目录
关闭
更新日期：2025年10月15日
姓 名 查龙应 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 农学博士学位
行政职务 系主任 Email lyzha@smu.edu.cn
工作单位 公共卫生学院 邮政编码 510515
个人简介

南方医科大学公共卫生学院教授、博导，营养与食品卫生学系党支部书记、系主任。博士毕业于浙江大学，曾先后于香港浸会大学和美国北卡罗来纳大学教堂山分校（UNC-CH）从事营养学访问学者和博士后研究。

长期从事营养与健康领域的科研、教学及科普工作，主要研究方向为慢性代谢性疾病分子机制及其膳食营养防治。主持国家自然科学基金（6项）、广东省自然科学基金等课题20多项，在J. Adv. Res.、 Mol. Nutr. Food Res.、Food Res.Int.等SCI期刊发表论文70多篇。已培养研究生56名（含博士生11名，留学生26名），指导博士后2名。主持省、校级教改课题3项；获省级教学竞赛一等奖；副主编教材1部，参编教材5部，专著1部。入选广东省千百十工程；获评南医优秀教师（第10届）、感动南医·立德树人好导师（第11届）。

目前担任中国营养学会理事；广东医学微量元素学会理事长；广东省营养学会副理事长；广东省营养学会精准(个性化)营养分会主任委员；中国营养学会营养与保健食品分会委员；中国营养学会营养与组学技术分会委员；中国生物化学与分子生物学学会会员；美国营养学会会员、北美华人营养学会会员；广东省保健协会体重管理分会副主任委员等学术兼职。

研究领域

本课题组主要从事膳食营养与慢性代谢性疾病（Chronic metabolic diseases, CMDs）防治领域的科学研究工作，主要研究方向包括：

1. 植物化学物与慢性代谢性疾病防治研究

随着我国社会经济的快速增长，国民的营养健康问题却日趋严重，其中包括肥胖（Obesity）、II型糖尿病（Type 2 Diabetes, T2D）、癌症（Cancer）、心脑血管疾病（Cardiovascular Diseases, CVDs）、代谢相关脂肪性肝病（Metabolic Dysfunction-associated Fatty Liver Disease, MAFLD）等慢性病的发病呈逐年增长趋势。此类疾病不但严重损害国民的健康，降低生活质量，而且已成为致死的主要原因。现代营养学研究认为，植物性食物中的植物化学物（phytochemicals）具有抗癌、抗炎、抗氧化等多种生物活性，可有效预防或缓解慢性代谢性疾病。研究和阐明食物中各类植物化学物的活性及其作用机理是当前国内外营养学研究的热点。近年来，本课题组主要围绕皂苷类植物化学物的抗炎活性与分子机理，在细胞、动物和人群层面开展了系列研究，此研究方向持续获得国家自然科学基金、广东省自然科学基金以及行业横向课题的资助。

2. 代谢性炎症的分子机制研究

慢性代谢性疾病的发病机理复杂多样，其中代谢性炎症（Metabolic inflammation）是促进其发生发展的一个关键因素。代谢性炎症的发生本质上是因为机体免疫系统与代谢相关的器官和组织之间的信息交流发生紊乱，其分子机制一直是现代营养学关注的热点领域。本课题组综合运用现代分子细胞生物学（如WB、FQ-PCR、蔗糖梯度超速离心等）和免疫学（如IP、ELISA等）技术以及各种动物模型（如肥胖小鼠、代谢相关脂肪性肝病小鼠、ApoE-/-基因敲除小鼠等），围绕TLR4/NF-kB、脂筏信号传导、巨噬细胞外泌体等探究代谢性炎症的分子机制。此研究方向获得国家自然科学基金面上项目的资助。

个人成果

1. Huiyu Luo, Yudi Ding, Jiazhi Lu, Jiexian Wang, Junbin Chen, Zhongdaixi Zheng, Qing Li, Xiangyi Zheng, Longying Zha*. Soyasaponins alleviate nonalcoholic steatohepatitis by augmenting the DDX5-TSC1/2-mTOR signaling-mediated autophagy. Food Bioscience, 2025 (Jun), 68: 106596. (SCI论文，IF=4.8, 中科院JCR小类分区2区) (ISSN: 2212-4292)

2. Huiyu Luo, Jiexian Wang, Fengjuan Lin, Yuguo Liu, Xinglong Wu, Gan Li, Chuhong Su, Junbin Chen, Fei Xiong, Jiaqi Mo, Zhongdaixi Zheng, Xiangyi Zheng, Qing Li, Longying Zha*. Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling. Journal of Advanced Research, 2025 (May), 71:501-509. DOI: 10.1016/j.jare.2024.06.024. (SCI收录，IF=13.0, 中科院JCR分区I区) (ISSN: 2090-1232)

3. Alieu Tommy, Augustus Osborne, Ola Farid Jahanpour, Lovel Fornah, Joseph Sam Kanu, Longying Zha*. Exclusive breastfeeding and its associated factors among children aged 0-5 months in Sierra Leone: a multilevel analysis. International Breastfeeding Journal, 2025 (Apr 29), 20(1): 34. doi: 10.1186/s13006-025-00725-5. (SCI论文，IF=2.9, 中科院JCR小类分区1区) (ISSN: 1746-4358)

4. Jiaqi Mo, Yudi Ding, Junyi Yang, Zhongdaixi Zheng, Jiazhi Lu, Huiyu Luo, Jiexian Wang, Fengjuan Lin, Junbin Chen, Qing Li, Xiangyi Zheng, Longying Zha*. Milk exosomes from gestational diabetes mellitus parturients demonstrate weaker ability to promote intestinal development in offspring. Molecular Nutrition and Food Research, 2025 (Apr 10), 0: e70026. doi: 10.1002/mnfr.70026.(SCI论文，IF=4.5, 中科院JCR小类分区2区) (ISSN:1613-4125 )

5. Jiexian Wang, Yanhua Wu, Junyi Yang, Shihao Ying, Huiyu Luo, Longying Zha*, Qing Li*. Xylooligosaccharide and Akkermansia muciniphila synergistically ameliorate insulin resistance by reshaping gut microbiota, improving intestinal barrier and regulating NKG2D/NKG2DL signaling in gestational diabetes mellitus mice. Food Research International, 2025 (Feb), 201: 115634. DOI: 10.1016/j.foodres.2024.115634. (SCI论文，IF=8.1, 中科院JCR小类分区1区) (ISSN: 0963-9969)

6. Lingyu Xiao#, Chuhong Su#, Junbin Chen, Xiangfu Gu, Yue Zhao, Jiaqi Tang, Yuguo Liu, Huiyu Luo, Longying Zha*. Soyasaponin Bb has poor absorption and bioavailability in Sprague-Dawley rats and Caco-2 intestinal epithelial cell model. Food, Nutrition and Health, 2025 (Fed 5), 2: 4. https://doi.org/10.1007/s44403-025-00014-3. (E-ISSN: 3059-2658)  

7. Fengjuan Lin#, Huiyu Luo#, Jiexian Wang, Qing Li, Longying Zha*. Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases. Frontiers in Immunology, 2025 (Jan 17), 15:1479330. DOI: 10.3389/fimmu.2024.1479330. (SCI论文，IF=5.7, 中科院JCR小类分区2区)  (ISSN: 1664-3224)

8. Chuhong Su, Jiexian Wang, Huiyu Luo, Junbin Chen, Fengjuan Lin, Jiaqi Mo, Fei Xiong, Longying Zha*. Gut Microbiota Plays Essential Roles in Soyasaponin’s Preventive Bioactivities Against Steatohepatitis in the Methionine and Choline Deficient (MCD) Diet-induced Nonalcoholic Steatohepatitis (NASH) Mice. Molecular Nutrition and Food Research. 2024, Jan 17, 68(4): e2300561. DOI: 10.1002/mnfr.202300561.

9. Zhongdaixi Zheng, Jiaqi Mo, Fengjuan Lin, Jiexian Wang, Junbin Chen, Huiyu Luo, Yuguo Liu, Chuhong Su, Xiangfu Gu, Fei Xiong, Longying Zha*. Milk Exosomes from Gestational Diabetes Mellitus (GDM) and Healthy Parturient Exhibit Differential miRNAs Profiles and Distinct Regulatory Bioactivity on Hepatocyte Proliferation. Molecular Nutrition and Food Research. 2023, Aug 23, 67(16): e2300005. DOI: 10.1002/mnfr.202300005.

10. Longying Zha, Huiyu Luo, Fengjuan Lin, Yuguo Liu, Junbin Chen, Chuhong Su, Zhongdaixi Zheng. Macrophage Exosomes Transfer miR-3064-5p to Target IκBα and Activate NF-κB Signaling: A Novel Mechanism of Palmitate-induced Metabolic Inflammation. Current Developments in Nutrition. 2023, 7 (Suppl 1): 101498. DOI: 10.1016/j.cdnut.2023.101498. (Abstract ASN NUTRITION 2023, BOSTON, USA)

11. Biao Li, Wan Li, Tiancai Liu*, Longying Zha. Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases. Frontiers in Molecular Biosciences, 2023 Jan 9; 9: 1024786. DOI: 10.3389/fmolb.2022.1024786.

12. Huiyu Luo, Junbin Chen, Chuhong Su, Longying Zha*. Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis. Nutrients, 2022, Nov 24, 14(23): 4998. DOI: 10.3390/nu14234998. (SCI收录，IF=6.706, 中科院JCR分区II区)

13. Huiyu Luo, Gan Li, Yuguo Liu, Yuanhao Wei, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Chuhong Su, Lingyu Xiao, Fei Xiong, Zhongdaixi Zheng, Shiying Wang, Longying Zha*. The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes. Current Issues in Molecular Biology, 2022(Oct 13), 44(10): 4822-4837. 2. DOI: 10.3390/cimb44100328. (SCI收录，IF=2.976, 中科院JCR分区小类IV区)  

14. Junbin Chen, Yuguo Liu, Huiyu Luo, Guoxun Chen, Zhongdaixi Zheng, Tiannan Wang, Xinge Hu, Yue Zhao, Jiaqi Tang, Chuhong Su and Longying Zha*. Inflammation Induced by Lipopolysaccharide and Palmitic Acid Increases Cholesterol Accumulation via Enhancing Myeloid Differentiation Factor 88 Expression in HepG2 Cells. Pharmaceuticals, 2022 (30 June), 15(7): 813. DOI: 10.3390/ph15070813. (SCI收录，IF=5.215, 中科院JCR分区小类II区)

15. Xiangfu Gu#, Jiaqi Tang#, Yue Zhao#, Chuhong Su, Lingyu Xiao, Huiyu Luo, Yuguo Liu, Fei Xiong, Zhongdaixi Zheng, Junbin Chen, Longying Zha*. Soyasaponin A1 inhibits the lipid raft recruitment and dimerization of TLR4, MyD88, and TRIF by maintaining cholesterol homeostasis in palmitic acid-stimulated inflammatory Raw264.7 macrophage cell line. Journal of Functional Foods, 2021 (Nov), 87: 104789. DOI:10.1016/j.jff.2021.104789. (SCI收录，IF=5.223, 中科院JCR分区II区)

16. Fei Xiong#, Zhongdaixi Zheng#, Lingyu Xiao#, Chuhong Su, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Huiyu Luo, Longying Zha*. Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline Deficient (MCD) Diet-induced Non-alcoholic Steatohepatitis (NASH) Mice. Molecular Nutrition and Food Research, 2021 (July 21), 65(14): e2100067, DOI: 10.1002/mnfr.202100067. (SCI收录，IF=6.575, 中科院JCR分区I区，封面论文)

17. Chen JB#, Ullah H#, Zheng Z#, Gu XF, Su CH, Xiao LY, Wu XL, Xiong F, Li Q*, Zha LY*. Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts. BMC Complementary Medicine and Therapies, 2020 (Jun 3), 20: 167. DOI: 10.1186/s12906-020-2864-2. (SCI收录，IF=2.838, 中科院JCR分区II区)

18. Xie Q#, Xiong F#, Wu X#, Chen J, Gu X, Su C, Xiao L, Zheng Z, Wei Y, Ullah H, Zha LY*. Soyasaponin A1 and A2 exert anti-atherosclerotic functionality by decreasing hypercholesterolemia and inflammation in high fat diet (HFD)-fed apoE-/- mice. Food and Function, 2020 (Jan 29), 11: 253. DOI: 10.1039/C9FO02654A. (SCI收录，IF=6.317, 中科院JCR分区II区)

19. Guo Yi, Zhang Peiwen, Liu Yongji, Zha Longying, Ling Wenhua, Guo Honghui*. A dose-response evaluation of purified anthocyanins on inflammatory and oxidative biomarkers and metabolic risk factors in healthy young adults: A randomized controlled trial. Nutrition, 2020 (June), 74: 110745.

20. Xuebin Gao, Dinghe Zhu, Yongji Liu, Longying Zha, Dixin Chen, Honghui Guo*. Physicochemical properties and anthocyanin bioaccessibility of downy rose-myrtle powder prepared by superfine grinding. International Journal of Food Properties, 2019, 22(1): 2022-2032.

21. Iboyi AJK*, Zha LY. Severe acute malnutrition (SAM) evaluation of associated risk factors, screening tools, and therapeutic management among South Sudanese children aged 6-59 months in emergency settings: case reports and review of literature. Journal of Tropical Diseases, 2019, 7(2): 1000298.

22. Chai SC, Davis K, Zhang Z, Zha LY, Kirschner KF*. Effects of tart cherry juice on biomarkers of inflammation and oxidative stress in older adults. Nutrients, 2019, 11(2): pii: E228. DOI: 10.3390/nu11020228. (SCI收录，IF=6.706, 中科院JCR分区II区)

23. Xie QY#, Gu XF#, Chen JB#, Liu MS, Xiong F, Wu XL, Zhang YJ, Chen FP, Chen HE, Li MJ, Sun SX, Chu XW, Zha LY*. Soyasaponins reduce inflammation and improve serum lipid profiles and glucose homeostasis in high fat diet-induced obese mice. Molecular Nutrition and Food Research, 2018 (Oct 1), 62(19): e1800205 (DOI: 10.1002/mnfr.201800205). (SCI收录，IF=6.575, 中科院JCR分区I区)

24. Bili AAM, Zha LY*. Knowledge of type 2 diabetes mellitus and adherence to management guidelines: a cross-sectional study in Juba, South Sudan. South Sudan Medical Journal, 2018, 11 (4): 84-88.

25. Zhang YJ, Chen FP, Chen JD, Huang SQ, Chen JB, Huang J, Li N, Sun SX, Chu XW, Zha LY*. Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species. Molecular Nutrition and Food Research, 2016 (Jul 8), 60(7): 1532-1543. DOI: 10.1002/mnfr.201600015. (SCI收录，IF=6.575, 中科院JCR分区I区)

26. Zhang JT, Yi N, Zha LY, Chen SQ, Li ZJ, Li C, Gong MX, Deng H, Chu XW, Chen JH, Zhang ZQ, Mao LM, Sun SX*. Sodium butyrate induces endoplasmic reticulum stress and autophagy in colorectal cells: implications for apoptosis. PLOS ONE, 2016, 11(1): e0147218. (SCI收录，IF=3.534, 中科院JCR分区III区)

27. Li WL, Zha LY, Li ZQ*, Huang YS, Zhou YP*. The expression profile of aquaporin 1 in rat myocardium after severe burns. Turkish Journal of Medical Sciences, 2015, 45(3):481-488. (SCI收录，IF=0.973, 中科院JCR分区IV区)

28. Zha LY*, Chen JD, Sun SX, Mao LM, Chu XW, Deng H, Cai JW, Li XF, Liu ZQ, Cao WH*. Soyasaponins can blunt inflammation by inhibiting reactive oxygen species (ROS)-mediated activation of PI3K/Akt/ NF-κB pathway. PLOS ONE, 2014, 9(9): e107655. (SCI收录，IF=3.534, 中科院JCR分区III区)

29. Chen JD#，Sun SX#, Zha DS, Wu JG, Mao LM, Deng H, Chu XW, Luo HJ, Zha LY*. Soyasaponins prevent H2O2-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells. Nutrition and Cancer, 2014, 66(8): 1342-1351. (SCI收录，IF=2.9, 中科院JCR分区III区)

30. He GZ, Chen JD, Hu YH, Chen JB, Lv JL, Zha LY*. Soyasaponins protect against palmitic acid-induced oxidative stress in primary mouse hepatocytes: structure-activity relationship. Acta Nutrimenta Sinca, 2014, 36(6): 570-576. (中文核心期刊营养学报英文版)

31. Yang XF#, Mei S#, Gu HH, Guo HL, Zha LY, Cai JW, Li XF, Liu ZQ, Cao WH*. Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet. Journal of Endocrinology, 2014, 221: 469-480. (SCI收录，IF=4.286, 中科院JCR分区III区)

32. Mei S#, Yang XF#, Guo HL, Gu HH, Zha LY, Cai JW, Li XF, Liu ZQ, Bennett BJ, He L, Cao WH*. A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level. PLOS ONE, 2014, 9(7): e100875. (SCI收录，IF=3.534, 中科院JCR分区II区)

33. Sun SX#, Li WJ#, Zhang H#, Zha LY, Xue Y, Wu XB, Zou F*. Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells. Bioscience Reports, 2012, 32: 83-90. (SCI收录，IF=2.853, 中科院JCR分区III区)

34. Zha LY*, Mao LM, Lu XC, Deng H, Ye JF, Chu XW, Sun SX, Luo HJ. Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression. Bioorganic & Medicinal Chemistry Letters, 2011, 21(8): 2415-2418. (SCI收录，IF=2.823, 中科院JCR分区III区)