调控研究。2023.1-2026.12。52万元

2. 国家自然科学基金面上项目。多域泛素化连接酶UHRF1作为HIV潜伏逆转剂新靶点的研究。2021.1-2024.12。 55万元

3. 广东省基础与应用基础研究基金自然科学基金面上项目，靶向BRD4蛋白的新型HIV潜伏促进剂调控HIV潜伏的作用及分子机制研究，2022.01-2024.12。10万元。