目录
关闭
更新日期：2025年10月24日
姓 名 杨新平 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 理学博士学位
行政职务 其他 Email xpyang1@smu.edu.cn
工作单位 南方医科大学南方医院 邮政编码
跨学科招生 是
跨学科招生专业1 临床遗传学 招生层次类型1 学术学位博导
跨学科招生专业2 招生层次类型2
个人简介

杨新平 （Xinping Yang）

博士，教授，博士生导师 (PhD, Professor, Advisor of PhD students)

南方医科大学南方医院 (Southern Medical University Nanfang Hospital)

Email: xpyang1@smu.edu.cn

Phone: +86-191-2823-7076

ORCID：https://orcid.org/0000-0003-4086-4180

Lab Page：https://lab.rjmart.cn/10490/E4988009074DE263

 

个人简介：

杨新平，湖南师大读学士（1979-1983）、中科院遗传所读硕士（1991-1994）、中南大学湘雅医学院博士毕业（1995-1998，师从夏家辉院士)，2000年中国科学院上海生理所博士后出站（1998-2000，师从贺林院士），2000年赴美国哈佛大学医学院做博士后（2000-2005师从Richard Stone教授，2005-2014 Marc Vidal教授），2015年作为高层次人才引进到南方医科大学。

1998-2000年在中科院上海生理所和中科院生命科学中心读博士后期间，研究成果发表在American Journal Human Genetics 和 Nature Genetics上。研究成果获得了国家自然科学奖二等奖和国家科学技术进步一等奖。

2000至2015年在哈佛医学院，从事分子网络研究，以第一作者在世界顶级刊物Cell、Nature Methods、Nature Communications等杂志上发表多篇研究论文。

2015年以来在南方医科大学任教授，是南方医院妇产科、南方医科大学基础医学院教育部精神健康研究院和南方医科大学基础医学院生物信息的多重PI，建立了遗传发育系统生物学研究中心（实验室），主要从事胎盘发育疾病以及发育相关的重大精神疾病研究。

主持国家自然科学基金面上项目4项、广东省自然科学基金重大培育项目1项、区域联合项目1项、广东省科技计划重点项目1项，广州市科技计划重点项1项。2015年以来，在Cell (2016)、Advanced Sciences (2020)、Hypertension (2020)、Theranostics (2021a, 2021b, 2024)、Molecular Autism (2020)、Molecular Therapy -Nuclei Acids (2020)、iScience (2021, 2023)、Journal of Translational Medicine（2023）、BMC Biology（2024, 2025）、Brain Behavior and Immunity（2025）等杂志连续发表高质量研究论文；培养了多名研究人员、博士后、博士生和硕士研究生；获得10项发明专利；研究成果获得广东省医学科技奖二等奖。

《生命科学研究》杂志第三届编辑委员会、广东省遗传学第十届理事会理事、广东省医学会医学遗传学分会委员。

 

Biography

Yang Xinping earned his Bachelor’s degree from Hunan Normal University (1979-1983). He subsequently obtained his Master’s degree from the Institute of Genetics, Chinese Academy of Sciences (1991-1994), and his Ph.D. from Xiangya School of Medicine, Central South University (1995-1998), under the supervision of Academician Xia Jiahui. He completed his first postdoctoral fellowship at the Shanghai Institute of Physiology, Chinese Academy of Sciences (1998-2000), mentored by Academician He Lin. In 2000, he moved to Harvard Medical School for further postdoctoral research (2000-2005 under Professor Richard Stone; 2005-2014 under Professor Marc Vidal). In 2015, he was recruited as a high-level talent to Southern Medical University.

During his postdoctoral fellowship at the Shanghai Institute of Physiology and the Life Science Research Center, CAS (1998-2000), his research findings were published in the American Journal of Human Genetics and Nature Genetics. This work contributed to projects that received the National Natural Science Award (Second Class) and the National Scientific and Technological Progress Award (First Class).

From 2000 to 2015 at Harvard Medical School, he focused on molecular network research, publishing several first-author papers in top-tier international journals including Cell (2016), Nature Methods (2008, 2011), and Nature Communications (2014), Cancer Research (2005).

Since joining Southern Medical University in 2015 as a professor, he has held multiple Principal Investigator (PI) roles at the Nanfang Hospital (Obstetrics and Gynecology Department), the Institute of the Ministry of Education Mental Health at the School of Basic Medical Sciences, and the Bioinformatics Department of the School of Basic Medical Sciences. He founded the Center for Genetics and Development Systems Biology primarily focusing on placental developmental disorders and major mental illnesses.

He has served as principal investigator for four grants from the National Natural Science Foundation of China, one Major Cultivation Project from the Guangdong Natural Science Foundation, one Regional Joint Fund Project, one Key Project from the Guangdong Science and Technology Program, and one Key Project from the Guangzhou Science and Technology Program. Since 2015, he has consistently published high-quality research papers in journals such as Cell (2016), Advanced Science (2020), Hypertension (2020), Theranostics (2021a, 2021b, 2024), Molecular Autism (2020), Molecular Therapy - Nucleic Acids (2020), iScience (2021, 2023), Journal of Translational Medicine (2023), BMC Biology (2024, 2025), and Brain, Behavior, and Immunity (2025). He has trained numerous researchers, postdocs, doctoral, and master's students; obtained 10 invention patents; and received the Guangdong Medical Science and Technology Award (Second Class).

He is a member of the Third Editorial Board of Life Science Research, a council member of the 10th Guangdong Provincial Society of Genetics, and a committee member of the Medical Genetics Branch of the Guangdong Medical Association.

 

 
 
研究领域

研究方向：

一、遗传和环境因素参与精神疾病发病的分子机制

本方向旨在通过系统生物学的方法，深入解析遗传易感性与环境压力如何协同作用，共同导致精神疾病的发生。我们不仅关注与疾病显著相关的基因位点，更致力于揭示这些遗传变异如何通过影响基因转录、蛋白质表达与修饰、表观遗传调控（如lncRNA参与DNA甲基化调控）等中间分子表型，最终破坏神经环路功能。具体而言，我们利用多组学整合分析（基因组、转录组、表观基因组、蛋白质组），在细胞模型、动物模型及不同病程的人体组织样本中，构建从遗传风险到环境应激、再到分子网络紊乱和细胞功能异常的完整因果链条。例如，研究特定环境因素（如早期应激）如何“打开”或“放大”个体的遗传风险，引发下游分子网络的级联反应，从而阐明自闭症、精神分裂症、抑郁症等复杂脑疾病的精准发病机制，并为开发个体化干预策略提供生物学靶点。

二、胎盘源性疾病对脑发育和脑功能的影响，及其导致精神疾病的机制

本方向聚焦于胎盘这一关键但常被忽视的脑发育调控器官，探讨胎盘功能紊乱如何作为生命早期起源，程序化地影响远期脑功能与精神健康。我们重点研究胎盘在应对母体压力、营养、感染等挑战时，其内分泌功能、免疫应答和营养转运能力的改变。这些改变会通过释放特定的信号分子（如激素、细胞因子），或通过影响母胎界面的营养物质与氧气的供应，直接干扰胎儿大脑的关键发育进程，包括神经发生、突触形成和髓鞘化。我们利用临床队列、胎盘特异性基因敲除动物模型及类器官共培养系统，系统解析胎盘源性信号如何塑造胎儿大脑的转录蓝图与表观遗传景观，并探寻其与产后神经发育障碍（如自闭症、精神分裂症）及成年后精神疾病风险增加之间的内在联系，旨在将胎盘确立为精神疾病早期预警和干预的新靶点。

三、环境对胎儿期和婴幼儿期脑发育和脑功能的影响，及其导致精神疾病的机制

本方向致力于系统阐明生命最早期的关键窗口期（胎儿期至婴幼儿期）内，各种环境暴露如何对快速发育的大脑产生深远的影响。研究的环境因素涵盖母体孕期心理与生理应激、营养状况、药物/毒素暴露、微生物组以及出生后的早期养育环境等。我们运用前瞻性出生队列，在个体发育的多个时间节点进行行为评估和神经影像学及生物样本采集，纵向追踪环境暴露与儿童脑结构/功能连接、认知情感发展轨迹的关联。在机制层面，我们重点研究环境因素通过表观遗传机制（如DNA甲基化、组蛋白修饰）对关键神经发育基因进行“编程”的分子过程，以及其对小胶质细胞、星形胶质细胞等非神经元细胞的调控，从而改变神经免疫稳态和突触修剪效率。最终目标是揭示不良早期环境导致精神疾病易感性增加的“编程”机制，为早期识别高风险个体和实施精准的早期生命干预提供科学依据。

 

Research directions：

1. Molecular Mechanisms by Which Genetic and Environmental Factors Contribute to the Pathogenesis of Psychiatric Disorders

This research line employs systems biology approaches to decipher the synergistic effects of genetic susceptibility and environmental stressors in triggering psychiatric diseases. We focus not only on identifying risk gene loci but also on elucidating how these variants disrupt intermediate molecular phenotypes—such as gene transcription, protein expression and modification, and epigenetic regulation (e.g., DNA methylation modulated by lncRNAs)—ultimately leading to neural circuit dysfunction. By integrating multi-omics data (genomics, transcriptomics, epigenomics, proteomics) from cellular and animal models as well as human tissue samples across disease stages, we aim to reconstruct the causal pathway from genetic risk and environmental exposure to molecular network disruption and cellular functional deficits. For instance, we investigate how specific environmental factors (e.g., early-life stress) activate or amplify individual genetic risks, triggering cascading molecular responses that underlie the precise pathogenesis of complex brain disorders such as autism, schizophrenia and depression, thereby identifying biological targets for personalized interventions.

 

2. Impact of Placental Disorders on Brain Development and Function, and Their Mechanisms in Inducing Psychiatric Diseases

This direction focuses on the placenta—a crucial yet often overlooked regulator of brain development—investigating how placental dysfunction acts as an early-life origin to program long-term brain function and mental health. We examine how maternal challenges (e.g., stress, nutrition, infection) alter the placenta’s endocrine functions, immune responses, and nutrient transport capacity. These alterations may directly interfere with critical fetal brain development processes—including neurogenesis, synaptogenesis, and myelination—via the release of specific signaling molecules (e.g., hormones, cytokines) or by affecting nutrient and oxygen supply at the maternal-fetal interface. Using clinical cohorts, placenta-specific gene knockout animal models, and organoid co-culture systems, we systematically analyze how placental-derived signals shape the fetal brain’s transcriptional and epigenetic landscape, and explore their link to postnatal neurodevelopmental disorders (e.g., autism, schizophrenia) and increased risk of adult psychiatric diseases, aiming to establish the placenta as a novel target for early warning and intervention in mental disorders.

 

3. Influence of Environmental Exposures During Fetal and Early Infant Stages on Brain Development and Function, and Underlying Mechanisms Leading to Psychiatric Disorders

This research aims to systematically elucidate how environmental exposures during critical early-life windows (fetal to infant stages) exert profound and lasting impacts on the rapidly developing brain. The studied environmental factors include maternal prenatal psychological and physiological stress, nutritional status, drug/toxin exposure, microbiome, and the early postnatal care environment. We employ prospective birth cohorts, combined with neuroimaging, behavioral assessments, and multi-timepoint biospecimen collection, to longitudinally track associations between environmental exposures and trajectories of childhood brain structure/functional connectivity, as well as cognitive-emotional development. Mechanistically, we focus on how environmental factors "program" key neurodevelopmental genes via epigenetic mechanisms (e.g., DNA methylation, histone modifications) and regulate non-neuronal cells such as microglia and astrocytes, thereby altering neuroimmune homeostasis and synaptic pruning efficiency. The ultimate goal is to uncover the "programming" mechanisms through which adverse early environments increase susceptibility to psychiatric disorders, providing a scientific basis for early identification of high-risk individuals and implementation of precise early-life interventions.

 

个人成果

主持和参加各类科研项目：

在研：

国家自然科学基金面上项目，32571172，MAZ和TYMP缺失导致嘧啶代谢异常参与自闭症发病的分子机制研究，2026/01-2029/12，万元，在研，主持。

已结题：

1.    国家自然科学基金面上项目，81571097，自闭症蛋白质互作网络中神经突触功能相关模块的关键节点研究，2016/01-2019/12，57万元，已结题，主持。

2.    广东省自然科学基金，2016A030308020，自闭症发病的相关信号通路的研究，2016/01-2021/12,100万元，已结题，主持。

3.    广州市科技计划项目，201704020116，自闭症精准分子分型检测试剂及其临床应用，2017/05-2021/04,100万元，已结题，主持。

4.    广东省科技计划项目，2017B020227010，精神分裂症精准分子分型和个性化诊疗模式及其临床应用，2017/07-2022/06，300万元，已结题，主持。

5.    国家自然科学基金面上项目，31771434，系统绘制人类胚胎脑组织lncRNA-蛋白相互作用二元网络图谱，2018/01-2021/12，60万元，已结题，主持。

6.    广东省区域联合基金-重点项目，2019B1515120080，通过对自闭症核心家系的单细胞组学研究阐明自闭症发病分子机理，2020.01.01-2023.12.31，已结题，主持。

7.    国家自然科学基金委员会，面上项目，82071503，通过高通量构建精神分裂症分子网络阐明免疫激活导致发病的分子机理，2021.01-2024.12，55万，已结题，主持。

8.    国家重点研发项目，2018YFA0507800；2018YFA0507803，遗传性血液病蛋白质机器及其标志物的发现与机制研究，2018/05-2023/04，70.3万元，已结题，参与。

9.    广东省科技计划项目，2018B030335001，自闭症的诊疗方法研究，2019/01-2023/12，117.647万元，已结题，参与。

10.  横向项目（事业单位合作），利用自体细胞来源的iPSC进行肾脏类器官3D重建的研究，2018/11-2021/12，50万元，已结题，参与。

发表论文（选用论文代表主要研究经历和方向）：

  1. Xinping Yang#, Jasmin Coulombe-Huntington#, Shuli Kang#, Gloria M Sheynkman#, Tong Hao#, Aaron Richardson, Song Sun, Fan Yang, Yun A Shen, Ryan R Murray, Kerstin Spirohn, Bridget E Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J Pevzner, Quan Zhong, Shelly A Trigg, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A Chen, Michael A Calderwood, Patrick Aloy, Frederick P Roth, David E Hill, Lilia M Iakoucheva, Yu Xia, Marc Vidal. Widespread expansion of protein interaction capabilities by alternative splicing. Cell, 2016, 164(4): 805-817. PMID: 26871637. （第一作者）
  2. Roser Corominas#, Xinping Yang#, Guan Ning Lin#, Shuli Kang#, Yun Shen, Lila Ghamsari, Martin Broly, Maria Rodriguez, Stanley Tam, Shelly A Trigg, Changyu Fan, Song Yi, Murat Tasan, Irma Lemmens, Xingyan Kuang, Nan Zhao, Dheeraj Malhotra, Jacob J Michaelson, Vladimir Vacic, Michael A Calderwood, Frederick P Roth, Jan Tavernier, Steve Horvath, Kourosh Salehi-Ashtiani, Dmitry Korkin, Jonathan Sebat, David E Hill, Tong Hao, Marc Vidal, Lilia M Iakoucheva. Protein interaction network of alternatively-spliced isoforms from brain links genetic risk factors for autism. Nature Communications 2014, 5:3650. PMID: 24722188.  （并列第一）
  3. Kourosh Salehi-Ashtiani#, Xinping Yang#, Adnan Derti#, Weidong Tian#, Tong Hao#, Chenwei Lin, Kathryn Makowski, Lei Shen, Ryan R Murray, David Szeto, Nadeem Tusneem, Douglas R Smith, Michael E Cusick, David E Hill, Frederick P Roth, Marc Vidal Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing. Nature Methods 2008, 5(7):597-600. PMID: 18552854. （并列第一）
  4. Xiaoping Yang#, Jesse S Boehm#, Xinping Yang#, Kourosh Salehi-Ashtiani#, Tong Hao#, Yun Shen#, Rakela Lubonja, Sapana R Thomas, Ozan Alkan, Tashfeen Bhimdi, Thomas M Green, Cory M Johannessen, Serena J Silver, Cindy Nguyen, Ryan R Murray, Haley Hieronymus, Dawit Balcha, Changyu Fan, Chenwei Lin, Lila Ghamsari, Marc Vidal, William C Hahn, David E Hill, David E Root. A public genome-scale lentiviral expression library of human ORFs. Natture Methods 2011, 8(8):659-61. PMID: 21706014.（并列第一）
  5. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJ, Lindquist S, Vidal M. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 2015, 161(3):647-60. PMID: 25910212.
  6. Lin GN, Corominas R, Lemmens I, Yang X, Tavernier J, Hill DE, Vidal M, Sebat J, Iakoucheva LM. Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cu l3-RhoA pathway in psychiatric diseases. Neuron 2015, 85(4):742-54. PMID: 25695269.
  7. Rolland T, Ta an M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC,Vega K, Walsh J, Cusick ME, Xia Y,  AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M. A proteome-scale map of the human interactome network. Cell 2014, 159(5):1212-26. PMID:25416956.
  8. Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Coté AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovács IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP, Calderwood MA.. A reference map of the human binary protein interactome. Nature, 2020. 580(7803):402-408. PMID: 32296183.
  9. Zhiwei Guo#, Fang Yang#, Jun Zhang, Zhigang Zhang, Kun Li, Qi Tian, Hongying Hou, Cailing Xu, Qianwen Lu, Zhonglu Ren, Xiaoxue Yang, Zenglu Lv, Ke Wang, Xinping Yang,* Yingsong Wu,* and Xuexi Yang*.Whole-Genome Promoter Profiling of Plasma DNA Exhibits Diagnostic Value for Placenta-Origin Pregnancy Complications. Advanced Science. 2020;7(7):1901819. PMID: 32274292.（共同通讯作者）
  10. Xiaoxue Yang, Jing Yang, Xiaozhen Liang, Qian Chen, Sijia Jiang, Haihua Liu, Yue Gao, Zhonglu Ren, Yi-Wu Shi, Sheng Li, Yanhong Yu, Mei Zhong*, Xinping Yang*. Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia. Hypertension. 2020 Jun;75(6):1532-1541. PMID: 32306769.（通讯作者）
  11. Cuixia Fan#, Yue Gao#, Guanmei Liang, Lang Huang, Jing Wang, Xiaoxue Yang, Yiwu Shi, Ursula C Drager, Mei Zhong, Tian-Ming Gao, Xinping Yang*. Transcriptomics of Gabra4 Knockout Mice Reveals Common NMDAR Pathways Underlying Autism, Memory, and Epilepsy. Molecular Autism. 2020 Feb 7;11(1):13. PMID: 32033586.（通讯作者）
  12. Qian Chen#, Sijia Jiang#, Haihua Liu#, Yue Gao, Xiaoxue Yang, Zhonglu Ren, Yunfei Gao, Lu Xiao, Haoyue Hu, Yanhong Yu, Xinping Yang* and Mei Zhong1*Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells. Cell Death & Diseases. 2020, 11(7):583. PMID: 32719429. （共同通讯作者）
  13. Sijia Jiang#, Qian Chen#, Haihua Liu#, Yue Gao, Xiaoxue Yang, Zhonglu Ren, Yunfei Gao, Lu Xiao, Yongli Shan, Mei Zhong, Yanhong Yu and Xinping Yang*. Preeclampsia-Associated lncRNA INHBA-AS1 Regulates the Proliferation, Invasion, and Migration of Placental Trophoblast Cells. Moelcular Therapy-Nucleic Acid, 2020. 2:684-695. PMID: 33230466.（通讯作者)
  14. Zhonglu Ren#, Yunfei Gao#, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang*. Distinct placental molecular processes associated with early-onset and late-onset preeclampsia. Theranostics, 2021 Mar 5;11(10):5028-5044. PMID: 33754042. （通讯作者)
  15. Lang Huang#, Jing Wang#, Guanmei Liang#, Yue Gao#, Xiaoxue Yang, Cuixia Fan, Jianpei Lao, Jinfa Chen, Zhoucai Luo, Li Xiong, Xinhong Zhu, Tian-Ming Gao, Mei Zhong*, and Xinping Yang*. Upregulated NMDAR-mediated GABAergic transmission underlies autistic-like deficits in Htr3a knockout mice. Theranostics, 2021; 11(19):9296-9310. PMID: 34646371.（通讯作者)
  16. Yue Gao, Yanjun Li, ShuangYan Li, Xiaozhen Liang, Zhonglu Ren, Xiaoxue yang, Bin Zhang, Yanhui Hu and Xinping Yang*. Systematic discovery of signaling pathways linking immune activation to schizophrenia. iScience 2021. Oct 2;24(11):103209. PMID: 34746692. （通讯作者）
  17. Qian Chen#, Jiexing He#, Haihua Liu#, Qiuyu Huang, Shuoshi Wang, Ailan Yin, Shuying Chen, Xinyang Shen, Yanxuan Xiao, Haoyue Hu, Jiayi Jiang, Wenqian Chen, Song Wang, Zhenqin Huang, Jiaqi Li, You Peng, Xiaocong Wang, Xinping Yang* , Zhijian Wang* and Mei Zhong*., Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia. Journal of Translational Medicine, 2023. 21(1): p. 21. PMID: 37488572. （共同通讯作者）
  18. Jing Wang#, Yue Gao#, Liuyan Xiao#, Yanmei Lin, Lang Huang, Jinfa Chen, Guanmei Liang, Weiming Li, Wenjuan Yi, Jianpei Lao, Bin Zhang, Tian-Ming Gao, Mei Zhong, and Xinping Yang*., Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1(-/-) mice. iScience, 2023. 26(8): p. 107476. PMID: 37599823.（通讯作者）
  19. Guanmei Liang, Wenjuan Yi, Yanjun Li, Yue Gao, Lang Huang, Yanmei Lin, Chunlin Chen*, and Xinping Yang*, Systematic discovery of virus-perturbed molecular pathways linking to schizophrenia. The Innovation Medicine, 2024. 2(1): 100062. （通讯作者）
  20. Jing Yang#, Wenjun Yu#, Runmiao Zhu, Shuangyan Li, Yue Gao, Jinfa Chen, Bin Zhang, Wanshan Wang*, Xinping Yang*. Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain. Theranostics 2024 Sep 3;14(14):5682-5697. (通讯作者)
  21. Haihaya Liu#, Zhijian Wang#, Yanjun Li#, Qian Chen, Sijia Jiang, Yue Gao, Jing Wang, Yali Chi, Jie Liu, Xiaoli Wu, Qiong Chen, Chaoqun Xiao, Mei Zhong, Chunlin Chen* and Xinping Yang*. Hierarchical lncRNA regulatory network in early‑onset severe preeclampsia. BMC Biol 2024 Jul 29;22(1):159.  (通讯作者)
  22. Yali Chi#, Tao Feng#, Zixin Du#, Ping Huang, Wenjun Yu, Haihua Liu, Wanshan Wang*, Xinping Yang*, Liping Huang*. Doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish. BMC Biol 2025 Jul 1;23:167. (共同通讯作者)
  23. Jiexing He#, Qian Chen#, Mingzheng Zhu, Yanxuan Xiao, Qiuyu Huang, Ailan Yin, Sijia Jiang, Pei Zhu, Tingyu Xiang, Jing Li*, Zhongjun Li*, Xinping Yang*, Mei Zhong*. Maternal exposure to advanced oxidation protein products induces neurodevelopmental abnormalities in the offspring of mice. Brain Behav Immun 2025 Aug 22:130:106091.  (共同通讯作者)