孙海涛，外科学博士，主任医师、副研究员，博导、博士后合作导师（神经外科学），医院脑科学与脑智能研究院PI、广东省医学检验临床医学研究中心PI。
        主要研究方向为：脑重大疾病（出血性脑血管病、脑肿瘤、脑退行性疾病等）基础与临床转化、临床生物样本资源库标准化建设与转化应用。作为项目负责人承担包括国家自然科学基金（1项）、广东省自然科学基金（3项）、香港医疗卫生研究基金HMRF（1项）等9项科研课题。以第一作者/共一作/通讯作者发表SCI收录文章30余篇，包括Cell Research、Gut、Brain Behavior and Immunity、Cancer Letters、CNS Neuroscience & Therapeutics、Aging and Disease等。曾获“香江学者”、“广州市珠江科技新星”、“广东省100位博士博士后创新人物”等人才荣誉称号；中组部、共青团中央第24批赴赣博士服务团成员。

       学术兼职：主要包括中国神经科学学会神经损伤与修复分会委员、中国医药生物技术协会组织生物样本库分会委员、中国研究型医院学会细胞外囊泡研究与应用专业委员会委员、广东省人类遗传资源保藏应用学会副会长兼副理事长、广东省医学会精准医学与分子诊断学分会常委、广东省精准医学应用学会神经肿瘤分会常委、微生态分会委员、广东省医学会检验医学分会青年委员会副主任委员等；担任Interdisciplinary Medicine、Aging & Disease和Brain-X青年编委；担任南方医科大学研究生学院《临床医学科研思维与方法》-专业型研究生公共选修课程负责人及主讲人；广东省大学生“攀登计划”、“挑战杯” 广东省二等奖指导老师；南方医科大学博雅书院第三届学业导师、南方医科大学临床医学卓越创新班本科生导师等。

1. 重大脑疾病（脑血管病、脑肿瘤、脑退行性疾病等）基础与临床转化研究（新型生物标志物、疾病新机制、干预新靶点）；聚焦肠-脑轴、类器官、细胞外囊泡、组织透明三维成像、多组学、空间转录、人脑资源库等新技术、新方法及新平台：

2. 临床生物样本库的标准化建设与转化应用

1. Haitao Sun# * , Kaijian Sun#, Hao Tian#, Xiheng Chen, Shixing Su, Yi Tu, Shilan Chen, Jiaxuan Wang,
   Meichang Peng, Meiqin Zeng, Xin L, Yunhao Luo, Yugu Xie, Xin Feng, Zhuang Li, Xin Zhang, Xifeng Li, Yanchao Liu, Wei Ye, Zhengrui Chen1, Zhaohua Zhu, Youxiang Li, Fangbo Xia*, Hongwei Zhou*, Chuanzhi Dua*. Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms. Gut. 2024,73(10):1662-1674. (中科院JCR 小类1区, IF: 25.8)
2. Zhang X#*, Li J#, Huang Y, Yang A, Liu X, Luo Y, Tian H, Wen M, Zhong C, Peng B, Sun H*, Zheng L*. Plasma extracellular vesicles from recurrent GBMs carrying LDHA to activate glioblastoma stemness by enhancing glycolysis. Theranostics. 2025,15(8):3655-3672.(中科院JCR 小类1区, IF: 13.3)
3. Xiaodu Yang#, Xinyue Wang#, Dian He#, Feiyang Luo#, Chenyang Li, Yunhao Luo, Ting Li, Zhaoyu Ye, Chun Ye, Minglin Zhang, Hei Ming Lai, Yingying Xu*, Haitao Sun*. Three-Dimensional Visualisation of Blood Vessels in Human Gliomas Using Tissue Clearing and Deep Learning. Neuropathol Appl Neurobiol. 2025. doi: 10.1111/nan.70027.(中科院JCR 小类2区, IF: 3.4)

4. Li T^#, Zhao Z^#, Peng M, Zhang L, Wang C, Luo F, Zeng M, Sun K, Fang Z, Luo Y, Xie Y, Lv C, Wang J, Huang J-D, Zhou H, Sun H*. Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma. mSystems. 2025,10(1):e0045724. (中科院JCR 小类2区, IF: 5.0)

5. Cai X^#, Cai X^#, Xie Q^#, Xiao X, Li T, Zhou T*, Sun H*. NLRP3 inflammasome and gut microbiota-brain axis: a new perspective on white matter injury after intracerebral hemorrhage. Neural Regen Res.2026,21(1):62-80. (中科院JCR 小类2区, IF: 6.7)

6. Wang Y#, Wang Z#, Mao X#, Zhang H, Zhang L, Yang Y, Liu B, Li X, Luo F, Sun H*. Cutting-edge technologies illuminate the neural landscape of cancer: Insights into tumor development. Cancer Lett. 2025,619:217667.(中科院JCR 小类2区, IF: 9.1)

7. Cheng Wang#, Yiqi Fan#, Lu Zhang#, Zhanyi Zhao, Feiyang Luo, Kaijian Sun, Meiqin Zeng, Hao Tian, Meichang Peng, Yunhao Luo, Hailin Zhao, Shuai He*, and Haitao Sun*. Deciphering the contributions of fecal microbiota from patients with high-grade glioma to tumor development in a humanized microbiome mouse model of glioma. Neurooncol Adv. 2025,7(1):vdaf085.(中科院JCR3区, IF: 4.1)

8. Chen S#, Liang J#, Chen D, Huang Q, Sun K, Zhong Y, Lin B, Kong J, Sun J, Gong C, Wang J, Gao Y*, Zhang Q*, Sun H*. Cerebrospinal fluid metabolomic and proteomic characterization of neurologic post-acute sequelae of SARS-CoV-2 infection. Brain Behav Immun. 2024,115:209-222. (中科院JCR 1区, IF: 8.8)
9. Zhang L#, Wang Y#, Cai X#, Mao X, Sun H*. Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential.Journal Of Central Nervous System Disease. 2024 16:11795735241292188.(中科院JCR3区, IF: 4.8)
10. Chen J, Li T, Zhou N, He Y, Zhong J, Ma C, Zeng M, Ji J, Huang JD, Ke Y*, Sun H*. Engineered Salmonella inhibits GPX4 expression and induces ferroptosis to suppress glioma growth in vitro and in vivo. J Neurooncol. 2023 ,163(3):607-622. (中科院JCR小类2区, IF: 4.506)
11. Haitao Sun#, Hei Ming Lai#*, Wutian Wu. Three-dimensional visualization and analysis of dendritic spines in human brain tissue. BioTechniques. 2024, 76(1):37-42.(中科院JCR小类4区, IF: 2.2)
12. Chen S, Cai X, Lao L, Wang Y, Su H*, Sun H*. Brain-Gut-Microbiota Axis in Amyotrophic Lateral Sclerosis: A Historical Overview and Future Directions. Aging Dis. 2024,15(1):74-95. (中科院JCR小类1区, IF: 9.968)
13. Jing Li, Jianhao Liang, Meiqin Zeng, Kaijian Sun, Yunhao Luo, Huaping Zheng, Feng Li, Wen Yuan, Hongwei Zhou, Junshan Liu, Haitao Sun*. Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice. CNS Neuroscience & Therapeutics. 2023, Suppl 1(Suppl 1):18-30. (中科院JCR小类 1区, IF: 7.035)
14. Sun K#, Zhang X#, Li X#, Li X, Su S, Luo Y, Tian H, Zeng M, Wang C, Xie Y, Zhang N, Cao Y, Zhu Z, Ni Q, Liu W, Xia F, He X, Shi Z*, Duan C*, Sun H*. Plasma metabolic signatures for intracranial aneurysm and its rupture identified by pseudotargeted metabolomics. Clin Chim Acta. 2023,538:36-45. (中科院JCR小类 2区, IF: 6.314)
15. Zeng M, Peng M, Liang J, Sun H*.  The Role of Gut Microbiota in Blood-Brain Barrier Disruption after Stroke. Mol Neurobiol. 2023,61(12):9735-9755. (中科院小类JCR 2区, IF: 5.1)
16. Zhou Y, Chen Y, He H, Peng M, Zeng M, Sun H*. The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases. Neuropharmacology. 2023,239:109690. (中科院JCR小类 2区, IF: 4.7)
17. Xiao L^#, Wang M^#, Shi Y^#, Xu Y^#, Gao Y, Zhang W, Wu Y, Deng H, Pan W, Wang W*, Sun H*. Secondary white matter injury mediated by neuroinflammation after intracerebral hemorrhage and promising therapeutic strategies of targeting NLRP3 inflammasome[J]. Current Neuropharmacology.2023, 21(3):669 - 686.(中科院JCR小类 2区, IF: 7.708)
18. Xiao L^#, Zheng H^#, Li J^#, Zeng M, He D, Liang J, Sun K, Luo Y, Li F, Ping B, Yuan W, Zhou H, Wang Q*, Sun H*. Targeting NLRP3 inflammasome modulates gut microbiota, attenuates corticospinal tract injury and ameliorates neurological deficits after intracerebral hemorrhage. Biomedicine & Pharmacotherapy.2022,149:112797. (中科院JCR 小类1区, IF: 7.419)
19. Xinyi Yang, Zhaoyu Ye,Minglin Zhang,Ye Ouyang,Dian He,Xinyue Wang,Hei Ming Lai, Haitao Sun*. Tissue clearing to examine glioma complexity in three dimensions. Journal of Neuropathology & Experimental Neurology. 2023, 82(5):376-389. (中科院JCR小类3区, IF: 3.2)
20. Wenlong Guo, Lei Jin, Jianhao Liang, Guowang Lin, Jiantao Zheng, Dong Zhou, Shengquan Zhan, Haitao Sun*, Xiaodan Jiang*. Detection of mutation profiles and tumor mutation burden of cerebrospinal fluid circulating DNA by a cancer genomic panel sequencing in glioma patients. Clinica Chimica Acta. 2022,534:81-92. (中科院JCR 小类2区, IF: 6.314)
21. Kaijian Sun#,Ying Cao#,Yiting Chen#, Qing Peng,Yugu Xie, Yunhao Luo, Hao Tian, Xin Li, Meiqin Zeng, Xin Zhang, Xifeng Li, Shixing Su, Xuying He, Chuanzhi Duan*, Haitao Sun*. Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms.Frontiers in Neuroscience. 2022, doi:10.3389/fnins.2022.1056785. (中科院JCR小类 3区, IF: 5.152)
22. Ding Z#, Zhong Z#, Wang J#, Zhang R, Shao J, Li Y, Wu G, Tu H, Yuan W, Sun H*, Wang Q*. Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results. J Inflamm Res. 2022,15:5917-5933.  (中科院JCR 2区, IF: 4.631)
23. Jiajia Zhao#, Dian He#, Hei Ming Lai, Yingying Xu, Yunhao Luo, Ting Li, Jianhao Liang, Xiaodu Yang, Linlang Guo, Yiquan Ke, Hongwei Zhou, Wutian Wu*, Hongbo Guo*, Haitao Sun*. Comprehensive histological imaging of native microbiota in human glioma [J]. Journal of Biophotonics. 2021, e202100351. (中科院JCR 2区, IF: 3.207)
24. Jiajia Zhao*, Hei Ming Lai, Yuwei Qi, Dian He, Haitao Sun*. Current status of tissue clearing and the path forward in neuroscience [J]. ACS Chemical Neuroscience.  2021, 12 (1), 5-29. (中科院JCR 2区, IF: 4.486)
25. Xiao L, Zheng H, Li J, Wang Q*, Sun H*. Neuroinflammation mediated by NLRP3 inflammasome after intracerebral hemorrhage and potential therapeutic targets [J]. Molecular Neurobiology. 2020, 57: 5130–5149. (中科院JCR 2区, IF: 5.592)
26. Anson Cho Kiu Ng^#, Min Yao^#, Yin Stephen Cheng, Jing Li, Jiandong Huang, Wutian Wu*, Gilberto Ka Kit Leung*, Haitao Sun*. Protracted morphological changes in the corticospinal tract within the cervical spinal cord after intracerebral hemorrhage in the right striatum of mice [J]. Frontiers in Neuroscience. 2020, 14:506.  (IF: 3.707)
27. Min Yao^#, Haitao Sun^#, Qiuju Yuan, Ning Li, Heng Li, Yinjuan Tang, Gilberto KK Leung*, Wutian Wu*. Targeting proteoglycan receptor PTPσ restores sensory function after spinal cord dorsal root injury by activation of Erks/ CREB signaling pathway [J]. Neuropharmacology, 2019,144:208-218 (中科院JCR 1区, IF: 5.250)
28. Raozhou Lin^#, Zhigang Duan^#, Haitao Sun^#, Man-Lung Fung^#, Hansen Chen, Jing Wang, Chi-Fai Lau, Di Yang, Yu Liu, Yanxiang Ni, Zai Wang, Ju Cui, Wutian Wu, Wing-Ho Yung, Ying-Shing Chan, Amy C. Y. Lo , Jun Xia , Jiangang Shen, Jian-Dong Huang*. Kinesin-1 regulates extrasynaptic targeting of NMDARs and neuronal vulnerability towards excitotoxicity [J]. iScience, 2019,13:82–97. (中科院JCR 2区, IF:5.458)
29. Tian Zhou^#, Yiming Zheng^#*, Li Sun, Smaranda Ruxandra Badea, Yuanhu Jin, Yang Liu, Alyssa J. Rolfe, Haitao Sun, Xi Wang, Zhijian Chen, Zhaoshuai Huang, Na Zhao, Xin Sun, Jinhua Li, Jianqing Fan, Choogon Lee, Timothy L. Megraw, Wutian Wu, Guixue Wang*, Yi Ren*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury [J]. Nature Neuroscience, 2019, 22:421–435. (IF: 21.126)
30. Yang H^#, Wang G^#, Sun H^#, Shu R^#, Liu T, Wang C, Liu Z, Zhao Y, Zhao B, Ouyang Z, Yang D, Huang J, Zhou Y, Li S, Jiang X*, Xiao Z*, Li X*, Lai L*.Species-dependent neuropathology in transgenic SOD1 pigs [J].Cell Res. 2014, 24(4):464–481. (中科院JCR 1区, IF: 12.413)
31. 朱艺琳,刘嘉棋,田昊,孙海涛*. 循环miRNA作为颅内动脉瘤生物标志物的研究进展 [J] . 中华神经医学杂志, 2022, 21(12) : 1269-1275.
32. 贺电,李婷,唐爱伟,孙海涛*.癌症-神经科学的再认识及其在脑胶质瘤研究中的进展[J].中华神经医学杂志,2021,20(10):1050-1053.
33. 贺电,李静,赵佳佳,孙海涛*.组织透明技术在脑重大疾病研究中的应用进展[J].中华神经医学杂志,2020,19(3):296-301.
34. 孙海涛，段传志，田昊，孙凯健，夏方博，周宏伟. 一组肠道菌群衍生代谢物作为颅内动脉瘤破裂风险评估生物标志物的用途，专利（发明专利），专利权人，南方医科大学珠江医院，申请号/专利号：202410845408.2，2024-06-27（已受理）
35. 孙海涛，骆韵豪，李婷. 一种肿瘤组织采样袋（实用新型专利），专利权人，南方医科大学珠江医院，专利号：ZL202020583377.5，2021-04-17
36. 孙海涛，李婷，赵佳佳，贺电，骆韵豪.一种组织透明方法和组织学方法联合用于检测肿瘤内细菌的应用（发明专利），专利权人，南方医科大学珠江医院，申请号/专利号：202110810278.5，2021-08-31（审查通过，公示阶段）
37. 孙海涛，李昕，段传志，孙凯健，王成. 一组颅内动脉瘤相关的血浆代谢标志物及其应用（发明专利），专利权人，南方医科大学珠江医院，申请号/专利号：202210007393.3，2022-01-06（审查通过，公示阶段）
38. 孙海涛、徐莹莹、杨小渡、贺电、骆韵豪、李晨阳、汪新月，基于组织透明的人脑胶质瘤血管分割方法及系统（发明专利），专利权人：南方医科大学珠江医院，申请号/专利号：202410757314X， 2024-06-13（审查通过，公示阶段）