1. 工作经历：

2016-7至现在    南方医科大学，法医学院，副研究员

2012-7至2016-7  南方医科大学，基础医学院法医学系，副研究员

2004-8至2009-1  南方医科大学，基础医学院病理学教研室，实验师

2003-5至2004-8  第一军医大学，基础医学病理学教研室，实验师

1993-7至2003-5  第一军医大学，基础医学院细胞生物学教研室，助理实验师/实验师

2009-1至2012-7  University of Georgia,博士后

2. 学习经历：

2003-9至2006-7  第一军医大学，病理学，博士

1998-9至2001-7  暨南大学，医学遗传学，硕士

1990-8至1993-7  第一军医大学，医学实验技术，大专

1. 主要研究领域：

         1）新型毒品毒性损伤分子机制；

         2）心血管疾病发生机制。

          2. 承担课题情况：

1）. 国家自然科学基金面上项目：Nupr1介导血管稳态失衡在甲基苯丙胺相关的肺动脉高压发生中的作用及机制（82170438）, 2022.01-2025.12, 55万, 主持，在研

2）.广东省基础与应用基础研究基金项目：Nupr1在肾纤维化发生发展中的作用及分子机制（2019A1515010271）, 2019.10-2022.9, 10万，主持，在研

3）.国家卫生健康委员会毒品依赖和戒治重点实验室开放课题：甲基苯丙胺通过Nupr1调控STIM1/Orai钙离子通道开放诱导肺动脉高压发生（2020DAMOP-010），2020.8-2022.7,15万，主持，在研

4）.广州科技计划项目：甲基苯丙胺（METH）致动脉夹层发生机制及防治（201707010302），2017.5-2020.4， 20万，主持，结题

5）.国家自然科学基金面上项目：NDRG1在血管损伤后新生内膜形成中的作用及其分子机制（81370227），2014.1-2017.12，65万，主持，结题

1.  发表论文：【第一作者(#)或者通讯作者(*)】

2025年

1. Zhou J, Xu Z, Peng DB, Li X, Chang S, Duan K, Jiang Y, Gu C, Peng X, Xie WB*. Macrophage-Derived LCN2 Promotes Methamphetamine-Induced Pulmonary Hypertension. Hypertension. 2025 Aug;82(8):1355-1367.doi: 10.1161/HYPERTENSIONAHA.124.24548.

2024年

1. Zhou J, Guo D, Xu ZZ, Liao JS, Li XT, Duan K, Chen SY, Xie WB*. Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension. Cell Biol Toxicol. 2024 Feb 13;40(1):13. doi: 10.1007/s10565-024-09849-6.

2. Xu ZZ, Zhou J, Duan K, Li XT, Chang S, Huang W, Lu Q, Tao J, Xie WB*. Blocking Sigmar1 exacerbates methamphetamine-induced hypertension. Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167284. doi: 10.1016/j.bbadis.2024.167284.

3. Tian Q, Zhou J, Xu Z, Wang B, Liao J, Duan K, Li X, Huang E, Xie WB*. STIM1 mediates methamphetamine-induced neuronal autophagy and apoptosis. Neurotoxicology. 2024 Jul;103:134-145. doi: 10.1016/j.neuro.2024.06.006

2022年

1. Luo BY, Zhou J, Guo D, Yang Q, Tian Q, Cai DP, Zhou RM, Xu ZZ, Wang HJ*, Chen SY*, Xie WB*. Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ.  Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166447. doi: 10.1016/j.bbadis.2022.166447.

2021年

1. Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lü, Shi-You Chen*, Wei-Bing Xie*.Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition FASEB J 2021 Mar; 35(3): e21381. doi: 10.1096/fj.202000926RR

2. Tan X#, Cai D#, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W*, Wang H*. Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. Toxicol Lett. 2021 Oct 10;350:98-110. doi: 10.1016/j.toxlet.2021.06.019.

2019年

1. Sun X, Wang Y, Xia B, Li Z, Dai J, Qiu P, Ma A, Lin Z, Huang J, Wang J, Xie WB*, Wang J*. Methamphetamine produces cardiac damage and apoptosis by decreasing melusin Toxicol Appl Pharmacol. 2019 Sep 1;378:114543. doi: 10.1016/j.taap.2019.03.015. Epub 2019 Mar 20. PMID: 30904475

2. Qiao HH, Zhu LN, Wang Y, Hui JL, Xie WB, Liu C, Chen L, Qiu PM. Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in vitro and in vivo. Neural Regen Res. 2019 Feb;14(2):319-327. doi: 10.4103/1673-5374.244795. PMID: 30531016

2018年

1. Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H*, Xie WB*. CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.  Toxicol Lett. 2018 Aug;292:97-107. doi: 10.1016/j.toxlet.2018.04.027. Epub 2018 Apr 26. PMID: 29705343

2. Xu X, Huang E, Luo B, Cai D, Zhao X, Luo Q, Jin Y, Chen L, Wang Q, Liu C, Lin Z, Xie WB*, Wang H*. Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPβ-related signaling pathway. FASEB J. 2018 Jun 25:fj201701460RRR. doi: 10.1096/fj.201701460RRR. Online ahead of print. PMID: 29939784

2017年

1. Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660. doi: 10.1007/s12035-015-9637-9. Epub 2016 Feb 12. PMID: 26873849

2. Du SH, Qiao DF, Chen CX, Chen S, Liu C, Lin Z, Wang H*, Xie WB*. Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes. Front Mol Neurosci. 2017 Dec 12;10:409. doi: 10.3389/fnmol.2017.00409. eCollection 2017. PMID: 29311802

3. Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H*, Xie WB*. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017. PMID: 28694771

2016年

1. Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660. doi: 10.1007/s12035-015-9637-9. Epub 2016 Feb 12. PMID: 26873849

2. Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicol Lett. 2016 Jan 5;240(1):149-60. doi: 10.1016/j.toxlet.2015.10.020. Epub 2015 Oct 30. PMID: 26524635

3. Chen R, Wang B, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes.  Toxicol Appl Pharmacol. 2016 Mar 15;295:1-11. doi: 10.1016/j.taap.2016.01.017. Epub 2016 Jan 26. PMID: 26825372

4. D Cai, E Huang, B Luo, Y Yang, F Zhang, C Liu, Z Lin, W-B Xie*, H Wang*.Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine Cell Death Dis . 2016 Mar 31;7(3):e2161. doi: 10.1038/cddis.2016.67.

2015年

1. Huang W, Xie WB, Qiao D, Qiu P, Huang E, Li B, Chen C, Liu C, Wang Q, Lin Z, Wang H*. Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Sci. 2015 May;145(1):68-79. doi: 10.1093/toxsci/kfv014. Epub 2015 Jan 27. PMID: 25631491

2. Hu ZY#, Xie WB#, Yang F, Xiao LW, Wang XY, Chen SY*, Li ZG*. NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling.  Biochim Biophys Acta. 2015 Sep;1852(9):1876-86. doi: 10.1016/j.bbadis.2015.06.009. Epub 2015 Jun 10. PMID: 26071641

2014年

1. Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB*, Wang H*. Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.  Toxicol Lett. 2014 Nov 4;230(3):444-53. doi: 10.1016/j.toxlet.2014.08.010. Epub 2014 Aug 13. PMID: 25127757

2013年

1. Wei-Bing Xie#, Zuguo Li#, Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Erwin P Bottinger, Yang Chai, Pedro A Jose, Shi-You Chen* Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells Circ Res 2013 Sep 27;113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921. Epub 2013 Jul 1.

2012年

1. Shi N, Xie WB, Chen SY. Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation. J Biol Chem. 2012 Feb 24;287(9):6860-7. doi: 10.1074/jbc.M111.306209. Epub 2012 Jan 5. PMID: 22223649

2011年

1. Li Z#, Xie WB#, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY*. Response gene to complement 32 is essential for fibroblast activation in renal fibrosis. J Biol Chem. 2011 Dec 2;286(48):41323-41330. doi: 10.1074/jbc.M111.259184. Epub 2011 Oct 11. PMID: 21990365

2. Xie WB, Li Z, Miano JM, Long X, Chen SY*. Smad3-mediated myocardin silencing: a novel mechanism governing the initiation of smooth muscle differentiation. J Biol Chem. 2011 Apr 29;286(17):15050-7. doi: 10.1074/jbc.M110.202747. Epub 2011 Mar 14. PMID: 21402709

3. Wang JN, Shi N, Xie WB, Guo X, Chen SY. Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):e19-26. doi: 10.1161/ATVBAHA.111.230706. Epub 2011 Jun 2. PMID: 21636805