广东省“珠江青年学者”，2013年博士毕业于西南大学（与军事医学科学院联合培养）2014年起在英国爱丁堡大学皇后医学研究所从事博士后研究，师从著名造血干细胞发育专家Elaine Dzierzak 教授。2018年以南方医科大学“第三层次人才”引进回国。主要从事造血干细胞发育及白血病发病机理调控研究，研究成果发表于Cell Stem Cell、Blood、Nature Communications（已接受）、 The EMBO Journal（已接受）、Haematologica 等杂志10余篇，引用超过500余次。主要学术贡献：小鼠胚胎头部作为造血干细胞发育新位点，并贡献成体造血系统（Cell Stem Cell, 2012）；卵黄囊来源的巨噬细胞通过促炎性因子调控胚胎头部造血发生（Blood, 2019）；发掘胚胎主动脉-性腺-中肾区和头部造血干祖细胞发育的调控因素（Haematologica, 2021）；阐明了微环境因素-巨核细胞调控胚胎AGM区内皮生血及造血干细胞前体形成的分子机制（Nature Communications，已接受,2024）；揭示了细胞自噬影响AGM区Pre-HSC成熟的调控机理（The EMBO Journal，已接受,2024）。先后主持国家自然科学基金项目3项，以课题负责人和项目骨干参与国家科技部重点研发计划2项。

1. 造血干细胞发育微环境异质性
2. 炎性通路对造血干细胞发育调控机理
3. 肿瘤微环境对血液肿瘤的调控作用

1. Wenyan He*^,#, Ying Zhang*, Zhan Cao, Zehua Ye, Xun Lu , Junwan Fan, Wei Peng, Zhuan Li^#. Wild-Type p53-Induced Phosphatase 1 Plays a Positive Role in Hematopoiesis in the Mouse Embryonic Head. Frontiers in Cell and Developmental Biology, 2021,9.
2. Wenyan He, Xiaobo Wang, Yanli Ni, Zongcheng Li, Wei Liu, Zhilin Chang, Haowen Li, Zhengyu Ju^#, Zhuan Li^#. Wip1 regulates hematopoietic stem cell development in the mouse embryo, Haematologica, 2021,106(2): 580-584.
3. Zhuan Li^#, Samanta A. Mariani, Carmen Rodriguez-Seoane, Wenyan He, Xiaowei Ning, Bing Liu, Chris S. Vink, and Elaine Dzierzak^#. A role for macrophages in hematopoiesis in the embryonic head. (2019). Blood, 134(22), 1929-1940.
4. Samanta Antonella Mariani^#, Zhuan Li, Siobhan Rice, Carsten Krieg, Stamatina Fragkogianni, Mark Robinson, Christeun Sebastiaan Vink, Jeffrey William Pollard and Elaine Dzierzak^#. Pro-inflammatory aorta-associated macrophages are involved in embryonic development of hematopoietic stem cells. (2019). Immunity. 50(6), 1439-1452.
5. David AD Munro*, Yishay Wineberg, Julia Tarnick, Chris S Vink, Zhuan Li, Clare Pridans, Elaine Dzierzak, Tomer Kalisky, Peter Hohenstein,
Jamie A Davies. Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development. (2019). eLIFE.8:e43271.
6. Zhuan Li, Chris S. Vink, Samanta A. Mariani, Elaine Dzierzak. (2016) Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head. Developmental Biology. 416(1-1), 34-41.
7. Fan Zhou*, Xianlong Li*, Weili Wang*, Ping Zhu*, Jie Zhou*, Wenyan He*, Meng Ding, Fuyin Xiong, Xiaona Zheng, Zhuan Li, Yanli Ni, Xiaohuan Mu, Lu Wen, Tao Cheng, Yu Lan, Weiping Yuan^#, Fuchou Tang^# & Bing Liu^#. (2016) Tracing haematopoietic stem cell formation at single-cell resolution. Nature. 533(7604), 487-92.
8. Yunze Zhao, Jie Zhou, Dan Liu, Fang Dong, Hui Cheng, Weili Wang, Yakun Pang, Yajie Wang, Xiaohuan Mu, Yanli Ni, Zhuan Li, Huiyu Xu, Sha Hao, Xiaochen Wang, Shihui Ma, Qian-fei Wang, Guozhi Xiao, Weiping Yuan^#, Bing Liu^#, and Tao Cheng^#. (2015). ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 126(21), 2383-2391.
9. Yu Lan*, Wenyan He*, Zhuan Li, Yu Wang, Jun Wang, Jiao Gao, Weili Wang, Tao Cheng, Bing Liu^#, and Xiao Yang^#. (2014). Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation. Blood. 123(14), 2161-2171.
10. Zhuan Li*, Fan Zhou*, Dongbo Chen, Wenyan He, Yanli Ni, Lingfei Luo, Bing Liu. (2013). Generation of Hematopoietic Stem Cells from Purified Embryonic Endothelial Cells by a Simple and Efficient Strategy. Journal of Genetics and Genomics 40, 557-563.
11. Zhuan Li*, Yu Lan*, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang^#, and Bing Liu^#. (2012). Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell 11, 663-675.
12. Wei-xi Niu, Huang He, Liang-yu Zhao, Zhuan Li, Wen-yan He, Bing Liu, Long-gui Li, and Jia-xiang Xiong. (2012). Characterization of hemangioblast in umbilical arteries of mid-gestation mouse embryos. Int J Hematol 95, 632-639.
13. Xinlong Yan, Yu Lan, Xiaoyan Wang, Wenyan He, Huiyu Yao, Dongbo Chen, Jiaxiang Xiong, Jiao Gao, Zhuan Li, Xiusen Li, Jiyan Zhang, Bing Liu, and Ning Mao. (2011).Migration of dorsal aorta mesenchymal stem cells induced by mouse embryonic circulation. Development Dynamics 240(1), 67-74.
14. Wen-yan He, Yu Lan, Hui-yu Yao, Zhuan Li, Xiao-yan Wang, Xiu-sheng Li, Ji-yan Zhang, Yu Zhang, Bing Liu^#, and Ning Mao^#. (2010). Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region. Haematologica 95, 875-883.