南方医科大学口腔医院（广东省口腔医院）口腔颌面外科住培基地教学主任，盘福院区党支部副书记，盘福院区口腔颌面外科副主任/盘福院区医疗美容中心负责人，主任医师，博士后合作导师，专业型博士导师，学术型硕士生导师/专业型硕士导师，博士，博士后。

中华口腔医学会口腔急诊专业委员会委员；中华医学会整形外科分会微创学组委员；中华医学会整形外科分会颅颌面学组委员；中国抗衰老促进会创新与应用分会再生医学创新研究部常务副主任；中华医学会整形外科分会数字化学组委员；中国抗衰老促进会创新与应用分会执行委员；中国整形美容协会精准与数字医学分会理事；中国整形美容协会精准与颅颌面整复专业委员会委员；广东省青年科学家协会理事；粤港澳合作促进会医药卫生大健康委员会委员；广东省牙及牙槽外科专业委员会委员；广东省口腔医学会口腔急诊专业委员会青年委员；广东省抗癌协会头颈肿瘤专业委员会青年委员会委员；广东省材料研究学会青年委员会委员；广东省医学美容学会口腔医学会委员。

主持国家级、省部级、厅局级课题10余项，主持课题科研经费500余万，以第一／通讯作者发表SCI论文30余篇，累计影响因子200余分，获得国家授权专利7项。曾获“广东特支计划”卫生健康人才项目-青年拔尖人才项目、第五届羊城青年好医生，广东省青年优秀人才国际培养计划项目等。

擅长：1、口腔微生物与口腔疾病及系统疾病的关系及其机 制研究；2、干细胞、外泌体及生物材料在面部年轻化中的应用研究 ；3、人工智能检测唾液在口腔及系统疾病的早筛早诊和治疗中的应用。

研究方向：1、口腔微生物与口腔疾病及系统疾病的关系及其机 制研究；2、干细胞、外泌体及生物材料在面部年轻化中的应用研究 ；3、人工智能检测唾液在口腔及系统疾病的早筛早诊和治疗中的应用。

1. Huang Z, Yang X, Huang Y, Tang Z, Chen Y, Liu H, Huang M, Qing L, Li L, Wang Q, Jie Z, Jin X*, Jia B*. Saliva - a new opportunity for fluid biopsy. Clin Chem Lab Med. 2022 Oct 27. doi: 10.1515/cclm-2022-0793. Epub ahead of print. PMID: 36285724. （IF 2025=3.7，JCR分区＝1区）（大类及分区：医学2区，小类及分区：医学实验技术2区）

2. Huang M, Huang Y, Liu H, Tang Z, Chen Y, Huang Z, Xu S*, Du J*, Jia B*. Hydrogels for the treatment of oral and maxillofacial diseases: current research, challenges, and future directions. Biomater Sci. 2022 Sep 7. doi: 10.1039/d2bm01036d. Epub ahead of print. PMID: 36069391.（IF 2025=5.7，JCR分区＝2区）（大类及分区：医学3区，小类及分区：材料科学：生物材料3区）

3. Tsai HI, Wu Y, Liu X, Xu Z, Liu L, Wang C, Zhang H, Huang Y, Wang L, Zhang W, Su D, Khan FU, Zhu X, Yang R, Pang Y, Eriksson JE, Zhu H, Wang D, Jia B*, Cheng F*, Chen H*. Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection. Adv Sci (Weinh). 2021 Nov 5:e2102634. doi: 10.1002/advs.202102634. Epub ahead of print. PMID: 34738731.（IF 2025=14.1，JCR分区＝1区）（大类及分区：材料科学1区TOP ，小类及分区：纳米科技1区；材料科学：综合1区；化学：综合1区）

4. Liu H, Huang Y, Huang M, Huang Z, Wang Q, Qing L, Li L, Xu S*, Jia B*. Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment. Int J Nanomedicine. 2022 Jun 16;17:2679-2705. doi: 10.2147/IJN.S365594. （IF 2025=6.5，JCR分区＝1区）（大类及分区：医学2区，小类及分区：药学2区，纳米科技3区）

5. Huang Y, Huang Z, Tang Z, Chen Y, Huang M, Liu H, Huang W, Ye Q*, Jia B*. Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models. Front Cell Dev Biol. 2021 Nov 16;9:740574. doi: 10.3389/fcell.2021.740574. PMID: 34869324; PMCID: PMC8635113. （IF 2025=4.3，JCR分区＝1区）（大类及分区：生物学2区，小类及分区：发育生物学2区，细胞生物学3区）

6. Jia B†, Chen J†, Wang Q, Sun X, Han J, Guastaldi F, Xiang S, Ye Q, He Y. SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1. Front Cell Dev Biol. 2021 Jun 22;9:648627. doi: 10.3389/fcell.2021.648627. PMID: 34239868; PMCID: PMC8258422. （IF 2025=4.3，JCR分区＝1区）（大类及分区：生物学2区，小类及分区：发育生物学2区，细胞生物学3区）

7. Xin S, Wu Y, Huang Z, Huang Y, Jia B*, Zhao J*. Engineering Cell Membrane-Based Nanovesicles for Melanoma Tumor Treatment. J Biomed Nanotechnol. 2021 May 1;17(5):838-845. doi: 10.1166/jbn.2021.3072. PMID: 34082870.  （IF 2023=2.9，JCR分区＝3区）（大类及分区：工程技术2区，小类及分区：纳米科技4区，材料科学：生物材料3区）

8. Tang Z, Huang Z, Huang Y, Chen Y, Huang M, Liu H, Ye QA*, Zhao J*, Jia B*. Ferroptosis: The Silver Lining of Cancer Therapy. Front Cell Dev Biol. 2021 Nov 29;9:765859. doi: 10.3389/fcell.2021.765859. PMID: 34912804; PMCID: PMC8667274. （IF 2025=4.3，JCR分区＝1区）（大类及分区：生物学2区，小类及分区：发育生物学2区，细胞生物学3区）

9. Chen Y, Huang Z, Tang Z, Huang Y, Huang M, Liu H, Ziebolz D, Schmalz G, Jia B*, Zhao J*. More Than Just a Periodontal Pathogen -the Research Progress on Fusobacterium nucleatum. Front Cell Infect Microbiol. 2022 Feb 3;12:815318. doi: 10.3389/fcimb.2022.815318. PMID: 35186795; PMCID: PMC8851061. （IF 2025=4.8，JCR分区＝1区）（大类及分区：医学2区，小类及分区：免疫学2区，微生物学2区）

10. Wen, L; Liu, P; Chen, Q; Ge, J; Jia, B*; Li, Q*. Impaired Proliferation, Apoptosis, and Angiogenesis of Adipose-Derived Stem Cells Isolated from Rats during the Course of Diabetes. Coatings 2021, 11, 1549, doi:10.3390/coatings11121549.（IF 2025=2.8，JCR分区＝2区）（大类及分区：材料科学3区，小类及分区：材料科学：膜3区，材料科学：综合4区，物理：应用3区）

11. Jia B, Wang Z, Sun X, Chen J, Zhao J, Qiu X. Long noncoding RNA LINC00707 sponges miR-370-3p to promote osteogenesis of human bone marrow-derived mesenchymal stem cells through upregulating WNT2B. Stem Cell Res Ther. 2019 Feb 22;10(1):67. doi: 10.1186/s13287-019-1161-9. PMID: 30795799; PMCID: PMC6387535. （IF 2025=7.3，JCR分区＝1区）（大类及分区：医学2区TOP，小类及分区：细胞与组织工程2区，细胞生物学2区，医学：研究与实验2区）

12. Jia B†, Dao J†, Han J, Huang Z, Sun X, Zheng X, Xiang S, Zhou H, Liu S. LINC00958 promotes the proliferation of TSCC via miR-211-5p/CENPK axis and activating the JAK/STAT3 signaling pathway. Cancer Cell Int. 2021 Mar 3;21(1):147. doi: 10.1186/s12935-021-01808-z. PMID: 33658048; PMCID: PMC7931557. （IF 2025=6.0，JCR分区＝1区）（大类及分区：医学3区，小类及分区：肿瘤学3区）

13. Jia B†, Qiu X†, Chu H, Sun X, Xu S, Zhao X, Zhao J. Wnt7a predicts poor prognosis, and contributes to growth and metastasis in tongue squamous cell carcinoma. Oncol Rep. 2019 Mar;41(3):1749-1758. doi: 10.3892/or.2019.6974. Epub 2019 Jan 22. PMID: 30747225. （IF 2025=3.9，JCR分区＝2区）（大类及分区：医学3区，小类及分区：肿瘤学4区）

14. Jia B, Zhang Z, Qiu X, Chu H, Sun X, Zheng X, Zhao J, Li Q. Analysis of the miRNA and mRNA involved in osteogenesis of adipose-derived mesenchymal stem cells. Exp Ther Med. 2018 Aug;16(2):1111-1120. doi: 10.3892/etm.2018.6303. Epub 2018 Jun 13. PMID: 30116362; PMCID: PMC6090261. （IF 2025=2.3，JCR分区＝3区）（大类及分区：医学4区，小类及分区：医学：研究与实验4区）

15. Jia B†, Zheng X†, Qiu X, Jiang X, Liu J, Huang Z, Xiang S, Chen G, Zhao J. Long noncoding RNA MIR4713HG aggravates malignant behaviors in oral tongue squamous cell carcinoma via binding with microRNA let7c5p. Int J Mol Med. 2021 May;47(5):84. doi: 10.3892/ijmm.2021.4917. Epub 2021 Mar 24. PMID: 33760127; PMCID: PMC7992924. （IF 2025=5.8，JCR分区＝1区）（大类及分区：医学2区，小类及分区：医学：研究与实验2区）

16. Qiu X†, Jia B†, Sun X, Hu W, Chu H, Xu S, Zhao J. The Critical Role of Long Noncoding RNA in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells. Biomed Res Int. 2017;2017:5045827. doi: 10.1155/2017/5045827. Epub 2017 Apr 27. PMID: 28536698; PMCID: PMC5425846. （2025=2.3，JCR分区＝3区）（大类及分区：医学4区，小类及分区：生物工程与应用微生物学4区，医学：研究与实验4区）

17. Zheng X†, Jia B†, Lin X, Han J, Qiu X, Chu H, Sun X, Hu W, Pan J, Chen J, Zhao J. FRMD4A: A potential therapeutic target for the treatment of tongue squamous cell carcinoma. Int J Mol Med. 2016 Nov;38(5):1443-1449. doi: 10.3892/ijmm.2016.2745. Epub 2016 Sep 21. PMID: 27666346; PMCID: PMC5065292. （IF 2025=5.8，JCR分区＝1区）（大类及分区：医学2区，小类及分区：医学：研究与实验2区）

18. Chu H†, Jia B†, Qiu X, Pan J, Sun X, Wang Z, Zhao J. Investigation of proliferation and migration of tongue squamous cell carcinoma promoted by three chemokines, MIP-3α, MIP-1β, and IP-10. Onco Targets Ther. 2017 Aug 29;10:4193-4203. doi: 10.2147/OTT.S132855. PMID: 28919775; PMCID: PMC5587132. （IF 2025=2.8，JCR分区＝2区）（大类及分区：医学4区，小类及分区：生物工程与应用微生物4区，肿瘤学4区）

19. Sun X†, Jia B†, Qiu XL, Chu HX, Zhang ZQ, Wang ZP, Zhao JJ. Potential functions of long noncoding RNAs in the osteogenic differentiation of human bone marrow mesenchymal stem cells. Mol Med Rep. 2019 Jan;19(1):103-114. doi: 10.3892/mmr.2018.9674. Epub 2018 Nov 20. PMID: 30483739; PMCID: PMC6297760. （IF 2025=3.5，JCR分区＝2区）（大类及分区：医学4区，小类及分区：医学：研究与实验4区，肿瘤学4区）

20. Liu F, Chu HX, Han JS, Sun X, Chen J, Qiu XL, Zheng XH, Jia B*, Zhao JJ*. Inhibitory effect of the Notch pathway-inhibitor DAPT on invasion and metastasis of tongue cancer via lncRNA-KAT14 regulation. Eur Rev Med Pharmacol Sci. 2020 Jan;24(1):189-199. doi: 10.26355/eurrev_202001_19911. PMID: 31957832. （IF 2023=3.3，JCR分区＝3区）（大类及分区：医学3区，小类及分区：药学3区）

21. Huang Z, Huang Y, Chen J, Tang Z, Chen Y, Liu H, Huang M, Qing L, Li L, Wang Q*, Jia B*. The role and therapeutic potential of gut microbiome in severe burn. Front Cell Infect Microbiol. 2022 Nov 17;12:974259. doi: 10.3389/fcimb.2022.974259. PMID: 36467727; PMCID: PMC9714625. （IF 2025=4.8，JCR分区＝1区）（大类及分区：医学2区，小类及分区：免疫学2区，微生物学2区）

22. Chen W, Ming Y, Wang M, Huang M, Liu H, Huang Y, Huang Z, Qing L, Wang Q, Jia B. Nanocomposite Hydrogels in Regenerative Medicine: Applications and Challenges. Macromol Rapid Commun. 2023 May 4;e2300128. doi: 10.1002. （IF 2025=4.3，JCR分区＝2区）（大类及分区：化学3区，小类及分区：高分子科学3区）

23. Huang M, Chen W, Wang M, Huang Y, Liu H, Ming Y, Chen Y, Tang Z, Jia B. Advanced Delivery Strategies for Immunotherapy in Type I Diabetes Mellitus. BioDrugs. 2023 May 13:1–22. doi: 10.1007/s40259-023-00594-6. Epub ahead of print. PMID: 37178431; PMCID: PMC10182560. （IF 2025=6.9，JCR分区＝1区）（大类及分区：医学2区，小类及分区：免疫学2区，药学2区，肿瘤学2区）

24. Liu H, Huang Y, Chen Y, Tang Z, Huang M, Ming Y, Wang M, Chen W, Huang Z, Qing L, Wang Q, Jia B. Family with Sequence Similarity 72 (FAM72) - A prospective biomarker for poor prognosis in patients with oral squamous cell carcinoma. Arch Oral Biol. 2023 Jul;151:105695. doi: 10.1016/j.archoralbio.2023.105695. Epub 2023 Apr 7. PMID: 37086493. （IF 2025=2.1，JCR分区＝2区）（大类及分区：医学4区，小类及分区：牙科和口腔外科4区）

25. Bi J, Mo C, Li S, Huang M, Lin Y, Yuan P, Liu Z*, Jia B*, Xu S*. Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes. Biomater Sci. 2023 May 10. doi: 10.1039/d3bm00271c. Epub ahead of print. PMID: 37161951. （IF 2025=5.7，JCR分区＝2区）（大类及分区：医学3区，小类及分区：材料科学：生物材料3区）

26. Yuanxin Chen , Zhijie Huang , Jianjiang Zhao* , Bo Jia*. Fusobacterium Nucleatum Stimulates the Progression of Oral Squamous Cell Carcinoma through CCL20. Journal of Biological Regulators and Homeostatic Agents. 2023, 37(4): 2243-2257 https://doi.org/10.23812/j.biol.regul.homeost.agents.20233704.221.（IF 2025=0.8，JCR分区＝2区）（大类及分区：医学4区；小类及分区：内分泌学与代谢4区，免疫学4区，医学：研究与实验4区，生理学4区）

27. Huang R†, Jia B†, Su D, Li M, Xu Z, He C, Huang Y, Fan H, Chen H, Cheng F. Plant exosomes fused with engineered mesenchymal stem cell-derived nanovesicles for synergistic therapy of autoimmune skin disorders. J Extracell Vesicles. 2023 Oct;12(10):e12361. doi: 10.1002/jev2.12361. PMID: 37859568; PMCID: PMC10587508.（IF 2025=14.5，JCR分区＝1区）（大类及分区：医学 1区TOP；小类及分区：细胞生物学 2区）

28. Wang M, Liu H, Huang M, Huang Y, Ming Y, Chen W, Chen Y, Tang Z, Jia B. Immunomodulatory functions of microorganisms in tissue regenerative healing. Acta Biomater. 2023;172:38-52. doi:10.1016/j.actbio.2023.10.007.（IF 2025=9.6，JCR分区＝1区）（大类及分区：工程技术 1区 TOP；小类及分区：材料科学：生物材料 1区、工程：生物医学 1区）

29. Liu H, Huang Y, Huang M, Wang M, Ming Y, Chen W, Chen Y, Tang Z, Jia B. From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease. Eur J Med Res. 2023 Oct 11;28(1):425. doi: 10.1186/s40001-023-01413-y. PMID: 37821966; PMCID: PMC10566198.（IF 2025=3.4，JCR分区＝2区）（大类及分区：医学 3区；小类及分区：医学：研究与实验 4区）

30. Liu J, Liu X, Luo Y, Huang F, Xie Y, Zheng S, Jia B, Xiao Z. Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation. J Mol Med (Berl). 2023 Nov 28. doi: 10.1007/s00109-023-02391-8. Epub ahead of print. PMID: 38015241. （IF 2025=4.2，JCR分区＝1区）（大类及分区：医学 3区；小类及分区：遗传学3区、医学：研究与实验3区）

31. Ming, Yue; Huang, Mingshu; Huang, Yisheng; Liu, Danqing; Sun, Min*; Jia, Bo*; Du, Jianzhong*. Nanozyme-enhanced ferroptosis for cancer treatment. Materials Chemistry Frontiers. DOI: 10.1039/d3qm01202f.  Published Date: 2024 MAR 25  （IF 2025=6.0，JCR分区＝1区）（大类及分区：材料科学3区；小类及分区：化学：综合3区、材料科学：综合3区）

32. Jia B†, Zhang B†, Li J†, Qin J, Huang Y, Huang M, Ming Y, Jiang J, Chen R, Xiao Y, Du J. Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment. Chem Soc Rev. 2024 Apr 2;53(7):3273-3301. doi: 10.1039/d3cs01039b. PMID: 38507263.（IF 2025=39.0，JCR分区＝1区）（大类及分区：化学1区TOP；小类及分区： 化学：综合1 区）

33. Tang Z, Chen Y, Huang Y, Zhao J*, Jia B*. Novel ferroptosis signature for improving prediction of prognosis and indicating gene targets from single-cell level in oral squamous cell carcinoma. Heliyon. 2024;10(11):e31676. Published 2024 May 22. doi:10.1016/j.heliyon.2024.e31676（IF 2025=3.6，JCR分区＝1区）（大类及分区：综合性期刊4区；小类及分区：综合性期刊4区）

34. Guo J†, Huang Z†, Wang Q, Wang M, Ming Y, Chen W, Huang Y, Tang Z, Huang M, Liu H, Jia B*. Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. J Nanobiotechnology. 2025 Jan 3;23(1):4. doi: 10.1186/s12951-024-02935-1. PMID: 39754127; PMCID: PMC11697683.（IF 2025=12.6，JCR分区＝1区）（大类及分区：生物学1区TOP；小类及分区： 生物工程与应用微生物1 区、纳米科技2区）

35. Tang Z, Huang Z, Huang Y, Huang M, Liu H, Du J*, Jia B*. Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks. J Nanobiotechnology. 2025 Mar 2;23(1):158. doi: 10.1186/s12951-025-03210-7. PMID: 40025537; PMCID: PMC11874145.（IF 2025=12.6，JCR分区＝1区）（大类及分区：生物学1区TOP；小类及分区： 生物工程与应用微生物1 区、纳米科技2区）

36. Liu H, Wang M, Wang Q, Guo J, Chen W, Ming Y, Huang Y, Tang Z, Huang M, Jia B. Promoting scarless wound closure utilizing an injectable thermosensitive hydrogel with anti-inflammatory, antioxidant, and scar formation inhibiting properties. Biomater Adv. 2025 Aug;173:214295. doi: 10.1016/j.bioadv.2025.214295. Epub 2025 Mar 25. PMID: 40157113.（IF 2025=6.0，JCR分区＝2区）（大类及分区：医学2区TOP；小类及分区： 材料科学：生物材料2区）

37. Wang M, Chen J, Chen W, Ming Y, Guo J, Wang Q, Xu S, Kang Y, Huang Y, Jia B. Grape-Derived Exosome-Like Nanovesicles Effectively Ameliorate Skin Photoaging by Protecting Epithelial Cells. J Food Sci. 2025 Jun;90(6):e70309. doi: 10.1111/1750-3841.70309. PMID: 40504599.（IF 2025=3.4，JCR分区＝2区）（大类及分区：农林科学3区；小类及分区：食品科技3区）

38. Wang Q, Huang Z, Guo J, Chen W, Wang M, Ming Y, Liu H, Huang M, Huang Y, Tang Z, Jia B. Plant-Derived Vesicle-like Nanoparticles: Pioneering Sustainable and Effective Approaches for Tissue Repair and Regeneration. Biomolecules. 2025 Jul 22;15(8):1055. doi: 10.3390/biom15081055. PMID: 40867501; PMCID: PMC12383455.（IF 2025=4.8，JCR分区＝1区）（大类及分区：生物学2区；小类及分区：生化与分子生物学3区）