一、主持科研课题
1. 国家自然科学基金青年科学基金,81901362,miRNA-139-5p通过靶向PDE4D调控cAMP/PKA/CREB信号通路抗抑郁的机制,2020.01--2022.12,结题,主持;
2. 广东省基础与应用基础研究基金省市联合基金地区培育项目(粤基金字[2022]18号),2022A1515140127 Guangdong Basic and Applied Basic Research Foundation (2022A1515140127),基于单细胞核测序联合空间转录组测序的人类胎儿脑皮质颞下回发育细胞多样性及放射状胶质细胞空间异质性的研究,2022.10--2025.09,在研,主持;
3. 佛山市妇幼保健院院内立项项目,FEYJZX-2021-003,基于单细胞多组学的人类胎儿脑发育过程中基因表达模式和细胞类型及功能改变的研究(伦理批件号:FSFY-MEC-2021-129,伦理跟踪审查批件号:FSFY-MEC-2022- 098),2022.01--2027.12,在研元;
4. 博士后科学基金面上资助(中博基字[2019]2号),2019M652969,miRNA-139-5p通过靶向PDE4D发挥抗抑郁作用的机制,2019.07--2021.12,结题,主持;
5. 广东省中医药局中医药科研项目(粤中医函[2019]476号),20201340,加味逍遥散颗粒抗抑郁作用机制的网络药理学研究,2020.01--2021.12,结题,主持;
6. 佛山市科技局医学攻关项目(佛科[2019]128号),1920001000269,miR-124-3p通过靶向BDNF减少小鼠海马神经发生诱导抑郁症的机制研究,2020.01--2021.12,结题,主持;
7. 佛山市妇幼保健院引进高层次人才科研经费项目,FY2021006,基于单细胞多组学的人类胎儿脑发育过程中基因表达模式和细胞类型及功能改变的研究,2022.10--2025.12,在研,主持元。
二、发表文章
发表SCI文章16篇,其中,通讯作者文章2篇,第一作者文章6篇,共同作者文章8篇。
(一)通讯作者论文(2篇):
1. Jing Ren#, Chenyang Li#, Songren Wei, Yanjun He, Peng Huang*, Jiangping Xu*. Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data, Frontiers in Genetics, 2022, 13: 890961. (IF=4.772/3.7, JCR 3区)
2. Li Xiao, Wanhua Zhang, Yin Huang, Peng Huang. Intestinal ischemia-reperfusion induces the release of interleukin 17A to regulate cell inflammation, apoptosis and barrier damage. Experimental and Therapeutic Medicine, 2022, 23(2): 158. (IF=2.751, JCR 3区)
(二)第一/共同第一作者论文(6篇):
1. Peng Huang#, Songren Wei#, Meng Luo, Zhuohong Tang, Qingmei Lin, Xing Wang, Mi Luo, Yanjun He, Chuan Wang, Dezhan Wei, Chenglai Xia*, Jiangping Xu*. MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway. Annals of Translational Medicine, 2021.9(20):1594. (IF=3.616, JCR 3区)
2. Peng Huang#, Songren Wei#, Jing Ren, Zhuohong Tang, Mingjuan Guo, Fen Situ, Dan Zhang, Jianghua Zhu, Li Xiao*, Jiangping Xu*, Guoqing Liu*. microRNA-124-3p alleviates cerebral ischaemia-induced neuroaxonal damage by enhancing Nrep expression. Journal of Stroke and Cerebrovascular Diseases, 2022, 32(2): 106949. (IF=2.677/2.5, JCR 4区)
3. Peng Huang#, Zhaoyang Dong#, Weiliang Huang, Chuying Zhou, Weichao Zhong, Peiqian Hu, Ge Wen, Xuegang Sun, Heyu Hua, Huihui Cao, Lei Gao*, Zhiping Lv*. Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice. Behavioural brain research, 2017, 330: 17-24. (IF=3.352/2.7,JCR 3区,)
4. Peng Huang, Tingting Gao, Zhaoyang Dong, Chuying Zhou, Yuling Lai, Ting Pan, Yuan Liu, Xiaohua Zhao, Xuegang Sun, Heyu Hua, Ge Wen*, Lei Gao*, Zhiping Lv*. Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD - fMRI signals. Brain research bulletin, 2018, 142: 107-115. (IF=4.077/3.8,JCR 2区)
5. Chen Rui#,Huang Peng#,Wei Songren,Cui Zhang, Xiaoping Lai, Huijun Wang, Jianpin Tang. Methamphetamine exposure increases cardiac microvascular permeability by activating the VEGF-PI3K-Akt-eNOS signaling pathway, reversed by Bevacizumab. Human & Experimental Toxicology. 2022;41: 9603271221121795. (IF=3.247 )
6. Lei Gao#, Peng Huang#, Zhaoyang Dong, Tingting Gao, Shaohui Huang, Chuying Zhou, Yuling Lai, Guanghui Deng, Bin Liu*, Ge Wen*, Zhiping Lv*. Modified Xiaoyaosan (MXYS) Exerts Anti-depressive Effects by Rectifying the Brain Blood Oxygen Level-Dependent fMRI Signals and Improving Hippocampal Neurogenesis in Mice. Frontiers in pharmacology, 2018, 9: 1098.(IF=5.988/5.6,JCR 2区)
三、授权专利
1. 发明专利,黄鹏,一种用于药理学的药物加热搅拌反应器,2022.11.29,中国,CN115193325B(申请号202211125247.7)。
四、著作
1. 专著,刘凯,武文鹏,裴思颖,于杰,赵惠,王虹,黄鹏(主编),临床中西医结合治疗经验,中医古籍出版社,ISBN 978-7-5152-2541-8,国家版本图书馆CIP数据核字(2022)第136452号,2022年12月版。