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更新日期：2025年9月11日
姓 名 许顶立 性 别 男
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术&专业型
最后学历 硕士研究生毕业 最后学位 医学硕士学位
行政职务 主任 Email dinglixu@smu.edu.cn
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介

南方医科大学南方医院大内科主任，二级教授、心血管内科主任医师，学术带头人。博士生导师。

首批广东省医学领军人才。

担任国家心血管病专家委员会委员；国家心血管病专家委员会心力衰竭专业委员会副主任委员；中国医师协会心血管内科医师分会常务委员兼心力衰竭学组副组长；中国医师协会心力衰竭专业委员会副主任委员；中国老年医学学会心血管病分会副会长；中国中药协会心血管药物研究专业委员会副主任委员等。

获聘为《中华心力衰竭和心肌病杂志》、《心脏杂志》、《中华心脏和心律电子杂志》副总编辑；《中华高血压杂志》、《内科急危重症杂志》常务编委；《中华心血管病杂志》、《中华内科杂志》、《中华老年心脑血管病杂志》、《中国循环杂志》、《临床心血管病杂志》、《中国动脉硬化杂志》、《疑难病杂志》、《保健医苑》编委。

 

研究领域

1. 心力衰竭的发生机制和防治

2. 高血压和钙化性主动脉瓣病的发生机制

个人成果
    1. Xian G, Huang R, Hu D, Xu M, Chen Y, Ren H, Xu D, Zeng Q（共同通讯作者）. Interleukin-37 attenuates aortic valve lesions by inhibiting m6A-mediated IRAK-M degradation. Cardiovasc Res. 2025 Feb 6:cvaf012. doi: 10.1093/cvr/cvaf012.
    2. Zhang H, Xu T, Mei X, Zhao Q, Yang Q, Zeng X, Ma Z, Zhou H, Zeng Q, Xu D, Ren H（共同通讯作者）. PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction. Clin Transl Med. 2025 Jan;15(1):e70166. doi: 10.1002/ctm2.70166.
    3. Zhou H, Wang X, Xu T, Gan D, Ma Z, Zhang H, Zhang J, Zeng Q, Xu D（共同通讯作者）. PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway. Cardiovasc Res. 2024 Nov 5:cvae238. doi: 10.1093/cvr/cvae238.
    4. Zeng X, Zhang H, Xu T, Mei X, Wang X, Yang Q, Luo Z, Zeng Q, Xu D, Ren H（共同通讯作者）. Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis. Transl Res. 2024 Jul 24; 273:90-103. doi: 10.1016/j.trsl.2024.07.005.
    5. Xian G, Huang R, Xu M, Zhao H, Xu X, Chen Y, Ren H, Xu D, Zeng Q（共同通讯作者）. Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions. Exp Mol Med. 2024 Jul; 56(7):1560-1573. doi: 10.1038/s12276-024-01256-5.
    6. Yang X, Zeng J, Xie K, Su S, Guo Y, Zhang H, Chen J, Ma Z, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q（共同通讯作者）. Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters. Mol Med. 2024 Jun 5;30(1):76. doi: 10.1186/s10020-024-00833-8.
    7. Yu H, Gan D, Luo Z, Yang Q, An D, Zhang H, Hu Y, Ma Z, Zeng Q, Xu D, Ren H（共同通讯作者）.α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice. Mol Med. 2024 Jan 22;30(1):15. doi: 10.1186/s10020-024-00783-1.
    8. Hu L, Li T, Wu X, Yu L, Zeng G, Han M, Xu J, Wang Z, Wang L, Xu D, Huang W, Wu Y（共同通讯作者）. Stretchable Alginate/GelMA Interpenetrating Network (IPN) hydrogel microspringsbased on coaxial microfluidic technique for skeletal muscle tissue engineering. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2024; 687 :133502.
    9. Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D（共同通讯作者）. Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function. Biology (Basel). 2023 Apr 11;12(4):582. doi: 10.3390/biology12040582
    10. 14. Zhong G, Su S, Li J, Zhao H, Hu D, Chen J, Li S, Lin Y, Wen L, Lin X, Xian G, Xu D, Zeng Q（共同通讯作者）. Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis. Sci Adv. 2023 Jun 2;9(22):eadg0478. doi: 10.1126/sciadv.adg0478.
    11.  Li S, Luo Z, Su S, Wen L, Xian G, Zhao J, Xu X, Xu D, Zeng Q（共同通讯作者）. Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice. BMC Med. 2023 Jul 13;21(1):252. doi: 10.1186/s12916-023-02888-6
    12.  Xie K, Zeng J, Wen L, Peng X, Lin Z, Xian G, Guo Y, Yang X, Li P, Xu D, Zeng Q（共同通讯作者）. Abnormally elevated EZH2-mediated H3K27me3 enhances osteogenesis in aortic valve interstitial cells by inhibiting SOCS3 expression. Atherosclerosis. 2023 Jan; 364:1-9. doi: 10.1016/j.atherosclerosis.2022.11.017.
    13.  Li J, Zeng Q, Xiong Z, Xian G, Liu Z, Zhan Q, Lai W, Ao L, Meng X, Ren H, Xu D（共同通讯作者）. Trimethylamine -N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice. Cardiovasc Res. 2022 Jun 29;118(8):2018-2030. doi: 10.1093/cvr/cvab243.
    14. Zhao H, Xian G, Zeng J, Zhong G, An D, Peng Y, Hu D, Lin Y, Li J, Su S, Ning Y, Xu D, Zeng Q（共同通讯作者）. Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease. Antioxidants (Basel). 2022 Oct 24; 11(11):2093. doi: 10.3390/antiox11112093.
    15. Peng X, Su S, Zeng J, Xie K, Yang X, Xian G, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q（共同通讯作者）. 4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury. Free Radic Biol Med. 2022 Aug 1; 188:404-418. doi: 10.1016/j.freeradbiomed.2022.06.246.
    16. An D, Zeng Q, Zhang P, Ma Z, Zhang H, Liu Z, Li J, Ren H, Xu D（共同通讯作者）. Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice. Redox Biol. 2021 Jul 30; 46:102088. doi: 10.1016/j.redox.2021.102088.
    17. Zeng Q, Cheng Z, Xia Y, Cheng R, Ou A, Li X, Xu X, Huang Y, Xu D（通讯作者）. Optimal antithrombotic therapy after transcatheter aortic valve replacement in patients with atrial fibrillation. Ther Adv Chronic Dis. 2020 Oct 14;11:2040622320949068. doi: 10.1177/2040622320949068.
    18. Liu Z, Tian H, Hua J, Cai W, Bai Y, Zhan Q, Lai W, Zeng Q, Ren H, Xu D（共同通讯作者）.A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs. Front Pharmacol. 2019 May 7;10:465. doi: 10.3389/fphar.2019.00465
    19. Huang Y, Deng Z, Se Z, Bai Y, Yan C, Zhan Q, Zeng Q, Ouyang P, Dai M, Xu D（通讯作者）. Combined impact of risk factors on the subsequent development of hypertension. J Hypertens. 2019, 37(4):696–701. doi: 10.1097/HJH.0000000000001956.
    20. Zhou HB, Xu TY, Liu SR, Bai YJ, Huang XF, Zhan Q, Zeng QC, Xu DL（通讯作者）. Association of serum uric acid change with mortality, renal function and diuretic dose administered in treatment of acute heart failure. Nutr Metab Cardiovasc Dis. 2019 Apr; 29(4):351-359. doi: 10.1016/j.numecd.2019.01.001.
    21. Peng Z, Zhan Q, Xie X, Li H, Tu Y, Bai Y, Huang X, Lai W, Zhao B, Zeng Q, Xu D（通讯作者）. Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study. Mol Med. 2019 Mar 28; 25(1):8. doi: 10.1186/s10020-019-0078-1.
    22. Xiong W, Hua J, Liu Z, Cai W, Bai Y, Zhan Q, Lai W, Zeng Q, Ren H, Xu D（共同通讯作者）. PTEN induced putative kinase 1 (PINK1) alleviates angiotensin II-induced cardiac injury by ameliorating mitochondrial dysfunction. Int J Cardiol. 2018 Sep 1; 266:198-205. doi: 10.1016/j.ijcard.2018.03.054.
    23. Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X（共同通讯作者）.Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1631-1636. doi: 10.1073/pnas.1619667114
    24. Liu Z, Liu H-Y, Zhou H, Zhan Q,Lai W, Zeng Q, Ren H, Xu D（共同通讯作者）. Moderate-intensity exercise affects gut microbiome composition and influences cardiac function in myocardial infarction mice. Front Microbiol. 2017 Sep 01; 8:1687.doi: 10.3389/fmicb.2017.01687
    25. Huang Y, Huang W, Mai W, Cai X, An D, Liu Z, Huang H, Zeng J, Hu Y, Xu D（共同通讯作者）. White-coat hypertension is a risk factor for cardiovascular diseases and total mortality. J Hypertens. 2017 Apr;35(4):677-688. doi: 10.1097/HJH.0000000000001226
    26. Huang Y, Xu S, Hua J, Zhu D, Liu C, Hu Y, Liu T, Xu D（共同通讯作者）. Association between job strain and risk of incident stroke: A meta-analysis. Neurology. 2015 Nov 10; 85(19): 1648 -1654. doi: 10.1212/WNL.0000000000002098.
    27. Chen PA, Xu ZH, Huang YL, Luo Y, Zhu DJ, Wang P, Du ZY, Yang Y, Wu DH, Lai WY, Ren H, Xu DL（共同通讯作者）. Increased serum 2-oxoglutarate associated with high myocardial energy expenditure and poor prognosis in chronic heart failure patients. Biochim Biophys Acta. 2014, 1842(11):2120-2125. doi: 10.1016/j.bbadis.2014.07.018.
    28. Wu ZL, Ren H, Lai WY, Lin S, Jiang RY, Ye TC, Shen QB, Zeng QC, Xu DL（通讯作者）. Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure. J Ethnopharmacol. 2014, 155:563-571. doi: 10.1016/j.jep.2014.05.054.
    29. Huang Y, Cai X, Li Y, Su L, Mai W, Wang S, Hu Y, Wu Y, Xu D（通讯作者）. Prehypertension and the risk of stroke: A meta-analysis. Neurology. 2014, 82(13):1153-1161.
    30. HuangY, Cai X, Zhang J, Mai W, Wang S, Hu Y, Ren H, Xu D（共同通讯作者）.Prehypertension and Incidence of ESRD: A Systematic Review and Meta-analysis. Am J Kidney Dis. 2014, 63(1):76-83. doi:10.1053/j.ajkd.2013.07.024.
    31. HuangY, Wang S, Cai X, Mai W, Hu Y, Tang H, Xu D（通讯作者）. Prehypertension and incidence of cardiovascular disease: a meta-analysis. BMC Med. 2013, 11:177. doi: 10.1186/1741-7015-11-177
    32. Zeng Q, Jin C, Ao L, Cleveland JC Jr, Song R, Xu D, Fullerton DA, Meng X（共同通讯作者）. Cross-talk between the toll-like receptor 4 and notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation. 2012, 126(11 Suppl 1):S222-230.