三级教授，主任医师，博士生导师/博士后合作导师。南方医科大学基础医学院病理学系党支部书记、副主任，南方医科大学顺德医院科技特派员、病理科学科带头人，首届全国党建样板支部负责人、广东省“珠江学者”特聘教授、广东省一流课程负责人、第四届南方医科大学本科教学优秀教师、“广东省特支计划”科技创新青年拔尖人才、广东省“千百十人才工程”省级培养对象，广东省杰出青年医学人才，先后获全国优秀博士学位论文、霍英东教育基金会青年教师基金、中国病理研究杰出青年奖、广东省自然科学杰出青年基金，现任中国医疗保健国际交流促进会病理学分会常务委员、中华医学会病理学分会青年委员会委员、广东省医师协会肿瘤MDT工作委员会副主任委员、广东省医师协会病理科医师分会常务委员。

以第一作者或通讯作者在Gut (2010)、EMBO J (2021)、Clin Cancer Res(2014)、Cell Death Differ (2019)、Cell Rep (2020)、Oncogene (2019, 2020, 2020, 2021)、EBioMedicine (2019, 2019)、Mol Cancer (2021)等SCI收录期刊发表学术论文，为Cancer Commun、Oncogene、J ImmunoTher Cancer、Clin Transl Med期刊通讯审稿人。主持国家自然科学基金5项，省部级课题8项，相关成果获得广东省科技进步、自然科学一等奖各1项、中华医学科技一等奖、二等奖各1项。作为指导老师指导本科生获得全国大学生基础医学创新论坛暨实验设计大赛金奖1项、银奖2项，“挑战杯”广东大学生课外学术科技作品竞赛一等奖1项、二等奖2项，广东省科技创新战略专项资金（“攀登计划”）6项及大学生创新创业训练计划项目（国家级）2项等。

研究方向：消化道肿瘤转移分子机制；肿瘤微环境与靶向治疗；肿瘤代谢与肿瘤演进

立足国内研究二十余年，围绕肿瘤转移分子机制这一肿瘤领域的重大科学问题，从肿瘤异质性对于肿瘤微环境的重塑及肿瘤微环境介导肿瘤转移的角度进行系列研究，提出肿瘤异质性，证实结直肠癌细胞异质性触发的“肿瘤细胞-肿瘤微环境”互作模式在肿瘤转移中发挥了关键作用，并在此基础上提出了针对肿瘤微环境遏制肿瘤转移的治疗策略。

1. 1. Jing Wang#, Yan Zhou#, Donghui Zhang, Weiyi Zhao, Yishi Lu, Chaoqun Liu, Wandie Lin, Yujie Zhang, Kunling Chen, Hui Wang, Liang Zhao*. CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma. EMBO J. 2022 Jul 1;e110218 (中科院小类1区，IF2022=11.4)
2. 2. Li R^#, Zhou R^#, Wang H, Li W, Pan M, Yao X, Zhan W, Yang S, Xu L, Ding Y^*, Zhao L^*.Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death Differ. 2019 Nov;26(11):2447-2463 (IF2022=12.4, 中科院小类1区)
3. 3. Pan Z^#, Liu C^#, Zhi Y, Xie Z, Wu L, Jiang M, Zhang Y, Zhou R^*, Zhao L^*. LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation. Oncogene. 2021 Apr;40(14):2581-2595 (IF2022=8, 中科院小类1区)
4. 4. Wu L^#, Lin W^#, Liao Q^#, Wang H^#, Lin C, Tang L, Lian W, Chen Z, Li K, Xu L, Zhou R, Ding Y^*, Zhao L^*. Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation. Cell Rep. 2020 Oct 27;33(4):108327 (IF2022=8.8，中科院小类2区)
5. 5. Yan P^#, Liu J^#, Zhou R^#, Lin C, Wu K, Yang S, Yang S, Zhou J, Xu L, Wang H, Zhao L^*. LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion. Oncogene. 2020 Aug;39(35):5743-5755 (IF2022=8, 中科院小类1区)
6. 6. Zhang F ^#, Wang H^#, Yu J, Yao X, Yang S, Li W, Xu L, Zhao L^*. LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM. Molecular Cancer. 2021 Jan 4;20(1):6 (IF2022=37.3,中科院小类1区，ESI高被引论文)
7. 7. Wang H^#, Shi J^#, Luo Y^#, Liao Q, Niu Y, Zhang F, Shao Z, Ding Y, Zhao L^*. LIM and SH3 protein 1 induces TGFbeta-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression. Clinical Cancer Research, 2014, 20(22): 5835-5847 (Cover story，IF2022=11.5, 中科院小类1区)
8. 8. Zhao L^#, Wang H, Liu C, Liu Y, Wang X, Wang S, Sun X, Li J, Deng Y, Jiang Y, Ding Y^*. Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1. Gut, 2010, 59(9): 1226-1235 (IF2022=24,5, 中科院小类1区)
9. 9. Han Q^#, Xu L^#, Lin W^#, Yao X^#, Jiang M, Zhou R, Sun X^*, Zhao L^*. Long noncoding RNA CRCMSL suppresses tumor invasive and metastasis in colorectal carcinoma through nucleocytoplasmic shuttling of HMGB2. Oncogene. 2019 Apr;38(16):3019-3032 (IF2022=8, 中科院小类1区)
10. 10. Qingzu Gao^#, Rui Zhou^#, Yuan Meng, Rongfei Duan, Ling Wu, Rui Li, Fengliu Deng, Chuang Lin, Zhao L^*. Long Noncoding RNA CMPK2 Promotes Colorectal Cancer Progression by Activating the FUBP3-c-Myc Axis. Oncogene. 2020 May;39(19):3926-3938 (IF2022=8 中科院小类1区)
11. 11. Fengliu Deng^#, Rui Zhou^#, Chuang Lin, Shibin Yang, Hui Wang, Weidong Li, Kehong Zheng, Wandie Lin, Xin Li, Xueqing Yao, Mingxin Pan, Zhao L^*. Tumor-secreted dickkopf2 accelerates aerobic glycolysis and promotes angiogenesis in colorectal cancer. Theranostics. 2019; 9(4): 1001-1014 (IF2022=12.4, 中科院小类1区)
12. 12. Zhang Feifei^#, Li Kaitao^#, Pan Mingxin^#, Li Weidong, Wu Juan, Li Mingyi, Zhao Liang^*, Wang Hui^*. miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop. J Exp Clin Cancer Res, 2018, 37(1): 152（IF2022=11.3, 中科院小类2区）
13. 13. Zhang Lanzhi^#, Zhou Rui^#, Zhang Weibin^#, Yao Xueqing, Li Weidong, Xu Lijun, Sun Xuegang^*, Zhao Liang^*. Cysteine-rich intestinal protein 1 suppresses apoptosis and chemosensitivity to 5-fluorouracil in colorectal cancer through ubiquitin-mediated Fas degradation, J Exp Clin Cancer Res. 2019, 38: 120 (IF2022=11.3, 中科院小类2区)
14. 14. Liu Chaoqun^#, Pan Zhihua^#, Chen Qian^#, Chen Zetao, Liu Weiwei, Wu Ling, Jiang Muhong, Lin Wandie, Zhang Yujie, Lin Weihao, Zhou Rui^*, Zhao Liang^*. Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer. J Exp Clin Cancer Res. 2021, 40(1): 297 (IF2022=11.3, 中科院小类2区)
15. 15. Tang Yujun^#, Lu Yishi^#, Chen Yuan, Luo Lei, Cai Lei, Peng Bangjian, Huang Wwenbin, Liao Hangyu, Zhao Liang^*, Pan Mmingxin^*. Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1. J Exp Clin Cancer Res. 2019 Nov 21;38(1):473 (IF2022=11.3, 中科院小类2区)