目录
更新日期:2025年9月24日
姓 名 刘灿昭 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 Email liucanzhao0521@163.com
工作单位 珠江医院 邮政编码 510282
个人简介

刘灿昭,南方医科大学珠江医院转化医学研究中心/心血管内科教授、博士生导师。国家优青(海外)获得者。广东省杰出青年基金获得者。2015年至2021年于美国加州大学圣地亚哥分校(UCSDJu Chen教授实验室从事心脏发育方向研究。主持多项国家和省级科技计划项目。研究成果以第一作者或通讯作者(含共同)在Circulation2025, 2020, 2019),Nature Communications, Genome Biology, STTT, Circulation: Heart FailureJCI InsightJournal of Controlled Release, Br J Pharmacol等发表多篇高质量SCI论文。

 

 

 

研究领域

1. 膜接触位点依赖的钙稳态与心血管病机理

2. 心肌细胞发育成熟的分子机制

3. 离子通道及下游信号通路在心血管疾病中的作用

4. 心血管病学新技术开发                                                         

 
个人成果

#第一或共同第一作者,*通讯或共同通讯作者)

1. Yang H #, Zhong Y#, Guo W#, Guo WJ#, Chen B, Lin Z, Zhang Q, Zou R, Cao X, Li FX, Feng W, Yan J, Zeng Z, Wang W, Ouyang K, Xu X, Fan X, Fang X, Ai S*, Liu CZ*. TAX1BP3 is a SUMOylated Nucleocytoplasmic Shuttling Protein and Protects Against Vascular Neointimal Hyperplasia. Circulation. 2025.(医学一区)

 

2. Guo W#, Guo WJ#, Chen B#, Lin Z, Wen Z, Ye J, Feng W, Feng X, Yan J, Yang P, Ouyang K, Li Y, Yang H*, Ou C*, Liu CZ*. NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization. Nature Communications. 2025.(医学一区)

 

3. Liu CZ#, Spinozzi S#, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimaraes-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM and Chen J*. Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019.(医学一区)

 

4. Chen R, Zhang H, Tang B, Luo Y, Yang Y, Chen S, Zhong X, Xu X*, Huang S*, Liu CZ*. Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 2024.(医学一区)

 

5.    Feng W#, Liu CZ#, Spinozzi S, Wang L, Evans SM and Chen J*. Identifying the Cardiac Dyad Proteome In Vivo by a BioID2 Knock-In Strategy. Circulation. 2020. (医学一区)

 

6. Lin Z#, Wang C#, Wen Z#, Cai Z, Guo W, Feng X, Huang Z, Zou R, Fan X, Liu CZ* and Yang H*. NEXN regulates vascular smooth muscle cells phenotypic switching and neointimal hyperplasia. JCI Insight. 2025.(医学一区)

 

7. Guo W #, Chen H #, Liu F, Chen B, Liu CZ* and Cai Y*. Peptide amphiphiles alleviate myocardial endoplasmic reticulum stress to enhance cardiomyocyte-macrophage communication and promote macrophage M2 polarization. J Control Release. 2025.(医学一区)

 

8. Shao Y #, Liu CZ#, Liao HK, Zhang R, Yang H, Li R, Zhu S, Fang X, Chen J* and Belmonte JCI*. In Vivo Rescue of Genetic Dilated Cardiomyopathy by Systematic Delivery of Nexilin. Genome Biology. 2024.(医学一区)

 

9.    Liu CZ#, Spinozzi S#, Feng W, Chen Z, Zhang L, Zhu S, Wu T, Fang X, Ouyang K, Evans SM and Chen J*. Homozygous G650del nexilin variant causes cardiomyopathy in mice. JCI Insight. 2020. (医学一区)

 

10.   Spinozzi S#, Liu CZ#, Chen Z, Feng W, Zhang L, Ouyang K, Evans SM and Chen J*. Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes. Circulation: Heart Failure. 2020. (医学一区)

 

11.   Ma MM#, Lin CX#, Liu CZ#, Gao M, Sun L, Tang YB, Zhou JG, Wang GL* and Guan YY*. Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl(-) current and migration in cultured vascular smooth muscle cells. Br J Pharmacol. 2016. (医学一区)

 

12.   Liu CZ#*, Li FY#, Lv XF, Ma MM, Li XY, Lin CX, Wang GL and Guan YY*. Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation. Acta Pharmacol Sin. (医学一区)

 

13.   Li XY, Lv XF, Huang CC, Sun L, Ma MM, Liu CZ* and Guan YY*. LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension. Cell Prolif. 2021. (医学一区)

 

14.   Yang HY, Zhang C, Hu L, Liu C, Pan N, Li M, Han H, Zhou Y, Li J, Zhao LY, Liu YS, Luo BZ, Huang XQ, Lv XF, Li ZC, Li J, Li ZH, Wang RM, Wang L, Guan YY, Liu CZ*, Zhang B* and Wang GL*. Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl(-) concentration and activation of SGK1 signaling pathway. Acta Pharmacol Sin. 2022. (医学一区)