杨清武教授，陆军军医大学新桥医院神经内科主任、主任医师、教授，博士研究生导师、博士后合作导师、陆军军医大学脑与智能研究院副院长，是国家杰出青年科学基金获得者、国家教育部长江学者特聘教授、国家万人计划科技创新领军人才、国家科技部科技创新领军人才，享受国务院特殊津贴，并获首届中国杰出神经内科青年医师奖、学术成就奖及2015年科学中国人杰出青年科学家奖，享受军队优秀人才岗位津贴，获评全军高层次创新人才工程拔尖人才，入选为重庆市英才计划优秀科学家、重庆市科技创新领军人才、重庆市首席专家工作室专家。杨清武教授在神经内科急危重症、疑难病及神经介入诊治方面有丰富经验，主要从事急性脑血管病防治的基础与临床转化研究。作为全军临床重点专科学科带头人，杨清武教授兼任重庆市神经病学临床医学研究中心、重庆市重点学科、重庆市临床重点专科、重庆市脑血管防治创新群体负责人，享受国务院特殊津贴。近年来主持国家自然科学基金重大项目、杰青项目等20余项，联合国际、国内近200家临床科研单位牵头开展8个国际多中心临床研究，总经费达6000余万元。以通讯作者在NEJM（1篇）、JAMA（5篇）等国际顶尖期刊发表论文近100篇，单篇最高影响因子158.5。3篇被评为ESI高引论文，论文他引5000余次，单篇最高他引412次，连续3年被评为高被引科学家。

急性脑血管病炎症损伤机制及脑保护策略研究

急性脑血管病防治的基础与临床转化研究

急性缺血性卒中

1.Zi W, Song J, Kong W, Huang J, Guo C, He W, Yu Y, Zhang B, Geng W, Tan X, Tian Y, Liu Z, Cao M, Cheng D, Li B, Huang W, Liu J, Wang P, Yu Z, Liang H, Yang S, Tang M, Liu W, Huang X, Liu S, Tang Y, Wu Y, Yao L, Shi Z, He P, Zhao H, Chen Z, Luo J, Wan Y, Shi Q, Wang M, Yang D, Chen X, Huang F, Mu J, Li H, Li Z, Zheng J, Xie S, Cai T, Peng Y, Xie W, Qiu Z, Liu C, Yue C, Li L, Tian Y, Yang D, Miao J, Yang J, Hu J, Nogueira RG, Wang D, Saver JL, Li F, Yang Q; RESCUE BT2 Investigators. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion. N Engl J Med. 2023 Jun 1;388(22):2025-2036. doi: 10.1056/NEJMoa2214299. PMID: 37256974.

2.RESCUE BT Trial Investigators; Qiu Z, Li F, Sang H, Luo W, Liu S, Liu W, Guo Z, Li H, Sun D, Huang W, Zhang M, Zhang M, Dai W, Zhou P, Deng W, Zhou Z, Huang X, Lei B, Li J, Yuan Z, Song B, Miao J, Liu S, Jin Z, Zeng G, Zeng H, Yuan J, Wen C, Yu Y, Yuan G, Wu J, Long C, Luo J, Tian Z, Zheng C, Hu Z, Wang S, Wang T, Qi L, Li R, Wan Y, Ke Y, Wu Y, Zhu X, Kong W, Huang J, Peng D, Chang M, Ge H, Shi Z, Yan Z, Du J, Jin Y, Ju D, Huang C, Hong Y, Liu T, Zhao W, Wang J, Zheng B, Wang L, Liu S, Luo X, Luo S, Xu X, Hu J, Pu J, Chen S, Sun Y, Jiang S, Wei L, Fu X, Bai Y, Yang S, Hu W, Zhang G, Pan C, Zhang S, Wang Y, Cao W, Yang S, Zhang J, Guo F, Wen H, Zhang J, Song J, Yue C, Li L, Wu D, Tian Y, Yang J, Lu M, Saver JL, Nogueira RG, Zi W, Yang Q. Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial. JAMA. 2022 Aug 9;328(6):543-553. doi: 10.1001/jama.2022.12584. PMID: 35943471; PMCID: PMC9364124.

3.Li Q, Abdalkader M, Siegler JE, Yaghi S, Sarraj A, Campbell BCV, Yoo AJ, Zaidat OO, Kaesmacher J, Pujara D, Nogueira RG, Saver JL, Li L, Han Q, Dai Y, Sang H, Yang Q, Nguyen TN, Qiu Z. Mechanical Thrombectomy for Large Ischemic Stroke: A Systematic Review and Meta-analysis. Neurology. 2023 Aug 29;101(9):e922-e932. doi: 10.1212/WNL.0000000000207536. Epub 2023 Jun 5. PMID: 37277200; PMCID: PMC10501098.

4.Zi W, Qiu Z, Li F, Sang H, Wu D, Luo W, Liu S, Yuan J, Song J, Shi Z, Huang W, Zhang M, Liu W, Guo Z, Qiu T, Shi Q, Zhou P, Wang L, Fu X, Liu S, Yang S, Zhang S, Zhou Z, Huang X, Wang Y, Luo J, Bai Y, Zhang M, Wu Y, Zeng G, Wan Y, Wen C, Wen H, Ling W, Chen Z, Peng M, Ai Z, Guo F, Li H, Guo J, Guan H, Wang Z, Liu Y, Pu J, Wang Z, Liu H, Chen L, Huang J, Yang G, Gong Z, Shuai J, Nogueira RG, Yang Q; DEVT Trial Investigators. Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial. JAMA. 2021 Jan 19;325(3):234-243. doi: 10.1001/jama.2020.23523. PMID: 33464335; PMCID: PMC7816099.

5.Xiong XY, Pan XR, Luo XX, Wang YF, Zhang XX, Yang SH, Zhong ZQ, Liu C, Chen Q, Wang PF, Chen XW, Yu SG, Yang QW. Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation. Theranostics. 2024 Jul 8;14(11):4297-4317. doi: 10.7150/thno.96375. PMID: 39113798; PMCID: PMC11303085.

6.Xie L, Zhang S, Huang L, Peng Z, Lu H, He Q, Chen R, Hu L, Wang B, Sun B, Yang Q, Xie Q. Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury. Brain Behav Immun. 2023 Jan;107:330-344. doi: 10.1016/j.bbi.2022.11.001. Epub 2022 Nov 9. PMID: 36371010.

7.Xiong XY, Tang Y, Yang QW. Metabolic changes favor the activity and heterogeneity of reactive astrocytes. Trends Endocrinol Metab. 2022 Jun;33(6):390-400. doi: 10.1016/j.tem.2022.03.001. Epub 2022 Apr 5. PMID: 35396164.

8.Guo C, Li L, Huang J, Yang J, Song J, Huang J, Peng Z, Yu N, Liu C, Kong W, Hu J, Chen L, Guo M, Yue C, Yang D, Liu X, Miao J, Wang M, Luo X, Tang Z, Bai X, Wang D, Li F, Yang Q, Zi W. Endovascular treatment versus standard medical treatment in patients with established large infarct: a cohort study. Int J Surg. 2024 Aug 1;110(8):4775-4784. doi: 10.1097/JS9.0000000000001539. PMID: 38716876; PMCID: PMC11326037.

9.Kong W, Yuan J, Huang J, Song J, Zhao C, Sang H, Luo W, Xie D, Gao F, Li H, Luo J, Liu S, Xue D, Yu Y, Li F, Qiu Z, Zi W, Yang Q. Outcomes of Endovascular Therapy in Acute Basilar Artery Occlusion With Severe Symptoms. JAMA Netw Open. 2021 Dec 1;4(12):e2139550. doi: 10.1001/jamanetworkopen.2021.39550. PMID: 34913974; PMCID: PMC8678675.

10.Writing Group for the BASILAR Group; Zi W, Qiu Z, Wu D, Li F, Liu H, Liu W, Huang W, Shi Z, Bai Y, Liu Z, Wang L, Yang S, Pu J, Wen C, Wang S, Zhu Q, Chen W, Yin C, Lin M, Qi L, Zhong Y, Wang Z, Wu W, Chen H, Yao X, Xiong F, Zeng G, Zhou Z, Wu Z, Wan Y, Peng H, Li B, Hu X, Wen H, Zhong W, Wang L, Jin P, Guo F, Han J, Fu X, Ai Z, Tian X, Feng X, Sun B, Huang Z, Li W, Zhou P, Tu M, Sun X, Li H, He W, Qiu T, Yuan Z, Yue C, Yang J, Luo W, Gong Z, Shuai J, Nogueira RG, Yang Q. Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry. JAMA Neurol. 2020 May 1;77(5):561-573. doi: 10.1001/jamaneurol.2020.0156. PMID: 32080711; PMCID: PMC7042866.