目录
更新日期:2025年10月9日
姓 名 官键 性 别
民 族 汉族 导师层次 博士导师
技术职称 主任医师 导师类型 学术&专业型
最后学历 博士研究生毕业 最后学位 医学博士学位
行政职务 副主任 Email 51643930@qq.com
工作单位 南方医科大学南方医院 邮政编码 510515
个人简介
 南方医院放疗科负责人,党总支部书记,头颈肿瘤亚专科主任
 医学博士,哈佛医学院博士后
 首届国家优秀青年医师
 兼任中华医学会放射肿瘤学分会第十一届委员、中国抗癌协会中西整合鼻咽癌专业委员会常务委员、中国抗癌协会肿瘤放射防护专业委员会委员、中国抗癌协会鼻咽癌整合防筛专业委员会委员、广东省医师协会放射治疗医师分会主任委员暨青年学组组长、广东省医学会放射肿瘤学分会副主任委员、广东省抗癌协会鼻咽癌专业委员会常委、广东省科协委员等。
 从事肿瘤放疗工作20余年。临床方向是头颈肿瘤放射治疗,研究方向是肿瘤放疗抵抗与肿瘤微环境的分子机制,肿瘤大数据挖掘与生物信息学分析,肿瘤多模态组学研究。
 近5年以第一或通讯作者发表论文30余篇,临床方向是头颈肿瘤放疗为基础的综合治疗,科研方向是肿瘤放射防护和放疗抵抗的基础与临床研究。通讯作者的代表作包括Cancer Cell. (2025, IF 48.8), J Hepatol. (2022, IF 30.083),Adv Sci. (2024, IF 15.1),Clin Cancer Res.(2024, IF 11.5), J Exp Clin Cancer Res. (2021, IF 12.658),J Nanobiotechnol. (2024,IF 10.2),Clin Transl Med. (2021/2024, IF 10.6),J Pathol. (2023, IF 9.883),Radiother Oncol. (2021, IF 5.7),Br J Cancer (2019, IF 8.8) 等。
 承担科技部重点项目子课题1项,国家自然科学基金2项,省级课题5项,申报(含授权)国家发明专利8项,牵头执笔国内专家共识3项。获得软著版权1项。2008年牵头完成广东省放射肿瘤学专业精品课程。指导4项国家级大学生创新创业训练计划项目。指导学生33人,其中5人次获国家奖学金,5人次获一等学业奖学金,3人次获优秀研究生,2人次获优秀毕业生。
 荣获中国生物与物理学会 2023 年度中国女科学家奖、第 16 届 2023 年度国际肿瘤学和癌症研究“最佳研究者奖 ”、广东省“千百十”人才工程第四梯队成员、羊城好医生、广东省最具实力中青年医师、人民好医生(鼻咽癌领域)优秀典范专家(2022年)等荣誉称号;先后荣获广东省科技进步一等奖、二等奖及军队医疗成果二等奖各1项,总后勤部及中华医学会优秀卫生电视教材一等奖各1项,南方健康科普彩虹奖(视频类)二等奖、第十七届广东省科普作品创作大赛二等奖各1项。

 

研究领域
辐射损伤和肿瘤放疗抵抗的分子机制,肿瘤大数据挖掘与生物信息学分析,肿瘤多模态组学研究。
个人成果

科研课题:

 1.2023年国家科技重大专项“放射性口腔黏膜炎的中医药防治体系研究”(项目编号:2023ZD0503005,2024年8月-2028年7月,582万元,在研)

 2.2023年国家自然科学基金面上项目“COMMD10低表达诱导肝星状细胞铜代谢重编程促进肝癌放疗抵抗的分子机 制研究”(项目编号82272729,2023年1月-2026年12月,52万元,在研)

 3.2024年广东省自然科学基金面上项目“铜离子通过MTF1调控巨噬细胞脂代谢重编程促进M2型极化在肝癌放疗抵抗的机制探索”(项目编号:2024A1515010280,2024年1月-2026年12月,15万元,主持,在研)

 4.2018年南方医院临床研究专项“寡转移鼻咽癌患者放化疗后卡瑞利珠单抗维持治疗的II期临床研究”(项目编号2018CR021,2019年1月-2023年5月,56万元,在研)

 5.2019年南方医科大学临床研究启动计划“调强放疗联合顺铂或卡铂放化疗对局部晚期鼻咽癌疗效对比的Ⅲ期临床研究”(项目编号LC2019ZD008,2019年6月-2024年6月,60万元,在研)

 6.2020年南方医院临床研究专项“调强放疗联合顺铂或卡铂放化疗对局部晚期鼻咽癌疗效对比的Ⅲ期临床研究”(项目编号2020CR025,2020年12月-2025年11月,24万元,在研)

 7.2022年广东省自然科学基金面上项目“肝癌细胞中铜代谢相关蛋白COMMD10调控肝星状细胞活性在放射敏感性的机制研究”(项目编号2022A1515010509,2022年1月-2024年12月,10万元,已结题)

 8.2018年广州市科技计划“鼻咽癌综合防治研究”(纵向参与)(项目编号201803040003,2018年4月1日-2021年3月31日,10万元,已结题)

 9.2017年广东省自然科学基金“COMMD10调控肝癌放射敏感性的分子机制研究”(项目编号2017A030313486,2017年5月-2020年5月,10万元,已结题)

 10.2016年国家自然科学基金青年科学基金项目“COMMD10通过HIF-1介导的信号通路调控肝癌放射敏感性的机制研究”(项目编号81602685,2017年1月-2019年12月,17万元,已结题)

近 5 年的学术论文:

1.Yan-Pei Zhang 1, Ze-Qin Guo 1, Xiao-Ting Cai 1, Zi-Xuan Rong 1, Yuan Fang 1, Jia-Qi Chen 1, Kui-Mao Zhuang 1, Min-Jie Ruan 1, Si-Cong Ma 1, Le-Yi Lin 1, Duan-Duan Han 1, Yang-Si Li 2, Yuan-Yuan Wang 3, Jian Wang 1, Chuan-Hui Cao 1, Xin-Ran Tang 1, Qian-Kun Xie 1, Yue Chen 1, Yan Lin 1, Jia-Le Tan 1, Zi-Hang Yu 1, Ze-Nan Wu 1, Wei Wei 4, Da-Yong Zheng 5, Yu-Jie Zeng 6, Ying-Chen Ruan 1, Zi-Peng Xu 1, Jun-Zi Gu 1, Lu-Shan Xiao 7, Li Liu 8, Jian Guan 9, Xue Bai 10, De-Hua Wu 11, Zhong-Yi Dong 12.PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.CancerCell.2025Mar12:S1535-6108(25)00076-5.doi:10.1016/j.ccell.2025.02.024.(共同通讯作者,IF: 44.5

2.Mi Yang# , Xixi Wu#, Jinlong Hu#, Yingqiao Wang, Yin Wang, Longshan Zhang, Weiqiang Huang, Xiaoqing Wang, Nan Li, Liwei Liao,Min Chen, Nanjie Xiao, Yongmei Dai, Huazhen Liang, Wenqi Huang, Lu Yuan, Hua Pan, Lu Li, Longhua Chen, Laiyu Liu*, Li Liang*, Jian Guan*. COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma. J Hepatol. 2022 May;76(5):1138-1150. (通讯作者,IF: 25.7

3. Zhenhua Zhou#, Tingxi Tang#, Nan Li#, Qiaocong Zheng, Ting Xiao, Yunmin Tian, Jianda Sun, Longshan Zhang, Xiaoqing Wang, Yingqiao Wang, Feng Ye, Zekai Chen, Hanbing Zhang, Xiuting Zheng, Zhen Cai*, Laiyu Liu*, Jian Guan*. VLDL and LDL Subfractions Enhance the Risk Stratification of Individuals Who Underwent Epstein-Barr Virus-Based Screening for Nasopharyngeal Carcinoma: A Multicenter Cohort Study. Advanced Science, 2024 Mar 23:e2308765. (通讯作者,IF:14.3)

4.Weiqiang Huang#, Longshan Zhang#, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu*, Jian Guan*. Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-kappa B pathway, Journal of Experimental & Clinical Cancer Research. 2021 Mar 1;40(1):87.(通讯作者,IF:12.658)

5.Qianping Chen#, Wang Zheng#, Jian Guan#, Hongxia Liu, Yao Dan, Lin Zhu , Yimeng Song, Yuchuan Zhou, Xinrui Zhao, Yuhong Zhang, Yang Bai, Yan Pan*, Jianghong Zhang*, Chunlin Shao*. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death Differ. 2023 Jan;30(1):137-151.  (共同一作,IF: 12.4

6.Tingxi Tang 1, Zhenhua Zhou 1, Min Chen 2, Nan Li 1, Jianda Sun 1, Zekai Chen 1, Ting Xiao 1, Xiaoqing Wang 2, Longshan Zhang 2, Yingqiao Wang 1, Hanbin Zhang 1, Xiuting Zheng 1, Bei Chen 3, Feng Ye 1, Jian Guan 1.Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial.Clin Cancer Res. 2024 Jul 15;30(14):2925-2936.(通讯作者,IF: 10.4

7.Xiaoqing Wang#, Longshan Zhang#, Liwei Liao#, Nan Li, Tingxi Tang, Jianda Sun, Zhenhua Zhou, Yang Liu, Jihong Huang, Yingqiao Wang, Zekai Chen, Hanbin Zhang, Ting Xiao, Yunming Tian, Xiuting Zheng, Yi Yuan, Linlin Xiao, Laiyu Liu*,Jian Guan*. SAA1 and metabolomic signatures predicts hyperprogression with immunotherapy in pan cancers.Clin Transl Med 2024. 2024 Mar;14(3):e1624. (通讯作者,IF:7.9)

8.Nan Li#, Jingnan Huang#, Shangwen He#, Qiaocong Zheng#, Feng Ye#, Zhengxing Qin, Dong Wang, Ting Xiao, Mengyuan Mao, Zhenhua Zhou, Tingxi Tang, Longshan Zhang, Xiaoqing Wang, Yingqiao Wang, Ying Lyu, Laiyu Liu*, Lingyun Dai*, Jigang Wang* , Jian Guan*. The development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling.Journal of Nanobiotechnology, 2024 Apr 10;22(1):164.(通讯作者,IF: 10.6)

9.Chen Q#, Zheng W#, Zhu L, Liu H, Song Y, Hu S, Bai Y, Pan Y, Zhang J*Jian Guan*, Shao C*. LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.Cancer Lett. 2021 Oct 10;518:127-139.(并列通讯作者,IF:9.756

10.Wang Y, Zeng W, Liang H, Wu X, Li H, Chen T, Yang M, Wang X, Li W, Zhang F, Li Q, Ye F, Jian Guan*, Mei L*. Targeted Wolfram-Doped Polypyrrole for Photonic Hyperthermia-Synergized Radiotherapy. ACS Applied Materials & Interfaces,2022 Nov 02(共同通讯,IF: 9.5

11.Xue-Jun Guo # 1, Xiao-Ting Cai # 1, Zi-Xuan Rong # , Yan-Pei Zhang # , Yu-Xiang Wen, Xue Bai, Jian Wang, Qiang John Fu, Ze-Qin Guo, Li-Li Long, Si-Cong Ma, Xin-Ran Tang, Li Liu, Jian Guan, Zhong-Yi Dong, De-Hua Wu. Interstitial pneumonitis associated with combined regimen of immunotherapy and conventional therapies-pharmacovigilance database analysis with real-world data validation. BMC Med. 2023 Jan 5;21(1):6(共同通讯,IF: 9.3

12.Ting Liu # 1 2 3, Di Dong # 4 5, Xun Zhao # 4 5, Xiao-Min Ou # 6 7, Jun-Lin Yi # 8, Jian Guan # 9, Ye Zhang 8, Lv Xiao-Fei 1 10, Chuan-Miao Xie 1 10, Dong-Hua Luo 1 2, Rui Sun 1 2, Qiu-Yan Chen 1 2, Lv Xing 1 2, Shan-Shan Guo 1 2, Li-Ting Liu 1 2, Da-Feng Lin 1 2, Yan-Zhou Chen 1 2, Jie-Yi Lin 1 2, Mei-Juan Luo 1 2, Wen-Bin Yan 6 7, Mei-Lin He 8, Meng-Yuan Mao 9, Man-Yi Zhu 1 2, Wen-Hui Chen 11, Bo-Wen Shen 12, Shi-Qian Wang 12, Hai-Lin Li 4 5, Lian-Zhen Zhong 4 5, Chao-Su Hu 6 7, De-Hua Wu 9, Hai-Qiang Mai 13 14, Jie Tian 15 16, Lin-Quan Tang 17 18. Radiomic signatures reveal multiscale intratumor heterogeneity associated with tissue tolerance and survival in re-irradiated nasopharyngeal carcinoma: a multicenter study. BMC Med. 2023 Nov 27;21(1):464. (共同一作,IF:9.3

13.Yang M#, Wu X#, Li L#, Li S, Li N, Mao M, Pan S, Du R, Wang X, Chen M, Xiao N, Zhu X, He G, Zhang L, Huang W, Pan H, Deng L, Chen L*, Liang L*Jian Guan*. COMMD10 inhibits tumor progression and induces apoptosis by blocking NF-kappa B signal and values up BCLC staging in predicting overall survival in hepatocellular carcinoma.Clin Transl Med 2021 May;11(5):e403.(通讯作者,IF :8.554

14.Cui Y, Wu X, Lin C, Zhang X, Ye L, Ren L, Chen M, Yang M, Li Y, Li M, Li J*Guan J*, Song L*. AKIP1 promotes early recurrence of hepatocellular carcinoma through activating the Wnt/beta-catenin/CBP signaling pathway. Oncogene, 2019 Jul;38(27):5516-5529.(并列通讯作者IF:7.971

15.Xiaoqing Wang# , Yue Li# , Yunyun Xiao# , Xinjian Huang# , Xianqiu Wu, Zhen Zhao,  Muwen Yang, Lingzhi Kong, Dongni Shi, Xin Chen, Ying Ouyang, Xiangfu Chen, Chuyong Lin, Jun Li, Libing Song*, Ye Lin*, Jian Guan*. The phospholipid flippase ATP9A enhances macropinocytosis to promote nutrient starvation tolerance in hepatocellular carcinoma. J Pathol. 2023 May;260(1):17-31.  (通讯作者,IF: 7.3)

16.Huang J, Yuan L, Huang W, Liao L, Zhu X, Wang X, Li J, Liang W, Wu Y, Liu X, Yu D, Zheng Y, Guan J*, Zhan Y, Liu L. LATPS, a novel prognostic signature based on tumor microenvironment of lung adenocarcinoma to better predict survival and immunotherapy response.Front Immunol 2022 Nov 24;13:1064874. (共同通讯,IF: 7.3

17.Fan WJ#, Teng F#, Liu G#, Zhao DW, Li JF, Luo YR, Zhang XX*, Ma L*Jian Guan*. Diffusion weighted imaging in submandibular gland sparing helical tomotherapy for nasopharyngeal carcinoma. Radiother Oncol 2021 04;157(通讯作者,IF:6.901

18.Guan J#, Clermont AC#, Pham LD, Ustunkaya T, Revenko AS, MacLeod AR, Feener EP, Simão F*. Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats. Transl Stroke Res 2022 Apr;13(2):287-299.(第一作者,IF: 6.9

19.Chen Q#, Zheng W#, Zhu L, Yao D, Wang C, Song Y, Hu S, Liu H, Bai Y, Pan Y, Zhang J, Guan J*, Shao C*. ANXA6 Contributes to Radioresistance by Promoting Autophagy via Inhibiting the PI3K/AKT/mTOR Signaling Pathway in Nasopharyngeal Carcinoma. Front Cell Dev Biol. 2020 Apr 16;8:232. (并列通讯作者,IF:6.684

20.Hua Pan#, Wang Xiao Qing#, Weiqiang Huang#, Yong Mei Dai, Mi Yang, Luazhen Liang, Xixi Wu, Longshan Zhang, Wenqi Huang, Lu Yuan, Yuting Wu, Yin Wang, Liwei Liao, Jihong Huang, Guan J*. Interferon-induced protein 44 correlated with immune infiltration serves as a potential prognostic indicator in head and neck squamous cell carcinoma.Frontiers in Oncology, 2020 Oct 6;10:557157. (通讯作者,IF:6.244)

21.Longshan Zhang,Yao Fan, Xiaoqing Wang,Mi Yang, XiXi Wu. Weiqiang Huang, Jin Lan, Liwei Liao, Wenqi Huang, Lu Yuan, Hua Pan, Yuting Wu, Longhua Chen*Guan J*. Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors. Front Oncol.2020 Oct 15;10:554331.(通讯作者IF:6.244)

22.Zhu L, Chen Q, Zhang L, Hu S, Zheng W, Wang C, Bai Y, Pan Y, Konishi T, Guan J*, Shao C*. CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after gamma-rays but not carbon ions irradiation. AM J CANCER RES. 2020 May 1;10(5):1400-1415. (并列通讯作者,IF:6.166

23.Xiao H#, Fan Y#, Li Y, Dong J, Zhang S, Wang B, Liu J, Liu X, Fan S, Jian Guan*, Cui M*. Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice. Computational and Structural Biotechnology Journal. 2021 Oct 25;19:5898-5910. (并列通讯作者,IF:6.155

24.Chen M#, Huang W#, Yang D#, Huang J, Li G, Wang X, Xiao N, Zhang W, Jian Guan*, Wang S*, Liu L*. ΔCT Value of Amplified Refractory Mutation System Predicts Efficacy of EGFR-TKIs in Advanced Non-Small-Cell Lung Cancer  A Multi-Center Retrospective Study. Front Mol Biosci. 2021 Oct 8;8:684661.(并列通讯作者,IF:6.113

25.FanY#,ZhangL#,SunY#,YangM, WangX, WuX, HuangW, ChenL*, PanS*,Guan J*. Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.Cancer Gene Ther.2020Apr;27(3-4):216-225.(通讯作者IF:5.987)

26.Yang SS,Li XM,Yang M,Ren XL,Hu JL,Zhu XH,Wang FF,Zeng ZC,Li JY,Cheng AQ,Ding YQ, Guan J*, Liang L*. FMNL2 destabilizes COMMD10 to activate NF-KB pathway in invasion and metastasis of colorectal cancer.Br J Cancer.2017 Oct 10;117(8):1164-1175.(并列通讯作者,IF:5.922

27.Yuan L#, Wu X#, Zhang L#, Yang M, Wang X, Huang W, Pan H, Wu Y, Huang J, Liang W, Li J, Zhu X, Wang S*Jian Guan*, Liu L*. SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma.Cancer Immunol Immunother. 2022 Feb;71(2):399-415.(并列通讯作者,IF:5.8

28.Yang M, Huang W, Sun Y, Liang H, Chen M, Wu X, Wang X, Zhang L, Cheng X, Fan Y, Pan H, Chen L*, Guan J*.Prognosis and modulation mechanisms of COMMD6 in human tumours based on expression profiling and comprehensive bioinformatics analysis.Br J Cancer,2019Oct;121(8):699-709.(通讯作者IF:5.791

29.LiaoL#,ZhangL#,YangM,WangX,HuangW,WuX,PanH,YuanL,HuangW,WuY,Guan J*. Expression profile of SYNE3 and bioinformatic analysis of its prognostic value and functions in tumors.J Transl Med.2020 Sep 18;18(1):355.(通讯作者,IF:5.531)

30.Bingyao Meng 1, Minna Xu 2, Zihan Chen 2, Jia You 3, Rui Zhou 4, Jian Guan 5, Liang Zhou 6. SIRT7 sustains tumor development and radioresistance by repressing endoplasmic reticulum stress-induced apoptosis in cutaneous melanoma.Cell Signal.2024 Jan 18:116:111058. (共同通讯作者,IF:4.8

31.Wu X, Wang Y, Yang M, Wang Y, Wang X, Zhang L, Liao L, Li N, Mao M, Guan J*, Ye F. Exploring prognostic value and regulation network of PPP1R1A in hepatocellular carcinoma based on integrated bioinformatic analysis and expression profiling.Hum Cell  2022 Nov;35(6):1856-1868 (共同通讯,IF: 4.3

32.Shujun Liang, Xiuyu Dong, Kaifan Yang, Zhiqin Chu, Fan Tang, Feng Ye, Bei Chen, Jian Guan and Yu Zhang. A multi-perspective information aggregation network for automated T-staging detection of nasopharyngeal carcinoma.Phys Med Biol. 2022 Dec 9;67(24).(共同通讯,IF: 3.5

33.DaiY,ZhangY,YangM,ZhouL,PanH,XiaoT, YuanL, WuY,ChenM,ChenL,Guan J*. Radiosensitivity-Related Genes and Clinical Characteristics of Nasopharyngeal Carcinoma.Biomed Res Int. 2020 Nov 22;2020:1705867. (通讯作者,IF:3.411)

34.Ze-Kai Chen 1, Xiao-Qing Wang 1, Lin-Lin Xiao 1, Jian-Da Sun 2, Meng-Yuan Mao 1, Han-Bin Zhang 1, Jian Guan 3. Construction and application of nasopharyngeal carcinoma-specific big data platform based on electronic health records. Am J Otolaryngol.2023 Dec 19;45(3):104204. doi: 10.1016/j.amjoto.2023.104204.(通讯作者,IF: 2.5)

35.Weiqiang Huang, Yao Fan, Xiaoya Cheng, Huazhen Liang, Hua Pan, Ting Xiao, Min Chen*Guan J*. A preliminary Study on the Effect of Head and Neck Chemoradiotherapy on Systematic Immunity. Dose-Response.2019 Oct 28;17(4):1559325819884186. (通讯作者IF:2.438

36.GuanJ#,XiaoN#,QiuC,LiQ,ChenM,ZhangY,DaiY,LiL,ZhangY, YangM, ChenL*, LiuLY*. Fibrinogen is associated with EGFR mutation status and lymphatic metastasis in non-small cell lung cancer. Oncol Lett. 2019 Jan;17(1):739-746.(第一作者,IF:2.311

37.廖力为,张珑山,席菁乐*,官键* . 免疫检查点抑制剂所致肿瘤超进展的研究现状. 广东医学. 2022 43(7):849-854(通讯作者)

38.王映翘,杨密,王茵,刘来昱,官键* . 铜及铜相关蛋白在肿瘤中的研究进展. 肿瘤代谢与营养电子杂志,2022, 9(2): 265-270.(通讯作者) 

39.王茵,吴茜茜,刘来昱,官键* .肿瘤相关巨噬细胞在放疗中的研究进展. 国际放射医学核医学杂志,2021,45(8) : 532-538.(通讯作者)