闫文娟，口腔医学博士，主任医师，学术型博导，博士后合作导师，美国贝勒牙学院访问学者。现任南方医科大学南方医院口腔科主任，南方医院口腔临床学院教学主任。担任中国医师协会口腔医师分会委员，中华口腔医学会老年口腔专委会常委，中华口腔医学会牙体牙髓病学专委会委员，广东省医学教育协会口腔美学专委会主委，广东省口腔医学会牙体牙髓病学、老年口腔专委会副主任委员，研究方向：衰老相关疾病的机制研究、骨及牙髓再生修复研究；牙体缺损的椅旁CAD/CAM数字化修复临床研究。主持国家自然科学基金 3 项，广东省自然 2 项，广州市重点研发计划 1 项，临床研究 4 项；发表 SCI 文章 50 余篇，擅长疑难根管的诊断及显微治疗，椅旁CAD/CAM的数字化修复，前牙美学修复。

衰老相关疾病的机制研究；骨及牙髓再生修复研究；大面积牙体缺损的椅旁数字化修复临床研究。

主持项目：

1.国家自然科学基金面上项目 (NO.82571819): 2026.01-2029.12，49万，在研，主持

2.广东省自然科学基金面上项目（No,2026A1515010831）：2026.01-2028.12，10万，在研，主持

3.广州市科技计划重点研发计划（ No. 2025B03J0161）：2025.11-2028.10，50 万 在研，主持

4.中国高校产学研创新基金1项（No. 2024GR083）：2024.10-2026.11，10万，在研，主持

5.南方医科大学临床研究重点项目（No.LC2024NF008）：2025.1-2029.12 80万，在研，主持

6.国家自然科学基金面上项目（No.82171573): 2022.01-2025.12，55万，已结题，主持

近期以通讯作者发表文章 25 余篇，单篇最高IF 23.6:

1. Xiao, P, Zheng, Z, Zeng, Y, Lin, X, Mo, J, Chen, L, Wang, J, Wu, Y, Tong, Z^*, Yan, W^*. Multicenter RCT 6-Year Survival of Zirconia-Reinforced Lithium Silicate Endocrowns: 90° Shoulder Versus Butt-Joint Margins [J]. Int Endod J, 2026.（IF=6.4）
2. Deng Q, Zhang Y, Zeng Y, Luo X, Xiao P, Ding X, Qiu S, Li Q, Chen J, Yang D, Yan W^*. Reactive oxygen species-scavenging nanozymes for radioprotection of healthy tissues. Materials & Design. 2025;260:115232.（IF=8.2）
3. Chen, J, Zhang, Y, Luo, X, Zeng, Y, Xiao, P, Ding, X, Qiu, S, Li, Q, Deng, Q, Wang, S, Lin, R, Chen, X, Yang, D^*, Yan, W^*. Nanotherapies based on bacterial metabolism: Mechanisms, design and application. Mater Today Bio.2025-10-01; 34 102117.（IF=11）  
4. Wang S, Zhang Y, Zeng Y, Luo X, Chen J, Deng Q, Xiao P, Lin R, Chen X, Ding X, Li Q, Qiu S, Yang D*, Yan W*. Plant-derived vesicle-like nanoparticles for immunomodulation: Mechanisms and applications. Bioact Mater. 2025 Sep 19;55: 171-204.（IF=23.6）
5. Xian Ding, Yuxin Zhang, Yuting Zeng, Qianlin Li, Sijie Qiu, Ping Xiao, Xin Luo, Jiaping Chen, Qianwen Deng, Dehong Yang, Yanli Zhang^*, Wenjuan Yan^*.MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14. Angiogenesis.2025.（IF=11.2）
6. Ziting Zheng, Wenhui Li, Xiaoyan Yan, Wei Zhong, Yuting Zeng, Ping Xiao, Jiayao Mo, Wenjuan Yan^*. Biomechanical influence of residual lateral wall thickness and resin reinforcement on the performance of endocrowns in premolars. Dental Materials.2025 Aug 19: S0109-5641(25)00739-0.（IF=6.3）
7. Xin Luo; Yanli Zhang; Yuting Zeng; Dehong Yang; Zhiyan Zhou; Ziting Zheng; Ping Xiao; Xian Ding;Qianlin Li;Jiaping Chen; Qianwen Deng; Xincen Zhong; Sijie Qiu; Wenjuan Yan^*; Nanotherapie Based on ROS Regulation in Oral Diseases, Advanced Science, 2025, 22(11)39887942（IF=14.1）
8. Zhou Z, Zhang Y, Zeng Y, Yang D, Mo J, Zheng Z, Wang J, Zhang Y, Zhou Z, Zhong X,Yan W^*. Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix. ACS Nano, 2024,18(11):7688-7710.（IF=17.3）
9. Zhou C, Cai Z, Guo J, Li C, Qin C, Yan W^*, Yang D^*. Injective hydrogel loaded with liposomes-encapsulated MY-1 promotes wound healing and increases tensile strength by accelerating fibroblast migration via the PI3K/AKT-Rac1 signaling pathway. J Nanobiotechnology. 2024 Jul 5;22(1):396.（IF=15）
10. Li W, Zheng Z, Zeng Y, Zhou Z, Xiao P, Zhong X, Yan W^*. Chinese dentists’ restorative preferences and choices for endodontically treated teeth: a representative survey. BMC Oral Health. 2024; 24:1489.（IF=3.8）
11. Zhang Y, Mo J, Zheng C, Zeng Y, Zhou Z, Zhang Y, Li M, Shao L^*, Yang D^*, Yan W^*.MY-1 Loaded Nano-hydroxyapatite Accelerated Bone Regeneration by Increasing Type Ⅲ Collagen Deposition in Early-stage ECM via a Hsp47 Dependent Mechanism[J].Advanced Healthcare Materials. 2023, e2300332.（IF=11）
12. Ping Xiao, Ziting Zheng, et al, Yan W^*. Accuracy and adaptation of one-piece endodontic crowns fabricated through 3D printing and milling, The Journal of Prosthetic Dentistry. 2024; S0022-3913(24)00363-9.（IF=5.6）
13. He J, Sun J, Liu Y, Luo W, Zheng Z, Yan W^*. Optimizing restorative procedure and material selection for pulpotomized primary molars: Mechanical characterization by 3D finite element analysis. Heliyon. 2024 Jul 30;10(15): e35402.
14. Xiao P, Zhang Y, Zeng Y, Yang D, Mo J, Zheng Z, Wang J,Zhang Y,Zhou Z,Zhong X, Yan W^*. Impaired angiogenesis in ageing: the central role of the extracellular matrix. J Transl Med. 2023 Jul 11;21(1):457.（IF=9.7）
15. Zhou C, Guan D, Guo J, Niu S, Cai Z, Li C, Qin C, Yan W^*, Yang D^*. Human Parathyroid Hormone Analog (3-34/29-34) promotes wound re-epithelialization through inducing keratinocyte migration and epithelial-mesenchymal transition via PTHR1-PI3K/AKT activation. Cell Commun Signal. 2023 Aug 23;21(1):217.（IF=11.6）
16. Zheng Z, Wang H, Mo J, Yan W^*. Effect of virtual cement space and restorative materials on the adaptation of CAD-CAM endocrowns. BMC Oral Health. 2022(1):580.（IF=3.8）
17. Ruan W, Zheng Z, Jiang L, He J, Sun J, Yan W^*. Optimal cuspal coverage of ceramic restorations using CAD/CAM: Biomechanical characteristic analysis by 3D finite element analysis and in vitro investigation. Int J Comput Dent. 2022;24(1)545-547
18. Zheng Z, Sun J, Jiang L, Wu Y, He J, Ruan W, Yan W^*. Influence of margin design and restorative material on the stress distribution of endocrowns: a 3D finite element analysis. BMC Oral Health. 2022 Feb 5;22(1):30.（IF=3.8）
19. He J, Zheng Z, Wu M, Zheng C, Zeng Y, Yan W^*. Influence of restorative material and cement on the stress distribution of endocrowns: 3D finite element analysis. BMC Oral Health. 2021;21(1):495.（IF=3.8）
20. Zeng Y, Pan Y, Mo J,Ling Z, Jiang L,Xiong Fu^*, Yan W^*. A Novel COL1A1 Missense Mutation Associated With Dentineogenesis Imperfecta Type I. Frontiers in Genetics.2021.699278.
21. Deng Z^#1, Yan W^#1, Dai X, Chen M, Qu Q,Wu B,Zhao W. N-Cadherin Regulates the Odontogenic Differentiation of Dental Pulp Stem Cells via β-Catenin Activity. Front Cell Dev Biol. 2021 30;
22. Zhiting Ling, Ziting Zheng , Yuting Zeng，Lifang Jiang, Yuan Wu, Buling Wu* and Yan W^*. Effect of thermosolvation versus ultrosonic removement of root-end gutta-percha on the quality of root-end preparation for endodontic microsurgery.Scanning. 2021:8320234.34405033
23. Zheng Z, Yan W^* et al. Biomechanical behavior of endocrown restorations with different CAD/CAM materials: 3D Finite Element and In Vitro Analysis. The Journal of Prosthetic Dentistry. 2020; 20:480-485.
24. Wang J, Ling Z, Zheng Z, Zheng C, Gai Y, Zeng Y, Zhu X, Chen L, Wu B, Yan W^*. Clinical efficacy of ceramic versus resin-based composite endocrowns in Chinese adults: study protocol for a randomized controlled trial. Trials. 2020 Jun 22;21(1):559.
25. He Y, Li M, Tong G, Meng Y, Hao S, Hu S, Yan W^*, Yang D^*. hPTH(3-34)(29-34) selectively activated PKC and mimicked osteoanabolic effects of hPTH(1-34). Bone, 2020, 115326.
26. Sun J, Yan W^* et al. Clinical efficacy of different marginal forms of endocrowns: study protocol for a randomized controlled trial. Trials. 2019;20:454.