目录
更新日期:2025年9月26日
姓 名 王栋 性 别
民 族 汉族 导师层次 博士导师
技术职称 教授 导师类型 学术型
最后学历 博士研究生毕业 最后学位 工学博士学位
行政职务 Email wangdong79@smu.edu.cn
工作单位 基础医学院 邮政编码 510515
跨学科招生
跨学科招生专业1 生物与医药 招生层次类型1 专业学位博导
跨学科招生专业2 招生层次类型2
个人简介

教授,博士研究生导师。

研究方向是发育与干细胞计算系统生物学,长期致力于血液系统大数据分析研究,系统解析影响造血干细胞发育与分化的调控因素及血液系统疾病的致病机理。

主要学术成绩

1)运用大数据分析技术系统解析RNA结合蛋白、可变剪切和自噬在造血干细胞发生中的调控新机制,阐明粒/单谱系分化及命运决定的调控机制;

2)围绕RNA定位、互作与功能开发血液系统大数据资源平台与算法工具;

3)利用血液系统大数据资源平台与算法工具系统解析骨髓增殖性肿瘤致病机理。

        近年来以通讯作者(含共同)在Cell Stem Cell、Nucleic Acids Res、Sci Adv、Nat Commun、EMBO J、Adv Sci、AutophagyBrief Bioinform等期刊发表SCI论文50余篇,总被引用5000余次,ESI高被引论文12篇。主持国家自然科学基金项目4项、广东省自然科学基金项目3项等课题,骨干参与国家重点研发计划“发育编程及其代谢调节”专项2项。

学术任职

中国生物信息学学会重大疾病组学信息学专业委员会 常务委员

中国生物信息学会系统生物学专委会 常务委员

中国生理学会血液生理学专委会 委员

中国细胞生物学学会功能基因组信息学与系统生物学分会 委员

中国计算机学会生物信息学专业委员会 委员

中华预防医学会生物信息分会 委员

中国抗癌协会肿瘤标志专业委员会肿瘤测序及大数据分析专家委员会 常务委员

广东省生物信息学会理事会 理事

广东精准医学应用学会皮肤性病分会 副主任委员

研究领域

发育与干细胞计算系统生物学

长期致力于血液系统大数据分析研究,系统解析影响造血干细胞发育与分化的调控因素及血液系统疾病的致病机理。

课题项目

1.科学技术部,国家重点研发计划发育编程及其代谢调节专项,2022-12至2027-11,145万元,在研,子课题骨干    

2.科学技术部,国家重点研发计划发育编程及其代谢调节专项,2019-12至2024-11,51万元,结题,子课题骨干

3.国家自然科学基金面上项目,2024-01至2027-12,49万元,在研,主持

4.国家自然科学基金面上项目,2021-01至2024-12,55万元,结题,主持

5.国家自然科学基金面上项目,2018-01至2021-12,55万元,结题,主持

6.国家自然科学基金青年项目,2012-01至2014-12,23万元,结题,主持

7.广东省自然科学基金面上项目,2024-01至2026-12,15万元,在研,主持

8.广东省自然科学基金面上项目,2022-01至2024-12,10万元,结题,主持

9.广东省自然科学基金面上项目,2019-10至2022-09,10万元,结题,主持

个人成果

主要论文列表(*通讯或共同通讯)

1. Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li*, Xiaobo Li*, Dong Wang*(王栋). Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single-Cell Transcriptomic Data with MetaTF. Adv Sci (Weinh). 2025. 12(23):e10745. (SCI, IF=14.1, 小类1区)

2. Yongfei Hu, Xinyu Li, Ying Yi, Yan Huang*,  Guangyu Wang*, Dong Wang*(王栋). Deep learning-driven survival prediction in pan-cancer studies by integrating multimodal histology-genomic data. Brief Bioinform. 2025. 26(2):bbaf121. (SCI, IF=7.7, 小类1区)

3. Ying Yi, Yongfei Hu, Juanjuan Kang, Qifa Liu, Yan Huang*, Dong Wang*(王栋). Biological Data Resources and Machine Learning Frameworks for Hematology Research. Genom Proteom Bioinf. 2025. 23(2):qzaf021. (SCI, IF=7.9)

4.  Le Wu, Luqi Wang, Shijie Hu, Guangjue Tang, Jia Chen, Ying Yi, Hailong Xie,Jiahao Lin, Mei Wang, Dong Wang*(王栋), Bin Yang*, Yan Huang*. RNALocate v3.0: Advancing the Repository of RNA Subcellular Localization with Dynamic Analysis and Prediction. Nucleic Acids Res. 2025. 53(D1):D284-D292. (SCI, IF=13.1)

5. Hailong Zheng, Linfu Xu, Hailong Xie, Jiajing Xie, Yapeng Ma, Yongfei Hu, Le Wu, Jia Chen, Meiyi Wang, Ying Yi, Yan Huang, Dong Wang*(王栋). RIscoper 2.0: A deep learning tool to extract RNA biomedical relation sentences from literature. Comput Struct Biotechnol J. 2024. 23:1469-1476.  (SCI, IF=4.1)

6. Fanqi Zhou, Puwen Tan, Siqi Liu, Le Chang, Jiabin Yang, Mengyao Sun, Yuehong Guo, Yanmin Si, Dong Wang*(王栋), Jia Yu*, Yanni Ma*. Subcellular RNA distribution and its change during human embryonic stem cell differentiation. Stem Cell Reports. 2024. 19(1):126-140. (SCI, IF=5.1)

7. Jia Chen, Jiahao Lin, Yongfei Hu, Meijun Ye, Linhui Yao, Le Wu, Wenhai Zhang, Meiyi Wang, Tingting Deng, Feng Guo, Yan Huang, Bofeng Zhu*, Dong Wang*(王栋). RNADisease v4.0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction. Nucleic Acids Res. 2023. 51(D1):D1397-D1404. (SCI, IF=14.9)

8. Tianyuan Liu, Bohao Zou, Manman He, Yongfei Hu, Yiying Dou, Tianyu Cui, Puwen Tan, Shaobin Li, Shuan Rao, Yan Huang, Sixi Liu*, Kaican Cai*, Dong Wang*(王栋). LncReader: identification of dual functional long noncoding RNAs using a multi-head self-attention mechanism. Brief Bioinform.2023. 24(1):bbac579. (SCI, IF=9.5, 小类1区)

9. Tianyu Cui, Yiying Dou, Puwen Tan, Zhen Ni, Tianyuan Liu, DuoLin Wang, Yan Huang, Kaican Cai, Xiaoyang Zhao, Dong Xu*, Hao Lin*, Dong Wang*(王栋). RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation. Nucleic Acids Res. 2022. 50(D1):D333-D339. (SCI, IF=14.9)

10. Fang Wang, Puwen Tan, Pengcheng Zhang, Yue Ren, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*(王栋), Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022. 8(1):eabg5369. (SCI, IF=13.6, 小类1区)

11. Juanjuan Kang, Qiang Tang, Jun He, Le Li, Nianling Yang, Shuiyan Yu, Mengyao Wang, Yuchen Zhang, Jiahao Lin, Tianyu Cui, Yongfei Hu, Puwen Tan, Jun Cheng, Hailong Zheng, Dong Wang*(王栋), Xi Su*, Wei Chen*, Yan Huang*. RNAInter v4.0: RNA interactome repository with redefined confidence scoring system and improved accessibility. Nucleic Acids Res. 2022. 50(D1):D326-D332. (SCI, IF=14.9, ESI高被引论文)

12. Jingyuan Tong, Ting Sun, Shihui Ma, Yanhong Zhao, Mankai Ju, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen Loughran, Juan Li, Anthony R. Green, Emery H. Bresnick, Dong Wang*(王栋), Tao Cheng*, Lei Zhang*, Lihong Shi*. Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms. Cell Stem Cell. 2021. 28(3):502-513. (SCI, IF=23.9, 小类1区)

13. Lin Ning, Tianyu Cui, Boyang Zheng, Nuo Wang, Jiaxin Luo, Beilei Yang, Mengze Du, Jun Cheng, Yiying Dou, Dong Wang*(王栋). MNDR v3.0: mammal ncRNA-disease repository with increased coverage and annotation. Nucleic Acids Res. 2021. 49(D1):D160-D164. (SCI, IF=14.9, ESI高被引论文)

14. Yang Zhang, Tianyuan Liu, Jing Wang, Bohao Zou, Le Li, Linhui Yao, Kechen Chen, Lin Ning, Bingyi Wu*, Xiaoyang Zhao*, Dong Wang*(王栋). Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. Bioinformatics. 2021. 37(14):2025-2032. (SCI, IF=5.8)

15. Yang Zhang*, Tianyuan Liu, Xuesong Hu, Mei Wang, Jing Wang, Bohao Zou, Puwen Tan, Tianyu Cui, Yiying Dou, Lin Ning, Yan huang, Shuan Rao, Dong Wang*(王栋), Xiaoyang Zhao*. CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication. Nucleic Acids Res. 2021. 49(15):8520-8534. (SCI, IF=14.9, ESI高被引论文)

16. Xue Wang, Changyun Ping, Puwen Tan, Chenguang Sun, Guang Liu, Tao Liu, Shuchun Yang, Yanmin Si, Lijun Zhao, Yongfei Hu, Yuyan Jia, Xiaoshuang Wang, Meili Zhang, Fang Wang, Dong Wang*(王栋), Jia Yu*, Yanni Ma*and Yue Huang*. hnRNPLL controls pluripotency exit of embryonic stem cells by modulating alternative splicing of Tbx3 and Bptf. EMBO J. 2021. 40(4):e104729. (SCI, IF=11.4, 小类1区)

17. Duolin Wang, Zhaoyue Zhang, Yuexu Jiang, Ziting Mao, Dong Wang*(王栋), Hao Lin*, Dong Xu*. DM3Loc: Multi-label mRNA Subcellular Localization Prediction and Analysis Based on Multi-head Self-attention Mechanism. Nucleic Acids Res. 2021. 49(8):e46. (SCI, IF=14.9, ESI高被引论文)

18. ZhaoYue Zhang, YuHe Yang, Hui Ding, Dong Wang*(王栋), Wei Chen*, Hao Lin*. Design powerful predictor for mRNA subcellular location prediction in Homo sapiens. Brief Bioinform. 2021. 22(1):526-535. (SCI, IF=9.5, 小类1区, ESI高被引论文)

19. Yunqing Lin, Tianyuan Liu, Tianyu Cui, Zhao Wang, Yuncong Zhang, Puwen Tan, Yan Huang, Jia Yu, Dong Wang*(王栋). RNAInter in 2020: RNA interactome repository with increased coverage and annotation. Nucleic Acids Res. 2020. 48(D1):D189-197. (SCI, IF=14.9, ESI高被引论文)

20. Yang Zhang, Tianyuan Liu, Liqun Chen, Jinxurong Yang, Jiayi Yin, Yuncong Zhang, Zhixi Yun, Hao Xu, Lin Ning, Fengbiao Guo, Yongshuai Jiang, Hao Lin, Dong Wang*(王栋), Yan Huang*, Jian Huang*. RIscoper: a tool for RNA-RNA interaction extraction from the literature. Bioinformatics. 2019. 35(17):3199-3202. (SCI, IF=5.8)

21. Tianyu Cui, Lin Zhang, Yan Huang, Ying Yi, Puwen Tan, Yue Zhao, Yongfei Hu, Liyan Xu*, Enmin Li*, Dong Wang*(王栋). MNDR v2.0: an updated resource of ncRNA–disease associations in mammals. Nucleic Acids Res. 2018. 46(D1):D371-D374. (SCI, IF=14.9, ESI高被引论文)

22. Yan Huang, Puwen Tan, Xiaoshuang Wang, Ying Yi, Yongfei Hu*, Dong Wang*(王栋), Fang Wang*. Transcriptomic insights into temporal expression pattern of autophagy genes during monocytic and granulocytic differentiation. Autophagy. 2018. 14(3): 558-559. (SCI, IF=13.3)

23. Ying Yi, Yue Zhao, Chunhua Li, Lin Zhang, Huiying Huang, Yana Li, Lanlan Liu, Ping Hou, Tianyu Cui, Puwen Tan, Yongfei Hu, Ting Zhang, Yan Huang, Xiaobo Li*, Jia Yu*, Dong Wang*(王栋). RAID v2.0: an updated resource of RNA-associated interactions across organisms. Nucleic Acids Res. 2017. 45(D1):D115-D118. (SCI, IF=14.9, ESI高被引论文)

24. Yongfei Hu, Yan Huang, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*(王栋). Single cell RNA sequencing highlights transcription activity of autophagy-related genes during haematopoietic stem cell formation in mouse embryos. Autophagy. 2017. 13(4): 770-771. (SCI, IF=13.3)

25. Hongmei Zhao, Xiaoshuang Wang, Ping Yi, Yanmin Si, Puwen Tan, Jinrong He, Shan Yu, Yue Ren, Yanni Ma, Junwu Zhang, Dong Wang*(王栋), Fang Wang*, Jia Yu*. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nat Commun. 2017. 8(1):1428. (SCI, IF=16.6, 小类1区)

26. Deng Wu, Yan Huang, Juanjuan Kang, Kongning Li, Xiaoman Bi, Ting Zhang, Nana Jin, Yongfei Hu, Puwen Tan, Lu Zhang, Ying Yi, Wenjun Shen, Jian Huang, Xiaobo Li, Xia Li*, Jianzhen Xu*, Dong Wang*(王栋). ncRDeathDB: a comprehensive bioinformatics resource for deciphering network organization of the ncRNA-mediated cell death system. Autophagy. 2015. 11(10): 1917-1926. (SCI, IF=13.3)