赵小阳，二级教授，南方医科大学检验与生物技术学院院长。

长江学者特聘教授，国家优青，“万人计划”青年拔尖人才，青年长江，科技部重点研发项目首席专家。中国细胞生物学会生殖细胞分会副会长，广东省政协委员。

赵小阳教授在生殖细胞发育与分化，不孕不育发病机制研究方面取得了一系列进展。在Nature，Cell Stem Cell，Nature Cell Biology，Science Advances等杂志上发表论文60余篇，申报专利16项。荣获2014年国家自然科学奖二等奖1项（第五完成人）和国际转基因协会（ISTT）青年科学家奖，2017年中国干细胞协会“干细胞青年研究员”奖，2018年中源协和生命医学奖-创新突破奖。研究工作相继入选2009年中国十大科技进展和基础研究十大新闻，时代周刊评选的2009年十大医学突破，2012年中国科学十大进展，2016年度中国十大医学科技新闻和细胞出版社“2016中国年度论文”。

  主要研究体细胞重编程及干细胞技术、基因修饰技术等在生殖系统中的研究与应用，致力于研发干细胞再生医学及辅助生殖新技术。

   阐明人类精子发生过程中生殖细胞发育路径；诱导获得人原始生殖细胞，为人类不育症的治疗提供技术基础。以通讯或共同通讯在Nature，Cell Stem Cell, Cell Research等杂志发表论文26篇；以第一或共一作者在Nature等杂志发表论文10篇。体细胞重编程工作受到了国内外媒体的关注和同行的高度评价，入选美国《时代周刊》十大医学突破、中国基础研究十大新闻、中国十大科技进展。证明具有多能性的单倍体干细胞可以使卵母细胞受精，获得可育的转基因后代，该工作入选中国科学十大进展。体外分化获得单倍体精子细胞的工作被评为中国十大医学科技新闻和细胞出版社“中国年度论文”。荣获国家自然科学二等奖，中源协和生命医学-创新突破奖，中国干细胞协会青年研究员奖等奖励。

1. Cui MM^#, Zheng ZY^#, Bai SY^#, Ouyang ZX^#, Chen J, Yang XY, Wan C, Zheng Y, Zhao JX*, Chang G*, Zhao XY*. A visualized and quercetin-optimized three-dimensional culture model of mouse ovaries derived from fetal gonads. Acta Biochimica et Biophysica Sinica. 2025 .

2. Zhao JX^#, Tang K^#, Jiang GR^#, Yang XY, Cui MM, Wan C, Ouyang ZX, Zheng Y, Liu ZT, Wang M, Zhao XY*, Chang G*. Dynamic transcriptomic and regulatory networks underpinning the transition from fetal primordial germ cells to spermatogonia in mice. Cell Prolif. 2025,58(2):e13755.

3. Wan C^#, Huang YP, Xue XG, Chang G, Wang M, Zhao XY*, Luo F*, Tang ZZ*. HELQ deficiency impairs the induction of primordial germ cell-like cells. FEBS Open Bio. 2024 ,14(7):1087-1100.

4. Huang YP^#, Li L^#, An G^#, Yang XY^#, Cui MM^#, Song XL, Lin J, Zhang XL, Yao ZK, Wan C, Zhou C, Zhao JX, Song K, Ren SF, Xia XY,Fu X,Lan Y,Hu XS,Wang W,Wang M,Zheng Y,Miao K,Bai XC, Hutchins AP,Chang G*, Gao S*, Zhao XY*, Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination. Nature Cell Biology. 2023, 25(10):1520-34.

5. Zhang X ^#, Wang XL ^#, Lv J, Huang HX, Wang JH, Zhuo M, Tan ZH, Huang GJ, Liu JW, Liu YC, Li MR, Lin QX, Li L, Ma SF, Huang T, Lin Y*, Zhao XY*, Rong ZL*. Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing. Genome Biology. 2023,24(1):145.

6. Li CH ^#, Yao ZK ^#, Ma LZ^#, Song XL^#, Wang W, Wan C, Ren SF, Chen DY, Zheng Y, Zhu YT, Chang G, Wu SH, Miao K*, Luo F*,Zhao XY*. Lovastatin Promotes the Self-renewal of Murine and Primate Spermatogonial Stem Cells. Stem Cell Reports, 2023, 18(4):969-984.

7. Song K^#, Yang XY^#, An G^#, Xia XY^#, Zhao JX, Xu XH, Wan C, Liu TY, Zheng Y, Ren SF, Wang M, Chang G, Shane Cronin, Josef Penninger, Jing T, Ou XH, Rao S*, Liu ZT*^#, Zhao XY*. Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nature Communications. 2022, 13(1):7335 

8. Chen YH^#, Lu JS^#, Xu YW^#, Huang YP^#, Wang DZ^#,Liang PL,Ren SF,Hu XS,Qin YW,Ke W, Jauch R, Hutchins AP,Wang M*,Tang FC*, Zhao XY*.The Chemical Reprogramming of Unipotent Adult Germ Cells towards Authentic Pluripotency and de novo Establishment of Imprinting. Protein & Cell. 2023,14(7):477-496

9. Wang J^#, Zhou C^#, Gao S^#, Song XL^#, Yang XY^#, Fan JQ, Ren SF, Ma LZ, Zhao JX, Cui MM, Song K, Wang M, Li CH, Zheng Y, Luo F, Miao K, Bai XC, Hutchins AP, Li L*, Chang G*, Zhao XY*.Single-cell multi-omics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection. Science Advances.2022, 8(32):eabm3976 

10. Zhao JX^#, Lu P^#,Wan C^#, Huang YP^#, Cui MM, Yang XY, Hu YQ, Zheng Y, Dong J, Wang M, Zhang S, Liu ZT, Bian SH, Wang XM, Wang R, Ren SF, Wang DZ, Yao ZK, Chang G^#*, Tang FC^*& Zhao XY^*, Cell-fate transition and determination analysis of mouse male germ cells throughout development.Nature Communications. 2021 12(1):6839 

11. Zhang Y^#, Liu TY^#, Hu XS^#, Wang M, Wang J, Zou BH, Tan PW, Cui TY, Dou YY, Ning L, Huang Y, Rao S, Wang D^*, Zhao XY^*. CellCall: Integrating paired ligand-receptor and transcription factor activities for cell-cell communication. Nucleic Acids Research.2021 49(15):8520-8534. 

12. Wang XM^#, Veerapandian V^#, Yang XY^#, Song K^#, Xu XH, Cui MM, Yuan WY, Huang YP, Xia XY, Yao ZK, Wan C, Luo F, Song XL, Wang XR, Zheng Y, Hutchins AP, Jauch R, Liang MY, Wang CH, Liu ZT^*, Chang G^*, & Zhao XY^*. The Chromatin Accessibility Landscape Reveals Distinct Transcriptional Regulation in the Generation of Human Primordial Germ Cell-Like Cells from Pluripotent Stem Cells. Stem Cell Reports. 2021 16(5):1245-1261.

13. Wang M^#, Xu YW^#, Zhang YC^#, Chen YH^#, Chang G^#, An G, Yang XY, Zheng CH, Zhao JX, Liu ZT, Wang DZ, Miao K, Rao S, Dai M, Wang D, Zhao XY^*. Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis. Theranostics. 2021 11(10):5010-5027.

14. Wang M^#, Liu X^#, Chang G^#, Chen Y^#, An G^#, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F^*, & Zhao XY^*①, & Qiao J^*. Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis. Cell Stem Cell. 2018 23(4):599-614. (^①:lead contact) 

15. Wang XM, Shi YJ ,Liu ZT, Zhao XY^*. Gamete differentiation from pluripotent stem cells. National Science Review. 2017 4(4):525–528. 

16. Zhou Q^#, Wang M^#, Yuan Y^#, Wang W, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY^*, Sha J^*, & Zhou Q^*. Complete meiosis from ES-cell derived germ cells in vitro. Cell Stem Cell. 2016 18(3):330-40. 

17. Yuan Y^#, Zhou Q^#, Wan HF^#, Shen B^#, Wang X, Wang M, Feng C, Xie M, Gu T, Zhou T, Fu R, Huang X, Jiahao Sha^*, Zhou Q^*, & Zhao XY^*. Generation of fertile offspring from Kit^w/Kit^wv mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Research. 2015 25(7):851–863.

18. Wan HF^#, Feng CJ^#, Teng F^#, Yang SH^#, Hu BY, Niu YY, Xiang P, Fang WZ, Ji WZ, LI W^*, Zhao XY^*, & Zhou Q^*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Research. 2015 25(2):258-61.

19. Wan HF^#, He ZQ^#, Dong MZ, Gu TT, Luo GZ, Teng F, Xia BL, Li W, Feng CJ, Li X, Li TD, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY^*, & Zhou Q^*. Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Research. 2013 23(11):1330-1333. 

20. Li W^#, Shuai L^#, Wan HF^#, Dong MZ^#, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang XJ, Zhao XY^*, & Zhou Q^*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature. 2012 490(7420):407-411. 

21. Riaz A^#, Zhao XY^#, Dai XP^#, Li W, Liu L, Wan HF, Yu Y, Wang L, Zhou Q^*. Mouse cloning and somatic cell reprogramming using electrofused blastomeres. Cell Research. 2011 21(5):770-778. 

22. Li W^#, Zhao XY^#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L^*, & Zhou Q^*.  iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Research. 2011 21(3):550-553.

23. Zhao XY, Li W, Lv Z, Zeng FY^*, & Zhou Q^*. Production of mice using iPS cells and tetraploid complementation. Nature Protocols. 2010 5(5):963-71. 

24. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Wang X, Wang L, Zeng FY^*, & Zhou Q^*. Efficient and rapid generation of induced pluripotent stem cells using alternative culture medium. Cell Research. 2010 20(3):383-386. 

25. Zhou SY^#, Ding CH^#, Zhao XY^#, Wang EY, Dai XP, Liu L, Li W, Liu ZC, Wan HF, Feng CJ, Hai H, Wang L, Zhou Q^*. Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells. Cell Research. 2010 20(7):850-853. 

26. Zhao XY^#, Li W^#, Lv Z^#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng FY^*, & Zhou Q^*. iPS cells produce viable mice through tetraploid complementation. Nature. 2009 461(7260):86-U88.