主任医师、副教授,医学博士,学术型博士研究生导师。广东省高等学校"青年珠江学者"。近5年内主持国家重点研发计划子课题2项,国家自然科学基金项目2项,广东省自然科学基金项目4项,主持省部级课题经费合计500余万元。近5年以第一作者或通讯作者发表SCI收录论文16篇,参译专著4部,国家发明专利授权3项,获2022年度广东省自然科学奖一等奖。中华医学会骨科学分会创新与转化学组;青委委员中华预防医学会脊柱疾病防控委员会 全国委员;中华医学会结核病分会骨科专业委员会 全国委员;中国康复医学会骨与关节专业委员会脊柱脊髓畸形学组 委员;中国康复医学会枕颈外科与康复学组 委员;中国医疗保健国际交流促进会脊柱医学分会 全国委员;广东省康复医学会脊柱脊髓专业委员会 常务委员;广东省医学会骨科学分会青年委员会 委员 ;广东省医学教育协会脊柱外科专业委员会 常务委员 ;广东省康复医学会颈椎病分会 委员 ;SICOT Active Member 中国部 常务委员;医学参考报骨科频道青年编委会委员;AO Spine(国际脊柱内固定学会) Member
1、神经-内分泌因子参与调控肌腱修复的作用机制研究;
2、退行性脊柱关节病韧带损伤与修复机制研究;
3、联合数字与生物模型的退行性脊柱关节病重点人群疾病预测及治疗评价系统建设
4、特异性和和非特异性脊柱感染分型和治疗策略的相关临床研究。
1. Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma. Dev Cell. 2023 Feb 6;58(3):192-210.e11. doi: 10.1016/j.devcel.2022.12.012. Epub 2023 Jan 24.(中科院分区1区,IF:11.8)
2.Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling. Exp Mol Med. 2022 Sep;54(9):1549-1562. doi: 10.1038/s12276-022-00849-2. Epub 2022 Sep 21. (中科院分区2区,IF:12.153)
3.Revealing the novel autophagy-related genes for ligamentum flavum hypertrophy in patients and mice model. Front Immunol. 2022 Oct 5;13:973799. doi: 10.3389/fimmu.2022.973799. (中科院分区2区,IF:8.786)
4.Identification of SCRG1 as a Potential Therapeutic Target for Human Synovial Inflammation. Front Immunol. 2022 May 26;13:893301. doi: 10.3389/fimmu.2022.893301.(中科院分区2区,IF:8.786)
5.mTORC1 coordinates NF-κB signaling pathway to promote chondrogenic differentiation of tendon cells in heterotopic ossification. Bone. 2022 Oct;163:116507. doi: 10.1016/j.bone.2022.116507. Epub 2022 Jul 29. (中科院分区2区,IF:4.626)
6.Characterization of a Novel Model of Lumbar Ligamentum Flavum Hypertrophy in Bipedal Standing Mice. Orthop Surg. 2021 Dec;13(8):2457-2467. doi: 10.1111/os.13156. Epub 2021 Oct 15.(中科院分区2区,IF:2.071)
7.Melatonin Promotes Heterotopic Ossification Through Regulation of Endothelial-Mesenchymal Transition in Injured Achilles Tendons in Rats. Front Cell Dev Biol. 2021 Feb 11;9:629274. doi: 10.3389/fcell.2021.629274.(中科院分区2区,IF:6.684)
8.miR-10396b-3p inhibits mechanical stress-induced ligamentum flavum hypertrophy by targeting IL-11. FASEB J. 2021 Jun;35(6):e21676. doi: 10.1096/fj.202100169RR. (中科院分区2区,IF:5.191)
9.CRLF1 Is a Key Regulator in the Ligamentum Flavum Hypertrophy. Front Cell Dev Biol. 2020 Sep 18;8:858. doi: 10.3389/fcell.2020.00858.(中科院分区3区,IF:6.684)
10. Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats. Lab Invest. 2020 May;100(5):762-776. doi: 10.1038/s41374-019-0367-x. Epub 2020 Jan 2. (中科院分区2区,IF:5.662)
11.Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats. J Cell Mol Med. 2019 Apr;23(4):2595-2609. doi: 10.1111/jcmm.14150. Epub 2019 Jan 22.(中科院分区2区,IF:5.310)
12.Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice(2014)中科院分区1区,IF=27.4